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All Journal The Indonesian Biomedical Journal Universa Medicina Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Medik Veteriner Journal Of Widya Medika Junior Community Development Journal: Jurnal Pengabdian Masyarakat Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Peka: Jurnal Pengabdian Kepada Masyarakat Jurnal Widya Medika
Sianty Dewi
Departement Of Obstetrics And Gynecology, Faculty Of Medicine, Widya Mandala Surabaya Catholic University.
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary

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MENINGKATKAN PERAN AKTIF REMAJA SMA DALAM PROMOSI PENCEGAHAN INFEKSI MENULAR SEKSUAL Novita, Bernadette Dian; Dewi, Sianty; Hertanto, Maria Patricia Dian; Young, Andre; Khudrati, Wilson Christianto; Meredith, Jennifer
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 4 No. 6 (2023): Volume 4 Nomor 6 Tahun 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v4i6.21338

Abstract

Infeksi Menular Seksual (IMS) adalah salah satu penyakit menular yang sering ditemui pada kelompok remaja. Pengaruh internal dan lingkungan tidak didukung oleh pemahaman mengenai kesehatan reproduksi dan penyakit menular seksual, pengawasan dari orang tua serta budaya masyarakat yang menganggap informasi ini sebagai hal yang tabu sehingga remaja mencari informasi dari sumber yang tidak tepat. Fakultas Kedokteran Universitas Katolik Widya Mandala Surabaya bersama Komisi Remaja Keuskupan Surabaya merasa perlu diadakan penyuluhan untuk menghasilkan agen edukatif dari kelompok usia remaja yang dapat memberikan edukasi serta konseling terkait pencegahan serta bahaya dari IMS. Pelatihan ini bertujuan untuk meningkatkan kemampuan remaja melakukan promosi kesehatan terkait IMS, pentingnya vaksinasi Human Papilloma Virus (HPV) untuk mencegah IMS serta etika dalam menggunakan media sosial. Metode pelaksanaan kegiatan melalui tahap pengembangan modul pelatihan, tahap implementasi dan pelatihan, serta tahap monitoring dan evaluasi. Tahap implementasi dilaksanakan dengan melakukan pelatihan kepada remaja dalam bentuk seminar awam melalui Zoom sedangkan tahap monitoring dan evaluasi melalui lomba poster dengan menggunakan media sosial Instagram. Evaluasi menggunakan pre-test dan post-test, serta penilaian karya poster digital di media sosial Instagram oleh ahli dengan menggunakan rubrik penilaian. Melalui kegiatan abdimas ini, mitra dapat turut berperan aktif melalui pengetahuan yang telah diperoleh kepada masyarakat, khusunya remaja melalui media sosial dengan bahasa yang mudah dipahami. Saran untuk kegiatan berikutnya adalah dengan memperluas materi terkait IMS dan agar kegiatan ini dapat dilakukan secara rutin. 
Rapid isolation and characterization of Wharton's jelly-derived mesenchymal stem cells maintained in fresh-prepared human AB-serum Tjahjono, Yudy; Dewi, Sianty; Novita, Bernadette Dian; Wijaya, Hendy; Putra, Brilliant Dwi; Kuncorojakti, Suryo; Hendriati, Lucia; Jong, FX Himawan Haryanto; Widodo, Teguh; Malonda, Franklin Vincentius
Universa Medicina Vol. 44 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.65-72

Abstract

Background Mesenchymal stem cells (MSCs) are valued in regenerative medicine for their multipotency, proliferative capacity, and immunomodulatory properties. Wharton’s jelly-derived MSCs (WJ-MSCs) from the umbilical cord offer a non-invasive, promising source for clinical applications, because easy isolation, lack of ethical concerns, and the presence of both embryonic and adult stem cells have made them a valuable source for use in therapeutic applications and regenerative medicine. This study aimed to optimize WJ-MSC isolation and characterization methods. Methods Human umbilical cords from three healthy donors were collected post-cesarean under strict inclusion criteria. WJ-MSCs were isolated using the explant culture method, with cells adhering to T75 flasks pre-coated with 2% gelatin. Cultures were maintained in Dulbecco’s Modified Eagle Medium (DMEM) supplemented with 10% freshly prepared Human AB serum and monitored for 21 days. Flow cytometry (BD FACSAria) was performed at passages 1 and 5 to assess MSC markers CD105, CD73, CD90, and CD44, alongside the exclusion marker CD45. Results WJ-MSCs exhibited fibroblast-like morphology by passage 1 and showed robust proliferation. Flow cytometry revealed high CD44 expression (~60%) at passage 1, while CD105, CD73, and CD90 became prominent by passage 5. CD45 remained low, suggesting minimal hematopoietic contamination. Conclusion This study confirms the feasibility of isolating and expanding WJ-MSCs using DMEM with 10% human AB serum. While consistent cell growth was achieved, the 21-day culture period may require optimization for scalability, including serum concentration, substrate coatings, and oxygen levels. CPJ-MSCs may be preferable for applications demanding rapid expansion and early marker expression.
A randomized controlled trial on the effectiveness and safety of tranexamic acid in decreasing blood loss in cesarean section Sianty Dewi
JURNAL WIDYA MEDIKA Vol. 2 No. 1 (2014)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v2i1.1647

