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Florentinus Dika Octa Riswanto
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INDONESIA
Jurnal Farmasi Sains dan Komunitas
Published by Universitas Sanata Dharma
ISSN : 16935683     EISSN : 25277146     DOI : https://doi.org/10.24071/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 247 Documents
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A Study of Potential Drug-Drug Interactions in Peptic Ulcer Patients in Dr. M. Djamil Hospital Padang in 2019 Lola Azyenela; Ringga Novelni; Viora Lusiana Satri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.003909

Abstract

A peptic ulcer is a gastrointestinal tract disorder caused by excessive secretion of acid and pepsin by the gastric mucosa. The combined use of drugs in peptic ulcer management may potentially cause drug-to-drug interactions. Drug interactions are caused when two or more drugs interact and may affect the effectiveness of the other drugs. This study aims to analyze the potential drug reactions in peptic ulcer patients in the internal medicine ward of Dr. M. Djamil General Hospital Padang in 2019. This study was a descriptive, non-experimental study with retrospective data, while data analysis used Drugs.com and Medscape applications. The study results revealed that 29 patients fit the inclusion criteria and 5 (16.6%) potential drug pharmacokinetic interactions. The severity of drug interactions shows 4 cases (80%) with moderate severity potential and 1 case (20%) with minor severity potential. The study concluded that there were potential drug interactions in peptic ulcer patients in the internal medicine ward of Dr. M. Djamil General Hospital Padang in 2019.
Formulation of Wound Healing Hydrogel from 70% Ethanol Extract of Kelakai Roots (Stenochlaena palustris (Burm. F.) Bedd) with Polymer Combination of PVA/HPMC Forestryana, Dyera; Pebrianie, Shilpa; Ramadhan, Hafiz; Restapaty, Ratna
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005291

Abstract

Kelakai root contains alkaloids, saponins, tannins, and flavonoids. This compound is known to have medicinal properties such as wound healing. The effectiveness of wound healing increased by using hydrogel to deliver the active substance. The use of polymers played a role in delivering the active substance. This study aimed to formulate hydrogels for wound healing with various concentrations of polyvinyl alcohol (PVA) and hydroxy propyl methyl cellulose (HPMC) K4M. Preparation of hydrogel by the solvent casting method used 0.2% Kelakai root extract. The physical characteristics of hydrogel investigated before and after the stability test included organoleptic, weight uniformity, thickness, pH, moisture content, and hedonic test of Kelakai roots extract hydrogel.  The optimum formula was tested for wound healing activity. The data obtained were then analyzed using Wilcoxon testswith p0.05 considered significant. Physically, Kelakai root extract hydrogel met the test requirements. The results of the wound-healing activity showed that the hydrogel extract of the Kelakai root was able to heal the wounds within seven days. There was a significant difference in wound healing time with p=0.014. The optimum formula obtained based on the stability test was F4 with a 1:4 ratio of PVA and HPMC. 
Optimization of Crospovidone and Copovidone in Fast Disintegrating Tablet (FDT) Diphenhydramine HCl Using Factorial Design Agatha Budi Susiana Lestari; Aldo Christian Jonathan
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006396

Abstract

Diphenhydramine HCl is a drug used to treat motion sickness. Treatment of motion sickness needs rapid onset for successful therapy. Fast Disintegrating Tablet (FDT) is one dosage form that provides fast onset. The purpose of this study was to identify the dominant factors of crospovidone and copovidone, their interactions, and discover the optimum composition area to produce a FDT dosage form with optimum parameters involving hardness, friability, disintegration time, wetting time, and water absorption ratio. This study was experimental and used a factorial design. The result showed that copovidone significantly influenced friability, disintegration time, wetting time, and water absorption ratio, while their interactions significantly influenced the hardness of FDT diphenhydramine HCl. At the level studied, the optimum composition area was found, which can be predicted as a diphenhydramine HCl FDT dosage form formula.
Implementation of Hospital Management Information Systems: Obstacles and Challenges (Case Study at Santo Antonio Baturaja Hospital) Sumiyem, Sr. M. Karla; Hartayu, TB. Titien Siwi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006777

