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Rachmat Kosman
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As-syifaa Jurnal Farmasi
Published by Universitas Muslim Indonesia
ISSN : 20854714     EISSN : 25029444     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
As-Syifaa Jurnal Farmasi receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmacology and Toxicology, Pharmaceutical Microbiology and Biotechnology, Herbal Medicines, Pharmaceutics, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 397 Documents
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UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETER DAUM MIMBA (Azadirachta indica A.Juss) SECARA KLT-BIOAUTOGRAFI TERHADAP BAKTERI Staphylococcus aureus Dan Pseudomonas aeruginosa Rachmat Kosman
As-Syifaa Jurnal Farmasi Vol 1, No 1 (2009): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v1i1.89

Abstract

Research of antimicrobial activity assay of mimba leaves (Azadirachta indica A.Juss) the pleminary research has been done by screening test several microbes such as Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus mutans, Bacillus subtilis, Pseudmonas aeruginosa, Salmonella thyposa, Escherchia coli, Vibrio sp and  Candida albicans, to the methanol, ether, and n-Butanol extract of mimba leaves (Azadirachta indica A.Juss) in consentration 1 mg/ml. The result showed that the ether extract inhibited bacterial growth actively of Staphylococcus aureus and Pseudomonas aeruginosa. Antimicrobe potency assessment on ether extract of mimba leaves (Azadirachta indica A.Juss) has done by liquid-liquid dilution methode to find out the MIC value in consentration 10 mg/ml; 5 mg/ml; 1 mg/ml; 0.5 mg/ml and 0.1 mg/ml respectively which continue on solidified medium ti find out the MLC to predict the compound group in other extract which antimicrobe activity it was done bioautography TLC. The best result has been obtained from separating compound by TLC methode which used mixed eluen n-Hexane : Ethyl Acetate (6:4). The result showed that MIC could not be determined due to the turbidity of test solution, whilw manimum MLC of ether extract of mimba leaves (Azadirachta indica A.Juss) 10 mg/ml toward Staphylococcus aureus nor Pseudomonas aeruginosa bacteria. Bioautography TLC test on Staphylococcus aureus and Pseudomonas aeruginosa showed that the compound group which predicted to impart the antimicrobe activity to the ether extract of mimba leaves (Azadirachta indica A.Juss) was alkaloid.Key words : Azadirachta indica, Bioautography TLC, antimicrobe
ISOLASI DAN IDENTIFIKASI BAKTERI ASAM LAKTAT DARI LIUR BASA (LIMBAH SAYUR BAYAM DAN SAWI) Sasmita Sasmita; Aliansyah Halim; Aisyah Nur Sapriati; Sukriani Kursia
As-Syifaa Jurnal Farmasi Vol 10, No 2 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (543.289 KB) | DOI: 10.33096/jifa.v10i2.339

Abstract

Lactic acid bacteria (BAL) is a gram-positive bacterium in the form of stems or round, not forming spores, anaerobic facultative fermentation and has the ability to ferment glucose into lactic acid. The purpose of this study was to isolate and identify lactic acid bacteria from spinach and mustard vegetable waste which can be used as food preservative. The isolation result was obtained by 10 isolates suspected as lactic acid bacteria. The isolates obtained were identified macroscopically, fermentation test, gram staining, spore staining and catalase test. From the macroscopic identification of samples of spinach and mustard, the isolates were white milk, rounded circular edges, kensitri surface and convex elevation. The fermentation test indicates that are heterofermentative and. All isolates obtained in the form of gram-positive bacteria had no negative spores and catalases and its alleged are Lactobasillus.
STABILITAS DAN MASA SIMPAN SEDIAAN SUSPENSI KERING ERITROMISIN ETILSUKSINAT DENGAN VARIASI BAHAN PENSUSPENSI Faradiba Faradiba; Amran Ilyas Tandjung; Nur Fadillah
As-Syifaa Jurnal Farmasi Vol 3, No 1 (2011): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v3i1.121

Abstract

An Investigation on how to know the chemist stability and the expired date on dry suspension formulation of erythromycin ethylsuccinate has been done in variation of suspending agents.Evaluation of Chemical stability has been done by inspection a rate of eritromisin degradation with accelerated stability test by stored sample on temperature above room temperature (250C) that is 30, 40, 50 and 600C during 4 days and decided the remain of the erythromicyn concentration each 1 day (24 hours).The Results is rate of erythromycin degradation in stored by normal temperature (250C) for the formula I, II and III to follow that is 0,00043 day-1; 0,00026 day-1 and 0,00064 day-1.  Th stored time for the formula I, II and III to follow that is 0,7; 1,13; and 0,5 years. The result have been shown that formula II (Gum xanthan as a suspending agent) was the most stable dry suspension chemically.Key Words : Stability , Expired Date,  Dry Suspension , Erythromycin Ethylsuccinate , Suspending Agent
PEMBUATAN NATA DE RICE DARI AIR CUCIAN BERAS DALAM BEBERAPA KONSENTRASI DENGAN BAKTERI Acetobacter xylinum A. Suparlan Isya Syamsu; Sirajul Firdaus; Ali Imran
As-Syifaa Jurnal Farmasi Vol 7, No 1 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (97.699 KB) | DOI: 10.33096/jifa.v7i1.25

