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Jurnal Farmasi Sains dan Komunitas
Published by Universitas Sanata Dharma
ISSN : 16935683     EISSN : 25277146     DOI : https://doi.org/10.24071/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 247 Documents
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Formulation of Nanoemulsion Sunscreen of Centella asiatica (L.) Extract and Its Effectivity Test Dwiastuti, Rini; Kinanti, Valentina Putri Embun; Gelu, Maria Andriani; Setiawati, Agustina; Chabib, Lutfi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009910

Abstract

Sunscreen protects against ultraviolet (UV) rays. It has a Sun Protection Factor (SPF) value. Centella asiatica (L.) is a herbal plant that contains flavonoid and triterpenoid compounds as antiphotoaging agents. Development of Centella asiatica (L.) extract in nanoemulsion preparation increases its solubility in water and absorption. This study aims to obtain the optimum formula of Centella asiatica (L.) nanoemulsion preparation from the combined use of Tween-80 and Propylen glycol surfactants and determine the effectiveness of Centella asiatica (L.) extract in vitro. The effectiveness of Centella asiatica (L.) extract was tested in vitro using UV-Vis spectrophotometry expressed by SPF value. Development of Centella asiatica (L.) extract nanoemulsion formula using a combination of surfactants Tween-80 and Propylen glycol with factorial design 2 factors and 2 levels. P-value0.05 stated that there is a statistically significant difference in the formula. Centella asiatica (L.) extract has protective power against UV rays at concentrations of 120, 240, and 360 xg with SPF-values of 8.999, 19.219, and 29.569, respectively. Meanwhile, the nanoemulsion response analysis revealed the response of the nanoemulsion produced (p0.05). The optimum formula obtained was found in the nanoemulsion formula with a combination of Tween-80 and PG at a low level.
Antimicrobial Activity Test of Silver Nanoparticle Gel from Green Synthesis using Kelor Leaf (Moringa oleifera) as a Bioreductant Against Cutibacterium acne Pabuang, Afrianse; Dwiastuti, Rini
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008272

Abstract

Moringa oleifera leaves contain flavonoid compounds that have the potential to act as bioreducers in the synthesis of silver nanoparticles. The antibacterial activity of silver nanoparticles can reduce topical antibiotic resistance, especially against acne-causing bacteria. This study aims to determine the antimicrobial activity of silver nanoparticles formulated in a gel form at concentrations F1 10%, F2 20%, and F3 30%, using Medi-Klin Gel® as a positive control. Testing was conducted on Nutrient Agar medium using the paper disk method with Cutibacterium acne bacteria, incubated for 24 hours at 37°C. Additionally, physical evaluations of the gel, including organoleptic properties, spreading ability, and pH, were performed. The results of the physical properties of the gel were analyzed using one-way ANOVA. Organoleptic evaluation results indicated that F1 had a more transparent gel color, while F2 and F3 had darker gel colors, and all three gels had a characteristic extract aroma. Physical evaluation results for spreading ability (5.5±0.25; 5.7±0.12; 6.27±0.08) and pH values (4.42±0.17; 5.35±0.15; 5.27±0.17) were obtained. Antimicrobial research results showed inhibition zones for F1 10% (7.53±0.20), F2 20% (9.43±0.32), F3 30% (11.16±0.12), and the positive control Medi-Klin Gel® (25.15±0.26). Based on this study, concentration differences influenced the physical evaluation results of the gel formulation. Our finding suggests that the formula with the highest concentration (30%) has physical properties reaching the requirements and exhibited the highest inhibitory effect and potential as an antibacterial agent for acne.
Knowledge and Attitudes towards Antibiotic Use among Non-Health Undergraduate Students at Andalas University Juwita, Dian Ayu; Almasdy, Dedy; Fitri, Maharani Reskia
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007052