Abstract

The Hospital Information System (HIS) handles and integrates the entire flow of hospital services. This study aimed to identify factors that affect the effectiveness and efficiency of HIS implementation and select strategies that can be used to overcome the inhibiting factors. In-depth interviews were used in this study with a qualitative and case-study strategy. The respondents were 26 officers selected by non-random purposive sampling. Data analysis used triangulation of in-depth interviews, document observations, and observations of HIS implementation. Data were transcribed verbatim and analyzed thematically. The results showed that the positive behavior of officers, leadership support, and officer abilities supported the implementation of HIS. However, there are still obstacles due to the attitude of officers and management policies. From document observations, it was found that officers had incorrect input, doubled input, and forgotten input. Due to a lack of Standard Operating Procedures (SOPs) and guidelines for implementing HIS, observations on its deployment revealed inconsistent data input. The strategy suggested to deal with the barriers included designing monitoring programs, creating SOPs, conducting extensive socializing programs, and conducting training programs to enhance officers' soft skills. It is clear that Human Resources play a crucial role for the effectiveness of HIS implementation. 
Quality of Extemporaneous Preparation Containing Theophylline, Salbutamol Sulphate and Methylprednisolone Sri Hartati Yuliani; Bernadetta Karina Sekar Maheswari; Melynia Sintha Dewi; Michael Raharja Gani; Dina Christin Ayuning Putri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005316

Abstract

Capsule preparations containing theophylline, salbutamol sulfate, and methylprednisolone were frequently prescribed in a private hospital in Yogyakarta. Theophylline is a narrow therapeutic index drug. Extemporaneous preparation products that contain narrow therapeutic index drugs have to meet the quality requirement. This study aimed to evaluate the quality of the capsule preparations. The sample was taken from a private hospital in Yogyakarta. The samples were assessed for physical characteristics, content uniformity, and chemical stability during storage. The result found that the physical characteristics of the product were good. The coefficients of variance of the content uniformity percentage for theophylline, salbutamol sulfate, and methylprednisolone were 11.96%, 3.33%, and 45.74%, respectively. During 30 days of storage, the content of theophylline, salbutamol sulfate, and methylprednisolone decreased by 1.44%, 7.64%, and 15.7%, respectively. Capsule preparations containing theophylline, salbutamol sulfate, and methylprednisolone did not meet the quality requirement.
Quality Assessment of Extemporaneous Capsule Preparation containing Methylprednisolone, CTM, and Theophylline using Spectrophotometrics and Chemometrics Techniques Darmawangzah, Muhammad; Riswanto, Florentinus Dika Octa; Irnawati, Irnawati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008772

Abstract

Currently, doctors in developing countries still prefer to prescribe compounding drugs because certain drugs are not available in ready-made dosage forms. It is considered that the capsule formulation can increase patient compliance because it requires a smaller amount of medication. In particular, for asthma patients, extemporaneous capsule preparation containing methylprednisolone, CTM, and theophylline is usually prescribed. However, theophylline, which has a narrow therapeutic index, combined with small doses of methylprednisolone and CTM, may result in inconsistent drug content in the compounded drug. This study aimed to assess the quality of the capsule mixture containing methylprednisolone, CTM, and theophylline formulated at the “X” Kolaka Community Health Center, Southeast Sulawesi, Indonesia. Extemporaneous capsules are tested using various methods such as organoleptic tests, water content tests, disintegration time tests, and content uniformity tests of compounding drugs. The quality test results of the compounding capsule with the active substance a combination of methylprednisolone, CTM, and theophylline formulated at the “X” Kolaka Health Center met the quality requirements with organoleptic tests, moisture content tests, and disintegration time tests. The content uniformity test does not meet the requirements according to the Indonesian Pharmacopoeia VI edition based on the acceptance values of L1% and L2%.
Determination of Sun Protection Factor Value and Physical Stability of Wungu Leaf (Graptophylum pictum (L.) Griff) Extract Spray Sunscreen Rahmayanti, Mayu; Buana Putra, M. Bayu Firdaus; Maulidina, Annisa Tri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006632

Abstract

Sunscreen can protect the skin from ultraviolet (UV) radiation. The inorganic active ingredients in sunscreens can have detrimental effects on the skin. Wungu leaf (Graptophylum pictum (L.) Griff) is a suitable alternative due to its antioxidant activity and similar mechanism of action to other antioxidants with lower side effects. This study employed a true experimental method, and the data were analyzed using one-way ANOVA and T-tests. The effectiveness of sunscreen is determined by the Sun Protection Factor (SPF) value. This study aims to determine the SPF value and physical stability of Wungu leaf extract spray sunscreen at concentrations of 500 ppm, 1,000 ppm, and 1,500 ppm. The results show that the spray sunscreens provide ultra-protection. The difference in extract concentration significantly affected the SPF value (p0.05). Stability tests showed a negligible effect on color variation and a notable effect on pH and spray diameter. Despite its noticeable impact, the outcome remains within an acceptable range. The study concluded that the Wungu leaf extract spray sunscreen provides excellent photoprotection, as demonstrated by the high SPF values observed for Formula 1 (18.63), Formula 2 (23.87) and Formula 3 (29.56). In addition, the product exhibits robust physical stability, as assessed by relevant parameters.
Health Related Quality of Life (HRQoL) in Type 2 Diabetes Mellitus Patients Based on Antidiabetic Prescription Patterns Sari, Seftika; Pratiwi, Erniza; Farahdilla, Dinda; Ghozali, MT; Sulistyaningrum, Indriyati Hadi; Pribadi, Prasojo
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008444

