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All Journal Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) JPSCR : Journal of Pharmaceutical Science and Clinical Research Svāsthya: Trends in General Medicine and Public Health Joong-Ki
Veonika, Dea Anenta
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Religion Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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Cholecalciferol Effects on Lipid Profile of Experimental Animals: A Scoping Review Dea Anenta Veonika; Budiyanti Wiboworini; Muthmainah Muthmainah
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.73400

Abstract

Vitamin D is an essential nutrient that has various beneficial effects on the human body. The results of cholecalciferol supplementation are varied, and there has yet to be a comprehensive review regarding its effect on animal models. Therefore, this scoping review aims to summarize the evidence regarding the effect of cholecalciferol (vitamin D3) supplementation on the lipid profiles of animal subjects. PubMed, Scopus, and DOAJ were searched for original research articles published until 2022. Studies were included if they were experimental studies, cholecalciferol was used as a supplement, and the changes in the lipid profile were analyzed. A total of 260 articles were collected, of which 250 articles were excluded, and 10 articles were included for qualitative synthesis. All studies used oral routes to supplement cholecalciferol with various doses and duration ranging from several weeks to several months. Most studies reported reduced lipid parameters in serum or organ-specific animals supplemented with cholecalciferol. As conclusion, cholecalciferol reduces lipid content in animal subjects and may have a beneficial effect on populations with metabolic diseases such as diabetes and dyslipidemia. Further research is required to explore the mechanism of how cholecalciferol affects the lipid profiles of experimental animals.
Sinergi Edukasi Gizi Dan Pemanfaatan Bahan Lokal Dalam MPASI Untuk Cegah Stunting Pada Balita Esa Indah Ayudia; Hafizah, Hafizah; Mirna Marhami Iskandar; Patrick Wiliam Gading; Zahra Frizki Asty; Dea Anenta Veonika; Denok Tri Hardiningsih; Miftahurrahmah, Miftahurrahmah
Joong-Ki : Jurnal Pengabdian Masyarakat Vol. 5 No. 1: November 2025
Publisher : CV. Ulil Albab Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56799/joongki.v5i1.12278

Abstract

Stunting merupakan masalah kesehatan masyarakat yang serius dengan prevalensi yang masih tinggi di Indonesia, termasuk peningkatan di Provinsi Jambi pada tahun 2024. Periode 1.000 Hari Pertama Kehidupan (HPK), terutama masa Pemberian Makanan Pendamping ASI (MPASI) sejak usia 6 bulan, menjadi jendela kritis pencegahan. Kesenjangan pengetahuan ibu mengenai praktik MPASI yang tepat dan kurangnya optimalisasi pemanfaatan bahan pangan lokal yang bergizi dan terjangkau menjadi kendala. Program pengabdian ini bertujuan untuk mendukung percepatan penurunan stunting di wilayah kerja Puskesmas Olak Kemang, Kota Jambi, dengan meningkatkan pengetahuan dan keterampilan ibu serta kader kesehatan tentang gizi seimbang, stunting, dan praktik MPASI berbasis pangan lokal. Metode yang digunakan adalah penyuluhan interaktif, pre-test, post-test, dan identifikasi bahan lokal. Hasil menunjukkan adanya peningkatan signifikan pada skor pengetahuan ibu balita setelah penyuluhan, dengan rata-rata peningkatan sebesar 27,35% (rata-rata skor pre-test 71 menjadi post-test 98). Program ini berhasil meningkatkan literasi gizi dan keterampilan praktis ibu dalam menyiapkan MPASI bergizi berbasis sumber daya lokal, yang merupakan pendekatan strategis dan efektif biaya dalam pencegahan stunting.
Recovery of vitamin D levels by cholecalciferol supplementation on obese rats Veonika, Dea Anenta; Wiboworini, Budiyanti; Muthmainah, Muthmainah
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 12 ISSUE 1, 2024
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2024.1(1).40-48