Abstract

The knowledge and understanding of the community about antibiotic usage are crucial to avoid inaccuracies in drug utilization. Negative impacts that can arise include the occurrence of resistance and the reduction in antibiotic effectiveness. Students with non-health related educational backgrounds are among the parts of the community that have a limited grasp of issues related to antibiotic usage. The aim of this research is to assess the level of knowledge and attitudes of non-health related major students towards antibiotic usage. This study utilized a cross-sectional method with validated questionnaires. Inclusion criteria for this research were non-health undergraduate students at Andalas University who were willing to complete the questionnaire comprehensively. The obtained data were statistically analyzed using SPSS version 26. The research findings indicate that non-health related major students at Andalas University possess moderate knowledge (54.7%) while their attitudes tend to be positive (71.1%) towards antibiotic usage. A significant correlation between students' knowledge and attitudes towards antibiotic usage was found, with a p-value 0.05. There was no significant correlation found between students' sociodemographic characteristics (faculty, age, gender, presence of family members working in the healthcare field) and their knowledge level. However, concerning attitudes, factors that influence include gender and the presence of family members working in the healthcare field.
The Predisposing Factors to Communicate Effectively in Providing Drug Information Hastama, Ryo; Mendra, Ni Nyoman Yudianti; Antari, Ni Putu Udayana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007028

Abstract

Effective communication in providing drug information is essential to achieve the expected outcome in implementing pharmaceutical care. This study aims to analyze factors that influence the occurrence of effective communication in providing drug information. Data were collected using a Likert-scale questionnaire survey technique with a cross-sectional design. The study involved 100 samples from all districts in Denpasar City, which were taken by convenience sampling technique. The characteristics of the respondents are described descriptively. Bivariate and multivariate tests are used to analyze the effect of independent variables on effective communication. The pharmacy atmosphere has no significant impact on effective communication. Pharmacists' technical and interpersonal communication skills can facilitate effective communication on the Chi-squared test, but only the interpersonal communication competencies of pharmacists can encourage effective communication in the logistic regression analysis (p-value 0.008; CI: 95%; OR 4.751: 1.492-15.133). Communication factors, in general, predispose to effective communication. Besides paying attention to the message's contents, pharmacists must pay more attention to how drug information is conveyed to patients. Thus, there is a common understanding between the communicator and the communicant. The patient will also be encouraged to use the drug according to the instructions given so that the ultimate goal of treatment can be achieved.
Routine Stock Opname in Enhancing Service of Halodoc's Order and Increasing Transactions Megantara, I Nyoman Arya Purnata; Hartayu, Titien Siwi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008323

Abstract

In partnering with the e-commerce platform Halodoc, one of the challenges encountered is unfulfilled orders due to discrepancies between the system's stock and conventional stock. Therefore, the researcher aims to determine whether maintaining drug availability through routine stock opname in an online (e-commerce) setting can also enhance service quality. This study is quasi-experimental research conducted at Manut Farma Pharmacy from July to September 2023. The research involves daily routine stock opname of 312 registered drug items on the Halodoc application. These 312 drug items met the inclusion criteria, which were "Drugs included in the list of drugs available in the pharmacy and registered in the Halodoc program," and the exclusion criterion of "Physical stock of drugs having an expiration date of not less than 6 months." The research findings indicate that almost all incoming Halodoc orders can be served effectively (86%), which represents a significant increase of 19% (A sig. 0.003; p=0.05) compared to the previous three months (67%). The product is one of the key aspects of marketing, and by maintaining up-to-date stock conditions, it directly affects the fulfillment of incoming drug orders by enhancing the serving process. Routine stock opname can help improve the service of Halodoc orders, Although the number of incoming orders for Halodoc transactions is still relatively low, on the other hand, routine stock checks have also contributed to a 10% increase in conventional transactions.
Effectiveness of Nano Spray From Extract of Kelubut Leaf (Passiflora foetida L.) as Antibiofilm on catheters of Patients with Urinary Tract Infection Hamzah, Hasyrul; Astriani, Nur Atika; Farida, Norma Feti; Kamilah, Lila Zulfa; Azizah, Aryantinur; Rahman, Fathur
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008198

