cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Florentinus Dika Octa Riswanto
Contact Email
editorial.jpsc@usd.ac.id
Phone
-
Journal Mail Official
editorial.jpsc@usd.ac.id
Editorial Address
Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia
Location
Kab. sleman,
Daerah istimewa yogyakarta
INDONESIA
Jurnal Farmasi Sains dan Komunitas
Published by Universitas Sanata Dharma
ISSN : 16935683     EISSN : 25277146     DOI : https://doi.org/10.24071/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 247 Documents
 21   22   23   24   25 
Development of an Information System with an Herbal Database of East Java Suppliers and Distributors Yunita, Oeke; Savitri, Melania Dwi; Dinata, Hendra; Krisnawan, Alfian Hendra
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008086

Abstract

The production and marketing operations of small traditional medicine businesses (UKOT) in Indonesia heavily depend on the availability and choice of distributors of herbal products as well as suppliers of raw materials. The guarantee of accuracy and convenience of access to supplier and distributor data at UKOT PT X in Surabaya, East Java, can be supported by an internal information system that includes a database of East Java suppliers and distributors. Data was gathered via an interview with the Responsible Pharmacist (APJ) and documentation on PT X's records. Subsequently, the completed data generated from the chosen documentation is entered into the database that is a component of PT X's internal information system. The analysis was conducted on PT X's internal database, with an emphasis on its completeness, correctness, and accessibility. This result was obtained by 80% of data completeness evaluation ranges. All respondents properly answered questions about data about finished product suppliers and distributors from PT X's internal information system database. Ninety-three percent of respondents agree that the database in PT X's information system is very easy to access in terms of data display, language, and search feature functions.
The Relationship of Medication Adherence to Controlled HbA1c and ASCVD Risk in Type II Diabetes Mellitus Patients in Minggir Primary Health Care Dewita, Aquina Nino Rama Dhanti; Hendra, Phebe; Virginia, Dita Maria
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007464

Abstract

Type II diabetes mellitus (DM) therapy can be evaluated from the controlled HbA1c. Another aspect that needs to be controlled in patients with DM is lipid levels. Lipid levels should be controlled in a patient with type II DM to prevent atherosclerotic cardiovascular disease (ASCVD). The study was conducted to determine the relationship between medication adherence with controlled HbA1c and ASCVD risk in patients with type II DM. The study was an analytical observational study with a cross-sectional research design used to examine the relationship between medication adherence with controlled HbA1c and ASCVD risk. Our respondents were patients following a chronic disease management program at Minggir Primary Health Care. The level of medication adherence was measured using the Medication Adherence Report questionnaires. The ASCVD risk was measured using the American College of Cardiology/American Heart Association tools. The chi-squared test was applied to determine the relationship between medication adherence with HbA1c values and ASCVD risk in patients with type II DM. Most patients with type II DM had high medication adherence (60%), controlled HbA1c values (56.4%), and high ASCVD risk (70.9%). There was no significant relationship between medication adherence in type II DM patients with controlled HbA1c values and ASCVD risk.
Comparison of GPU-accelerated Molecular Dynamics Simulation Efficiency for the Acetylcholinesterase-Huprine X Complex using YASARA, GROMACS, and AMBER Wiranata, Bonifacius Ivan; Istyastono, Enade Perdana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009061

Abstract

Molecular dynamics simulations are a valuable tool in identifying potential acetylcholinesterase inhibitors for Alzheimer's disease therapy. Recent advancements in hardware and software, particularly the implementation of graphics processing units (GPUs), have significantly improved the efficiency of MD simulations. This study aims to compare GPU-accelerated molecular dynamics (MD) simulations of the acetylcholinesterase-Huprine X complex using YASARA, GROMACS, and AMBER. The complex was obtained from Protein Data bank with code 1E66 and was prepared with same conditions. MD simulations were performed for 50 ns with three replicates per software. GROMACS exhibited the shortest average simulation duration (45,104 seconds), followed by AMBER (48,884 seconds) and YASARA (649,208 seconds). RMSD analysis of protein backbone and ligand movement indicated stable simulations across all platforms. Interaction analysis at 25 ns and 35 ns of YASARA’s run revealed that Huprine X maintained key aromatic interactions within the AChE binding pocket, despite undergoing a 180° rotation. YASARA proved more efficient in MD preparation and produced more precise results, while GROMACS was most efficient in simulation runtime. The study highlights the trade-offs between ease of use, simulation speed, and result consistency among these software packages for AChE-HUX MD simulations.
Antihypertensive Effects of Fig Leaves (Ficus carica L.) Ethanolic Extract: An In Vitro and In Silico Study Kurniawan, Muhammad Fariez; Apriliyanti, Suci
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006449

