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Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
Arjuna Subject : -
Articles 589 Documents
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Waist circumference as a predictor for blood glucose levels in adults Hardiman, Shinta L; Bernanthus, Intan Nevita; Rustati, Puspa K; Susiyanti, Eva
Universa Medicina Vol 28, No 2 (2009)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2009.v28.77-82

Abstract

Anthropometric indexes such as body mass index (BMI), waist circumference (WC), hip ciucumference (HC), and waist–hip ratio (WHR), are all useful anthropometric measurements to provide important information on blood glucose concentrations. The aim of this study was to determine different anthropometric measurements, in particular BMI, waist circumference, hip circumference and waist-to-hip ratio, in their ability to predict the blood glucose levels in men and women 40 to 60. A cross-sectional study was conducted on a sample of 44 men and 127 women aged 40 to 50 who lived in Cipete Selatan subdistrict, South Jakarta. Blood glucose levels was assessed and anthropometric measurements comprising BMI, WC, HC, WHR were collected. Multiple linear regression analysis was used to determine the best predictor for blood glucose levels. The study showed that the prevalence of DM type 2 was 25.7% and the prevalence was higher in men (40.9%) compared to women (23.5%). The significant predictive variables in the simple regression analysis were age and waist circumference. Multiple linear regression showed that after adjustment for age, WC was positively associated with blood glucose levels. Standardized a value was 0.172 (p=0.026). WC predict blood glucose levels, beyond that explained by traditional diabetic risk factors and BMI. These findings provide support for the recommendation that WC be a routine measure for identification of diabetes mellitus type 2 in men and women aged 40 to 60 years.
Safety of cerebral digital subtraction angiography : complication rate analysis Usman, Fritz Sumantri; Sani, Achmad Firdaus; Husain, Shakir
Universa Medicina Vol 31, No 1 (2012)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.27-33

Abstract

Background Cerebral digital subtraction angiography (DSA) continues to be used for the examination of patients with cerebrovascular diseases. In the past decade, safer contrast agents have been used and there have been important technical advances including smaller catheters, hydrophylic guide wires, and digital imaging systems. The objective of this study was to determine the neurological complication rates of cerebral angiography performed for inpatients. MethodsA prospective study was conducted from January 2009 until December 2011. The patient’s demographic characteristics, the procedural details as well as complications appearing during and after the procedure were documented. Neurological complications are classified based on the international classification: (a) transient, disappearing within 24 hours; (b) reversible, lasting more than 24 hours but less than 7 days; (c) permanent, if the complication last for more than 7 days. The complications were examined by a neurologist.ResultsThe patients comprised 82 (41%) women and 118 (59%) men, ranging from 11 to 86 years of age. From 200 patients who underwent the procedure, permanent neurological complications were found in 1 (0.50 %) patient. Neither reversible nor transient neurological complications were found. ConclusionThe cerebral digital subtraction angiography procedure, when conducted by a neuro interventionist, is relatively save, both from the aspect of neurological and non-neurological complications, and from the number of deaths. The overall neurological complication rate fell within the limits recommended by quality improvement and safe practice guidelines.
Annona muricata aqueous extract suppresses T47D breast cancer cell proliferation Ika Fidianingsih; Ety Sari Handayani
Universa Medicina Vol. 33 No. 1 (2014)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2014.v33.19-26

Abstract

BackgroundCancer is a dreadful disease caused by abnormal and uncontrolled cell division. Annona muricata L, also known as soursop, is useful as an anticancer herbal medication since its leaves, seeds and fruits contain active compounds called annonaceous acetogenins. The objective of this study was to scientifically justify the traditional application of soursop for anticancer treatment in the community, by comparing the antiproliferative effect of Annona muricata L leaf, seed and fruit aqueous extracts on T47D breast cancer cells. Methods     This study used an experimental post test trial with control group design. Infusions of soursop leaves, seeds, and fruits collected from Kaliurang, Sleman district, Yogyakarta were used for cytotoxicity tests on T47D cells, in comparison with tamoxifen as standard cancer therapy. Proliferative inhibition was determined by 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide [MTT] assay. The parameter of proliferative inhibition was IC50 which is defined as 50% proliferative inhibition ability of soursop and tamoxifen. Significant differences between groups were determined at p<0.05 by Kruskal-Wallis test. ResultsThe leaves, fruits, and seeds Annona muricata and tamoxifen were proven to be able to inhibit T47D cell proliferation. The IC50 of Annona muricata leaf, seed, fruit aqueous extracts and tamoxifen were 31,384.21 µg/ml; 1.528,800 µg/ml; 329,194.81 µg/ml and 114.52 µg/ml, respectively (p=0.016). The IC50 of Annona muricata aqueous extract was significantly different from that of tamoxifen.ConclusionsThe proliferative inhibition of soursop leaves against T47D breast cancer cells is higher than that of soursop fruits and seeds. Annona muricata fruit, seed, and leaf aqueous extracts were less toxic than tamoxifen
Performance of osteoporosis self-assessment tool in detecting low bone mineral density in menopausal women Haryono, Ignatio Rika; Prastowo, Nawanto Agung
Universa Medicina Vol 36, No 2 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.123-130

