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All Journal The Indonesian Biomedical Journal Plexus Medical Journal Biomedika Indonesian Basic and Experimental Health Sciences
Irawan, Amelia Tjandra
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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The Relationship Between Measurements Of Medial Tibial Plateau Depth And Femoral Notch (Notch Witdh & Shape) On Genu Mri And The Severity Of The Isolated Anterior Cruciate Ligament Tear Cross Sectional Study At Tertiary Refferal Hospital Dr. Moewardi General Hospital & Prof. Soeharso Orthopedic Hospita Irawan, Amelia Tjandra; Adhie, Anistyaning Wahyu; Anindyarani, Yutrisa Sasti; Lillah, Yudhi
Indonesian Basic and Experimental Health Sciences Vol. 12 No. 2 (2024): April
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol12iss2pp63-72

Abstract

Background: The knee is a complex joint, composed of ligament components, one of which is the Anterior cruciate ligament which functions as a knee stabilizer. ACL injury is the most common ligament injury in the knee joint. Anatomical factors are one of the factors that predict the severity of an ACL tear. Medial Tibial Plateau Depth and Femoral Notch are one of the influencing factors. Genu MRI examination plays an important role in assessing these factors regarding the severity of an Isolated ACL tear. Objective: To determine the relationship between measurements of Medial Tibial Plateau Depth and Femoral Notch (Notch Witdh & Shape) on MRI genu with the severity of Isolated Anterior Cruciate Ligament Tear at Dr. Moewardi Hospital Surakarta and Prof. Soeharso Orthopedic Hospital Surakarta Method: Quantitative analytical research with a cross-sectional design was conducted from May to June 2023. The research sample was patients who underwent a Knee MRI examination with clinical Isolated ACL Tear in the period 1 January 2021 to 30 June 2023. Patients were assessed for the severity of the ACL tear and measurements of the Medial Tibial Plateau Depth and Notch Width and the shape of the Femoral Notch Os Femur Results: Medial tibial plateau depth on MRI Genu was positively correlated with the severity of isolated ACL tear (p value <0.001 and r correlation value of 0.943). Femoral Notch Shape, especially the A shape, has a relationship with the severity of isolated ACL tear (p value = 0.036 (p < 0.05) and r value = 0.274). Meanwhile, the relationship between femoral notch width on MRI Genu and the degree of isolated ACL tear is not significant because the p value obtained is 0.484 (p>0.05) Conclusion: Medial Tibial Plateau Depth and Femoral Notch Shape on MRI Genu have a relationship with the Severity of Isolated Anterior Cruciate Ligament Tear, whereas Femoral Notch Witdh has no relationship
Hubungan Volume Iodiksanol dengan Perubahan Kadar Serum Kreatinin dan Hematokrit pada Pasien Pasca Angiografi Kalua, Karla; Putro, Prasetyo Sarwono; Irawan, Amelia Tjandra; Wujoso, Hari; Dewi, Ratih Tri Kusuma
Plexus Medical Journal Vol. 4 No. 6 (2025): Desember
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v4i6.2435

