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Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
Arjuna Subject : -
Articles 589 Documents
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Isoflavone supplementation reduces low-density lipoprotein cholesterol levels in postmenopausal women Yenny Yenny; Pusparini Pusparini
Universa Medicina Vol. 32 No. 3 (2013)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.197-207

Abstract

Background Cardiovascular disease is the main cause of death in postmenopausal women. This study aimed at evaluating the effect of soy isoflavone supplementation on plasma lipid profile in postmenopausal women, since this effect is still unclear. MethodsA double-blind randomized placebo-controlled trial was conducted from January 2010 until February 2011. In total 180 postmenopausal women were randomized into an isoflavone group and a control group of 90 subjects each. The isoflavone group received tablets containing 100 mg soy isoflavones and 500 mg calcium carbonate, while the control group received 500 mg calcium carbonate only. Supplementation was given once daily for 1 year. Plasma lipid levels [triacylglycerol, total, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) cholesterols] were assessed at baseline, and after 6 and 12 months of supplementation using an enzymatic colorimetric method (Cobas c 111, Roche). Independent t-test was used for data analysis. ResultsBaseline subject characteristics and lipid profile in the two groups were comparable. In the isoflavone and control groups after 6 months of supplementation LDL cholesterol levels were 124.9 ± 35.2 mg/dL vs 112 .7 ± 29.7 mg/dL (p=0.013*), respectively, and after 12 months 116.9 ± 31.7 mg/dL vs 109.1 ± 29.8 mg/dL (p=0.086). There were no significant differences in the other lipid levels at 6 and 12 months. Conclusions Soy isoflavone supplementation for 6 months was capable of significantly reducing LDL cholesterol levels in postmenopausal women. No significant changes in total cholesterol, triacylgycerol, and HDL cholesterol were found after isoflavone supplementation.
Cytotoxicity assay of Typhonium flagelliforme Lodd against breast and cervical cancer cells Endang Purwaningsih; Etty Widayanti; Yulia Suciati
Universa Medicina Vol. 33 No. 2 (2014)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2014.v33.75-82

Abstract

BACKGROUNDCancer is one of the causes of high mortality. Breast and cervical cancers are two of the most frequent cancers affecting women around the world, including Indonesia. Natural materials such as rodent tuber (Typhonium flagelliforme) have anticancer potentials. The rodent tuber extract contains ribosome inactivating proteins (RIPs) capable of cutting the DNA or RNA of cancer cells and blocking the growth of cancer cells. The purpose of this study was to evaluate the cytotoxic effects of Typhonium flagelliforme Lodd extract on HeLa cervical cancer and Michigan Cancer Foundation-7 (MCF-7) breast cancer cells.METHODSSubjects were cultured cell lines of HeLa cells in Rosswell Park Memorial Institute (RPMI) and of MCF-7 cells in Dulbecco’s Minimum Essential Medium (DMEM). Rodent tuber ethanolic extract was diluted in dimethyl sulfoxide (DMSO). The cytotoxicity assay used the 3-(4,5-dimethyl thiazol-2-yl,5-diphenyl) tetrazolium bromide (MTT) method. Absorbance was read in an ELISA reader at a wavelength of 595 nm.RESULTSRat tuber extract at all dilutions (500; 250; 125; 62.5; 31.25; 15.625;7.81; 3.9 ì g/ mL) showed cytotoxic effects against HeLa and MCF-7 cells. Higherconcentrations of the extract gave a higher proliferation inhibition effect.Calculated IC50 values of the extract by probit analysis were 30.19 ìg/mL against HeLa cells and 5.586 ì g/mL against MCF-7 cells.CONCLUSIONSEthanolic extract of Typhonium flagelliforme Lodd has cytotoxic effects against HeLa cells and MCF-7 cells. The cytotoxic effects against MCF-7 cells are greater than the cytotoxic effects against HeLa cells.
Increased matrix metalloproteinase-9 in male elderly with low 25-hydroxy-vitamin D Pusparini, Pusparini; Merijanti, Lie Tanu; Sudharma, Novia I.
Universa Medicina Vol 35, No 3 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.171-180

