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Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
Arjuna Subject : -
Articles 589 Documents
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Relationship between presenting symptoms and tumor location in colorectal cancer patients Ismida, Fitri Dewi; Maghfirah, Desi; Salam, Nurbahri L; Yusuf, Fauzi; Mulia, Vera Dewi; Purnomo, Avisena Gatot
Universa Medicina Vol. 43 No. 3 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.321-328

Abstract

BackgroundColorectal cancer (CRC) often shows symptoms at an advanced stage, causing delayed diagnosis and poorer prognosis. Initial symptoms, or chief complaints, are usually identified through patient history and can vary based on tumor location. This can help in establishing a diagnosis. This study aimed to determine the relationship between presenting symptoms and tumor location in CRC patients at Zainoel Abidin Regional General Hospital, Banda Aceh. Methods This cross-sectional study was conducted using secondary data from medical records (2019–2022) for 163 CRC patients. Information on symptoms of patients were collected from patient files: anemia, anorexia, diarrhea, constipation, abdominal pain, rectal bleeding, and palpable abdominal mass. Tumor locations were classified as right colon, left colon, rectum, and left colon plus rectum. Bivariate analysis was used to analyze the data. Results Of the 163 patients, 98 (58%) were aged e”50 years, 82 (50.3%) were male, and 99 (60.7%) had rectal tumors. The percentage of patients presenting with rectal bleeding was significantly higher in rectal cancers (47.47%) as compared with cancers in the left colon (28.57%) and left colon and rectal (33.33%) cancers (p=0.000). The percentage of patients presenting a palpable abdominal mass was significantly higher in right colon (31.58%) compared with left colon (4.76%) and rectal cancer (1.01%) (p=0.000). ConclusionsTumor location in the right colon is associated with palpable abdominal mass, while rectal location is associated with rectal bleeding in CRC patients. Familiarity with clinical symptoms of CRC could make patients more sensitive to undergo more frequent screening for cancer.
Risk factors of doxorubicin-induced cardiomyopathy in non-muscle- invasive bladder cancer Sabudi, I Made Nugraha Gunamanta; Hendri, Ahmad Zulfan
Universa Medicina Vol. 43 No. 3 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.297-303

Abstract

BackgroundDoxorubicin is an anthracycline antibiotic widely used as a chemotherapeutic agent to treat solid tumors and hematologic malignancies. Bladder cancer is the second most common genitourinary malignancy and can be classified into muscle-invasive bladder cancer and non-muscle-invasive bladder cancer (NMIBC). In Indonesia, NMIBC is treated by doxorubicin instillation. Several risk factors have been suggested to be associated with doxorubicin-induced cardiomyopathy, but on their quantitative effects no consensus has as yet been reached. This study aimed to determine the risk factors of doxorubicin-induced cardiomyopathy in NMIBC patients with intravesical doxorubicin instillation. MethodsA cross-sectional study was conducted involving 74 NMIBC patients who received local treatment by doxorubicin instillation after transurethral resection of bladder tumor (TURBT). Data were collected on the risk factors that may be favorable to doxorubicin-induced cardiomyopathy, namely age, sex, hypertension, type 2 diabetes mellitus, smoking, and NMIBC risk classification. The dependent variable was cardiomyopathy with decreasing left ventricular ejection fraction (LVEF) below 50 %. Multiple logistic regression was used to analyze the data. ResultsThe prevalence of cardiomyopathy was 6.75% (5/74). Type 2 diabetes mellitus was a significant risk factor for doxorubicin-induced cardiomyopathy among our subjects (aOR=34.30;95% C.I.:1.36-865-86;p=0.032). In contrast, age, sex, risk classification, hypertension, and smoking were nonsignificant predictors for doxorubicin-induced cardiomyopathy (p>0.05). ConclusionThis study demonstrated that type 2 diabetes mellitus increased the risk of cardiomyopathy in doxorubicin users among patients with NMIBC. More research is necessary regarding the mechanisms underlying type 2 diabetes mellitus as a risk factor for doxorubicin-induced cardiomyopathy.
Stereoacuity test as a screening tool for amblyopia and binocular vision in children 6-12 years of age Surasmiati, Ni Made Ayu; Wetarini , Krisnhaliani; Wijayati , Made Paramita; Suryathi, Ni Made Ari
Universa Medicina Vol. 43 No. 3 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.280-286

