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All Journal JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Molecular and Cellular Biomedical Sciences (MCBS) Medica Hospitalia Acta Odontologica Indonesia
Fulyani, Faizah
Department Of Medical Science, Division Of Medical And Biochemical Biology, Faculty Of Medical Science, Diponegoro University, Semarang,
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Sulforaphane Promotes Adipocyte Thermogenesis: Molecular Insights, Anti-Obesity Potential, and Future Perspective Widayanti, Iftitan Setya; Noer, Etika Ratna; Fulyani, Faizah
Journal of Biomedicine and Translational Research Vol 11, No 3 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i3.28102

Abstract

Over the past five decades, the increasing incidence of obesity has sparked considerable interest in nutraceuticals as promising natural alternatives for effective weight management and metabolic health improvement. Sulforaphane (SFN), an isothiocyanate abundant in cruciferous vegetables, has gained attention for its potential in obesity management, particularly by promoting the browning of white adipose tissue (WAT) and transforming it into energy-burning fat. While its potential is significant, the underlying molecular mechanisms are complex and require a comprehensive synthesis. Therefore, this review explores sulforaphane (SFN) as a potential nutraceutical alternative by examining the scientific evidence of its anti obesity effects, focusing on its ability to activate multiple signalling pathways, including Nuclear Factor Erythroid 2-related factor 2 (Nrf2), AMP-activated protein kinase (AMPK), and sirtuin 1 (SIRT1), as well as upregulation of uncoupling protein 1 (UCP1). These are the key pathways in mitochondrial biogenesis, lipid metabolism, and thermogenesis. Additionally, SFN can mitigate oxidative stress and modulate inflammatory responses, further contributing to improved metabolic function and energy expenditure. While much of the research on SFN has focused on its effects on mature cruciferous vegetables, current research increasingly directs attention to microgreens, which contain significantly higher concentrations of bioactive compounds, including SFN. This review highlights SFN’s molecular mechanisms underlying its role in the context of obesity, specifically its effects on WAT browning, metabolic regulation, and thermogenesis. We also explored the potential of microgreen-derived SFN as a promising nutraceutical for obesity intervention and metabolic regulation, highlighting the novel bioactive chemical and biological properties of these plants.
Ramadan Fasting and Anthropometric Parameters: The Role of MC4R rs17782313 Genotype in Adults Semarang, Indonesia Kurniawan, Kezia Yunandra; Yocku, Monica Hermina Sharon Otline; Savitri, Rachmania Anggita; Haq, Arynal; Maharani, Nani; Fulyani, Faizah; Noer, Etika Ratna; Pramono, Adriyan
Journal of Biomedicine and Translational Research Vol 12, No 1 (2026): April 2026
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v12i1.29501

Abstract

Background: The melanocortin-4 receptor (MC4R) gene regulates energy balance and food intake. The rs17782313 variant has been linked to altered homeostasis and eating behavior, and may also affect anthropometric and body composition responses during Ramadan fasting.Objective: To examine the effects of Ramadan fasting on anthropometric parameters, body composition, and macronutrient intake across different MC4R genotypes in adults.Methods: Thirty-five subjects were genotyped and grouped into recessive (TT, n=15) and dominant (TC+CC, n=20) allele carriers. Anthropometric and body composition measurements, dietary intake (SQ-FFQ), and physical activity (IPAQ-SF) were assessed before, during, and after Ramadan. Genetic data for rs17782313 were obtained from a prior investigation. Repeated Measures ANCOVA, adjusted for energy intake and physical activity, evaluated genotype and time effects.Results: The recessive group (TT) showed higher values than the dominant group (TC+CC), with significant differences in body weight, BMI, hip circumference, and visceral fat across all time points (p<0.05). Waist circumference differed significantly during and after Ramadan, while BMR differed only before fasting (p<0.05). Macronutrient intake and physical activity did not differ significantly, although protein and fat intake changes post-Ramadan were notable (p<0.05). A significant time–activity interaction was found for body weight (p=0.041). TT carriers experienced greater anthropometric benefits from Ramadan fasting compared to TC+CC carriers.Conclusion: Ramadan fasting significantly influences anthropometric parameters, body composition, and macronutrient intake across MC4R genotypes. Greater responses were observed in recessive carriers (TT), although fasting outcomes were also shaped by nutrition and physical activity. These findings highlight the interplay of genetic and environmental factors in energy regulation during Ramadan.
Co-Authors Adriyan Pramono Alifiati Fitrikasari Anjani, Gemala Aulia Sandriani Ayu Khoirun Nisa Devina Afraditya Paveta Diah Ajeng Purbaningrum Djuara P Lubis Donna Hermawati Dwi Ngestiningsih Endang Mahati Etika Ratna Noer Eva Annisaa Haq, Arynal Hernanda Haudzan Hakim Innawati Jusup Kurniawan, Kezia Yunandra Lusiana Batubara Maulana, Reza Achmad Muhammad Rizky Caniago Nadia Hardini Nani Maharani Oedijani Santoso Prajogo, Johanna Kezia Purnomo, Brigitta Natania Renata Putri Theresia Lemmo Ate Bancin Putri, Sylvia Rahmi Rahmadani Widya Atmani Rani Rahayu Santoso Santoso Savitri, Rachmania Anggita Shauma, Claradhita Ayu Tyagita Haning Ratnasari Widayanti, Iftitan Setya Yocku, Monica Hermina Sharon Otline Yoghi Bagus Prabowo