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Rachmat Kosman
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As-syifaa Jurnal Farmasi
Published by Universitas Muslim Indonesia
ISSN : 20854714     EISSN : 25029444     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
As-Syifaa Jurnal Farmasi receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmacology and Toxicology, Pharmaceutical Microbiology and Biotechnology, Herbal Medicines, Pharmaceutics, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 397 Documents
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AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL BATANG Phytocrene macrophylla BLUME Herwin, Herwin; Mile, Firna Anggriani
Jurnal Ilmiah As-Syifaa Vol 9, No 2 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (174.711 KB) | DOI: 10.33096/jifa.v9i2.304

Abstract

Antibacterial activity test has been done on Phytocrenemacrophylla Blume stem ethanol extracts. The aim of the research was to determine the antibacterial activity of  Phytocrenemacrophylla Blume Stem Ethanol extracts delivered from Gowa District of South Sulawesi by means of Agar Diffusion. The results of the screening antibacterial activity of ethanol extracts of stem Phytocrenemacrophylla Blume possessed activity against Escherichia coli, Streptococcus mutans, and Pseudomonas aeroginosa. At the minimum inhibitory concentration tests used the concentrations of 0,2%, 0,4%, 0,6%, 0,8%, 1%, 5%, 10%, and 15% of the bacteria Streptococcus mutans, Pseudomonas aeroginosa, and Escherichia coli can inhibit 0,2%. At the minimum kill concentration test against the bacteria Streptococcus mutans and Pseudomonas aeroginosa inhibited at the concentration of 0,8% and the bacteria Escherichia coli at the concentration of 1%. The test results of antibacterial activity of ethanol extract of stem Phytocrenemacrophylla Blume at the concentrations of 0.8%, 1%, and 5% inhibited the growth of bacteria. The biggest inhibitory zone of the test conducted, that is, at the concentration of 5% by 16 mm against to the bacteria Pseudomonas aeroginosa and Streptococcus mutans, and 14 mm to Escherichia coli.
PENETAPAN KADAR NITRIT (NO2-) DALAM BAYAM MERAH DAN BAYAM HIJAU DENGAN METODE SPEKTROFOTOMETRI VISIBEL Emma Emawati; Anne Yuliantini; Yusiana Yusiana
As-Syifaa Jurnal Farmasi Vol 11, No 2 (2019): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (241.59 KB) | DOI: 10.33096/jifa.v11i2.573

Abstract

Green and red spinach is a vegetable that has a lot of nutritional content and is needed by the body. Besides containing many nutrients that are beneficial to the body, spinach vegetables also contain compounds that are toxic, can harm the body such as nitrite (NO2-) and cause methemoglobinemia. The purpose of this study was to analyze the levels of nitrites in green and red spinach with a visible spectrophotometric method and to determine whether the nitrites contained were still within safe limits of consumption in accordance with the ADI (Acceptable Daily Intake) value. Before the content analysis, a validation method was conducted with parameters including linearity with r = 0.9994, BD = 0.0499 µg / mL, BK = 0.1664 µg / mL,% recovery of day 1 = 1.5597 to 2 = 1.7547, the 3rd = 1.0126 and accuracy at a concentration of 0.3 μg / mL = 88.800%, 0.5 μg / mL = 95.332% and 0.7 μg / mL = 107.410%. Nitrite levels in fresh green spinach obtained an average of 23.4084 mg / kg, and 12.7272 mg / kg in red spinach. Furthermore, the green spinach after boiling yields an average of 16.8392 mg / kg and red spinach was 5.3359 mg / kg. Nitrite levels from all green and red spinach samples are still within safe limits for consumption in accordance with the ADI (Acceptable Daily Intake) value of 0.07 mg / kg of a predetermined human body weight.
EFEK PENGHAMBATAN KENAIKAN SGPT TABLET EKSTRAK CURCUMA TERHADAP KELINCI (Oryctolagus cuniculus) YANG DIBERI KLOROKUIN DAN TETRASIKLIN Rahmawati, Rahmawati; Arisanti, Arisanti
Jurnal Ilmiah As-Syifaa Vol 1, No 2 (2009): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v1i2.98

Abstract

This research’s aim to determined inhibition effect of the elevate of SGPT levels by Extract Curcuma Tablets had given Tetracycline and Chloroquine. This research use 12 male rabbits were classified into 4 groups. The first group is chloroquine, the second group is Tetracycline,  the third group are chloroquine and Tetracycline, and the fourth are chloroquine –Tetracycline plus Curcuma Extract Tablets. Each of them was measured by SGPT measurement for 3 times. Before the treatment, the first week and the second week after the treatment. Statistical analysis was involved by One-way ANOVA Descriptives Analyzing Data. The result indicated that Curcuma Extract Tablets gift with hepatotoxic medicines could inhibited the elevate of SGPT levels.Key words : Hepatoprotector, chloroquine, SGPT, Tetracycline
UJI EFEK HIPOLIPIDEMIK EKSTRAK ETANOL KAYU SECANG (Caesalpinia sappan L.) TERHADAP TIKUS WISTAR (Rattus norvegicus) JANTAN Rahman, Safriani; Kosman, Rachmat; Wijaya, Ika Indra
Jurnal Ilmiah As-Syifaa Vol 7, No 2 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.916 KB) | DOI: 10.33096/jifa.v7i2.1