Abstract

BackgroundStereoacuity is essential for depth perception and daily activities, complementing visual acuity. Assessing stereoacuity in children is vital for detecting binocular vision disorders and amblyopia. This study aimed to compare the Toegepast Natuurwetenschappelijk Onderzoek (TNO) test and the Titmus Fly test in school-based vision screening for children aged 6-12 years. MethodsA cross-sectional study was conducted in social service settings with 122 elementary school children aged 6-12 years. Examinations included visual acuity, refraction, Ishihara color vision, and stereoacuity using both the TNO and Titmus Fly tests. Statistical comparisons were made using the Wilcoxon Signed-Ranks Test, and stereoacuity differences based on demographic factors and visual acuity were assessed using the Mann-Whitney U Test. The level of agreement between the two tests was determined using Bland-Altman analyses. Results Visual acuity significantly influenced stereoacuity results in the Titmus Fly test (p=0.001), with children having abnormal visual acuity performing worse. Approximately 68% of children reported that the Titmus Fly test was easier to perform. The mean difference between TNO and Titmus Fly measurements was 79.52 ± 63.75 (95% CI = 68.14–90.90; p=0.001), demonstrating a consistent bias between the two tests. Conclusion The Titmus Fly test is easier for children (6–12 years) to perform, but it tends to overestimate stereoacuity values compared to the TNO test, making the two methods non-interchangeable and not reliable. Stereoacuity assessment remains essential in school-based vision screening for evaluating binocular vision and amblyopia, especially in children with refractive errors.
Comparison of natural versus artificial cycles for endometrial preparation prior to frozen embryo transfer Tyagitha, Galuh Anindya; Nuryanto, Kartiwa Hadi; Pratama, Gita; Maidarti, Mila; Harzif, Achmad Kemal; Sumapraja, Kanadi; Lestari, Silvia Werdhy; Ampri, Irfan Arieqal Hatta; Talya, Natasha; Yanfaunas, Atika Mahira
Universa Medicina Vol. 43 No. 3 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.304-312

Abstract

BackgroundThe endometrial preparation phase preceding embryo transfer assumes pivotal significance in achieving optimal endometrial receptivity and ensuring the success of pregnancy. The natural cycle (NC) and artificial cycle (AC) are the preferred methods for many in vitro fertilization (IVF) specialists. The objective of this study was to compare the difference between NC and AC in women undergoing frozen-thawed embryo transfer (FET) after IVF. MethodsA cross-sectional study was conducted involving 150 adult women who underwent FET with a single autologous blastocyst stage embryo in a 5-year period (2014-2019). Bivariate analysis was conducted to discern implantation and pregnancy rates associated with NC and AC for endometrial preparation. Multiple logistic regression was used to assess the association between endometrial preparation and clinical outcomes while adjusting for potential confounders. ResultsOf the 150 subjects meeting study criteria, 19 underwent NC, while 131 underwent AC for endometrial preparation. Natural cycle exhibited a higher biochemical pregnancy rates compared to AC (89.5% vs. 53.4%; p=0.003). Artificial cycle is a significant determinant for biochemical pregnancy rates compared to NC (aOR: 0.132;95% CI: 0.028 – 0.623; p=0.010) ConclusionIn women undergoing FET, NC resulted in higher biochemical pregnancy rates compared to AC. However, clinical pregnancy rates and ongoing pregnancies rates did not exhibit significant disparities between NC and AC. Future studies will hopefully further illuminate which protocol is most suitable for the individual patient. Further multi-center randomized clinical trials are needed to confirm the relationship between biochemical pregnancy rates and NC.
Dysmenorrhea and recent treatment options in adolescents and young adults Innocent Rani , Vanitha; Dash, Biswajit; Nancy Lal, Monica; P, Muthu Prasanna; Bagchi, Sovan; Aruna, V.; Prabha, K. Suria
Universa Medicina Vol. 43 No. 3 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.349-362