Abstract

Background: WHO reported more than 100,000 maternal death due to obstetric hemorrhage annually, in other hand Cesarean Section (CS) is a common surgery done to save mother and child with one of the complications is hemorrhage. tranexamic acid (TXA) as antifibrinolytic might improve maternal outcome by decreasing blood loss in CS. Objectives:Determine effectiveness and safety of tranexamic acid in decreasing blood loss in cesarean section. Method:A prospective, double blinded, randomized controled study in Obstetrics and Gynecology Department of Southern Philippines Medical Center. The participants are 124 women underwent CS, 62 women given tranexamic acid after cord cut compared to 62 given placebo. Estimated blood loss, cardiac rate, systolic blood pressure before and after CS, events during CS and additional medicines. Hemoglobin and hematocrit was taken before and after CS, course in the ward, blood transfusion, adverse events, mortality and length of hospital stay were compared. Results: Socio demographic, clinical profile, events after interventions, need of additional medicines and complications are similar for both group (p-value>0.05). The cardiac rate after CS is significantly higher in TXA group (tranexamic:85.1±11.5 placebo:80.1±15. 6, p-value=0.0441), but still in normal range. Conclusion: Tranexamic acid is not recommended to be given routinely to reduce blood loss in CS, instead its more beneficence to abort severe bleeding hence its should be available during CS. There was no adverse events recorded in both treatment and placebo group showed safety of tranexamic acid.
EPIDEMIOLOGIC STUDY OF ENDOMETRIAL LESION CHARACTERISTICS BY AGE IN PATHOLOGY DIAGNOSTIC CENTER IN SURABAYA 2015-2017 Sianty Dewi; Imelda Theodora; Bernadette Dian Novita; Yulia Widyasari; Ricardo Gunadi; Maria Amelia Suhardi; Vincentius Diamantino Supit
JURNAL WIDYA MEDIKA Vol. 7 No. 1 (2021): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v7i1.3167

Abstract

Background: The etiology of endometrial lesions varies from benign to malignant. Early detection and management of malignancy give the best prognosis for the patient. While studies in America and Europe report a 3-5% risk of malignancy in women below 50 years and a significant increase up to 75-80% in postmenopausal, the availability of national epidemiologic data is limited, therefore the study is held.Method: A descriptive- retrospective study. Total sampling obtained from endometrial specimens in Pathology Diagnostic Center-Prof JH Lunardhi, Sp.PA(K) from 2015 to 2017, while gestation-related, inadequate sample, and incomplete report are excluded. Data analyzed by IBM SPSS 23.0 version. Result: Data of 560 samples, 90% from curettage, 8% hysterectomy, and 2% hysteroscopy. The majority belonged to the 40-49 age group (44.3%). Secretory phase endometrium is the most common finding in the age group of 20-29 years (26.9%). Proliferative phase endometrium is the most common finding. The highest incidence of endometrial hyperplasia occurred in the age group of 40-49 years, for both typical and non-atypical. Endometrial malignancy was found mostly in the 50-59 years (37.03%). Conclusion: The prevalence of endometrial lesions differed according to age groups, with physiological changes, endometritis, polyps, and hyperplasia were most common under 50 years old and the risk of malignancy increased 4.39 times (p.00) beyond 50 years old.
TELEMEDICINE AS AN OPTION FOR HEALTH SERVICE LIMITATIONS IN COVID-19 PANDEMIC ERA Bernadette Dian Novita; Sianty Dewi; Evelyn Ongkodjojo; Agatha Christi Palupi; Immanuel Michael; Paul L. Tahalele
JURNAL WIDYA MEDIKA Vol. 7 No. 2 (2021): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v7i2.3430

