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All Journal JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Molecular and Cellular Biomedical Sciences (MCBS) Medica Hospitalia Acta Odontologica Indonesia
Fulyani, Faizah
Department Of Medical Science, Division Of Medical And Biochemical Biology, Faculty Of Medical Science, Diponegoro University, Semarang,
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Sulforaphane Promotes Adipocyte Thermogenesis: Molecular Insights, Anti-Obesity Potential, and Future Perspective Widayanti, Iftitan Setya; Noer, Etika Ratna; Fulyani, Faizah
Journal of Biomedicine and Translational Research Vol 11, No 3 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i3.28102

Abstract

Over the past five decades, the increasing incidence of obesity has sparked considerable interest in nutraceuticals as promising natural alternatives for effective weight management and metabolic health improvement. Sulforaphane (SFN), an isothiocyanate abundant in cruciferous vegetables, has gained attention for its potential in obesity management, particularly by promoting the browning of white adipose tissue (WAT) and transforming it into energy-burning fat. While its potential is significant, the underlying molecular mechanisms are complex and require a comprehensive synthesis. Therefore, this review explores sulforaphane (SFN) as a potential nutraceutical alternative by examining the scientific evidence of its anti obesity effects, focusing on its ability to activate multiple signalling pathways, including Nuclear Factor Erythroid 2-related factor 2 (Nrf2), AMP-activated protein kinase (AMPK), and sirtuin 1 (SIRT1), as well as upregulation of uncoupling protein 1 (UCP1). These are the key pathways in mitochondrial biogenesis, lipid metabolism, and thermogenesis. Additionally, SFN can mitigate oxidative stress and modulate inflammatory responses, further contributing to improved metabolic function and energy expenditure. While much of the research on SFN has focused on its effects on mature cruciferous vegetables, current research increasingly directs attention to microgreens, which contain significantly higher concentrations of bioactive compounds, including SFN. This review highlights SFN’s molecular mechanisms underlying its role in the context of obesity, specifically its effects on WAT browning, metabolic regulation, and thermogenesis. We also explored the potential of microgreen-derived SFN as a promising nutraceutical for obesity intervention and metabolic regulation, highlighting the novel bioactive chemical and biological properties of these plants.
Co-Authors Adriyan Pramono Alifiati Fitrikasari Anjani, Gemala Aulia Sandriani Ayu Khoirun Nisa Devina Afraditya Paveta Diah Ajeng Purbaningrum Djuara P Lubis Donna Hermawati Dwi Ngestiningsih Endang Mahati Etika Ratna Noer Eva Annisaa Hernanda Haudzan Hakim Innawati Jusup Lusiana Batubara Maulana, Reza Achmad Muhammad Rizky Caniago Nadia Hardini Oedijani Santoso Prajogo, Johanna Kezia Purnomo, Brigitta Natania Renata Putri Theresia Lemmo Ate Bancin Putri, Sylvia Rahmi Rahmadani Widya Atmani Rani Rahayu Santoso Santoso Shauma, Claradhita Ayu Tyagita Haning Ratnasari Widayanti, Iftitan Setya Yoghi Bagus Prabowo