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Florentinus Dika Octa Riswanto
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Jurnal Farmasi Sains dan Komunitas
Published by Universitas Sanata Dharma
ISSN : 16935683     EISSN : 25277146     DOI : https://doi.org/10.24071/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 13 Documents
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Search results for , issue "Vol 20, No 2 (2023)" : 13 Documents clear
Beneficial Fruit-Derived Phytochemicals in Treating Alzheimer’s Disease – A Review Yurida Ni'ma Annisa; Vania Amanda Samor; Muthi Ikawati; Nunung Yuniarti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004491

Abstract

Fruits, as a major source of nutrition have been investigated for their emerging evidence of several neuroprotective activities beneficial to Alzheimer’s disease (AD). This paper discusses recent evidence suggesting several fruit-derived bioactive substances that possess anti-AD activity. The original articles from 2011–2022 were collected from Pubmed and Scopus with related keywords and filtered. Several fruit constituents have shown significant inhibitory action against β-amyloid and tau hyperphosphorylation, either directly or indirectly via secretase inhibition. Some were also found to be cholinesterase inhibitors with specific antioxidative roles, disruptors of the neuroinflammation system, and promoters of neurogenesis and the neurogenic process. Many fruit phytochemicals remarkably alter the capability defects shown in AD animal models, such as catechin, nobiletin, and alpha-mangostin. Therefore, further investigations exploring a certain bioactive isolate or formulated dosage form and its mechanism of action are necessary to provide effective prevention and supplementary treatment for AD.
COVID-19 Vaccine Acceptance in A Private Islamic Boarding School, West Nusa Tenggara Siti Rahmatul Aini; Iman Surya Pratama; Raisya Hasina; Candra Eka Puspitasari; Ni Made Amelia Ratnata Dewi; Muhammad Abdurrahman Fardiaz; Nurmayanggi Aulia Safitri; Shifa Hasanah; Yazid Maula Arzaqi; Khairun Nissa
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006418

Abstract

The COVID-19 vaccination program began in Indonesia in 2020, but it is still unknown how well it has been received by particular communities in places like the West Nusa Tenggara region's Islamic boarding schools. This research aimed to identify the characteristics and factors that contribute to the COVID-19 vaccine's acceptance at the Nurul Islam Sekarbela Islamic Boarding School. In August 2022, a cross-sectional survey was conducted on a stratified random sample of chosen boarding school students using a validated questionnaire. Data on demographic factors, COVID-19 history, religious acceptance, and opinions were all examined descriptively. A total of 124 students, or 62%, gave their informed permission. Based on the findings, it was determined that the Nurul Islam Sekarbela Islamic Boarding School's level of acceptance of the COVID-19 vaccine is still considered low (35%) and in doubt (65%). Acceptance of vaccines is mostly influenced by efficacy, safety, and family recommendations. Acceptance of vaccines is impeded by the dominant fatalistic religious mindset.
Success Factors in Improving Patients’ Adherence to Tuberculosis Treatment Program: Case Study in Sleman, Yogyakarta, Indonesia Mario Yedi Mau; Titien Siwi Hartayu
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005770

Abstract

Improving patients’ adherence to treatment programs is important for the success of tuberculosis (TB) treatment. The study aims to identify the underlying factors of TB treatment program success. A qualitative approach, i.e., an in-depth interview, and the purposive sampling method in selecting respondents were used to conduct this study. There are 15 persons involved, i.e., 3 persons each: pharmacists as providers, TB programmers, medicines supervisor (MS), TB cadres as supporters, and recovered TB patients as actors (17 years old and over). The data obtained were analyzed using the triangulation method (providers, actors, and supporters). The results of the study show that the family's role is very important in MS by taking medicines from primary health care and giving medicines on time. TB counselors play a role in monitoring the treatment program and making occasional home visits to motivate patients to recover. TB  programmers and pharmacists play a role in providing patients’ education and MS, as well as monitoring medication-taking schedules and medical check-ups. Patients play a role in motivating themselves to get back to work soon. In conclusion, the underlying factors in TB treatment program success are the discipline of providers, supervisors, supporters, and patients’ motivation.
Physical Properties Investigation on Sunscreens with Red Dragon Fruit Peel Extract Ruth Febriana Kesuma; Rokiy Alfanaar; Markus Angkawijaya
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004537