Abstract

ABSTRAKLatar Belakang: Obesitas disebabkan oleh penumpukan lemak dalam tubuh karena faktor biologis, psikososial, dan perilaku. Prevalensi obesitas mencapai 42,24% di Amerika Serikat, sementara overweight dan obesitas mencapai 59% di Eropa. Obesitas dapat menyebabkan defisiensi vitamin D melalui berbagai mekanisme.Tujuan: Untuk mengatahui pengaruh pemberian suplementasi cholecalciferol terhadap kadar 25(OH)D pada tikus obesitas. Metode: Dalam penelitian ini, kami melakukan penelitian  true experiment with.        pre-post test control group design. Penelitian ini menganalisis 3 kelompok tikus galur Sprague Dawley jantan yang diinduksi dengan diet tinggi lemak tinggi fruktosa (HFHF)  menjadi tikus obesitas. Masing-masing kelompok mendapatkan cholecalciferol sebanyak 2,500 IU/200gr/hari pada kelompok P1, 5,000IU/200gr/hari pada kelompok P2, dan 10,000 IU/200gr/hari pada kelompok P3 selama 8 minggu. Tikus kemudian dianalisis kadar serum 25(OH)D sebelum dan sesudah perlakuan.Hasil: Suplementasi cholecalciferol secara signifikan meningkatkan kadar vitamin D pada setiap kelompok intervensi yang diberikan cholecalciferol. Rerata kadar 25(OH)D kelompok P1,P2, dan P3 sebelum perlakuan  berturut-turut adalah 29,43±0,83 ng/mL, 28,61±1,57 ng/mL, dan 28,86±1,46 ng/mL. Rerata kadar 25(OH)D setelah suplementasi cholecalciferol untuk kelompok P1,P2, dan P3 berturut-turut adalah 74,27±0,77 ng/mL, 100,30±1,48 ng/mL, dan 126,73±2,30 ng/mL. Ada perbedaan yang signifikan antara nilai 25(OH)D sebelum dan sesudah perlakuan  pada ketiga kelompok intervensi dengan nilai (p<0,05). Kesimpulan: Pemberian cholecalciferol mampu meningkatkan kadar 25(OH)D pada tikus jantan yang diinduksi obesitas. KATA KUNCI: cholecalciferol; obesitas; vitamin D ABSTRACT Background: Obesity is caused by the accumulation of fat in the body due to biological, psychosocial and behavioral factors. The prevalence of obesity reaches 42.24% in the United States, while overweight and obesity reaches 59% in Europe. Obesity can cause vitamin D deficiency through various mechanisms.Objectives: To determine the effect of cholecalciferol supplementation on 25(OH)D levels in obese mice.Methods: In this research, we conducted a true experiment research with pre-post test control group design. This study analyzed 3 groups of male Sprague Dawley rats that were induced by a high-fat, high-fructose (HFHF) diet to become obese rats. Each group received 2,500 IU/200gr/day of cholecalciferol in group P1, 5,000IU/200gr/day in group P2, and 10,000 IU/200gr/day in group P3 for 8 weeks. The mice were then analyzed for serum 25(OH)D levels before and after treatment.Results: Cholecalciferol supplementation significantly increased vitamin D levels in each intervention group given cholecalciferol. The mean 25(OH)D levels in groups P1, P2, and P3 before treatment were 29.43 ± 0.83 ng/mL, 28.61 ± 1.57 ng/mL, and 28.86 ± 1.46, respectively. ng/mL. The mean 25(OH)D levels after cholecalciferol supplementation for groups P1, P2, and P3 were 74.27±0.77 ng/mL, 100.30±1.48 ng/mL, and 126.73±2 respectively. .30 ng/mL. There was a significant difference between the 25(OH)D values before and after treatment in the three intervention groups with values (p<0.05).Conclusion: Administration of cholecalciferol can increase 25(OH)D levels in male mice that are induced by obesity. KEYWORDS: cholecalciferol, vitamin D, obesity
Dose-dependent effects of cholecalciferol supplementation on hepatocyte ballooning in Sprague–Dawley rats Veonika, Dea Anenta
Svāsthya: Trends in General Medicine and Public Health Vol. 2 No. 6 (2025): November 2025
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v2i6.134

Abstract

Obesity is an accumulation of fat body condition due to calories and energy imbalance. Low vitamin D levels are also associated with lower HDL levels, increased triglyceride levels, and increased triglyceride deposition levels in hepatocytes and liver parenchyma. Vitamin D supplementation has various benefits for obesity, such as by improving lipid profiles, reducing BMI, reducing waist circumference, and reducing hip circumference. This study aims to analyze the histopathological changes in the liver of male rats induced by a high-fat, high-fructose diet and supplemented with cholecalciferol. Thirty male Sprague-Dawley rats aged 6-8 weeks were randomly allocated into 5 groups. The normal control (KN) group only received the BR-2 pellet and PAM ad libitum. The negative control (K-) group received a high-fat, high-fructose diet (HFHF) for 28 days. The P1 group received only HFHS for the first 28 days and was supplemented with cholecalciferol 2500 IU thereafter. The P2 group received only HFHF for the first 28 days and was supplemented with cholecalciferol 5000 IU thereafter. The P3 group received only HFHF for the first 28 days and was supplemented with cholecalciferol 10000 IU thereafter. Histopathological analysis involves analyzing the microscopic image of the liver tissue of the obese rat models after receiving treatment with cholecalciferol for 56 days. After 8 weeks of intervention, cholecalciferol supplementation resulted in different findings on histopathological analysis. After intervention with cholecalciferol, there is no significant difference in the degree of steatosis and lobular inflammation on rat liver histopathology (p>0.05). Cholecalciferol supplementation resulted in a significant difference in hepatocyte ballooning on liver histopathology (p<0.05).  Administration of cholecalciferol at doses of 2,500 IU, 5,000 IU, and 10,000 IU was not significant in improving liver steatosis and lobular inflammation, but could reduce the occurrence of liver ballooning
Co-Authors Budiyanti Wiboworini Denok Tri Hardiningsih Esa Indah Ayu, Esa Indah Hafizah Hafizah Iskandar, Mirna Marhami Miftahurrahmah Miftahurrahmah, Miftahurrahmah Muthmainah Muthmainah Muthmainah, Muthmainah Patrick Wiliam Gading Wiboworini, Budiyanti Zahra Frizki Asty