Abstract

Pathological conditions of hypertension can occur due to contractions of blood vessels. Vascular contraction response occurs when epinephrine successfully binds to adrenergic receptors. Objective: This study aims to determine the antagonistic activity of giving ethanolic extracts of fig leaves (Ficus carica L. Folium) in β-adrenergic receptors of isolated aortic organs and to determine the value of the affinity of one of the compounds present in fig leaf extract, which has a strong potential as a vasodilator agent to treat hypertension. This study uses in silico and in vitro methods. The in silico method test used molecular docking, and the in vitro method test used an organ bath on a guinea pig's aortic organs. An in silico docking test was conducted on compounds suspected to have a vasodilator effect, namely Quercetin and β-adrenergic receptor test with native ligand timolol (PDB ID: 6PS6). The in vitro testing of foliar ethanolic extracts was done by administering 0.5 mg of extracts at 100 µL and 200 µL. The resulting data included a percent of aortic contraction data on administering epinephrine concentration series, which was transformed into a pD2 value. The result from the in silico method showed that quercetin binding affinity value (-7.8 kcal/mol) was better than timolol as a comparison (-6.4 kcal/mol). The result from the in vitro method showed that the fig leaf's ethanolic extract could shift the percentage curve of contraction response to the administration of epinephrine series by decreasing the pD2 value. A dose of 0.5 mg volume 200 µL is effective because it gives a significant difference to the control group but does not show a significant difference in the comparison group. Conclusively, the ethanolic extract of fig leaves can be developed as a vasodilator agent. 
W/O/W Emulsions Formula of Bacteriophages ϕPT1b As a Fruit Wash to Inhibit Pathogenic Escherichia coli Contamination Khairunnisa, Icha; Narulita, Erlia; Winarti, Lina; Febrianti, Riska Ayu; Kuswati, Kuswati; Yulian, Ria
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007143

Abstract

Pathogenic Escherichia coli infect fruit through irrigation contaminated water. Bacteriophage ϕPT1b has ability to infect E. coli and act as food security. Bacteriophage formulations as emulsion preparations increase the efficiency of application and the stability of long-term storage, one of it is W/O/W emulsions. The objective of this study was to examine the effect of cremophor RH 40, span 80 and their interaction on viscosity, droplet size and inhibition of bacteriophage ϕPT1b W/O/W emulsions against pathogenic E. coli. Factorial design method was used to get the optimum formula. The results showed that the cremophor RH 40, span 80, and their interactions increased the viscosity response, decreased the emulsion droplet size, and increased the inhibition against E. coli. FB is the optimum formula for ϕPT1b W/O/W emulsions which has 1% cremophor RH 40 and 4.5% span 80. The formula produced a viscosity of 29 dPas, an average emulsion droplet diameter size of 10.483, and an inhibition against E. coli of 8.65 m. The desirability index value of 0.905 indicates that FB meets 90.5% of the specified criteria.
Pharmacist Interventions regarding Cancer Patient-Related Medication Issues at RSUP Dr. Kariadi Semarang Permatasari, Anggraeni; Septiantoro, Bayu Prio; Luthfiah, Luthfiah; Perwitasari, Dyah Aryani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007298