Abstract

Background One of the extra-skeletal roles of vitamin D for health is associated with cardiovascular disease. Poor vitamin D status has been associated with vascular endothelial dysfunction. There were controversial results about the association between vitamin D deficiency and matrix metalloproteinase 9 (MMP-9) concentration. The purpose of the present study was to determine the concentrations of 25(OH) vitamin D [25(OH)D] in an elderly population and to find any association between 25(OH)D and MMP-9 concentrations.MethodsThis study was of cross-sectional design involving 160 male and female subjects aged 55–65 years, in South Jakarta, Indonesia. Determination of MMP-9 and 25(OH)D concentrations was done concurrently on subjects who met the inclusion and exclusion criteria after all study subjects had been selected. 25(OH)D and MMP-9 concentrations were assessed by direct competitive chemiluminescence immunoassay (CLIA) and enzyme-linked immunosorbent assay (ELISA) respectively. Statistical analysis used chi square and t tests.ResultsMean 25(OH)D concentration in the study subjects was 14.4 ± 6.4 ng/mL. A total of 68.8% of subjects had a 25(OH)D level of <20 ng/mL, and 31.2 % had a 25(OH)D level of >20 ng/mL.There was an increased MMP-9 concentration in male subjects with a 25(OH)D level of <20 ng/mL compared with subjects with 25(OH)D level of >20 ng/mL (p=0.011), but not among female subjects (p=0.809).ConclusionThe MMP-9 concentration was increased among male subjects with low level of (OH)D. This study confirmed that 25(OH)D concentration may have a potential role in endothelial function.
Perbandingan antara high density lipoprotein, lipoprotein(a) dan small dense low density lipoprotein sebagai parameter pertanda risiko penyakit jantung koroner Priyana, Adi
Universa Medicina Vol 26, No 1 (2007)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2007.v26.11-17

Abstract

Latar Belakang Penyakit jantung koroner (PJK) merupakan penyebab kematian utama di Indonesia seperti juga di berbagai negara industri di dunia. Aterosklerosis merupakan penyebab utama dari PJK. Faktor risiko utama sebagai penyebab aterosklerosis dan PJK adalah hipertensi, diabetes melitus, dislipidemia, kurang aktifitas dan merokok. Beberapa faktor risiko lainnya adalah high density lipoprotein (HDL) kolesterol (HDL-k), low density lipoprotein (LDL) kolesterol (LDL-k), lipoprotein a [Lp(a)], dan small dense LDL (sd-LDL). Penelitian ini bertujuan untuk membandingkan HDL-k, Lp(a) dan sd-LDL sebagai pertanda risiko terjadinya PJK. MetodeSubyek penelitian dibagi dalam dua kelompok yaitu kelompok risiko mengikutsertakan 94 subyek yang memiliki minimal 2 faktor risiko PJK dan kelompok kontrol 49 subyek tanpa faktor risiko PJK. Pemeriksaan sampel darah vena dilakukan pada subyek yang sebelumnya telah berpuasa 12–14 jam. Pertanda faktor risiko yang diperiksa adalah HDL-k, Lp(a) dan sd-LDL. Tiga alternatif multivariat model dibandingkan sd-LDL, sd-LDL + HDL-k, dan sd-LDL, HDL-k + Lp(a). HasilHasil penelitian menunjukkan sd-LDL merupakan pertanda risiko PJK yang akurat. Ternyata Lp(a) dan HDL-k kurang akurat bila digunakan sebagai pertanda risiko PJK dibandingkan dengan sd-LDL. KesimpulanSmall dense LDL merupakan pertanda risiko PJK yang akurat. Perlu dilakukan penelitian lebih lanjut dengan mengikut sertakan lebih banyak penderita PJK dan kontrol dengan usia yang sebanding.
Prognosis and management of polymyalgia rheumatica Samara, Diana
Universa Medicina Vol 30, No 1 (2011)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2011.v30.63-70