Abstract

The research has  maked  nata De rice water in several concentrations using bacteria Acetobacter xylinum. This study aims to determine the concentration of the right rice washing water, which meets the criteria of thickness, texture and color nata most optimum. This study uses three rice water concentration of 25%, 50% and 75%, with the addition of 10% sugar. Nata formation is based on the decomposition of sugar into a pellicle layer cellulose (nata). The cellulose layer thickness calculated using the rule and the specified quality textures and colors to use assessment of panelists. The final conclusion is that making nata of rice washing water indicates nata layer. This study showed that the addition of rice washing water at a concentration of 75% produces nata with a thickness of 2 cm with a good texture and color.
UJI AKTIVITAS ANTIOKSIDAN BUAH SEMANGKA (Citrullus lanatus) DENGAN METODE FRAP Masdiana Tahir; Anda Cahya Heluth; Harti Widiastuti
As-Syifaa Jurnal Farmasi Vol 8, No 1 (2016): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (193.358 KB) | DOI: 10.33096/jifa.v8i1.155

Abstract

Have been conducted a research about antioxidant activity assay at watermelon (Citrullus lanatus) using FRAP method. Watermelon is known contains vitamin A, B, C, and lycopene. The aim of research were to determine the antioxidant activity relationship between watermelon juice and vitamin C with FRAP method using ascorbic acid as a comparative standard measure by UV-Vis spectrophotometer at a wavelength of 692 nm. The research result was obtained the antioxidant capacity on the watermelon red meat juice 0,1329 mg AAE/g.
FORMULASI SHAMPO CAIR TRANSPARAN SARI BUAH JERUK NIPIS (Citrus aurantifolia S.) Fauzia Ningrum Syaputri; Amran Ilyas Tandjung; Faradiba Faradiba
As-Syifaa Jurnal Farmasi Vol 9, No 1 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (302.457 KB) | DOI: 10.33096/jifa.v9i1.232

Abstract

The objective of this research was to determine a stable formula and determine the influence of carbopol enhancing in the preparation of lime extract (Citrus aurantifolia S.) transparent liquid shampoo (TLS). Shampoo made from TLS formulation lime extract in three different concentration of carbopol (0.5% : 0.6% : 0.7%). Shampoo were then characterized for stability test before and after accelerated storage include organoleptic test, the foam test, test the pH stability, viscosity measurements, and rheological. The result of organoleptic observation before and after accelerated storage, either formula with concentration of carbopol 0.5%, 0.6%, or 0.7%, did not show a change for the color, smell and consistency. There are no differences in foam test from TLS with shampoo preparations comparison. There are no change of PH test in TLS with concentration of carbopol 0.5%, 0.6%, or 0.7% before and after accelerated storage. There are no change of viscosity test in TLS with concentration of carbopol 0.5%, 0.6%, or 0.7% before and after accelerated storage. Third shampoo formula has plastic flow. Formulation of TLS with concentration of carbopol 0.5% have the most optimal stability than TLS with concentration of carbopol 0.6% and 0.7%.  
UJI EFEK ANTIDIABETES KOMBINASI EKSTRAK HERBA SAMBILOTO (Andrographis paniculata (Burm. F.) Nees.) DAN DAUN SIRSAK (Annona muricata L.) PADA TIKUS JANTAN YANG DIINDUKSI ALOKSAN Maya Dwi Anggraini; Eka Wisnu Kusuma
As-Syifaa Jurnal Farmasi Vol 11, No 1 (2019): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (146.532 KB) | DOI: 10.33096/jifa.v11i1.498

Abstract

Diabetes mellitus(DM) is a disease characterized by an increase in blood sugar levels above normal. A lot of research about the medicine focusing on the use of plants that can be used in traditional medicines. This report is to know the combination of extract ethanol sambiloto herb and leaves the soursop to lower blood glucose levels on male rats wistar are induced alloxan. The research is an experimental research to pre and post test randomized controlled group. Treatment test consists of 8 groups: normal control, negative (alloxan), positive (glibenclamide 1,26 mg/kgBB), dose I SA 100 (sambiloto herb 20,5 mg/kgBB), dose II SR 100(leaves the soursop100 mg/kgBB), dose III SA:SR 25:75, dose IV SA:SR 50:50, dose V SA:SR 75:25. All groups (except normal) induced by alloxan 160 mg / KgBB. Then proceed with treatment test each drug group from day 0 to 14 in oral. Intake of blood glucose levels is done on days 0, 7 and 14. The results of the measurement of blood glucose levels followed by ANOVA. Combination sambiloto herb and leaves the soursop more effective to reduce blood glucose levels than single. Doses combination SA:SR 50:50 give the efffect of 28,38073%
ANALISIS KADAR LOGAM BERAT TEMBAGA (Cu) DAN KADMIUM (Cd) PADA IKAN KAKAP (Lates calcalifer) ASAL TAKALAR SECARA SPEKTROFOTOMETRI SERAPAN ATOM A. Muflihunna
As-Syifaa Jurnal Farmasi Vol 4, No 2 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.984 KB) | DOI: 10.33096/jifa.v4i2.80