Abstract

Cancer has been a global health issue. In 2018, cases related to cancer reached 18.1 million and the number of cancer-related deaths was 9.6 million. Pharmacists, play a crucial role in preventing and addressing Drug-Related Problems (DRPs) through pharmaceutical services. This research aims to examine the overview of Drug-Related Problems (DRPs) in inpatient cancer patients undergoing chemotherapy and to define the pharmacist's interventions regarding DRPs in cancer patients at RSUP Dr. Kariadi Semarang. This study employed a retrospective data collection approach. The materials were obtained from pharmacist prescription reviews and the medical records of cancer inpatients undergoing chemotherapy in January 2022. The classification of Drug-Related Problems (DRPs) followed PCNE V9.1 guidelines. A total of 239 DRPs were identified. The main issues were related to treatment effectiveness (44%), treatment safety (43.9%), and others (12.1%). Common causes of DRPs included dosing selection (63.7%), drug selection (28.4%), and treatment duration (0.4%). Pharmacists' interventions were carried out at the prescription writing level in 376 cases (61.4%) and at the drug utilization level in 294 cases (38.6%). The verification of prescriptions by clinical pharmacists before drug preparation is a crucial step to reduce the potential occurrence of DRPs
Molecular Dynamics Simulations of Ethyl-4-[(α-L-rhamnosyloxy)-benzyl]carbamate from Moringa oleifera Lam. as a Dipeptidyl Peptidase-4 Inhibitor Dewi, I Gusti Ayu Intan Puspita; Istyastono, Enade Perdana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009791

Abstract

Diabetes mellitus is a global health problem that requires innovative solutions. Ethyl-4-[(α-L-rhamnosyloxy)-benzyl]carbamate (ERBC) compound contained in Moringa oleifera Lam. showed potential as a potent dipeptidyl peptidase-4 (DPP4) inhibitor, with an IC50 value of 0.798 µM. Molecular dynamics simulations indicated that ERBC interacts specifically with the active site of DPP4, providing a mechanistic basis for its inhibitory activity. The research utilized the latest technique developed by previously published plug-ins. The molecular docking simulations were performed 100 times. Then, the poses were clustered to sample the probable poses which were then subjected as the inputs in molecular dynamics simulations. Molecular dynamics simulations have shown that the ERBC compound interacts with the DPP4 protein at two possible poses. PyPLIF HIPPOS analysis demonstrated that ERBC, during its second replication, interacts with Glu205 and Glu206, two key amino acids involved in DPP4 activity.
The Analysis of Medicine-taking Compliance Towards Therapy Outcome in Hypertension Patients at Community Health Centers in Yogyakarta Municipality Fortinasari, Rimanita; Virginia, Dita Maria; Hendra, Phebe
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008656

Abstract

Compliance to medication has a significant role in regulating the blood pressure and the risk for Atherosclerosis Vascular Disease (ASCVD) in Diabetes Mellitus Type 2 (DMT2) patients with hypertension as comorbidity. This study (n=523) aimed to analyzed this relationship at community health centers Yogyakarta municipality. We conducted an observational study with a cross-sectional design to analyze the medical record data collected during January-December 2023 among patients categorized under the inclusion criteria. Compliance was measured using the Medication Possession Ratio (MPR) then descriptively and correlatively with Chi-square analyses. No significant relationship is showed between the compliance of antihypertensive therapy to blood pressure (p=0.8670.05) and ASCVD risk (p=0.0800.05; OR=0.662; 95%CI:0.416-1.052). Age (p=0.001), gender (p=0.001) and BMI (p=0.0014) had a highly significant relationship with ASCVD risk, but only BMI (p=0.0070.005; OR 1.812) showed significant relationship with controlled blood pressure. The research findings reveal that compliance to antihypertensive therapy does not have a significant relationship with blood pressure control or ASCVD risk in patients with DMT2 and hypertension as comorbidities in Yogyakarta municipality. Highlighting the need for further investigation, it is vital to include other factors into blood pressure management.
Combining Beers and STOPP Criteria to Identify Inappropriate Medication Use in Elderly Patients with Chronic Diseases and Polypharmacy Mursyid, Abdillah; Chairani, Farahdina; Yusransyah, Yusransyah; Pujiati, Devi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007965