Abstract

Catheter-associated urinary tract infections (CAUTI) have increased significantly every year. Approximately 70-80% of these infections involve biofilms. This study aims to determine the effectiveness of nano spray formula of kelubut leaf extract in inhibiting and eradicating biofilm formation on catheters. Kelubut (Passiflora foetida L.) leaf extract was obtained through maceration process to obtain useful compounds. Antibiofilm activity was assessed using microbroth dilution, with scanning electron microscopy for visualization. The nano spray formulation activity of kelubut (Passiflora foetida L.) leaf extract was able to inhibit biofilm growth by (77.74% ± 0.01), while ciprofloxacin was slightly more effective with a value of (80.22% ± 0.01). SEM analysis confirmed the ability of the kelubut leaf extract nanospray formulation to inhibit and damage Escherichia coli biofilms. The nano spray formulation of kelubut leaf extract (Passiflora foetida L.) coded NS1 is able to inhibit biofilm formation activity on catheters and has the potential to be developed as an antibiofilm candidate against bacteria that cause urinary tract infections.
Hematology Toxicities in Paclitaxel-Carboplatin Cancer Regiment Meitasari, Annisa Diyan; Ermawati, Dian Eka; Rohmani, Sholichah; Sasongko, Heru; Zulpadly, Muhammad Fiqri; Utami, Diyah Tri; Susanto, Nindita Clourisa Amaris; Untari, Meta Kartika; Darojati, Ulfa Afrinurfadhilah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007064

Abstract

Chemotherapy is one of therapy for patients with cancer. Treatment carboplatin paclitaxel regimen is usually use for cervix, breast, and ovarium cancer. But the data of ADRs in hematology toxicity caused paclitaxel-carboplatin regiment is minimal, so it is required to do research. The aim of this research is can give information about the hematology toxicity, incident, severity, relationship between risk factor due incident of myelosuppression, and relationship between pre post chemotherapy due the myelosuppression. The severity ADRs use CTCAE 5.0. The ADRs were evaluated by severity, descriptive statistics, and some bivariate analysis. Anemia (66.46%) has a highest incident and followed by leukopenia (18.18%), neutropenia (13.22%), and thrombocytopenia (9.09%). Type of cancer associate with incident of anemia, leukopenia, and thrombocytopenia. The number of cycle chemotherapy use carboplatin paclitaxel regiments affects significant with the incidence of anemia. Patients who use paclitaxel-carboplatin as a regimen chemotherapy confirmed decrease in hematologic data such as hemoglobin, leukocyte, and thrombocyte.
A Decade of Research about Honey as an Antioxidant in the Scopus Database: Bibliometric Analysis Setyawan, Eka Indra; Putra, Komang Dian Aditya; Ishfahan, Izzul; Lingling, Gek Niken Tasya
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007378

Abstract

Honeybees transform flowers' delicious, aromatic, and viscous nectar into the naturally occurring, antioxidant-rich honey. A growing scientific study increasingly supports honey's use in complementary and alternative medicine. No bibliometric analysis of published data on honey antioxidants has been conducted to ascertain the state of the research. Using VOSviewer and RStudio, we conducted a bibliometric analysis of the scholarly articles about honey's antioxidants in the Scopus database. Honey's antioxidant properties were covered in 765 papers between 2013 and 2023. Most publications (309 articles) are attributed to Malaysian researchers, with Universiti Sains Malaysia being the most productive, with 53 articles produced. Food Chemistry is the most productive source, with an average of 64.8 citations per article and 24 documents. Having the highest H-index of 10, Battino M significantly influenced the honey's antioxidant properties studies. "Honey" and "antioxidant activity" were the most frequent keywords. We can learn about the novelty of honey as an antioxidant research from this results.
Evaluation of the Level of Knowledge, Attitudes, and Behavior of High School Students in the City of Pekanbaru in the Use of Antibiotics Lubis, Nursyafni; Rahmawati, Ayu; Indriani, Lusi; Afandi, Ayu Indah Lestari
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007268

