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Florentinus Dika Octa Riswanto
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INDONESIA
Jurnal Farmasi Sains dan Komunitas
Published by Universitas Sanata Dharma
ISSN : 16935683     EISSN : 25277146     DOI : https://doi.org/10.24071/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 247 Documents
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Optimization and Physical Characterization of Kojic Acid Nanoemulsion Formula As A Whitening Agent Guanse, Yovi; Dwiastuti, Rini; Jenita Gandi, Brigita Tuelvin; Chabib, Lutfi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009968

Abstract

Kojic acid (KA) as a topical formulation prevents hyperpigmentation through the inhibition of tyrosinase activity. However, KA has higher solubility in nonpolar solvents. Nanoparticle technology can be a novel innovation to enhance KA absorption into the skin. This study aims to improve the delivery of topically applied KA by enhancing absorption into the stratum corneum by optimizing the concentration of surfactant Tween 80 and co-surfactant Span 80. The nanoemulsion uses KA as an active ingredient and virgin coconut oil as the oil phase. The optimum area was analyzed using Design-Expert® 13 software, with a pure experimental design based on a 2x2 factorial design. The results indicate that all formulas are within the optimal region. Therefore, the determination of the optimal point can be grounded on the smallest composition within the optimal region with the objective of maximizing material efficiency, which is a formula with a concentration of Tween 80 and Span 80 of 10 grams and 3 grams, respectively. The particles are a spherical smooth shape and demonstrate an efficacy of 94.117% in inhibiting tyrosinase activity.
Cost Analysis of Inpatient Heart Failure Treatment at PKU Muhammadiyah Hospital of Yogyakarta Based on INA-CBG’s Tariffs in 2023 Hadning, Ingenida; Wari, Lidya Prames; Lestari, Nina Dwi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008765

Abstract

The prevalence of heart failure in Indonesia has reached 1.5% of the entire population. Catastrophic heart failure requires long treatment, thus necessitating large costs. The Indonesian government regulates payments to advanced health facilities through INA-CBG tariffs. This study evaluated the INA-CBG tariffs based on the Ministry of Health Regulation No. 3 of 2023 for the treatment of inpatient heart failure. This study aims to determine the difference in the average actual costs of heart failure patients compared to the INA-CBG tariffs based on the Ministry of Health Regulation No. 3 of 2023. This research was conducted as an observational study with a cross-sectional design at PKU Muhammadiyah Hospital of Yogyakarta. Data on heart failure inpatients were gathered using a retrospective method from January to September 2023. Data were analyzed using descriptive analysis and a one sample t-test. The analysis found some average actual costs were higher than INA-CBG tariffs, with an insignificant difference. Real costs that the Social Security Agency (BPJS) on Health could not cover caused the hospital to suffer losses.The prevalence of heart failure in Indonesia has reached 1.5% of the entire population. Catastrophic heart failure requires long treatment, thus necessitating large costs. The Indonesian government regulates payments to advanced health facilities through INA-CBG tariffs. This study evaluated the INA-CBG tariffs based on the Ministry of Health Regulation No. 3 of 2023 for the treatment of inpatient heart failure. This study aims to determine the difference in the average actual costs of heart failure patients compared to the INA-CBG tariffs based on the Ministry of Health Regulation No. 3 of 2023. This research was conducted as an observational study with a cross-sectional design at PKU Muhammadiyah Hospital of Yogyakarta. Data on heart failure inpatients were gathered using a retrospective method from January to September 2023. Data were analyzed using descriptive analysis and a one sample t-test. The analysis found some average actual costs were higher than INA-CBG tariffs, with an insignificant difference. Real costs that the Social Security Agency (BPJS) on Health could not cover caused the hospital to suffer losses.
Cost Utility of Adjuvant and Neo-Adjuvant Treatment for Breast Cancer: A Systematic Review of Observational Economic Evaluations Study Larasanty, Luh Putu Febryana; Setyawan, Irfanianta Arif; Nurlita, Diah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007988

