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All Journal JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Molecular and Cellular Biomedical Sciences (MCBS) Medica Hospitalia JURNAL GIZI DAN KESEHATAN Acta Odontologica Indonesia
Fulyani, Faizah
Department Of Medical Science, Division Of Medical And Biochemical Biology, Faculty Of Medical Science, Diponegoro University, Semarang,
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Liprotide-encapsulated vitamin D3 modulates circulated PTH levels and improved bone microstructure Shauma, Claradhita Ayu; Fulyani, Faizah; Pramono, Adriyan; Mahati, Endang; Putri, Sylvia Rahmi; Maulana, Reza Achmad; Anjani, Gemala
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 12, No 1 (2023): December
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.12.1.44-52

Abstract

Background: vitamin D (25(OH)D) is a fat-soluble vitamin that is unstable in the gastrointestinal environment and has low bioavailability. A protein-lipid complex (liprotide) can be used as a shell to increase vitamin D stability and bioavailability. Liprotide can also serve as a delivery system for transporting vitamin D to its intended site. Little attention has been paid to utilizing liprotide as a delivery system for vitamin D and evaluating its functional activity.Objective: to investigate the effect of liprotide-encapsulated vitamin D3 on PTH levels and bone microstructure in vitamin D and calcium (VD-Ca) deficient rats.Materials and Methods: an overall of 24 Wistar rats had been divided into four groups, a normal control group (K), a VD-Ca group without treatment (K-), a VD-Ca group with 180 IU/200 gBW/day free vitamin D3 (FVD3), and a VD-Ca group with 180 IU/200 gBW/day liprotide-encapsulated vitamin D3 (LVD3). Before and after 28 days of vitamin D intervention, blood samples were taken and analysed for serum PTH levels. The microstructure of the bone was analyzed using the Scanning Electron Microscope (SEM).Results: the VD-Ca rats supplemented with vitamin D3 (FVD3 and LVD3) had a significant decrease in serum PTH levels (p<0.001) and improved bone microstructure (p<0.05) compared to the (K-) group. The reduction of PTH in the LVD3 group was higher compared to the FVD3 group. The bone microstructure between the FVD3 and LVD3 groups is significantly different, as seen in the Ct.Wi parameter, with the LVD3 group having a higher Ct.Wi than the FVD3 group.Conclusion: liprotide-encapsulated vitamin D3 improves the serum PTH level and bone microstructure in a rat model of vitamin D and calcium deficiency.
Sulforaphane Promotes Adipocyte Thermogenesis: Molecular Insights, Anti-Obesity Potential, and Future Perspective Widayanti, Iftitan Setya; Noer, Etika Ratna; Fulyani, Faizah
Journal of Biomedicine and Translational Research Vol 11, No 3 (2025): December (Issue In Progress)
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i3.28102

Abstract

Over the past five decades, the increasing incidence of obesity has sparked considerable interest in nutraceuticals as promising natural alternatives for effective weight management and metabolic health improvement. Sulforaphane (SFN), an isothiocyanate abundant in cruciferous vegetables, has gained attention for its potential in obesity management, particularly by promoting the browning of white adipose tissue (WAT) and transforming it into energy-burning fat. While its potential is significant, the underlying molecular mechanisms are complex and require a comprehensive synthesis. Therefore, this review explores sulforaphane (SFN) as a potential nutraceutical alternative by examining the scientific evidence of its anti obesity effects, focusing on its ability to activate multiple signalling pathways, including Nuclear Factor Erythroid 2-related factor 2 (Nrf2), AMP-activated protein kinase (AMPK), and sirtuin 1 (SIRT1), as well as upregulation of uncoupling protein 1 (UCP1). These are the key pathways in mitochondrial biogenesis, lipid metabolism, and thermogenesis. Additionally, SFN can mitigate oxidative stress and modulate inflammatory responses, further contributing to improved metabolic function and energy expenditure. While much of the research on SFN has focused on its effects on mature cruciferous vegetables, current research increasingly directs attention to microgreens, which contain significantly higher concentrations of bioactive compounds, including SFN. This review highlights SFN’s molecular mechanisms underlying its role in the context of obesity, specifically its effects on WAT browning, metabolic regulation, and thermogenesis. We also explored the potential of microgreen-derived SFN as a promising nutraceutical for obesity intervention and metabolic regulation, highlighting the novel bioactive chemical and biological properties of these plants.
Co-Authors Adriyan Pramono Alifiati Fitrikasari Anjani, Gemala Aulia Sandriani Ayu Khoirun Nisa Devina Afraditya Paveta Diah Ajeng Purbaningrum Djuara P Lubis Donna Hermawati Dwi Ngestiningsih Endang Mahati Etika Ratna Noer Eva Annisaa Hernanda Haudzan Hakim Innawati Jusup Lusiana Batubara Maulana, Reza Achmad Muhammad Rizky Caniago Nadia Hardini Oedijani Santoso Prajogo, Johanna Kezia Purnomo, Brigitta Natania Renata Putri Theresia Lemmo Ate Bancin Putri, Sylvia Rahmi Rahmadani Widya Atmani Rani Rahayu Santoso Santoso Shauma, Claradhita Ayu Tyagita Haning Ratnasari Untari Widayanti, Iftitan Setya Yoghi Bagus Prabowo