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Kurniasih, Khamdiyah Indah
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Evaluasi Fisik Facial Wash Ekstrak Daun Sirsak (Annona Muricata L.) Berbasis Gelling Agent Ulinnuha, Alvin; Fauziah, Fauziah; Kurniasih, Khamdiyah Indah; Nawangsari, Desy; Prabandari, Rani
Pharmacogenius Journal Vol 3 No 3 (2024): Pharmacy Genius
Publisher : Yayasan Inspirasi El Burhani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/pharmgen.v3i03.396

Abstract

Pendahuluan: Perbedaan jenis Gelling Agent dapat memengaruhi sifat fisik dari sediaan dikarenakan perbedaan sifat fisika kimianya. Konsentrasi Gelling Agent yang tidak sesuai standar seperti pemakaian dengan konsentrasi tinggi atau bobot molekul besar dapat menghasilkan sediaan gel yang sulit dikeluarkan pada kemasan. Tujuan: Tujuan penelitian ini adalah untuk mengetahui sifat fisik, iritasi primer, dan hedonik sediaan gel Facial Wash ekstrak daun sirsak dengan variasi Gelling Agent Na-CMC, HPMC, Carbopol 940. Metode: Metode pada penelitian ini menggunakan metode eksperimental laboratorium dengan 3 formula dimana formula 1 menggunakan basis Na-CMC, formula 2 menggunakan basis HPMC, dan formula 3 menggunakaan basis Carbopol 940. Hasil: Hasil uji sifat fisik sediaan menunjukkan semua formula memenuhi rentang persyaratan sifat fisik gel yang baik. Hasil uji iritasi diketahui bahwa semua formula tidak menimbulkan edema dan eritema pada hewan uji dan mendapatkan skor indeks iritasi primer sebesar 0,0. Hasil uji hedonik didapatkan hasil formula 3 menempati ranking pertama paling disukai kemudian formula 1 pada ranking 2 dan formula 2 pada ranking terakhir. Hasil pengujian statistik sifat fisik semua parameter menunjukan signifikansi < 0,05 yang artinya terdapat perbedaan signifikan antara F1, F2, F3 kecuali parameter tinggi busa dan persen daya busa menunjukan tidak ada perbedaan sinifikan antara F1, F2, F3 dengan signifikansi > 0,05. Kesimpulan: Kesimpulan pada penelitian ini adalah semua formula memiliki sifat fisik yang baik, tidak menimbulkan iritasi dan memiliki hasil kesukaan yang berbeda beda.
FORMULASI SEDIAAN ORALLY DISINTEGRATING TABLET (ODT) ASPIRIN DENGAN SODIUM STARCH GLYCOLATE SEBAGAI SUPERDISINTEGRANT Putri, Arine Astika; Nawangsari, Desy; Kurniasih, Khamdiyah Indah
Pena Medika : Jurnal Kesehatan Vol. 14 No. 1 (2024): PENA MEDIKA: JURNAL KESEHATAN
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/pmjk.v14i1.3713

Abstract

Aspirin adalah NSAID salisilat yang digunakan sebagaiagen antiplatelet dalam pengobatan stroke. Kematianakibat stroke dalam waktu 5 tahun, lebih dari separuhpasien stroke berusia dangt; Seorang berusia 45 tahunyang meninggal. Banyak pasien lanjut usia yang tidak maumenerima/mengonsumsi tablet karena takut tersedak ataukesulitan menelan. Tablet yang hancur secara oral (ODT) adalah sediaan yang lebih cepat hancur, hancur dalamwaktu kurang dari 60 detik bila dimasukkan ke dalammulut, dan tidak memerlukan tambahan air untuk ditelan. Tujuan penelitian ini adalah untuk mengetahui pengaruhkonsentrasi bahan penghancur sodium starch glycolateterhadap sifat fisik dan kelarutan formulasi aspirin orally disintegrating tablet (ODT) serta mengetahui konsentrasibahan penghancur sodium starch glycolate. zat dalamformulasi aspirin orally disintegrating tablet (ODT) yang sesuai dengan sifat fisik. Tablet Aspirin ODT diproduksidalam empat formulasi dengan konsentrasi sodium starch glycolate 0%, 10%, 15% dan 20%. Evaluasi tablet ODT meliputi keseragaman bobot, keseragaman ukuran, kekerasan, kerapuhan, waktu larut tablet dan uji stabilitas. Data yang dihasilkan kemudian dianalisis menggunakanANOVA satu arah. Hasil penelitian menunjukkan bahwasifat fisik tablet F1, F2, F3 dan F4 meliputi uji keseragaman massa tablet yang menunjukkan hasilANOVA sebesar 0,000 kurang dari 0,05 yaitu selisih uji keseragaman ukuran diameter. . hasilnya 0,056 lebih dari0,05 jadi tidak ada bedanya dan hasilnya kental Selisih0,086 lebih dari 0,05 hasil uji kekerasan 0,000 kurang dari0,05 jadi ada beda hasil uji kerapuhan 0,125 lebih dari0,05 maka terdapat perbedaan, dan hasil uji waktu larut0,03 kurang dari 0,05 maka terdapat perbedaan. Uji disolusi menghasilkan F1 10,1%, F2 10,06%, F3 9,12% dan F4 9,3%. Pada uji kestabilan kimia uji disolusi, hasilpersentase disolusi mengalami perubahan kestabilan harike 14, F1 9,3%, F2 5,8%, F3 12,6% dan F4 12,6%, kestabilan 28 hari F1 10,6%, F2 8,88%, F3 8,9% . dan 8,9%. Mengenai kestabilan fisik, pengujian keseragamanberat tablet, keseragaman ukuran, kekerasan tablet, kerapuhan tablet dan waktu larut stabil tablet diperolehkarena uji stabilitas 0, 14 dan 28 memberikan hasil yang sama. Kata kunci: aspirin, sodium starch glycolate, orally disintegrating tablet
Pemanfaatan Tanaman Obat Keluarga (TOGA): Pelatihan Pembuatan Teh Herbal Bagi Ibu-ibu PKK Rahmawati, Nur; Fauziah, Fauziah; Kurniasih, Khamdiyah Indah; Kirana, Ade
Journal of Social Responsibility Projects by Higher Education Forum Vol 4 No 3 (2024): Maret 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jrespro.v4i3.5013

