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Paediatrica Indonesiana
Published by Ikatan Dokter Anak Indonesia
ISSN : 00309311     EISSN : 2338476X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of health practice throughout the world.
Arjuna Subject : -
Articles 2,118 Documents
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The effect of iron versus iron plus zinc supplementation in children with malaria Bugis Mardina Lubis; Danny Dasraf; Nelly Rosdiana; Bidasari Lubis; Munar Lubis; Syahril Pasaribu; Chairuddin P Lubis
Paediatrica Indonesiana Vol 46 No 1 (2006): January 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi46.1.2006.7-12

Abstract

Introduction Little is known about the potential interaction of ironand zinc given to increase hemoglobin and serum ferritin in chil-dren with malaria.Objective To study the effect of iron compared with a combination ofiron and zinc supplementation on children with falciparum malaria.Method Children with positive Plasmodium falciparum (n=86) wererandomly assigned to a daily supplementation of 6 mg iron/kg perday plus placebo or plus 10 mg zinc per day for 30 days. All childrenwere treated with the same regimen for the treatment of P. falciparum.Venous blood samples were collected at the start and end of thestudy. After 30 days of supplementation, the baseline and follow-upblood samples were analyzed.Results The increase of hemoglobin concentration in the ironplus placebo group was 0.58 g/dl, while in the iron plus zinc groupwas 0.09 g/dl (P<0.05). Serum ferritin concentration was high inboth groups before trial, yet there was no significant differenceafter iron supplementation.Conclusions Iron supplementation showed significant increasein hemoglobin concentration in children with positive P. falciparumtreated with the same regimen of treatment. Supplementation ofiron alone as well as iron plus zinc had been proven ineffective toiincrease serum ferritin in children with malaria.
Health for all: the urgent need of health by the people concept Muzief Munir
Paediatrica Indonesiana Vol 21 No 7-8 (1981): July - August 1981
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi21.7-8.1981.175-80

Abstract

lndonesia which consists of more than 13.000 islands has 147 minion population distributed 900 inhabited tislands.Around 66% of the total population live an Java which is only 7% of Indonesia's total land area. As in other developing countries, 80% of her population live in rural areas, and 40% of the total populaton consist of the vulnerable groups namely children under five of age and women in the child bearing age.
Leukemic Infiltration of the Kidney Widagdo Widagdo; Iskandar Wahidiyat; A. H. Markum
Paediatrica Indonesiana Vol 14 No 9-10 (1974): September - October 1974
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (699.492 KB) | DOI: 10.14238/pi14.9-10.1974.159-62

Abstract

The case presented below is probably the first report concerning renal involvement of leukemia ever published in the Indonesian literature.
Quality assurance for increasing growth monitoring and promotion (GMP) performance Oktora Wahyu; Endy Paryanto; Tonny Sadjimin
Paediatrica Indonesiana Vol 47 No 3 (2007): May 2007
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (389.434 KB) | DOI: 10.14238/pi47.3.2007.95-9

Abstract

Background Measuring body weight of under-five children is oneof the Family Nutritional Improvement Program or UsahaPerbaikan Gizi Keluarga (UPGK) activities which was integratedin Integrated Health Post (Posyandu) activities. Growthmonitoring and promotion (GMP) has been used as the maincomponent of the health and nutritional program in severaldeveloping countries. Unfortunately, this activity did not run asexpected. This study aimed to understand how quality assurance/total quality management (QA/TQM) influence the performanceof the GMP.Methods This 6 month operational research included 76 Posyandusin four subdistricts of Jogyakarta Province. The results of thePosyandus’s GMP score performance were used as a basis toimprove the performance for the next consecutive months withQA system. Data were transformed as a score index. Student’s t-test was used to analyze the data.Results The quality assurance could increase the performance ofGMP, which was done in Posyandus intervention group for 3consecutive months. The baseline scores for both groups were0.47±0.12 vs 0.42±0.17 (P=0.302), at the second monthmonitoring: 0.58±0.07 vs 0.42±0.16, for the intervention group(P<0.001). The mothers’ index (percentage of the children underfive attendance and mothers who brought KMS at weighingsession), however, did not significantly change.Conclusion Total quality management increased the generalperformance of Posyandus, but the program could not influencethe mothers’ index.
Correlation between chest x-ray findings and outcomes of patients with mechanical ventilation Indah Nurhayati; Muhammad Supriatna; Kamilah Budhi Raharjani; Eddy Sudijanto
Paediatrica Indonesiana Vol 53 No 1 (2013): January 2013
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (186.184 KB) | DOI: 10.14238/pi53.1.2013.6-11