Abstract

BackgroundThe osteoporosis self-assessment tool (OST) is a simple screening tool to assess risk of osteoporosis and to select high risk women for dual-energy x-ray absorptiometry (DXA) examination. This study aimed to evaluate OST performance in detecting low bone mineral density (BMD) in menopausal women.MethodsA cross-sectional study involving 60 menopausal women aged 50-65 years. The OST score was calculated from: [weight (kg) – age (yr)] x 0.2. Subjects were classified by OST score into low risk (OST ³2) and high risk (OST&lt; 2) groups. BMD was determined by DXA at 3 bone locations (L1-L4, femoral neck, and total hip). DXA T-scores were categorized into: normal BMD (T-score &gt;-1) and low BMD (T-score £-1). Independent t-test was used to compare subject characteristics between OST groups. Diagnostic performance of OST was evaluated by measuring sensitivity, specificity, positive &amp; negative predictive value (PPV, NPV), positive &amp; negative likelihood ratio (PLR, NLR) and receiver-operating characteristic (ROC). Significance was set at p&lt;0.05.ResultsSubject characteristics and BMD between groups were significantly different (p&lt;0.05). Most subjects (44/73.3%) had high risk of low BMD (OST &lt; 2). Low BMD (T score £-1) was found in 43 subjects (71.7%) at L1-L4, 41 subjects (68.3%) at femoral neck, and 37 subjects (61.7%) at total hip. Diagnostic performance of OST was significant at total hip BMD (sensitivity=0.946, AUC=0.777).Conclusion We conclude that use of the OST score in menopausal women is effective and has adequate sensitivity and specificity. The highest diagnostic performance of OST is on total hip BMD.
Red fruit oil increases trophoblast cells and decreases caspase-9 expression in placenta of lead exposed mice Sumarsono, Portia; Widjiati, Widjiati; Susilowati, Suherni
Universa Medicina Vol 35, No 2 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.110-118

Abstract

BACKGROUNDLead is able to pass through the placental barrier and interfere with fetal development. Red fruit has high antioxidant activity, due to carotenoids (pro-vitamin A), tocopherols (vitamin E) and unsaturated fatty acids. This study aims to examine the effect of red fruit oil towards placenta in pregnant mice before lead exposure.METHODSThis was a laboratory experimental post test only study, using 20 pregnant mice (Mus musculus) that were randomized into five groups. The negative control group was not exposed to lead; intervention group 0 (P0) was exposed to lead at 0.011 mg/20 g BW/day on days 6-15 of gestation. The intervention groups P1-P3 were given red fruit orally at 0.3 mL/20 g BW/day, 0.8 mL/20 g BW/day, 0.9 mL/20 g BW/day, respectively, before lead exposure. Normal trophoblast cell count and caspase-9 expression of trophoblasts were calculated. One-way ANOVA, Kruskal-Wallis and Mann Whitney tests were used to analyze the data.RESULTSThe intervention groups P2 and P3 given red fruit at 0.8 mL/20 g BW/day and 0.9 mL/20 g BW/day showed a significant increase in normal trophoblast cell count of 88.2% (p=0.024) and a decrease in caspase-9 expression of 70.8% compared with P0 to which was not given red fruit (p=0.020). CONCLUSIONRed fruit increased normal trophoblast cell count by 88.2% and decreased caspase-9 expression by 70.8% in pregnant mice before lead exposure. It should be noted that red fuit may prevent oxidative damage to cells.
The benefits and risks of Echinacea in treatment of common cold and influenza Yenny, Yenny; Djanun, Zunilda
Universa Medicina Vol 27, No 3 (2008)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2008.v27.132-142

Abstract

The common cold is one of the world’s most prevalent illnesses in adults and children. This upper respiratory tract infection is caused by different kinds of agents. Effects on health, well-being, and productivity are significant. Preparations made from plants of the genus Echinacea are widely used for the prevention and treatment of colds. Three species of Echinacea used for medicinal purposes are Echinacea purpurea, Echinacea angustifolia, and Echinacea pallida. The beneficial effects of Echinacea are thought to be due to its immunomodulatory activity, most notably activation of macrophages, polymorphonuclear leukocytes and natural killer cells. Many clinical trials, including a number of blind randomized trials, have reported health benefits. Although these studies show beneficial effects, recommendations on Echinacea use cannot be made due to lack of product standardization and variability in dosage, sample size and methodological quality used in the trials. Therefore, well-designed studies with consistent standardized measures are required for assessment of the efficacy of Echinacea in treatment of common cold and influenza.
Intestinal parasites from fingernails of sidewalk food vendors Suriptiastuti, Suriptiastuti; Manan, Widiastuti S.
Universa Medicina Vol 30, No 2 (2011)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2011.v30.120-125

