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All Journal Nusantara Medical Science Journal Tirtayasa Medical Journal International Journal of Cell and Biomedical Science Tirtayasa Medical Journal Jurnal Sains dan Kesehatan Masyarakat Mandiri: Jurnal Pengabdian Dan Pembangunan Lokal
Ghea Farmaning Thias Putri
Sultan Ageng Tirtayasa University
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Hipoksia Intermiten sebagai Pemicu Disfungsi Mitokondria: Tinjauan Naratif Mekanisme Seluler Dwi Widyawati; Ghea Farmaning Thias Putri
Tirtayasa Medical Journal Vol 5, No 2 (2026): May
Publisher : Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62870/tmj.v5i2.39071

Abstract

Intermittent hypoxia is characterized by recurrent cycles of oxygen deprivation and reoxygenation, commonly observed in chronic diseases such as obstructive sleep apnea, respiratory disorders, and metabolic conditions. Compared to continuous hypoxia, it induces more dynamic cellular stress, particularly affecting mitochondrial function. This review aimed to analyze the cellular mechanisms by which intermittent hypoxia triggers mitochondrial dysfunction. A structured narrative literature search was conducted using PubMed, Scopus, ScienceDirect, and Google Scholar. A total of 104 articles were identified, of which 22 met the inclusion criteria and were included in the analysis. Selected studies were descriptively synthesized to identify key mechanisms. Intermittent hypoxia disrupts mitochondrial electron transport chain activity, especially at complexes I and III, leading to electron leakage and increased reactive oxygen species (ROS). Recurrent oxidative stress causes mitochondrial membrane damage, protein oxidation, mitochondrial DNA injury, reduced ATP synthesis, and impaired cellular bioenergetics. It also alters mitochondrial dynamics and weakens antioxidant defenses. Intermittent hypoxia is a major trigger of mitochondrial dysfunction through repetitive oxidative stress, contributing to metabolic disturbances and organ dysfunction.
Co-Authors Ainina Al Shadrina Ainina Al Shadrina Al Shadrina, Ainina Ayu Tiara Fitri Devy Ariany Dwi Widyawati Dwi Widyawati Dwi Widyawati Dwi Widyawati Ekawati Rini Wulansari Firda Asma'ul Husna Firda Asma’ul Husna Galang Prahanarendra Hidayati, Mailani Dwi Husna, Firda Asma'ul Husna, Firda Asmaul Luluk Hermawati Nabila Aulia Tsaqifah Nabila Aulia Tsaqifah Nurfatihah Z, Zahara Nurlaely Mida Rachmawati Pratiwisitha, Maytia Rifdah Hanifah Rifdah Hanifah Rifdah Hanifah Rifdah Hanifah Rifdah Hanifah Rossa Amelia Widyawati, Dwi Yani Dwi Lestari