Abstract

The high use of antibiotics in the community will lead to resistance. According to the results of studies in Indonesia, the problem of antibiotic resistance is very complex and will continue to increase every year. Infectious diseases account for more than 13 million deaths per year in developing countries. Wise and rational use of antibiotics can reduce the disease burden, especially infectious diseases. Conversely, the widespread use of antibiotics that do not match the indications significantly increases antibiotic resistance. Students must know the proper use of antibiotics so as not to develop antibiotic resistance. They do not know much or fully understand antibiotics during the transition from childhood to adulthood. This study aims to determine the relationship between knowledge, attitudes, and behavior of SMAN Se-Kota Pekanbaru students in the use of antibiotics. This research uses a descriptive survey method with 360 respondents. Data analysis was done using a chi-square test with a significance level of p 0.05. The results of this study showed that there were students with good knowledge (67%), with some who showed a positive attitude (75%), and less behavior in the use of antibiotics (74%). The chi-square test showed a significant relationship between attitudes and antibiotic use behavior with a p-value of 0.001 (p 0.005). While the level of knowledge and attitude had a p-value of 0.605 (p 0.05) and the level of knowledge and behavior had a p-value of 0.118 (p 0.05), indicating there was no significant relationship. From the results of this study, it can be concluded that there is no significant relationship between students' knowledge with attitudes and behavior in the use of antibiotics, and there is a significant relationship between attitudes and student behavior in the use of antibiotics.
Acute and Sub-Acute Oral Toxicity Assessment of Marchantia paleacea Bertol. Liverwort Herb Extract in Mice on Liver and Kidney Function Purkon, Dicki Bakhtiar; Nainggolan, Aurelya Veny Kurnia; Ningsih, Padmasari Diah Ayu Kumala; Kusmiyati, Mimin; Sudaryat, Yayat; Srinati, Ine; Fadhlillah, Faizah Min; Sufa, Hafizah Ilmi; Hotimah, Alni Khusnul
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008218

Abstract

Herbaceous liverwort Marchantia paleacea Bertol. has been known as a potential source that has bioactive compounds with various pharmacological benefits, such as: antimicroorganism, antifungal, antioxidant, immunomodulator, hepatoprotector, antipyretic, diuretic, cardiotonic, and vasorelactan. However, information regarding oral acute and sub-acute toxicity data from ethanol extracts of Marchantia paleacea Bertol. liverwort herb is still very limited. Therefore, this study aimed to evaluate the acute and sub-acute toxicity of liverwort herb ethanol extract in female mice of ddY strains. The acute toxicity test method was carried out by giving ethanol extract of the liverwort herb Marchantia paleacea Bertol. (EEMP) in single doses at doses of 250, 500, 1000, and 2000 mg/kg bw orally for 14 days, while sub-acute toxicity tests were performed by administering EEMP test extracts at doses of 125, 250, 500, 1000, and 2000 mg/kg bw orally for 28 days in accordance with testing standards from BPOM (2022), Thompson-Weil, and OECD. Parameters observed include clinical symptoms (including: mortality), profile of body weight changes, biochemical analysis of serum, and histopathological analysis of vital organs (liver and kidney). Results from acute toxicity testing showed that a single dose of EEMP at the tested level did not cause significant clinical symptoms and histopathological disorders, and there were no deaths in test animals classified as mild toxic substances based on BPOM criteria ( 2000 mg/kg bw). And sub-acute toxicity tests from the 125, 250, and 2000 mg/kg bw test groups revealed a significant increase in average SGOT levels compared to the normal control group on the 28th test day (p0.05) but still within the normal range. Most other test parameter profiles show no significant changes. Some of the observed changes, particularly in the biochemical and histological parameters of the organs that occur are assumed to be transient reaction effects and are not a sign of toxicity. These findings suggest the need for further study of the potential toxic effects of the liverwort herb Marchantia paleacea Bertol. This study provides important insights in the understanding of the potential uses of the liverwort herb Marchantia paleacea Bertol. as a product of herbal ingredients (nutraseutics, supplements, and traditional medicine), and reinforces the need to understand the potential toxicity risks associated with it. 

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