Abstract

Red dragon fruit peel extract is reported as an active ingredient in sunscreen because of its ability to protect the skin. UV exposure to the skin can cause reddish skin to develop skin cancer. This study aimed to determine the characteristics of the cream made from ZnO and red dragon fruit peel extracts (Hylocereus costaricensis), such as sun protection factor (SPF), pH, stability, viscosity, spreadability, and adhesion. Red dragon fruit peel extract was obtained by maceration using methanol, and DPPH-scavenging activity resulted in an IC50 of 0.96 μg/mL. Measurement of diffuse UV-vis reflectance shows that ZnO has absorption at λex 385 nm, which correlates with a bandgap energy of 3.22 eV. F1 formulation cream (red dragon fruit peel extract and ZnO ratio of 0:1) has the highest SPF value of 17. The Kruskal-Wallis test shows that there is a significant difference in adhesion between the F1 formulation cream with F2 (p-value = 0.002) and F4 (p-value = 0.03).
Molecular Dynamics Simulation of Serotonin Transport Protein Complex with 6-Hydroxy-1-Methyl-1,2,3,4-Tetrahydro-β-Carboline Ligand from Chocolate (Theobroma cacao L.) Isolate Farach Khanifah; Enade Perdana Istyastono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005939

Abstract

6-hydroxy-1-methyl1,2,3,4-tetrahydro-β-carboline (6OHMTHβC) is a chocolate derivate that has antidepressant potency. It can increase dopamine and serotonin secretion, which leads to mood improvement. This method was carried out using computational molecular docking simulations (in silico). The research design was computational-based exploratory descriptive. The results of molecular docking showed the lowest energy score and the backbone RMSD value ≤2Å. The procedure performed was 6AWP receptor docking without ligand, with native ligand (6OHMTHβC), and with reference ligand (fluvoxamine). This study also performed molecular docking simulations of 6OHMTHβC towards 6AWP to find compounds in the receptor binding pocket. This study also performed dynamics simulations and identified the molecular determinants using PyPLIF-HIPPOS and YASARA Structure software 20.1.24.10 with the Windows 10 operating system. This study succeeded in determining the stability of the dynamics simulation of the serotonin transport protein complex with the reference ligand 6OHMTHβC for 50 ns, and this result corresponds to the RMSD value and binding energy. The determination of binding energy (BE) was calculated from the BE calculation available at YASARA and Ubuntu. The binding energy value of the original ligand was -11.6590 kJ/mol, and the reference ligand was -83880 kJ/mol. The highest RMSD value of the original ligand was 1.39292Å, while the RMSD value of the reference ligand was 1.71072Å. The essential amino acid carried out was 438Ser with hydrogen bond interactions, so 6OHMTHβC was considered a competent antidepressant candidate.
Secondary Metabolites Production of Bacillus spp. Isolated from Sea Cucumbers (Holothuria scabra) and their Activity against Mycobacterium smegmatis Maya Dian Rakhmawatie; Aida Zakiyatul Fikriyah; Ika Dyah Kurniati; Nanik Marfu'ati; Stalis Norma Ethica
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004843

Abstract

New anti-tuberculosis agents are very important due to Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis problems. Mycobacterium smegmatis can be used to replace Mycobacterium tuberculosis as bacteria test to increase the velocity of anti-tuberculosis screening. To answer the need for new drugs, exploration of secondary metabolites from Bacillus spp. can be conducted. Bacillus spp. are known to produce antimicrobials, including discovery of iturins, fengycins, and pumilacidins. This study explored the Bacillus spp. isolated from fermented intestines of Holothuria scabra. The production of Bacillus sp. Holothuria scabra Fermented Intestine (HSFI) secondary metabolites was done using culture media containing starch as a carbon source, as well as yeast and peptone as a nitrogen source. Production capacity of secondary metabolites of Bacillus sp. HSFI was calculated, to determine its potential as an antibacterial producer. Inhibition testing of secondary metabolites of Bacillus sp. HSFI against M. smegmatis was performed using the Kirby-Bauer disk diffusion method. Based on the results of the inhibition test, it was concluded that Bacillus sp. HSFI-9 has the greatest potential to inhibit the growth of M. smegmatis, with a moderate inhibition (7.67 mm). Production of secondary metabolites from Bacillus sp. HSFI-9 is exceptionally good with an extract production capacity of 24.6 mg/L.
Why Does the Poor Glycemic Control Among Type 2 Diabetes Mellitus Patients Remain High in Southeast Asia? Maria Lisa Nova; Dita Maria Virginia
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006214

Abstract

Presently, as well, 55% of the world’s diabetic population is Asian, with an estimated 230 million. The International Diabetes Federation (IDF) shows that the number of people with diabetes in the Southeast Asia (SEA) Region is 16.8% of all people with diabetes worldwide. To manage a patient’s blood glucose level, consider minimizing the worst effects of diabetes mellitus. Glycemic control using HbA1c levels is one of the important factors in the risk of diabetes that is associated with complications and mortality. A PubMed and Google Scholar databases were searched using the following: We only screened original-type articles for relevance and considered them further. Type 2 diabetes mellitus patients in Southeast Asia mostly experience uncontrolled blood glucose. More than 50% of research subjects show poor glycemic control. The influencing factors of poor glycemic control in Southeast Asia were age, BMI, hypertension, smoking activity, education, physical activity, and dyslipidemia. The awareness of glycemic control must be improved in type 2 diabetes mellitus patients.
Stability Evaluation of Candlenut Oil Capsule: Disintegration, Iodine Value, Omega Content, and Drug Kinetics Hery Sutanto; Wulan Sutardiman; Silvya Yusri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004982