Abstract

This study aimed to perform a systematic review of an observational cost-utility analysis of adjuvant and neo-adjuvant agents in breast cancer patients. The PRISMA flowchart was used to conduct the literature search and study selection. Through the use of two databases, PubMed and Scopus, a literature search was done. The eligible study was determined based on the established inclusion criteria. To evaluate the quality of the study, Drummond's checklist was used. Data extraction was conducted to assess characteristics, study perspective, cost and outcome measurement, the cost-utility ratio in ICER value, threshold, sensitivity or probability analysis, and the conclusion of the cost-utility study. There was a total of 7 studies included for review. Four studies compared chemotherapy regimens as adjuvant or neoadjuvant and three studies included hormone therapy or targeted therapy as an intervention that compared. Observational characteristic includes the use of cohort methods, and a large number of participants, the comparison is mostly for adjuvant therapy purposes and direct medical cost measured from a payer perspective. Anthracycline-based chemotherapy like the FAC regimen showed potential cost-effectiveness results. The use of targeted therapy (pertuzumab, trastuzumab) and hormonal therapy (goserelin) is associated with better utility outcomes and an increase in cost burden from intervention. Based to the reviewed studies, anthracycline-containing regimens such as FAC may have pharmacoeconomic properties as adjuvant or neo-adjuvant therapy. While the use of the most recent pharmacological drug has the potential to improve utility outcomes, but is associated with an increase in the intervention's cost burden.
Meropenem Determination in Human Plasma by LC-MS/MS and Evaluation for Therapeutic Drug Monitoring in ICU Patients Amalia, Dita; Lukitaningsih, Endang; Nugroho, Akhmad Kharis; Puspitasari, Ika
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.0011827

Abstract

Meropenem is a broad-spectrum beta-lactam antibiotic widely used in intensive care units (ICUs) for severe bacterial infections. Therapeutic drug monitoring (TDM) is essential to optimize its dosing, ensuring effective bacterial eradication while minimizing toxicity and resistance.This study aimed to determine meropenem concentrations in human plasma using LC-MS/MS and evaluate its application in TDM for ICU patients. Meropenem concentrations in plasma samples from ICU patients were analysed using a validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. The study included 40 plasma samples from 20 patients receiving meropenem continuous infusion. Validation followed ICH M10 (2022) guidelines, assessing specificity, accuracy, precision, stability, and dilution integrity. The developed LC-MS/MS method demonstrated high selectivity, sensitivity, and linearity (r = 0.9930.996) over the 102000 ng/mL range. Accuracy and precision met ICH M10 acceptance criteria, with %CV 15%. All ICU patients maintained %fTMinimum Inhibitory Concentration (MIC) 40%, ensuring adequate bacterial eradication. Notably, patients with renal impairment required dose adjustments, while those with high creatinine clearance needed increased dosing. The validated LC-MS/MS method is suitable for meropenem TDM in ICU patients, allowing individualized dosing adjustments to optimize therapy.
Evaluation of Drug Interactions in Polypharmacy: A Case Study of Patients with Heart Failure Hospitalized at Tangerang District Hospital Khairani, Sondang; Manninda, Reise Reise Manninda; Ariani, Lusiana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.0010033

