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All Journal Majalah Kedokteran Bandung KUMPULAN JURNAL DOSEN UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA Global Medical and Health Communication JURNAL IBNU SINA BIOMEDIKA Buletin Farmatera Hasil Pengabdian Kepada Masyarakat JURNAL ILMIAH MAKSITEK JURNAL ILMIAH SIMANTEK JURNAL ILMIAH KOHESI Muhammadiyah Medical Journal Jurnal Pandu Husada JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Nurfadly, Nurfadly
Universitas Muhammadiyah Sumatera Utara
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Journal : Buletin Farmatera

 1 
Resistance Test of Aedes aegypti Mosquito Larvae Against Organophosphate Insecticides at Medan Selayang Zahir Husni Lubis; Nurfadly Nurfadly
Buletin Farmatera Vol 5, No 2 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (571.725 KB) | DOI: 10.30596/bf.v5i2.2791

Abstract

Aedes aegypti is the main vector in several diseases such as Dengue Hemorrhagic Fever (DHF).Various types of efforts to control Aedes aegypti were carried out to terminate the transmission chain by spraying (organizing) the organophosphate insecticide. The use of irrational insecticides causes an increase in esterase enzymes, giving rise to the resistance of Aedes aegypti to insecticides. The purpose of this study is to determine the resistance status of Aedes aegypti larvae to organophosphate insecticides in Medan Selayang. The type of research used in this study is descriptive research with cross-sectional methods, using 276 larvae of Aedes aegypti. The results of this study are mosquito larvae that are susceptible (sensitive) to organophosphate insecticides by 66.3%, while mosquito larvae that are tolerant (moderate resistance) of organophosphate insecticides are 33.7% and resistant (high resistance) mosquito larvae were not found. There is 33.7% of Aedes aegypti larvae are tolerant (moderate resistance) to organophosphate insecticides and resistant (high resistance) mosquito larvae were not found.
Anti-Cervical Cancer Study of a Labdane-type Diterpene Obtained from Legundi Fruit (Vitex triolia L.) Targeting the Bcl-2 Gene Humairah Medina Liza Lubis; Emni Purwoningsih; Nurfadly Nurfadly
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.11728

Abstract

Abstract: The development and induction of cervical cancer carcinogenesis are linked to sexually transmitted Human Papillomavirus (HPV) infection, and can affect human genes, particularly those involved in the apoptotic process, one of which is the Bcl-2 gene. Several synthetic compounds, including pyrimidineylpiperazine, phenylpyrazole, kendomycin, and navitoclax, have been shown to be effective in inhibiting the antiapoptotic activity of Bcl-2, but it is the labdane-type diterpene content of the natural legundi fruit plant (Vitex trifolia L.) that has anticancer bioactivity, particularly in the process of genetic mutations, Apoptotic inhibition and therapeutic failure have yet to be discovered, particularly in cervical cancer. The study's goal was to investigate the mechanism of interaction (molecular docking) of labdane type-diterpene compounds with the antiapoptotic protein Bcl-2. In silico (docking molecular) research was used to determine the interaction between legundi fruit ligands and the Bcl-2 target protein in cervical cancer. The docking analysis results will then be visualized with the Discovery Studio 4.1, LigPlot+, and Ligand Scout 3.1 software. The interaction of proteins and ligands was studied to determine the number and type of bonds formed, such as hydrogen and hydrophobic bonds. The results were as follows: Gibbs energy -7.8, pKi 1.91 m, 10 hydrophobic bonds, and hydrophobic residues Leu80, Leu82, Thr83, Thr86, Ala87, Cys90, Met118, Glu121, Ser122, and Leu130. The findings presented here suggest that labdane-type diterpenes are powerful anticancer agents capable of inducing apoptosis and inhibiting the antiapoptotic action of the Bcl-2 gene, which should be investigated further in (pre)clinical studies.
Faktor Yang Mempengaruhi Kejadian Skabies Pada Santri Di Pondok Pesantren Hidayatullah Tanjung Morawa Br Ginting, Heni Sry Wahyuni; Faried Lubis, Taufik Akbar; Nurfadly, Nurfadly; Syafrin Lubis, Riri Arisanty
Buletin Farmatera Vol 10, No 2 (2025)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v10i2.24364

Abstract

Abstract: Scabies is a skin disease caused by infestation and sensitization to the hominis variant Sarcoptes scabei mite and its products.According to the Ministry of Health of the Republic of Indonesia, the prevalence of scabies in 2020 was 3.9%-6%.This states that Indonesia is still not free from scabies and is one of the infectious skin disease problems in Indonesia. The factors that cause the incidence of scabies to increase are high humidity, low sanitation, environmental density, poor personal hygiene, knowledge and attitudes and behaviors that are not supportive for a healthy lifestyle. The prevalence of scabies in Islamic boarding schools is still fairly high based on the results of the research conducted.This study aims to find out Factors Influencing the Occurrence of Scabies To students at Hidayatullah Islamic Boarding School Tanjung Morawa. cross seictional Observational analytics using a cross sectional design. Data were obtained through filling out questionnaires and physical examination of 94 samples then analyzed using univariate, bivariate analysis with the chi-square method and multivariate analysis will be carried out using multiple logistic regression tests to see the most dominant risk factors for Sarcoptes scabeii var infection. hominis. Data analysis using Chi Square showed that there was a relationship between Age and Personal hygiene Logistic regression analysis showed that the personal hygiene variable was the most dominant variable related to the event.
Co-Authors ALYA LAILATU ASSZIVA Amelia Eka Damayanty Amira, Daffa Rifqah Ance Roslina Andini, Leni Annisa Annisa Br Ginting, Heni Sry Wahyuni Ceri Permata Ayuni ELMAN BOY Faried Lubis, Taufik Akbar Fauziah, Ismatul Harahap, Sevani Ayu Humairah Medina Liza Lubis Iqrina Widia Zahara Isra Thristy MIFTAH KHOIRIAH Muhammad Fajar Muhammad Jabbar Rahman Tapiheru MURLINA, NELLI Nasution, Aisyah Khoiriyah Pudiyanti, Pinta Purwoningsih, Emni R. MUHAMMAD ZIKRI PRANOTO Ramadhani, Muhammad RIDO RAIS HUTABARAT Robitah Asfur SAID MUNAZAR RAHMAT Sarirah, Munauwarus Siregar, Nur Fitriani Syafrin Lubis, Riri Arisanty Yenita . Yenita Yenita Yulfi, Hemma Zahara, Iqrina Widia Zahir Husni Lubis ZIMLY KHATIF VALDIVIA RITONGA