Abstract

Candlenut oil, known for its high omega-3 fatty acid content (up to 90%), shows great promise as a valuable source of omega. However, its rich unsaturated fatty acid composition makes it susceptible to oxidation and quality degradation. To address this, candlenut oil is encapsulated for use as a food supplement product. This research aims to investigate the stability of omega oil content in capsulated candlenut oil as well as the physical and chemical properties of gelatin and seaweed-based hard capsules used for encapsulation. Additionally, the study explores the optimal capsule material, opacity, and storage conditions for preserving the quality of candlenut oil products. Three key factors were considered: capsule material (gelatin and seaweed-based), capsule opacity (colored and transparent), and storage temperature (cool temperature with relative humidity of 33% and ±8°C, or room temperature with relative humidity of 65% and ±28°C). The evaluation of the best capsule material and optimum storing temperature of candlenut oil capsules was based on disintegration time, iodine value analysis, and omega content analysis. The results indicate that the disintegration times for gelatin and seaweed capsules were 5.80 and 5.78 minutes, respectively. Transparent gelatin capsules demonstrated the best performance in preventing oil quality degradation, as confirmed by the iodine value analysis. Both gelatin and seaweed capsules exhibited the ability to prevent the degradation of omega oil when stored at cool temperatures, with an estimated kinetic shelf life of 2.92 years.
Corrective and Preventive Actions of Pharmacist Preceptor in Guiding Pharmacy Internship at Public Health Center during the COVID-19 Pandemic Nirma Atin Shintia; Yosef Wijoyo
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006316

Abstract

During the COVID-19 pandemic, a pharmacy internship at the Public Health Centers (PHC) was carried out by complying with the implementation of health protocols. There were risks for students to be exposed to COVID-19 when a pharmacy internship was carried out directly at the PHC, and some pharmacy internship materials could not be applied easily due to the pandemic. This study aimed to identify the corrective and preventive actions of the preceptor in guiding the pharmacy internship at the PHC during the COVID-19 pandemic. This descriptive study was conducted using the in-depth interview method and examined using qualitative data analysis. The results of interviews were categorized into six issues, namely: 1) roles and abilities as preceptors; 2) pharmacy college institution support; 3) pharmacy internship mentoring methods; 4) corrective and preventive actions to overcome problems in pharmacy internships during pandemics; 5) pharmacy internship modules; and 6) barriers and factors supporting the role of preceptors. Preventive action taken by the preceptor was generally in relation to government policies during the pandemic and infection prevention and control programs in PHC. Concurrently, the corrective actions were modifying learning methods and using information technology to support pharmacy internship learning outcomes during the pandemic and post-pandemic.
Antibacterial Activity of Extract Combination Gel of Cherry Leaf (Muntingia calabura L.) and Beluntas Leaf (Pluchea indica L.) againts Staphylococcus aureus Nanik Sulistyani; Tegar Prasetya Budi; Aprilia Kusbandari
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005267

Abstract

Staphylococcus aureus (S. aureus) infection is a critical problem, in health care because there are S. aureus found that are resistant to antibiotics. Some alternative treatments of infection include herbal plants such as cherry (Muntingia calabura L.) and beluntas (Pluchea indica L.) leaves since they contain antibacterial compounds. Cherry and beluntas leaves are formulated in gel form since they are easy to use. This study aims to determine the physical properties, microbial contamination and antibacterial activity of the gel preparation. Combination of cherry leaf extract and beluntas leaf extract with a concentration ratio of 2.5: 0.5 was formulated in gel preparations with concentrations of 3%, 6% and 12%. The gel was later tested for physical properties including tests for organoleptic, pH, spreadity diameter, adhesity, and viscosity. The gel was also tested for the number of yeasts and antibacterial activity by the agar well diffusion method. The results were analyzed with SPSS 20.0.0 with One-way ANOVA. The results of the physical properties test for the gel preparation for viscosity were: (5666.18; 6369.23; and 8540.11) cps, the pH value was (7.58; 7.11; and 6.45), the scattering diameter was ( 6.16; 5.88; and 5.00) cm, the value of adhesity (74.66; 80.99; and 98.18) seconds, respectively. The test results of the yeast mold number  obtained 3x102 CFU/mL. The results of the inhibition zone diameters were (6.00; 7.90; and 10.00) mm, respectively. Based on these research findings, the difference in extract concentration affects the physical properties of the gel. The gel formula with a 12% concentration has physical properties reaching the requirements, meets the requirements for the value of yeast mold numbers, and provides the most optimal antibacterial activity.

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