Abstract

Intestinal infections with soil-transmitted helminths and protozoa are still prevalent in Indonesia, particularly in urban communities. Transmission of parasitic infections is effected directly or indirectly through objects contaminated with feces, including food, water, fingers and fingernails, indicating the importance of fecal-oral human-to-human transmission. Sidewalk food vendors (SFVs) preparing food for their customers are a potential source of infections with many intestinal helminths and protozoa. Compared to other parts of the hand, the area beneath fingernails harbors the most microorganisms and is most difficult to clean. The objective of this cross-sectional study was to determine the prevalence of intestinal parasites in fingernail dirt of SFVs and to identify the associated factors. This study involved 112 SFVs in the vicinity of Hospital X in Central Jakarta, and used microscopic examination of SFV fingernail dirt for determining species prevalence of intestinal parasites. This study showed that 94 samples out of 112 (83.9%) were positive for intestinal parasites; 60 samples (63.8%) represented single infections and 34 (36.2%) mixed infections. Ascaris lumbricoides eggs were found in 30 (26.8%) samples and Giardia lamblia cysts in 12 (17.89%). The highest prevalence was found in subjects with primary school education, among whom 20 (30.8%) had single infections of A. lumbricoides and 16 (24.6%) mixed infections with A. lumbricoides and Trichuris trichiura. In conclusion, prevalence of intestinal parasites in SFV fingernail dirt is extremely high, with the highest prevalence among less educated SFVs. It is recommended to provide health education and training to all SFVs.
Does aspirin have a role in preventing unprovoked recurrent thromboembolism? Yenny Yenny
Universa Medicina Vol. 32 No. 1 (2013)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.1-2

Abstract

Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is a frequently recurring and serious complication after cessation of anticoagulant therapy. Several studies indicate that 10 years after cessation of anticoagulant therapy the risk of recurrent VTE is 39.9% and nearly 50% for unprovoked VTE.
Blood cadmium levels increase prostate specific antigen and insulin-like growth factor-1 among cadmium exposed workers Roestijawati, Nendyah; Maurits, Lintje Setyawati; Sugiyanto, Sugiyanto
Universa Medicina Vol 36, No 1 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.42-48

Abstract

BACKGROUNDCadmium (Cd) is a heavy metal that is classified as a human carcinogen (group IA), one of the cancers that it can cause being prostate cancer. The development of prostate cancer on a molecular basis involves oncogenes such as insuline-like growth factor-1 (IGF-1). Prostate cancer can be detected in the laboratory through the examination of prostate specific antigen (PSA). The present study aimed to determine the relationship of Cd levels with levels of PSA and IGF-1 in exposed and unexposed workers.METHODSThe study design was cross sectional. The subjects of the studycame from two groups of workers, ie. the group of Cd exposed workers who were welding shop workers and the group of unexposed workers who were office workers. The minimum samplesize was 85 people. The independent variable was blood Cd level. The dependent variables were PSA and IGF-1 levels. Blood Cd levels were measured by atomic absorption spectrometry (AAS), while PSA and IGF-1 were measured using ELISA. Data analysis was performed using the Mann-Whitney test and the Spearman correlation test.RESULTSMean blood Cd level in the exposed workers was 6.5 mg/L and in the unexposed workers 2.15 mg/L. There was a relationship between blood Cd and PSA levels (p&lt;0.05) and between blood Cd levels and IGF-1 (p &lt;0.05).CONCLUSIONSThere was a relationship of blood Cd with PSA and IGF-1 levels.among workers. PSA and IGF-1 could be a biochemical markers of disease control in cadmium exposed workers.
Nyeri muskuloskeletal pada leher pekerja dengan posisi pekerjaan yang statis Samara, Diana
Universa Medicina Vol 26, No 3 (2007)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2007.v26.137-142

Abstract

Nyeri leher pada pekerja pada umumnya lebih sering disebabkan oleh gangguan muskuloskletal di mana terjadi ketegangan dan peregangan otot dan ligamentum sekitar leher. Sebuah studi menunjukkan prevalensi nyeri muskuloskeletal pada leher di masyarakat selama satu tahun besarnya 40% dan prevalensi ini lebih tinggi pada wanita. Beberapa pekerjaan yang dapat memicu terjadinya nyeri leher antara lain bekerja dengan komputer dalam waktu yang lama atau bekerja di depan meja dengan posisi membungkuk dalam waktu lama. Mengangkat, mendorong atau membawa barang, penari, dan pengemudi angkutan umum. Gejala-gejala nyeri leher antara lain terasa sakit di daerah leher dan kaku, nyeri otot-otot leher, sakit kepala, dan migraine. Nyeri bisa menjalar ke bahu, lengan, dan tangan disertai keluhan terasa baal atau seperti ditusuk jarum selain itu nyeri juga bisa menjalar ke kepala menyebabkan rasa sakit kepala. Kebanyakan kasus nyeri leher dapat mengalami perbaikan dengan sendirinya. Hal yang penting bagi pekerja yang mengalami nyeri leher adalah modifikasi pekerjaan termasuk manajemen administrasi dan pengaturan ergonomik.

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