Abstract

Background Most infants and children admitted to the pediatricintensive care unit (PICU) have respiratory distress and pulmonarydisease as underlying conditions. Mechanical ventilation may beused to limit morbidity and mortality in children with respiratoryfailure.Objective To assess a correlation between chest x-ray findingsand outcomes of patients with mechanical ventilation.Methods This retrospective study was held in Dr. KariadiHospital, Semarang, Indonesia. Data was collected from themedical records of children admitted to the PICU from Januaryto December 2010, who suffered from respiratory distress andused mechanical ventilation. We compared chest x-ray findings tothe outcomes of patients. Radiological expertise was provided byradiologists on duty at the time. Chi-square and logistic regressiontests were used for statistical analysis.Results There were 63 subjects in our study, consisting of 28 malesand 35 females. Patient outcomes were defined as survived or died,43 subjects ( 68%) and 20 subjects (3 2%), respectively. Chest x-rayfindings revealed the following conditions: bronchopneumonia48% (P=0.298; 95%CI 0.22 to 1.88), pleural effusion 43%(P=0.280; 95%CI 0.539 to 4.837) , pulmonary edema 6%(P=0.622; 95%CI 0.14 to 14.62) and atelectasis 3% (P=0.538;95%CI 0.03 to 7 .62). None of the chest x-ray findings significantlycorrelated to patient outcomes.Conclusion Chest x-ray findings do not correlate to patientoutcomes in pediatric subjects with mechanical ventilation inthe PICU of Dr. Kariadi Hospital, Semarang, Indonesia.
Free testosterone level in patients with homozygous beta thalassemia on regular transfusions regimen Riadi Wirawan; Elly Santosa; Lyana Setiawan; Bulan Ginting Munthe; Dalima AW Astrawinata
Paediatrica Indonesiana Vol 44 No 2 (2004): March 2004
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (453.514 KB) | DOI: 10.14238/pi44.2.2004.73-9

Abstract

Background Patients with homozygous beta thalassemia requireregular transfusions which will lead to iron deposition in tissuesincluding testicles.Objective This study aimed to evaluate testicular function in syn-thesizing testosterone by measuring free testosterone level. Thecorrelation between free testosterone level and transferrin satura-tion was evaluated.Methods This was a cross sectional study. Sampling was doneconsecutively. Free testosterone level was measured by radioim-munoassay in 20 homozygous beta thalassemic patients receiv-ing regular transfusions and compared to 20 healthy subjects.Results Fourteen out of 20 patients showed free testosterone levelbelow the reference range. Out of 20 thalassemic patients, onepatient’s serum was not enough for transferrin saturation determi-nation. Among the 19 patients, 18 had transferrin saturation above55%, 1 less than 55%, while all healthy subjects had normal trans-ferrin saturation. A significant difference was found between thetwo groups, both in the free testosterone level (p=0.001) and trans-ferrin saturation (p<0.001). A very weak correlation was found be-tween free testosterone level and transferrin saturation (r=-0.215).Conclusion We concluded that there might be a relationship be-tween iron overload and testicular endocrine function in patientswith homozygous beta thalassemia receiving regular transfusions
Vitamin E effect on osmotic fragility in β thalassemia major Agus Fitrianto; Moedrik Tamam; Nyoman Suci Widyastiti
Paediatrica Indonesiana Vol 54 No 5 (2014): September 2014
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi54.5.2014.280-3

Abstract

Background Blood transfusion remains the main therapy for anemia in β thalassemia major patients. However, frequent transfusions can cause oxidative stress in response to iron overload. Vitamin E is considered to be the best lipid-soluble exogenous antioxidant in humans. It can protect phospholipid membrane from peroxidarion. Erythrocyte osmotic fragility is a useful test to assess for the improvement of red blood cells in thalassemia patients after vitamin E supplementation.Objective To investigate the effect of vitamin E for improving erythrocyte osmotic fragility in β thalassemia major and for decreasing the need for frequent transfusions.Methods T his was a double blind placebo controlled randomized clinical trial on children aged 2-14 years with thalassemia major who received frequent blood transfusions. Fifty subjects were divided into 2 groups: group I with vitamin E supplementation and group II with placebo, as a control group, for a period of 1 month. Pre- and post-treatment data on erythrocyte osmotic fragility and hemoglobin level were analyzed with non-paired T-test.Results Improved erythrocyte osmotic fragility was found: in group I, pre-treatment 31.59 (SD 6.342)% to post-treatment 38.08 (SD 7.165)%, compared to the control group pre-treatment 34.40 (SD 6.985)% to post-treatment 29.26 (SD 9.011)% (P=0.0001). Comparison of the mean delta Hb level in group  I was 0.94 (SD 0.605) gr% and that of group II was - 0.23 (SD 1.199) gr% (P=0.0001).Conclusion Vitamin E supplementation improves erythrocyte fragility and Hb level in β thalassemia major pediatric patients.
The Importance of Paediatrics in Developing Countries Thomas Stapleton
Paediatrica Indonesiana Vol 15 No 1-2 (1975): January - February 1975
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (458.202 KB) | DOI: 10.14238/pi15.1-2.1975.1-7