Abstract

Heart failure is a condition in which the heart is unable to pump enough blood to meet the body's metabolic needs. It is a clinical syndrome with signs and symptoms caused by abnormalities in the structure and/or function of the heart. Heart failure occurs when the heart can't pump enough blood to meet the body's needs. It is caused by problems with the structure or function of the heart. This can lead to polypharmacy, where several medications are often taken by patients with heart failure to manage their condition. This study aims to identify patient characteristics, treatment accuracy based on Indonesian Heart Association (PERKI) 2023 guidelines, and the relationship between drug interactions and polypharmacy in adult patients diagnosed with heart failure with or without comorbidities at Tangerang Regency Hospital in 2023. The research was conducted descriptively using a cross-sectional study design. A total of 78 samples specimens met the inclusion criteria, with a male majority of 37 (52.86%) patients. The most common age group was 56-65 years old with 25 (35.71%) patients. The most common length of stay was 1-5 days with 48 (68.57%) patients. Evaluation of the treatment accuracy showed that the appropriate drug class was achieved in 78 (100%) patients, the appropriate dose in 55 (70.51%) patients and the appropriate frequency in 45 (57.69%) patients. Statistical tests showed a correlation between polypharmacy and drug-drug interactions with p-value 0.05. Accordingly, it is important to enhance monitoring and assessment of drug interactions in heart failure patients to optimize treatment management and prevent the risk of complications
Development of Chemometric Methods for Determining Caffeine Content in Robusta Coffee as Alternative Standardization Techniques Handoyo, Theodorus Rexa; Primaharinastiti, Riesta; Yuwono, Mochammad
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009242

Abstract

There is a necessity for standardization to uphold coffee quality due to its frequent production and consumption. High-performance liquid chromatography (HPLC) serves as the benchmark for caffeine analysis in coffee in Indonesia. However, its high cost has prompted the exploration of alternative methods. This study aims to obtain a suitable alternative method for determining the caffeine content in robusta coffee as an effort toward standardization. Employing statistical and mathematical techniques in chemistry, chemometrics emerges as a promising alternative in analyzing caffeine in coffee. The approach was integrated with an ultraviolet (UV) spectrophotometer capable of analyzing substances across wavelengths from 200 to 400 nm. From the five replications, the HPLC method showed a caffeine content of 1.435 ± 0.011% (w/w), while the spectrophotometer showed a content of 1.723 ± 0.003% (w/w). Through the partial least squares regression (PLSR) and principal component regression (PCR) methods in RStudio, the results obtained were 1.432 ± 0.003% and 1.430 ± 0.002% (w/w), respectively. These results indicate good REP values of 0.022% for PLSR and 0.155% for PCR. With these findings, it is hoped that chemometrics can become an alternative method for analyzing caffeine in coffee.
Inhibitory Effect of Ethanol Extract of Cherry Mistletoe Leaves (Dendrophthoe pentandra (L.) Miq) on Xanthine Oxidase Enzyme Sabathania, Hana Daini; Subandrate, Subandrate; Sinulingga, Sadakata; Safyudin, Safyudin; Oswari, Liniyanti D; Fatmawati, Fatmawati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008252

Abstract

One plant that can be used as an alternative treatment for hyperuricemia is the cherry plant. The usefulness of these plants is due to the secondary metabolite compounds that can inhibit the enzyme xanthine oxidase. Cherry mistletoe is thought to have the same flavonoids, saponins, alkaloids, terpenoids, and tannins as the cherry plant, which can act as inhibitors. The aim of the study was to determine the inhibitory effect of an ethanol extract of cherry mistletoe leaves on the xanthine oxidase enzyme. This study was conducted as  an in vitro experimental study. Cherry mistletoe leaves were extracted with 96% ethanol. The extract was done with phytochemical screening, followed by an inhibition test on the xanthine oxidase enzyme using a spectrophotometer at a wavelength of 400 nm. Allopurinol was a positive control. The ethanol extract of cherry mistletoe leaves contains flavonoids, saponins, alkaloids, terpenoids, and tannins. The IC50 value of the ethanol extract of cherry mistletoe leaves was 23.44 mg/L. The ethanol extract of cherry mistletoe leaves has an inhibitory effect on the xanthine oxidase enzyme with moderate activity. Accordingly, the cherry mistletoe leaf extract can be considered as an alternative inhibitor of the xanthine oxidase enzyme in the control of hyperuricemia.
Enhancing Knowledge and Attitude Through mHealth App-Assisted Patient Education Among Elderly Patients with Uncontrolled Hypertension Ghozali, Muhammad Thesa; Cahyadi, Fachri Argya; Satibi, Satibi; Fortwengel, Gerhard
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.0011907