Abstract

The term Family Medicinal Plants (TOGA) has become more popular in the last decade or so. Before this, family medicinal plants were better known as Living Pharmacy. Family medicinal plants have long been utilized in an effort to overcome health problems. Therefore, the utilization of TOGA needs to be developed and disseminated in the community, especially for housewives. Among the many family medicinal plants used by the community to maintain health is bay leaf. The utilization of bay leaves is processed as a healthy drink innovation, herbal tea in the form of tea bags because it is more practical and easy to make. Bay leaf herbal tea can be used to prevent cancer, lower cholesterol, increase the body's immune system, reduce the risk of kidney stones, maintain blood sugar levels and overcome stomach pain. The main target of this service is one of the PKK women's groups in Karangnanas Village, Banyumas Regency. who work as housewives. The purpose of this activity is to increase community understanding about traditional drinks from bay leaves that can reduce cholesterol. The results of this herbal tea making training activity increase good information to the community and can manage traditional beverage products made from bay leaves. With bay leaves being one of the alternative natural ingredients that can be utilized as traditional medicine to help treat diseases such as cholesterol, hypertension, gout, diabetes mellitus.
Analisis penggunaan antidiabetik dan antihipertensi pada pasien diabetes komorbid hipertensi di Puskesmas Mrebet Melani, Reina; Kurniasih, Khamdiyah Indah; Fauziah, Fauziah
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.382

Abstract

Diabetes Mellitus (DM) is a chronic disease characterised by high blood sugar levels. Diabetes mellitus is considered the "mother disease" because it is the mother of various diseases such as hypertension, heart disease, stroke, kidney failure and blindness. There were 13,117 DM cases in Purbalingga Regency, and 14,035 people were provided services according to procedures. Increased blood glucose levels (hyperglycemia) cause intravascular fluid resistance, which results in an increase in body fluid volume and an increase in peripheral arterial resistance. These two conditions are the basis for hypertension. There is a need for appropriate antidiabetic therapy to treat hypertension comorbid DM disorders. This research was conducted at the Mrebet Community Health Center, Purbalingga Regency, where the results obtained were 55 data on the use of prolanis medication for DM comorbid hypertension patients. In this study, the most common single therapy was metformin (12.7%), then the two most common combinations were glimepiride and acarbose (41.8%), while the three combinations used were metformin, glimepiride and acarbose (12.7%). The most common single antihypertensive was Lisinopril (28.2%), and the most common combination was Lisinopril + Amlodipine (28.2%).
Potensi hepatoprotektif ekstrak daun Euphorbia heterophylla L. dalam menurunkan kadar bilirubin pada tikus Wistar yang diinduksi INH dan rifampisin Kurniasih, Khamdiyah Indah; Fauziah, Fauziah; Ratna, Uki Septi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.592

Abstract

Hepatitis is a liver damage disorder characterized by inflammation caused by various factors, one of which is medication use. Liver damage due to medication, or drug-induced liver injury (DILI), has a relatively high prevalence. Isoniazid (INH) + Rifampicin is a combination of drugs that poses a risk of DILI by causing liver damage. One parameter for assessing liver damage is through the measurement of total serum bilirubin levels. Katemas herb (Euphorbia heterophylla L) is a plant known to contain flavonoids, tannins, and saponins, with strong antioxidant properties. The high incidence of liver damage due to drug-induced liver injury (DILI) necessitates the exploration of alternative therapies to manage liver disorders. Katemas is a wild grass that grows abundantly but remains underutilized.The objective of this study is to evaluate the hepatoprotective activity of katemas herb leaves. The method used in this research involves maceration to obtain extracts, with ethanol 96% as the solvent. Testing was conducted on five groups of rats, with total serum bilirubin levels measured across all groups. All groups were induced using INH and RMP. The results showed that Groups III and IV, which were the dose variation groups, exhibited hepatoprotective activity. Group V, which received the highest dose of 200 mg/kg BW, demonstrated the greatest reduction in total bilirubin levels, with the largest mean decrease (-0.226) and a small standard deviation (±0.043).
Co-Authors Abely, Nastasya Anis Ardhana, I Putu Primanda Dodi Fauziah Fauziah , Fauziah Fauziah Fauziah Fitri, Ely Nurul Ikhwan Yuda Kusuma Kirana, Ade Lukman Hakim Melani, Reina Misworo, Misworo nawangsari, desi Nawangsari, Desy Nur Rahmawati Nurkholis, Fiqih Prabandari, Rani Prismadito, Hansen Putri, Arine Astika Ratna, Uki Septi Safitri, Cindy Ade Samodra, Galih Setyaningsih, Intan Wiji Siti Setianingsih Ulinnuha, Alvin