Abstract

Polymyalgia rheumatica (PMR) is commonly found in Northern Europe and in persons of Scandinavian extraction in the US, with an annual incidence of around 50 per 100,000 population over 50 years of age, in whom it should be           considered in the differential diagnosis of musculoskeletal disorders. The     disorder is twice more common in women than in men. PMR is closely related to giant cell arteritis and both disorders are considered to have a common    pathogenesis, associated with genetic and environmental factors (viral and   bacterial infections). There is no gold diagnostic standard for PMR and the diagnosis rests on a high index of suspicion in persons older than 50 years with musculoskeletal symptoms. As an aid in diagnosis, several sets of diagnostic criteria have been used, usually related to age at onset, duration, symptoms, inflammatory markers, and response to corticosteroids. Patients with PMR   usually present with acute onset of stiffness and pain in the shoulder and pelvic musculature, which may be accompanied by fever, malaise, and weight loss. The symptoms of PMR seem to be related to synovitis of proximal joints and extra-articular synovial structures. PMR may occur as an isolated syndrome or accompany other diseases, mainly giant cell arteritis. It usually responds quickly to once-daily, low-dose prednisone, but some patients require treatment for  several years. Monitoring for corticosteroid-associated side effects such as   osteoporosis and diabetes, as well as for relapses and flare-ups, is key to chronic management.
Nicotine supplementation blocks oocyte maturation in Rattus norvegicus Meitria Syahadatina Noor; H.M Bahkriansyah; Widjiati Widjiati; Budi Santoso
Universa Medicina Vol. 32 No. 2 (2013)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.92-98

Abstract

BACKGROUNDIndonesia has the third largest tobacco consumption in the world after China and India. Nicotine as the main component of cigarette smoke has negative effects on the reproductive system, such as oocyte maturation, ovulation, and fertilization, and increasing the diploidy of oocytes. The goal of this researchwas to evaluate the effect of nicotine on oocyte maturation in Rattus norvegicus.METHODSThis was an experimental study with post test only control group design. The subjects were 40 rats selected homogenously and randomly. They were divided into a control group (receiving carboxy-methyl-cellulose sodium and 3 treatment groups (I-III) receiving nicotine subcutaneously for 7 days at dosages of 21 mg/ kgBW, 41 kg/kgBW and 84/kgBW, respectively. The observations comprised oocyte maturation stage, viz. germinal vesicle (GV), germinal vesicle breakdown (GVBD), metaphase I and metaphase II. Data were analyzed by one-way Anova with á=0.05, followed by Tukey’s HSD test.RESULTSOne-way Anova showed significant differences in oocyte  maturation in all groups. Tukey’s HSD test showed that for GV, the differing groups were control and I, control and II, I and III. For GVBD, the differing groups were control and I, I andII, I and III. For metaphase I, the differing groups were control with I, II, and III, I and II, I and III. For metaphase II, the differing groups were control versus I, II, and III, I and II, I and III.CONCLUSIONLow dose of nicotine is capable of affecting oocyte maturation in Rattus norvegicus.
Hepatic enzyme concentrations as indicators of nonalcoholic fatty liver disease Alvina, Alvina
Universa Medicina Vol 28, No 3 (2009)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2009.v28.139-145

Abstract

Nonalcoholic fatty liver disease (NAFLD) has emerged as a world-wide problem because it runs an asymptomatic course, ultimately leading to cirrhosis of the liver and portal hypertension, resulting in death. The prevalence of the disease accounts for 3-24% of the population in several countries. Generally there are increased concentrations of hepatic enzymes as markers of liver damage, such as serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and gamma glutamyl transferase (GGT). The aim of the present study was to determine the concentrations of hepatic enzymes as markers of NAFLD. The study design was cross-sectional, involving 90 subjects meeting the inclusion and exclusion criteria. The degree of severity NAFLD was determined by ultrasonography and the concentrations of SGOT, SGPT and GGT by automated clinical chemistry analyzer. The results indicated that there were 32 subjects with mild NAFLD (35.6%), 35 subjects with moderate NAFLD (38.9%) and 23 subjects with severe NAFLD (25.6%). There was a significant difference in degree of NAFLD by gender (p<0.05), where severe NAFLD was more frequent in males than in females. Concentrations of SGOT, SGPT and GGT were significantly different between degrees of NAFLD (p<0.05). The conclusion is that SGOT, SGPT and GGT concentrations are indicators of degree of NAFLD.
Central obesity increases the risk of type 2 diabetes mellitus among urban adults Pradono, Julianty; Kusumawardani, Nunik; Delima, Delima
Universa Medicina Vol 34, No 3 (2015)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.187-196