Abstract

The analysis of Cuprum (Cu) and Cadmium (Cd) content had been done of Kakap fish  (Lates calcalifer)  in Tope Jawa and Satanga Island. This research aim to analyse and determine the quantity of Cuprum (Cu) and Cadnium (Cd) of Kakap fish  (Lates calcalifer)  by Atomic Absorption Spectrophotometry (AAS). This research was done by dry destruction both types of the metal, then the result of destruction dissolved in acid. Its result then analysed qualitative by specific reaktan and analysed quantitative by Atomic Absorption Spectrophotometry of wavelength 324,8 nm for the Cuprum and 228,8 nm for the Cadmium. The result of research obtained that Kakap fish in Tope Jawa and Satanga Island contain the metal of Cuprum (Cu) and Cadmium (Cd) but not exceed the boundary of rate maximum specified by DITJEN POMKey Word: Cuprum (Cu), Cadmium (Cd), Kakap fish  and AAS 
UJI AKTIVITAS HIPOLIPIDEMIK EKSTRAK ETANOL HERBA KROKOT (Portulaca oleracea L.) PADA TIKUS OBESITAS DENGAN PARAMETER TRIGLISERIDA Rizqi Nur Azizah; Bayu Putra; Rafika Tobis
As-Syifaa Jurnal Farmasi Vol 10, No 1 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.235 KB) | DOI: 10.33096/jifa.v10i1.332

Abstract

Hypolipidemics a drug used to lower plasma lipid levels in the blood. This study aimed to examine the hypolipidemic activity of ethanol extract of purslane herb (Portulaca oleracea L.) against the triglyceride level reduction in obese mice. The purslane herb contains omega-3, flavonoids and hight ascorbic acid as a lowering of triglyceride levels in the blood. This study used 15 malerats divided into 5 groups. Group I (negative control) was given Na.CMC 1%, group II (positive control) was given Gemfibrozil, group III, IV, and V were given ethanol extract of purslane herb with dose of 100 mg/kgBW, 200mg/kgBW, and 300 mg/kgBW as therapy group. All the administration were done orally once a day for 16 days. The measurement of triglyceride level was performed on early triglycerides before induction, after induction and after therapy. Before therapy, the rats were given hight-calorie diet. The results showed that the ethanol extract of purslanes herb has activity as hypolipidemic in lowering trygliseride level in obese mice. From the statistic result of One-Way ANOVA followed by LSD test, it can be concluded that the ethanol extract of purslane herb of the dose 100 mg/kgBW provide the most effective hypolipidemic activity that triglyceride level is not significantly different from positive control group (p>0,05).
AKTIVITAS ANTIMIKROBA EKSTRAK DIETIL ETER KARANG LUNAK Sinularia sp. TERHADAP BEBERAPA MIKROBA UJI SECARA KLT- BIOAUTOGRAFI Rachmat Kosman
As-Syifaa Jurnal Farmasi Vol 2, No 2 (2010): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v2i2.112

Abstract

   An antimicrobial assay has been done to Sinularia sp.  The preliminary research has done screening toward extract of ethanol, diethyl ether, and n-butanol concentration 1 mg/ml using 9 trial microbe. The result has been showed that diethyl ether extract actively to inhibiting growth of Pseudomonas aeruginosa, Salmonella thypi, and Streptococcus mutans. The antimicrobial activity assay toward diethyl ether extract of Sinilaria sp. is carried out by liquid dilution methode to find the Minimum Inhibitory Concentration (MIC) value by concentration 0,025%, 0,05%, 0,1%, 0,2%, 0,4%, and 0,8%. Experiment  has been continued by into solidified medium to decide the Minimum Lethality Concentration (MLC). The result showed that MIC could not  be determined due to turbidity of test solution, mean while the MLC toward Pseudomonas aeruginosa, Salmonella thypi, and Streptococcus mutans each of them 0,2%, 0,8%, and 0,8%. To identify the group of the compound in diethyl ether extract which gave antimicrobial activity by TLC-Bioautography test. Then obtained  best result from separation of compound by TLC  which using eluent combination n-Hexan : etil asetat (6 : 4). The result of TLC-Bioautography test showed that growth of Pseudomonas aeruginosa can inhibited by spot at the rate of flow (Rf) 0,9 , of Salmonella thypi can inhibited by spot at the rate of flow (Rf) 0,9 and 0,56 and then of Streptococcus mutans can inhibited by spot at the  rate of flow (Rf) 0,24. Result of identifying of chemical compound indicated that the active compound give the positive for steroid at Rf 0,9, Rf 0,24 and Rf 0,56.Key Words : Antimikroba, Sinularia sp, KLT-Bioautografi

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