Abstract

Elderly individuals often suffer from multiple chronic conditions thatrequire the prescription of various medications. This can increase therisk of being prescribed Potentially Inappropriate Medications (PIMs).The research objective was to evaluate the effectiveness of Beers 2019and STOPP version 2 2016 criteria in detecting PIMs and theircorrelation with adverse drug events among geriatric patients whowere admitted to the Hospital. The researchers conducted aretrospective analysis of the 100 patients' medical records admitted tothe hospital in 2022. Beers 2019 criteria were more effective inidentifying PIMs than STOPP version 2 2016 criteria. Using Beers 2019criteria, 31 cases of PIMs were identified among the 100 patients whomet the inclusion criteria, while only 25 cases were identified usingSTOPP version 2 2016 criteria. Alprazolam was the most frequentlyprescribed medication (19.54%) in the first criteria of Beers 2019,followed by ranitidine in category two and spironolactone in category5, each named for seven cases (22.58%). The most commonly foundPIMs, according to STOPP version 2 2016 criteria, were domperidone(40.00%) and spironolactone (28.00%). The study recommends thatclinicians and pharmacists work together to develop critical supportivedata to enhance the identification of potentially inappropriatemedications.
Relationship Between Knowledge and Fasting Plasma Glucose Values of Patients with Type 2 Diabetes Mellitus at Sleman Public Health Center Linawati, Yunita; Kaka, Damianus Andrian Putra Lere; Pandey, Monica Vini Hildegadris; Chandra, Angelica; Tukunang, Helen Angelique Julia; Nathaly, Angel Pricillia; Fitriana, Dhea Pricillia; Timur, Imelda Maharani Eka
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.0013216

Abstract

Diabetes Mellitus (DM) is a chronic disease caused by unstable blood sugar (glucose) levels, characterized by the body's inability to metabolize carbohydrates and fats. Unstable or uncontrolled blood sugar levels can be influenced by a lack of knowledge, which impacts the attitudes and behavior of people with DM. Controlling blood sugar levels in patients with DM is very important to avoid complications, both macrovascular and microvascular. The purpose of this study is to examine the connection between type 2 DM patients’ fasting plasma glucose (FPG) values and their degree of knowledge. This study was conducted at Mlati 2, Ngaglik 2, and Ngemplak 2 Health Centers of Sleman Regency Yogyakarta. This cross-sectional study used an analytical observational strategy. Purposive sampling was used to choose the 227 patients who participated in this study as respondents. The Diabetes Knowledge Questionnaire (DKQ-24) was the tool utilized in this study to gauge respondents’ knowledge levels and the outcomes of the FPG levels taken from medical records. The Spearman-rank test was used for data analysis with significance set as p0.05. The majority of patients, 99 (43.61%) had a moderate degree of knowledge and 207 (91.19%) had uncontrollable FPG levels. Based on bivariate analysis, there was no significant relationship between knowledge level and FPG values (p = 0.926), while the strength of the relationship was classified as a very low category (r = 0.006).

Page 23 of 25 | Total Record : 247

 21   22   23   24   25 

Filter by Year

2012 2025


Reset
Filter By Issues
All Issue Vol 22, No 2 (2025) Vol 22, No 1 (2025) Vol 21, No 2 (2024) Vol 21, No 1 (2024) Vol 20, No 2 (2023) Vol 20, No 1 (2023) Vol 19, No 2 (2022) Vol 19, No 1 (2022) Vol 18, No 2 (2021) Vol 18, No 1 (2021) Vol 17, No 2 (2020) Vol 17, No 1 (2020) Vol 16, No 2 (2019) Vol 16, No 1 (2019) Vol 15, No 2 (2018) Vol 15, No 1 (2018) Vol 14, No 2 (2017) Vol 14, No 1 (2017) Vol 13, No 2 (2016) Vol 13, No 1 (2016) Vol 12, No 2 (2015) Vol 12, No 1 (2015) Vol 11, No 2 (2014) Vol 11, No 1 (2014) Vol 10, No 2 (2013) Vol 10, No 1 (2013) Vol 9, No 2 (2012) More Issue