Abstract

Dysmenorrhea, or primary dysmenorrhea (PD), marked by menstrual cramps in the lower abdomen, is a common but often overlooked condition affecting a considerable number of women. The impact of dysmenorrhea extends beyond physical pain, often causing considerable disruption to daily activities, work, and social interactions. It significantly affects the quality of life, often causing absenteeism from school or work. Increased intrauterine prostaglandin secretion is linked to pelvic pain in PD. Diagnosis relies mainly on clinical assessment, considering symptoms and physical examination, with treatment aimed to enhance the quality of life. These menstrual cramps are frequently accompanied by other symptoms, such as headaches and nausea, which are believed to be due to prostaglandins released as the endometrium breaks down. A literature search using the keywords dysmenorrhea, menstrual pain, and hormonal contraceptives was done using the following databases: Google Scholar, ProQuest, ScienceDirect, Web of Science, Pubmed, and Scopus for articles published  from   2015 to 2024. The literature study was done to find the connection of dysmenorrhea and menstrual pain with hormonal contraceptives. Common treatments include nonsteroidal anti-inflammatory drugs, hormonal contraceptives, and non-pharmacological interventions. This review provides an in-depth analysis of recent treatment advancements for dysmenorrhea, focusing on its pathophysiology, clinical diagnosis, and impact on women's quality of life. It evaluates current and emerging treatments, including pharmacological interventions, non-pharmacological therapies, surgical approaches, hormonal treatments, and investigational drugs, aiming to identify improvements in efficacy and side effects.
Low albumin-to-creatinine ratio: a novel predictor of 90-day mortality in hepatocellular carcinoma with liver cirrhosis Pamungkas, Kadek Mercu Narapati; Dewi, Putu Itta Sandi Lesmana; Dewi, Ni Luh Putu Yunia; Dewi, Ni Nyoman Gita Kharisma; Sindhughosa, Dwijo Anargha; Mariadi, I Ketut
Universa Medicina Vol. 43 No. 3 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.313-320

Abstract

BackgroundDespite recent advances in the treatments of hepatocellular carcinoma (HCC), the prognosis of HCC patients remains controversial. Lowered serum albumin in hepatocellular carcinoma, an advanced stage of liver cirrhosis, indicates a worsening condition. Hepatorenal syndrome, marked by increased serum creatinine, is a key mortality indicator. The aim of this study was to determine the serum albumin-to-creatinine ratio (sACR) as a predictor of mortality in patients with HCC and liver cirrhosis. MethodsThis retrospective cohort study included 37 patients with HCC and liver cirrhosis. Patient characteristics, sACR, model of end-stage liver disease (MELD) score, and Child-Turcotte-Pugh (CTP) score were obtained from medical records. The optimal cut-off point for the sACR was determined using receiver operating characteristic (ROC) analysis to evaluate its predictive ability for 90-day mortality. Survival analysis was conducted using the Kaplan-Meier method with a log-rank test, and Cox regression was employed to obtain hazard ratios (HR) to estimate the patient’s prognosis. ResultsA low sACR cut-off of 2.32 was identified. Kaplan-Meier analysis confirmed that sACR met the proportional hazard assumption. sACR <2.32 was a significant predictor of 90-day mortality (HR 6.52; 95% CI 1.80-23.63; p=0.004), comparable to MELD 40 (HR 41.3; 95% CI 1.98-862.90; p=0.016) and CTP category (HR =2.19;95%CI: 0.79-6.06;p=0.131). Conclusion The sACR is a novel predictor of 90-day mortality in HCC patients with liver cirrhosis. Lower sACR is associated with overall survival and may help to design strategies to personalize management approaches among patients with HCC and liver cirrhosis.
Early radial band deflation after transradial access coronary catheterization reduces complications: a systematic review Nugroho, Rico Maulana; Waluyo, Agung; Herawati, Tuti
Universa Medicina Vol. 43 No. 3 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.363-377

Abstract

BACKGROUNDTransradial access (TRA) coronary catheterization is widely used for coronary artery disease (CAD) management. However, complications such as pain, hematoma, and radial artery occlusion (RAO) often occur due to prolonged use of radial compression bands. Early deflation protocols have been proposed to minimize these complications while maintaining effective hemostasis. This systematic review evaluates the impact of early radial band deflation protocols on reducing TRA-related complications. METHODSA systematic literature search was conducted in ProQuest, PubMed, ScienceDirect, Sage Journal, and Scopus databases, including studies published between 2018 and March 2024. Inclusion criteria focused on randomized controlled trials (RCTs), cohort studies, and quasi-experimental studies evaluating radial band deflation protocols in TRA coronary catheterization patients. Outcomes included pain, hematoma, and RAO. Twelve studies were critically appraised using the Joanna Briggs Institute (JBI) tools and synthesized using narrative and quantitative approaches. RESULTSThe review included eight RCTs, three cohort studies, and one quasi-experimental study involving a total of 4,477 patients. Findings revealed that early radial band deflation (1.5–2 hours) reduced pain and hematoma incidence compared to prolonged durations (>4 hours). RAO rates were significantly lower with gradual and early deflation protocols. However, shorter durations (<1.5 hours) slightly increased bleeding risk. Evidence supported the TR Band® Light Protocol as an effective and safe deflation strategy. CONCLUSIONEarly radial band deflation protocols effectively reduce TRA-related complications, enhancing patient comfort and safety. Standardized deflation protocols and further research, including innovative technologies, are recommended to optimize post-TRA care.
The effect of saffron serum on collagen density, inflammatory gene expression, and autophagy in UVB-exposed Wistar rats Octavia, Chitra; Gunadi, Julia Windi; Adhika, Oeij Anindita; Ishak, Lani; Jasaputra, Diana Krisanti; Rosali, Alexandrina Everdine; Sanjaya, Ardo
Universa Medicina Vol. 43 No. 3 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.329-339