Abstract

The rate of tuberculous infection is high. In many areas by the age of ten to fourteen years almost half the population have become tuberculin positive, not as a result of BCG vaccination, but as a result of infection acquired from someone in their environment.The fact that you have selected paediatric emergencies as one of the themes of this congress is merely a reflection that the overall mortality of children admitted to the children’s wards in a great teaching hospital such as you have here in Surabaya is of the order of fifteen to twenty per cent.
Variable Severity of B-Thalassemia/Hemoglobin E Disease - the Genetic Factors Sunarto Sunarto
Paediatrica Indonesiana Vol 37 No 1-2 (1997): January - February 1997
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi37.1-2.1997.6-12

Abstract

Hemoglobin E (Hb E) is prevalent in Southeast Asia. Heterozygotes give no manifestation, even homozygotes show no manifestation or only slight anemia. However, compound heterozygote with 6-thalassemia gives anemia with variable severity. The severely affected individuals show anemia similar to homozygous 6-thalassemia. Many factors play a role in determining the severity. SThnl/6E patients have increased superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities. The increased GSH-Px is thought to be needed for the elimination of hydrogen peroxide produced by SOD decomposition of peroxide. The content of antioxidants vitamine E and C is reduced, whereas MDA, the final product of lipid peroxidation increases significantly. The genotype of the Xmn 1 polymorphism, -158 bases upstream from the transcription site of the n-globin and the level of Hb F are associated with clinical severity, but the extent of the S' -globin mRNA cryptic splicing is more associated with the severity of tire manifestation than does the pattern of the Xmn I polymorphism.
Fever and laboratory profiles as predictors of serious bacterial infection in children Ni Putu Veny Kartika Yantie; BNP Arhana; Purnomo Suryantoro
Paediatrica Indonesiana Vol 52 No 6 (2012): November 2012
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (104.745 KB) | DOI: 10.14238/pi52.6.2012.313-6

Abstract

Background There is a debate on the use of high fever \\lith othermorbidities to predict serious bacterial infection (SBI). Bacterialinfection occurs in 3􀁉15% of children with fever of 2: 39°C.Various laboratory parameters including increased C􀁉reactiveprotein (CRP) levels, leukocyte counts, and absolute neutrophilcounts (AN C) have been studied for their usefulness in predictingthe occurrence of SBI, but with varied results. The ability todiscriminate whether a patient has a SBI can lead to improvedpatient management.Objective To evaluate fever of 2: 39°C, leukocyte counts of2: 15,000/mm3, ANC of 2: 1O,000/mm3 and CRP of 2: 10 mgiL aspredictors of SBI in children aged 1 month􀁉 18 years.Methods A case􀁉controlled study was conducted by collectingdata from medical records at Sanglah Hospital, Denpasar. Subjectsin the case group were diagnosed \\lith SBls (bacterial meningitis,bacterial pneumonia, bacteremia or sepsis, urinary tract infections,or bacterial gastroenteritis), and subjects in the control group nonserious bacterial infections (non􀁉SBI). Data was analyzed usingbivariate and multivariate methods \\lith 95% confidence intervalsand a statistical significance value ofP <0.05.Results Sixty subjects were studied, \\lith 30 subjects in the casegroup and 30 in the control group. Baseline characteristics ofsubjects were similar between the two groups. Fever and CRP werepredictors ofSBI [OR8.71 (95% CI 1.61 t046.98), P 􀀁 0.009; andOR 6.20 (95% CI 1.58 to 24.24), P 􀀁 0.012, respectively].Conclusion Fever 2: 39°C and CRP 2: 10 mgiL were significantpredictors of serious bacterial infections in children. [Paediatrrndones, 2012;52:313-6].

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