Abstract

Diabetes mellitus is characterized as a multifaceted metabolic disorder marked by elevated blood sugar levels or hyperglycemia. Among its types, type 2 diabetes mellitus is the most common globally, significantly affecting a large portion of the population. In Indonesia, there has been a notable increase in the prevalence of type 2 diabetes, indicating a rising trend. This condition necessitates continuous care and management since it is incurable, requiring patients to undergo lifelong treatment. The various therapeutic approaches available for managing type 2 diabetes have a significant impact on the quality of life of patients, highlighting the necessity for quality-of-life assessments. The primary objective of this study was to assess the quality of life among individuals diagnosed with type 2 diabetes mellitus. It also aimed to investigate the effects of different patterns of antidiabetic drug prescriptions on the Health-Related Quality of Life (HRQoL), employing the Diabetes Quality of Life Clinical Trial Questionnaire (DQLCTQ) for evaluation. This study was conducted as a quantitative, observational research using a cross-sectional approach and a descriptive analytical method. A total of 99 participants were included through purposive sampling, a non-probability sampling technique. The findings showed that the average quality of life score was 70.56, with 48 participants (48.5%) reported to have a good quality of life and 51 (51.5%) considered to have a poor quality of life. Importantly, significant results (p0.05) were found regarding the positive effects of combining oral antidiabetic drugs with insulin on enhancing the quality of life in individuals with type 2 diabetes, underscoring the influence of medication regimens on patient health outcomes.
Formulation of Lerak Extract (Sapindus rarak DC) and Aloe Vera Extract (Aloe vera Linn) as Paper Hand Soap: Application of Factorial Design Listyawati, Margaretta Berlinda; Putri, Ni Putu Aryaswari; Ayuning Putri, Dina Christin
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008106

Abstract

Soapberry contains saponin compounds and can be used as a surfactant in a soap. Aloe leaves contain lignin compounds as an emollient. Soapberry extract and aloe extract can be formulated into paper hand soap. This study aims to determine the optimum composition of soapberry extract and aloe extract in paper hand soap formulation. Quasi-experimental research was conducted using a 2-factor and 2-level factorial design. Physical property tests were done including organoleptic tests, pH, washing time, moisture content, foam height, reduction in Trans Epidermal Water Loss (TEWL) values and freeze-thaw physical stability tests. Data analysis used Design Expert version 13 (free-trial version) software with a two-way ANOVA test and 95% confidence level. The overlay plot obtained was used to determine the optimum composition area. The results found that the combination of soapberry extract and aloe extract had an effect on physical properties in the form of foam height and reduced TEWL and the optimum formula composition for soapberry extract was 63.5224 grams and aloe extract was 20.1866 grams.
Effectiveness of 70% Ethanol Extract of Pomegranate (Punica granatum Linn) Against the Healing Process of Incisions and Burns in Mice Dianti, Meilina Ratna; Maimunah, Siti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006779

Abstract

A wound is a traumatic occurrence that damages the skin's and subcutaneous tissue's continuity. For the treatment of skin wounds, it is normal practice in the medical community to administer analgesics, anti-inflammatories, antibiotics, and antiseptics. Anti-inflammatory, antibacterial, and antioxidant properties are required, as well as assistance for cell proliferation in the production of protein and collagen for the regeneration process. Pomegranate is frequently used as herbal medicine and is thought to heal various diseases and ailments, including burns. This investigation will assess the effects of 70% ethanol extract from pomegranate fruit on mouse incisions and second-degree burns. To assess the effect of the extract on the healing of cuts and burns in mice, wounds and second-degree burns were made and treated with a 70% ethanol extract of pomegranate at doses of 7%, 14%, and 28%. Administration of pomegranate fruit extract in 70% ethanol at the optimum dose of 28% was shown to considerably boost wound healing activity and this finding demonstrates the ability of pomegranate extract to treat wounds.

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