Abstract

BackgroundSkin aging is a complex biological phenomenon influenced by intrinsic and extrinsic factors. Photoaging can be prevented by applying phytochemicals that have sun-protective properties. This study aimed to evaluate the effect of saffron serum to restore collagen density and autophagy processes and reduce inflammatory gene expression in UVB-exposed Wistar rats. MethodsAn experimental laboratory study was conducted involving 20 male Wistar rats that were divided into 4 groups: control, UVB, UVB + base serum, UVB + saffron serum exposed to UVB radiation for 5 weeks with a total dose of 3100 mJ/cm2. The skin was extracted then underwent Masson Trichrome staining and real-time PCR to obtain collagen density and gene expression. ResultsThe gene expression of MMP1, IL6, TNFá, LC3, and p62 was significantly increased in the UVB group compared to the control group. Topical administration of saffron serum significantly increased collagen density (p=0.001). Induction by UVB significantly increased LC3 (p=0.020) and p62 (p=0.030) gene expression, indicating an inhibition of autophagy. The saffron serum might modulate autophagy by increasing LC3, but not significant (p=0.495) and significantly decreasing p62 gene expression (p=0.001). As for MMP1, IL6, and TNFá, no significant decrease in gene expression was found in the UVB + saffron serum group compared to the UVB group. ConclusionSaffron serum increases collagen density and modulates autophagy in the skin of UVB-exposed Wistar rats. Inflammatory markers were increased after UVB induction, but no differences were found after saffron serum topical administration.
Evaluating sarcopenia prevalence and relationship with disease activity of primary Sjögren syndrome in females Başaran, Pınar Özge; Eker Büyükşireci, Dilek
Universa Medicina Vol. 43 No. 3 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.340-348

Abstract

BackgroundPrimary Sjögren’s syndrome (pSS) leads to impaired muscle function and mass as well as pain and fatigue. Sarcopenia is the pathological reduction of skeletal muscle mass and strength. We aimed to investigate the prevalence of sarcopenia and determine its relationship with disease activity levels in females with primary Sjögren syndrome. MethodsThis cross-sectional study was performed on 62 female patients diagnosed with pSS and 62 female age matched healthy controls. Disease activity was evaluated with the EULAR Sjögren’s syndrome patient reported index (ESSPRI) and EULAR Sjögren’s syndrome disease activity index (ESSDAI), fatigue severity scale (FSS), hospital anxiety and depression scale (HADS), and numerical rating scale (NRS). A simple questionnaire to rapidly diagnose sarcopenia (SARC-F) was used to screen for sarcopenia. Degree of sarcopenia was evaluated by handgrip strength, anterior thigh muscle thickness by USG, the 6-meter walk test (6MWT), and the five times sit-to-stand test (FTSST). ResultsThe prevalence of sarcopenia was found to be 36/62 (58.1%) in pSS and 6/62 (9.7%) in healthy controls (p<0.001). HADS anxiety and depression scores and SARC-F scores were significantly higher in pSS (p<0.001). There were significant differences in 6MWT, FTSST, and hand grip strength results in pSS (p<0.001). Anterior thigh muscle thickness was similar in both groups (p=0.298). A positive correlation was found between SARC-F on the one hand and ESSPRI and NRS on the other (r=0.595, p=0.009; r=0.569, p=0.014). ConclusionSarcopenia prevalence was increased in female patients with pSS and there was a relationship of SARC-F scores with pain and disease activity levels.
Robotic-assisted total knee replacement: pioneering precision and the future of joint reconstruction Kholinne, Erica; Gani, Karina Sylvana; Mitchel, Mitchel
Universa Medicina Vol. 44 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.1-2

Abstract

The advent of robotic-assisted systems has revolutionized orthopedic surgery. By enhancing precision in bone registration and resection, this technology minimizes manual errors and soft tissue damage, promising more accurate implant positioning and improved postoperative outcomes. This editorial explores the technical nuances of robotic-assisted TKR, its clinical implications, and the long-term potential for transforming patient care.

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