Abstract

Coronavirus disease 2019 (COVID-19) pandemic era provides a new habit in form of self-quarantine or physical distancing. The recommendation is to delay visits to health facilities if it is not in the emergency condition to slow down the spread of COVID-19 transmission. This study aims to develop a telemedicine system that integrates three main components, namely doctors, patients, and hospital management in Gotong Royong Hospital Surabaya to minimize the transmission of COVID-19 while still provides comprehensive health services. The development of telemedicine service is divided into 3 stages. In the first stage, emergency screening was carried out by developing Frequently Asked Questions (FAQs). The second stage was continued with prototype testing and the last part was improving the system to create a better referral system. Gotong Royong Hospital telemedicine has been active since June 2021, within 2 months, 45 patients are willing to use telemedicine services. The results showed that telemedicine was easily accepted by patients in internal medicine clinic services (p
PHAGO PHARMACOLOGY ON THE GO. GAMIFICATION APPROACH IN CASE LEARNING PROCESS Evelyn Ongkodjojo; F.V Lanny Hartanti; Bernadette Dian Novita; Sianty Dewi; Dyana Sarvasti; Diga Albrian Setiadi; Fransiskus Reynaldy; Ivan Priyantono; Shavna Arfi Rasyid; Felix Kurniawan Adithia; Iwan Satria Djuanda
JURNAL WIDYA MEDIKA Vol. 8 No. 1 (2022): Supplement Juni
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v8i1.4024

Abstract

Learning process among medical students have developed along with technological advances so that it can be useful for users. One of the breakthroughs in the world of medical education is the development of serious games using multimedia technology that are relatively small in size so that they can be accessed using computers or devices named Pharmacology on the Go (PHAGO). The implementation stage was done by testing prototype game on 88 users October 20, 2021. Evaluation was done by using a feedback questionnaire for PHAGO users, shows 79 (89.8%) users who agree and strongly agree that the PHAGO application helps users understand the use of Pharmacology for clinical application. The results of the Wilcoxon test in evaluating the increase in students' knowledge with Pre Test and Post Test showed that there was a significant difference (p = 0.000). The existence of serious game stimulates an active learning process to create a learning environment that encourages the development of interpersonal, communication and problem solving skills. PHAGO is expected to be a forum that supports students to be able to independently study pharmacology in a fun and easy-to-understand way.
POST COVID-19 SYNDROME EFFECT ON DAILY LIFE ACTIVITIES Sianty Dewi; Bernadette Dian Novita Dewi; Niluh Suwasanti; Paul L Tahalele; Evelyn Ongkodjojo; Wilson Christianto Khudrati; Kevin Samsudin; Ni Nyoman Ratih Dharmapatni; Delvi Vorst; Theresia Cindy Limantoro
JURNAL WIDYA MEDIKA Vol. 9 No. 2 (2023): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v9i2.5061

Abstract

The Covid-19 pandemic had a big impact on the world over the past two years., and it is estimated that 1 in 10 people have been infected. The development of prevention and treatment systems can reduce mortality, but a new problem has emerged in the group of survivors. New clinical complaints, Getting COVID-19 again or having ongoing symptoms of COVID-19 for four weeks after the first infection, can affect a wide variety of organ functions. The long-term effects of having COVID-19, like feeling tired, having trouble breathing, chest pain, difficulty thinking, and joint pain, can make life worse. The study was conducted using a qualitative descriptive method using an online questionnaire. The results showed that some residual symptoms that respondents still felt after four weeks since being infected with COVID-19, such as fatigue easily (80%), joint pain (63.3%), insomnia (56.7%), depressive symptoms (53.3%), shortness of breath (50%), impaired concentration and memory (50%), livelihood disorders (43.3%), cough (40%), respiratory disorders (36.7%), weight loss and appetite (33.3%), fever (26.7%). Overall, it was found that 20% of COVID-19 survivors experienced daily activity disruptions assessed using the Modifications of Barthel Index and EQ-5D-5L questionnaires.
Optimized RT-qPCR Detection of Hepatic Lipopolysaccharide-Binding Protein in Diet-Induced Obese Mice Tjahjono, Yudy; Wedharga, I Gede Putu Adhi; Novita, Bernadette Dian; Tahalele, Paul; Wijaya, Hendy; Soediono, Endang Isbandiati; Hendrata, Adi Pramono; Dewi, Sianty; Wijaya, Sumi; Ervina, Martha; Kuncorojakti, Suryo
Jurnal Medik Veteriner Vol. 8 No. 2 (2025): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol8.iss2.2025.308-317