Abstract

Hypertension remains a critical health challenge worldwide, with uncontrolled hypertension being a significant contributor to cardiovascular morbidity and mortality. Elderly patients often face difficulties in hypertension management due to limited knowledge, adherence barriers, and lack of education. This study aimed to evaluate the impact of an mHealth-assisted patient education intervention on knowledge and attitude among elderly patients with uncontrolled hypertension. A pre-experimental one-group pre-test and post-test design was conducted among 39 patients aged 46–55 years (48%) and 56-65 years (52%). Patients accessed an mHealth application featuring interactive hypertension management modules. Knowledge and attitude were assessed using validated questionnaires pre- and post-intervention. Results showed a significant improvement in both knowledge and attitude scores post-intervention (p 0.05). The mHealth-based approach effectively increased patient understanding and encouraged a positive attitude towards hypertension management. The study highlights the potential of mHealth applications in enhancing hypertension knowledge and attitude among elderly patients, emphasizing the need for integrating digital tools in routine hypertension care.
Reducing Dispensing Time by Applying the Lean Hospital Approach in the Outpatient Pharmacy Department of SMC Telogorejo Hospital in Semarang Indonesia Wahyunengsih, Cicilia Tyasti; Hartayu, Titien Siwi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.0010115

Abstract

The outpatient pharmacy department is the last service unit visited by patients. One common concern is the delay in receiving medicine. Improvements in medicine dispensing time were made with a lean hospital. This study aims to analyze the impact of lean hospital interventions on waiting times and Value Added Ratio (VAR). This quasi-experiment was conducted with a non-equivalent control group before-after design. The study population included non-compounded medicine prescriptions with out-of-pocket healthcare from April to July 2024. The sample was 1,266 prescriptions. Direct observation gathered data for value stream mapping in non-compounded medicine dispensing, recording time for prescription screening, preparation, final checks, and delivery, including patient education. Activity time was considered value-added time. Value-added time divided by Cycle Time (CT) was used to calculate VAR. Critical waste identified by the root-cause analysis was conducted through in-depth interviews using the fishbone diagram guide. Data before and after intervention were analyzed using the Mann-Whitney U-test. Inventory waste significantly affected dispensing times. The lean hospital strategy improved the efficiency of pharmaceutical services by reducing the dispensing time from 19.68 to 16.18 minutes (p 0.001) and increasing the VAR from 51.34% to 57.21% (p 0.001) with an automated medicine planning system.
Caffeine and Caffeic Acid as Acetylcholinesterase Inhibitors: In Silico Perspectives Wira Waskitha, Stephanus Satria; Wiranata, Bonifacius Ivan; Mark, Julyus Jason; Krisantia, Herluin Sekar; Kristina, Natalia; Ardine, Glory Ivana; Prasetyo, Chrisologus Ivan; Gani, Michael Raharja; Riswanto, Florentinus Dika Octa; Istyastono, Enade Perdana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009687

Abstract

Alzheimer's disease (AD) has been recognized as a significant issue affecting population health globally and tended to increase over the years. The utilization of natural products for AD treatments has been widely studied, which possibly offers better outcomes with minimum side effects. Coffee consumption has been subjected as a lifestyle propensity, which offers beneficial advantages including reducing the risk of AD. Bioactive natural compounds contained in coffee such as caffeine and caffeic acid have been experimentally proven to be acetylcholinesterase (AChE) inhibitors, a pivotal target enzyme for AD treatments. This research aimed to explore the dynamics interactions of caffeine and caffeic acid in the AChE active site using the in silico approach. In this study, 100 redocking and docking simulations were implemented before the molecular dynamics (MD) simulations. The 55-ns MD simulations of huprine X, caffeine, and caffeic acid were implemented to study the dynamics interactions. Conformational stability, free energies of binding, and interaction hotspots were identified during the simulations. Our findings informed that caffeine interacted in the active site during the simulations, revealing the importance of the imidazole ring in maintaining the interactions. In contrast, caffeic acid interacted longer in the plausible allosteric site, forming ionic, hydrogen bonds, and aromatic interactions.

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