Abstract

Pendahuluan: Angiografi merupakan teknik memvisualisasikan vaskular dengan media kontras. Serum kreatinin dan hematokrit merupakan salah satu biomarker praktis dalam mendiagnosis gagal ginjal akut dan berpotensi memberikan nilai prognostik pada pasien dengan gagal ginjal akut. Namun, penelitian kejadian gagal ginjal akut pada media media kontras osmolalitas rendah (LOCM) maupun iso-osmolar (IOCM) pada angiografi jalur intraarterial masih menjadi perdebatan dan efek media kontras terhadap kadar hematokrit belum banyak dikemukakan. Penelitian ini bertujuan untuk mengetahui hubungan volume iodiksanol dengan perubahan kadar serum kreatinin dan hematokrit pada pasien pasca angiografi. Metode: Penelitian observasional analitik desain cohort prospektif pada pasien yang menjalani angiografi di Rumah Sakit Umum Daerah Dr. Moewardi Surakarta pada April 2024 hingga September 2024. Data didapat melalui hasil laboratorium dan rekam medis dan hubungan diantara variabelnya dianalisis dengan uji korelasi Pearson. Hasil: 31 orang ikut serta dalam penelitian ini. Terdapat signifikansi (p) sebesar 0.034 (p < 0.05) pada hubungan volume iodiksanol dengan perubahan kadar hematokrit pasca angiografi hari ke-2 dengan nilai koefisien korelasi (r) sebesar -0.381. Tidak terdapat signifikansi pada hubungan volume iodiksanol dengan perubahan kadar hematokrit pasca angiografi hari ke-5 (p=0,781; p>0,05), volume iodiksanol dengan perubahan kadar serum kreatinin pasca angiografi hari ke-2 (p=0,968; p>0,05) maupun hari ke-5 (p=0,914; p>0,05), serta hubungan volume iodiksanol dengan perubahan eGFR pasca angiografi hari ke-2 (p=0,820; p>0,05) maupun hari ke-5 (p=0,693; p>0,05). Kesimpulan: Terdapat hubungan yang signifikan antara volume iodiksanol dengan perubahan kadar hematokrit pada pasien pasca angiografi hari ke-2 di Rumah Sakit Umum Daerah Dr. Moewardi Surakarta.
DYNAMIC LUMBOSACRAL RADIOGRAPH IN COMPARISON WITH CONVENTIONAL LUMBOSACRAL RADIOGRAPH IN FINDING DEGENERATIVE DISEASE OF THE LUMBAR SPINE Adzhani , Fityay; Hanafi, Muchtar; Irawan, Amelia Tjandra; Wujoso, Hari
Biomedika Vol 18, No 1 (2026): Biomedika February 2026
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Degenerative lumbar spine disease is a leading cause of disability, reducing patient's quality of life. However, Magnetic Resonance Imaging (MRI), the primary diagnostic modality, is not routinely feasible due to high cost and limited availability. Routine anteroposterior (AP) and lateral plain radiographs remain inferior to MRI, highlighting the need for alternative modalities such as vertebral dynamic radiography (flexion-extension views) to assess intervertebral instability. This analytic observational study used a cross-sectional design analyzing 42 patients at RSUD Dr. Moewardi (February 2019 - February 2020) with MRI-confirmed degenerative disease, the study compared findings of spondylolisthesis, vacuum disk phenomenon, osteophytes, and intervertebral space narrowing. Statistical analysis obtained p-value <0.05, demonstrating that dynamic radiographs possess higher sensitivity for detecting degenerative diseases of the spine than conventional views. Furthermore, the vacuum disk phenomenon was most prevalent in extension radiographs and least frequent in flexion. While osteophyte detection and intervertebral space narrowing remained consistent across both modalities, the dynamic study proved superior in assessing joint instability. The study concludes that there was a significant difference in the findings of spondylolisthesis on dynamic lateral radiographs and conventional lateral radiographs.
Vitamin D and Magnesium Combination Lowers High-Sensitivity C-Reactive Protein, Interleukin-12, Renin, and Carotid Vessel in Diabetic Rats Rahayu, Rachmi Fauziah; Zahrah, Fathimah Afifah; Anugrah, Tessa Septian; Yudhani, Ratih Dewi; Yueniwati, Yuyun; Irawan, Amelia Tjandra; Kusumaningrum, Sulistyani; Fauzi, Adam; Wasita, Brian; Wiyono, Nanang; Muthaminah, Muthaminah; Sholikah, Tri Agusti; Wardhani, Lusi Oka; Suyatmi, Suyatmi; Yarso, Kristanto Yuli; Pesik, Riza Novierta; Siswanto, Febby Gunawan
The Indonesian Biomedical Journal Vol 18, No 2 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i2.4061

Abstract

BACKGROUND: Diabetes mellitus induces oxidative stress, inflammation, and endothelial dysfunction, accelerating atherosclerosis development marked by elevated high-sensitivity C-reactive protein (hs-CRP) and interleukin-12 (IL-12). Diabetes often causes significant vascular changes, which can be represented by carotid tunica intima thickening and elevated renin level. Metformin, which remains as the standard therapy, has limited vascular effects. Vitamin D and magnesium exhibit vasoprotective and anti-inflammatory properties; however, their combined effects on diabetic vascular injury remain unclear. This study evaluated the effects of vitamin D and magnesium combination on serum hs-CRP, IL-12, renin, and carotid tunica intima thickness in diabetic rats.METHODS: Wistar rats were diabetic-induced by 45 mg/kg streptozotocin and 110 mg/kg nicotinamide. Following the induction, the rats were subsequently assigned to receive no treatment, metformin, or a combination of vitamin D and magnesium. Healthy rats were also included as control. Blood sample was collected after 21 days of treatment. Serum hs-CRP, IL-12, and renin were measured using enzyme-linked immunosorbent assay (ELISA), while the carotid tunica intima thickness was assessed by Doppler ultrasound.RESULTS: Diabetic rats showed significant increases hs-CRP, IL-12, renin level, and intima thickness (p<0.001) compared to control. Both metformin and combination of Vitamin D and magnesium reduced these parameters, with combination of Vitamin D and magnesium showing the greatest improvement. Carotid intima thickness in the combination of Vitamin D and magnesium group was comparable to normal controls, indicating marked vascular protection.CONCLUSION: Vitamin D and magnesium combination provided superior glycemic, anti-inflammatory, and vascular protective effects compared to metformin alone. This adjunctive strategy might have potential in preventing vascular complications in diabetes.KEYWORDS: diabetes mellitus, oxidative stress, endothelial dysfunction, hs-CRP, IL-12, atherosclerosis
Co-Authors Adam Fauzi Adhie, Anistyaning Wahyu Adzhani , Fityay Anindyarani, Yutrisa Sasti Anugrah, Tessa Septian Brian Wasita Hari Wujoso Kalua, Karla Kusumaningrum, Sulistyani Lillah, Yudhi Muchtar Hanafi Muthaminah, Muthaminah Nanang Wiyono Putro, Prasetyo Sarwono Rachmi Fauziah Rahayu Ratih Dewi Yudhani Ratih Tri Kusuma Dewi, Ratih Tri Kusuma Riza Novierta Pesik Sholikah, Tri Agusti Siswanto, Febby Gunawan Suyatmi Suyatmi Wardhani, Lusi Oka Yarso, Kristanto Yuli Yuyun Yueniwati Zahrah, Fathimah Afifah