Abstract

High-throughput RT-qPCR results on hepatic lipopolysaccharide-binding protein (LBP) expression in obese subjects are essential, as they reveal the endotoxin’s role in the development of obesity and non-communicable disease (NCD). This study aimed to optimize RT-qPCR detection of LBP in diet-induced obese mice. This study primarily focused on addressing high variability through reference gene normalization. A total of six male C57BL/6 mice aged 6 weeks were randomly allocated into two dietary treatments (n = 3), consisting of mice fed with the standard chow diet (SCD group) and mice fed with the high-fat and high sucrose diet (HFHS group) ad libitum for 8 weeks. Relative quantification strategies involving the standard 2-ΔΔCt method (calibrator as mean) and the modified 2-ΔΔCt method (calibrator as individual sample-matched biological replicates) were compared in terms of their variability. Obesity was successfully induced in the HFHS treatment group, as indicated by significantly higher body weight, calorie intake, and LBP relative expressions compared to the SCD group. In addition, a sample-specific calibrator approach using the modified 2-ΔΔCt method resulted in lower variability in relative gene expression levels. A modified 2-ΔΔCt method, which utilizes a sample-specific calibrator to counteract sample-specific variability, was successfully employed to address high variability in RT-qPCR results.
HYPOGLYCEMIC, ANTI-INFLAMMATORY EFFECT OF PORANG (AMORPHOPHALLUS ONCHOPYLLUS) ON ALLOXAN-INDUCED DIABETIC RATS Young, Andre; Novita, Bernadette Dian; Ricardo, Evan; Dewi, I.G.A.P.D; Amadeo, Jovan; Dewi, Sianty; Tahalele, Paul
JURNAL WIDYA MEDIKA Vol. 9 No. 1 (2023): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v9i1.4173

Abstract

Introduction: Iles-iles / Porang is a tuber-producing plant that is commonly found in Indonesia. One of the most sought after content from Porang is Glucomannan. One of Porang’s health benefit is related to the effect of lowering blood glucose levels because it can prevent glucose absorption. These benefit is interesting to study because there has been no research linking the use of Porang to reduce inflammatory process in hyperglycmic conditions. Purpose: This study aims to analyze the anti-inflammatory, anti-oxidant and hypoglycemis effects of Glucomannan from Porang (Amorphophallus onchophyllus) extract in experimental animals. Method: The research design was a true experimental post-test only control group with random sampling to determine 5 white rats into the normal group, positive control group, negative control group and treatment 1, 2 and 3. The positive control group received Acarbose therapy thile the negative control group received carboxy-methyl-cellulose (CMC) therapy. This study used Porang extract (Amorphophallus onchophyllus) with concentrations of 200, 400 and 800 mg/Kg in hyperglycemic white rats that had been induced by Aloxan. The study was conducte for 50 days and then blood and serum samples were taken to assess the effect of hypoglycemia, anti-inflammatory and anti-oxidant using blood glucose, Malondialdehyde and C-reactiveprotein (CRP) measurement. Result and Discussion: The results showed no significant difference between the groups of rats receiving Porang extract and the positive and negative control groups. However, the MDA levels after 50 days of intervention between the negative control group and the therapy with doses of 200, 400 and 800 mg/Kg showed significant differences. Similarly found for blood glucose levels after intervention between negative control group and the 200 and 400 mg/Kg therapy group. This results may be caused by the type of Porang used, the form of the Porang and the concentration level of the Porang extract. Conclusion: Porang with the type of Amorphophallus onchophyllus can’t be used directly, but requires further processing to obtain the active substance Glucomannan.
Tumor Differentiation is Correlated with Estrogen Receptor Beta (ERβ) Expression but Not with Interleukin-6 (IL-6) Expression in Colorectal Carcinoma Theodora, Imelda; Sudiana, I Ketut; Budipramana, Vicky Sumarki; Erwin, Ferdinand; Dewi, Sianty; Novita, Bernadette Dian
The Indonesian Biomedical Journal Vol 16, No 5 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i5.3324

