Article Per Year (5 Year)
p-Index From 2021 - 2026
0.61
P-Index
This Author published in this journals
All Journal The Indonesian Biomedical Journal Indonesian Basic and Experimental Health Sciences
Irawan, Amelia Tjandra
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
The Relationship Between Measurements Of Medial Tibial Plateau Depth And Femoral Notch (Notch Witdh & Shape) On Genu Mri And The Severity Of The Isolated Anterior Cruciate Ligament Tear Cross Sectional Study At Tertiary Refferal Hospital Dr. Moewardi General Hospital & Prof. Soeharso Orthopedic Hospita Irawan, Amelia Tjandra; Adhie, Anistyaning Wahyu; Anindyarani, Yutrisa Sasti; Lillah, Yudhi
Indonesian Basic and Experimental Health Sciences Vol. 12 No. 2 (2024): April
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol12iss2pp63-72

Abstract

Background: The knee is a complex joint, composed of ligament components, one of which is the Anterior cruciate ligament which functions as a knee stabilizer. ACL injury is the most common ligament injury in the knee joint. Anatomical factors are one of the factors that predict the severity of an ACL tear. Medial Tibial Plateau Depth and Femoral Notch are one of the influencing factors. Genu MRI examination plays an important role in assessing these factors regarding the severity of an Isolated ACL tear. Objective: To determine the relationship between measurements of Medial Tibial Plateau Depth and Femoral Notch (Notch Witdh & Shape) on MRI genu with the severity of Isolated Anterior Cruciate Ligament Tear at Dr. Moewardi Hospital Surakarta and Prof. Soeharso Orthopedic Hospital Surakarta Method: Quantitative analytical research with a cross-sectional design was conducted from May to June 2023. The research sample was patients who underwent a Knee MRI examination with clinical Isolated ACL Tear in the period 1 January 2021 to 30 June 2023. Patients were assessed for the severity of the ACL tear and measurements of the Medial Tibial Plateau Depth and Notch Width and the shape of the Femoral Notch Os Femur Results: Medial tibial plateau depth on MRI Genu was positively correlated with the severity of isolated ACL tear (p value <0.001 and r correlation value of 0.943). Femoral Notch Shape, especially the A shape, has a relationship with the severity of isolated ACL tear (p value = 0.036 (p < 0.05) and r value = 0.274). Meanwhile, the relationship between femoral notch width on MRI Genu and the degree of isolated ACL tear is not significant because the p value obtained is 0.484 (p>0.05) Conclusion: Medial Tibial Plateau Depth and Femoral Notch Shape on MRI Genu have a relationship with the Severity of Isolated Anterior Cruciate Ligament Tear, whereas Femoral Notch Witdh has no relationship
Vitamin D and Magnesium Combination Lowers High-Sensitivity C-Reactive Protein, Interleukin-12, Renin, and Carotid Vessel in Diabetic Rats Rahayu, Rachmi Fauziah; Zahrah, Fathimah Afifah; Anugrah, Tessa Septian; Yudhani, Ratih Dewi; Yueniwati, Yuyun; Irawan, Amelia Tjandra; Kusumaningrum, Sulistyani; Fauzi, Adam; Wasita, Brian; Wiyono, Nanang; Muthaminah, Muthaminah; Sholikah, Tri Agusti; Wardhani, Lusi Oka; Suyatmi, Suyatmi; Yarso, Kristanto Yuli; Pesik, Riza Novierta; Siswanto, Febby Gunawan
The Indonesian Biomedical Journal Vol 18, No 2 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i2.4061

Abstract

BACKGROUND: Diabetes mellitus induces oxidative stress, inflammation, and endothelial dysfunction, accelerating atherosclerosis development marked by elevated high-sensitivity C-reactive protein (hs-CRP) and interleukin-12 (IL-12). Diabetes often causes significant vascular changes, which can be represented by carotid tunica intima thickening and elevated renin level. Metformin, which remains as the standard therapy, has limited vascular effects. Vitamin D and magnesium exhibit vasoprotective and anti-inflammatory properties; however, their combined effects on diabetic vascular injury remain unclear. This study evaluated the effects of vitamin D and magnesium combination on serum hs-CRP, IL-12, renin, and carotid tunica intima thickness in diabetic rats.METHODS: Wistar rats were diabetic-induced by 45 mg/kg streptozotocin and 110 mg/kg nicotinamide. Following the induction, the rats were subsequently assigned to receive no treatment, metformin, or a combination of vitamin D and magnesium. Healthy rats were also included as control. Blood sample was collected after 21 days of treatment. Serum hs-CRP, IL-12, and renin were measured using enzyme-linked immunosorbent assay (ELISA), while the carotid tunica intima thickness was assessed by Doppler ultrasound.RESULTS: Diabetic rats showed significant increases hs-CRP, IL-12, renin level, and intima thickness (p<0.001) compared to control. Both metformin and combination of Vitamin D and magnesium reduced these parameters, with combination of Vitamin D and magnesium showing the greatest improvement. Carotid intima thickness in the combination of Vitamin D and magnesium group was comparable to normal controls, indicating marked vascular protection.CONCLUSION: Vitamin D and magnesium combination provided superior glycemic, anti-inflammatory, and vascular protective effects compared to metformin alone. This adjunctive strategy might have potential in preventing vascular complications in diabetes.KEYWORDS: diabetes mellitus, oxidative stress, endothelial dysfunction, hs-CRP, IL-12, atherosclerosis
Co-Authors Adam Fauzi Adhie, Anistyaning Wahyu Anindyarani, Yutrisa Sasti Anugrah, Tessa Septian Brian Wasita Kusumaningrum, Sulistyani Lillah, Yudhi Muthaminah, Muthaminah Nanang Wiyono Rachmi Fauziah Rahayu Ratih Dewi Yudhani Riza Novierta Pesik Sholikah, Tri Agusti Siswanto, Febby Gunawan Suyatmi Suyatmi Wardhani, Lusi Oka Yarso, Kristanto Yuli Yuyun Yueniwati Zahrah, Fathimah Afifah