Abstract

BackgroundIn Indonesia the number of persons with type 2 diabetes mellitus (T2DM) was 8.5 million in 2013, and is estimated to be 11.8 million in 2030. The aim of this study was to determine the major risk factors associated with T2DM prevalence in urban aged >15 years.MethodsAn observational study with cross-sectional design was used with the data from Riskesdas 2007 and 2013 on population aged >15 years. Total respondents were 294,352 (2007) and 368,281 (2013). Data were collected by trained personnel through interviews, blood pressure and anthropometry measurements, and blood glucose and lipid tests. Odds ratio (OR) was used to test the relationship between T2DM and a number of other variables. Multiple logistic regression analysis was obtained to determine the main risk factor associated with T2DM prevalence.ResultsType 2 diabetes mellitus prevalence increased from 2.3% (2007) to 2.5% (2013). T2DM tended to be increased in the younger age groups. Low education, middle-to-high economic status, less physical activity, smoking >200 cigarettes, and high risk blood lipid levels were strongly associated with T2DM prevalence. The main risk factors were inadequate physical activity (2007: OR 1.9;95% CI:1.16–2.98 and 2013: OR 2.44;95% CI: 1.57-3.78) and central obesity (2007: OR 1.8;95% CI:0.99–3.10, and 2013:OR 3.84; 95% CI: 2.49-5.93) after controlling for age, gender, employment and economic status.ConclusionsType 2 diabetes mellitus prevalence in the population aged >15 years increased within 5 years. Lack of physical activity and central obesity were the major risk factors of T2DM prevalence in urban adults.
Frequent coconut milk intake increases the risk of vascular disease in adults Sulistyowati Tuminah; Marice Sihombing
Universa Medicina Vol. 34 No. 2 (2015)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.149-158

Abstract

Background Coconut milk is an essential ingredient of the Indonesian cuisine. In view of its saturated fatty acid content, coconut milk has frequently been blamed as a cause of cardiovascular disease. The objective of this study was to determine any association between coconut milk intake and vascular disease among adults.MethodsA cross-sectional study was conducted in 2011-2012 on adults aged 25-65 years. Self-reported health and nutritional data were collected by means of questionnaire-based interviews, with the aid of 3-D food models. Medical data comprised blood pressure and anthropometry (waist circumference and body mass index), neurological status, ECG, blood glucose and lipid profile. Data analysis was done using multiple logistic regression. ResultsA total of 4,187 respondents fullfilled the inclusion criteria. Frequent coconut milk intake (>3 times/week) significantly increased the risk of vascular disease by 1.3-fold compared with infrequent coconut milk intake (<2 times/week) (OR=1.33; 95% CI: 1.11-1.60; p=0.002) after controlling for age, gender, hypertension, diabetes mellitus and stress. The influence of coconut milk intake on vascular disease risk was lower than that of age, gender, hypertension and diabetes mellitus. ConclusionFrequent coconut milk intake increased the risk of vascular disease in adults. Further investigations are needed about the effect of coconut milk intake on noncommunicable diseases.
Decreased adiponectin level in adults with central obesity and low 25-hydroxy vitamin D level Pusparini, Pusparini; Merijanti, Lie Tanu; Lesmana, Alvina; Meiyanti, Meiyanti
Universa Medicina Vol 36, No 3 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.205-213

Abstract

Background Vitamin D insufficiency is associated with obesity and central obesity, which is in turn associated with the accumulation of visceral fat. Visceral fat secretes adiponectin which has a role in the pathogenesis of the metabolic syndrome, diabetes mellitus and cerebrovascular disease. The aim of this study was to determine the relationship between serum 25-hydroxy vitamin D [25(OH)D] level and adiponectin level in adults with central obesity. Methods This study was a cross sectional study with 80 subjects with central obesity and 80 healthy subjects as controls. The age of the subjects ranged from 55 to 65 years. The data collection included anthropometry and blood biochemistry (lipid profile, fasting blood glucose, 25(OH)D, and adiponectin). The data were analyzed using independent t test with p &lt;0.05.Results Mean waist circumference and 25(OH)D level in the central obesity group were 94.9 ± 7.8 cm and 14.3 ± 6.6 ng/mL, respectively, and in the control group 72.4 ± 5.0 cm and 19.2 ± 8.6 ng/mL respectively. There were significant differences in adiponectin level between the central obesity group and the control group at the 25(OH)D level of &lt;20 ng/mL (p=0.001), but no significant differences between the two groups at the 25(OH)D level of ³20 ng/mL (p=0.538).Conclusion The central obesity subgroup with 25(OH)D level of &lt;20 ng/mL have lower adiponectin levels compared with the control group. This study demonstrates the role of adiponectin as a link between insulin resistance and vitamin D status in adults.

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