Abstract

BACKGROUND: Colorectal carcinoma (CRC), the third most common malignant disease worldwide, is associated with estrogen receptor β (ERβ) and interleukin-6 (IL-6). ERβ is known to down-regulate IL-6 in prostate cancer, lung carcinoma, and CRC cell lines; however, its effect on human with CRC remains unclear. Therefore, this study was conducted to investigate the association between ERβ and IL-6 expressions with the clinicopathological features of CRC.METHODS: This was an analytic observational study using 40 paraffin blocks of CRC patients. ERβ and IL-6 expression was measured by immunohistochemistry (IHC) staining. The percentage of immunoreactive tumor cell per 1000 cells was manually recorded and tumor differentiation as well as tumor infiltration were determined. Tumor differentiation was graded according to the World Health Organization (WHO) 2010 criteria, while tumor infiltration was defined based on the American Joint Committee on Cancer (AJCC) 8th edition.RESULTS: Fifty percent of samples were well-differentiated CRC, and 57.5% samples were T3 infiltration tumors. IHC staining showed 35.5% of samples were positive for ERβ expression, while 70.86% were positive for IL-6 expression. There were negative correlation of ERβ expression with tumor differentiation (p=0.018; r=-0.371), but no correlation with tumor infiltration (p=0.836) were found. There was no correlation between ERβ expression with IL-6 expression (p=0.154).CONCLUSION: There is statistically significant correlation between tumor differentiation and ERβ expression, wherein improved tumor differentiation is linked to higher levels of positive ERβ expression. However, there is no discernible relationship between IL-6 and tumor differentiation. These findings suggest that while IL-6 was involved in the growth of the tumor, ERβ expression might have an impact on tumor differentiation.KEYWORDS: colorectal carcinoma, estrogen receptor beta, interleukin-6, cell differentiation
Co-Authors Agatha Christi Palupi Alvin Julian Amadeo, Jovan Amalia, Nindya Andre Young Angeline Rivia Simanjuntak Ari Christy Mulyono Belienda Gracella Bernadette Dian Novita Bernadette Dian Novita Bernadette Dian Novita Bernadette Dian Novita Bernadette Dian Novita Dewi Budipramana, Vicky Sumarki Delvi Vorst Dewa Al Dewi Dewa Ayu Liona Dewi Dewi, I.G.A.P.D Dian Putri, Maria Patricia Diga Albrian Setiadi Dyana Sarvasti Eddy Toynbee Erwin, Ferdinand Evelyn Ongkodjojo Evelyn Ongkodjojo Felix Kurniawan Adithia Ferry Ferry Ferry, Ferry Ferry, Ferry Fransiskus Reynaldy FX Himawan Jong Handoyo, Henry Ricardo Hendrata, Adi Pramono Hertanto, Maria Patricia Dian Icha, Icha Imelda Theodora Immanuel Michael Irene Lingkan Parengkuan Ivan Priyantono Iwan Satria Djuanda Jaya, Ferdinand Wiliam Jong, FX Himawan Haryanto Kevin Samsudin Khudrati, Wilson Christianto Kuncorojakti, Suryo Lanny Hartanti Laura Wihanto Lucia Hendriati Lukas Slamet Rihadi Malonda, Franklin Vincentius Maria Amelia Suhardi Maria Yuliastuti Marion Florentia Martha Ervina Meredith, Jennifer Mujib Hannan Natasha M Budiono Ni Nyoman Ratih Dharmapatni Ni Putu Sudewi, Ni Putu Niluh Suwasanti Niluh Suwasanti Nita Kurniawati Nova Mayasari Novita, Bernadette Dian Oscar Indra Kusuma Paul L Tahalele Putra, Brilliant Dwi Ricardo Gunadi Ricardo, Evan S.Pd. M Kes I Ketut Sudiana . Sandhy Prayudhana Sandhy Prayudhana Shavna Arfi Rasyid Soediono, Endang Isbandiati Soewangsa, Queency Amelia Steven Sumi WIjaya, Sumi Suwandito, Laurensius Teguh Widodo Theodora, Imelda Theresia Cindy Limantoro Tjahjono, Yudy Toynbee, Eddy Vincentius Diamantino Supit Wedharga, I Gede Putu Adhi Wijaya, Hendy Wilson Christianto Khudrati Young, Andre Yudhiakuari Sincihu Yulia Widyasari