Abstract

Sappan wood contains brazilin compounds that acts as antioxidants to inhibit the cholesterol synthesis, so it is efficacious hypolipidemic. It has been conducted the research on hypolipidemic effect assay of ethanol extract of sappan wood against male wistar rats. This research aims to determine the hypolipidemic effect from the ethanol extract of sappan wood based on a decrease in cholesterol content of rats. This research used 15 male rats were divided into 5 groups. Group I (control) was given suspension Na. CMC 1%, group II (comparator) was given simvastatin, the groups III, IV, and V were given ethanol extract of sappan wood at a dose 75 mg/kgbw, 150 mg/kgbw, and 300 mg/kgbw. All provisions were done orally once a day for 14 days. Cholesterol content measurements were done at the beginning of cholesterol before induction, after induction and after treatment. Before treatment rats were induced with propylthiouracil 0.01% and high cholesterol diet. The results showed that the ethanol extract of the sappan wood has a hypolipidemic effect and a dose 300 mg/kgbw was not significantly different (p > 0.05) with simvastatin.
OPTIMASI WAKTU PRODUKSI ANTIBIOTIKA ISOLAT MIKROORGANISME DARI AIR LAUT BAJOE KABUPATEN BONE DENGAN VARIASI SUMBER NITROGEN Rusli, Rusli; Fitriana, Fitriana
Jurnal Ilmiah As-Syifaa Vol 3, No 2 (2011): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v3i2.130

Abstract

Optimization research has been done time on the production of antibiotics from bacterial isolate from Bajoe Distric Bone waters with nitrogen sources of variation, the first stage of the selection of isolates that have the greatest obstacle zone and which inhibits microbial isolates most of the isolates tested ERB 3 which inhibited Staphylococcus aureus, Salmonella typhi, Pseudomonas aeruginosa, Vibrio sp, Candida albicans and Aspergillus niger. Determination of the growth curve of the isolates with inoculate into a nutrient broth medium and incubated for 2 times 24 hours. Each interval of 2 hour was measured transmittance on spectrophotometer to determine the stationary phase. Results from growth curve obtained from the stationary phase at the 20th until the 48th hour. Determination of optimum fermentation conditions by varying the nitrogen source is peptone and tryptone. ERB 3 isolate was inoculated into the production medium and fermented using the medium of production in which every interval of 4 hours is making fermented products ranging from hour to hour-20thto48th. Activity was tested using agar diffusion method in the medium Glucose Nutrient Agar (GNA) against Staphylococcus aureus, Streptococcus mutans and Salmonella typhi. The results showed that the optimum time to produce antibiotics is the 24, 40 and 48hour and nitrogen source tryptone better than peptone. Keywords : Optimasi, Isolat, Antibiotika
EVALUASI PENGGUNAAN ANTIBIOTIKA TERHADAP PASIEN PNEUMONIA KOMUNITI DI RUMAH SAKIT IBNU SINA MAKASSAR Usman, Dwi Anggara Putri; Herman, Hendra; Emelda, Andi
Jurnal Ilmiah As-Syifaa Vol 6, No 1 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (170.037 KB) | DOI: 10.33096/jifa.v6i1.34

Abstract

Pneumonia is an infectious disease that causes acute inflammation of the lung parenchyma. The purpose of this study was to compare the use of antibiotics and the appropriateness of antibiotics use in between Community acquired pneumonia patients include accuracy, appropriateness and administration duration of antibiotics compared with governance of community aquired pneumonia  treatment Infectious Diseases Society Of America (IDSA) and World Health Organization (WHO). This study was retrospective descriptive survey with sampling technique that was purposive sampling. The results showed that the type of antibiotic used was ampicillin, ceftriaxone, ciprofloxacin, Cefepime, pentohydrate ceftazidime, cefotaxime, Cefadroxil, cefditoren pivoxil, azitromicin, meropenem, gentamicin and levofloxacin. The accuracy of antibiotics to community Ibnu Sina hospital based management of IDSA and the WHO as many as 31(62.0%) patients who appropriate and 18(36.0%) patients inappropriately. The accuracy of dose antibiotics in community acquired pneumonia patients Ibnu Sina hospital based management of IDSA and the WHO as many as 31 (62.0%) patients who appropriate and 18(36.0%) patients inappropriately. The duration of antibiotics in community acquired pneumonia patients Ibnu Sina hospital based management of IDSA and the WHO as many as 29 (58.0%) patients who appropriate and 20 (40.0%) patients inappropriately.
ISOLASI KITOSAN DARI LIMBAH CANGKANG KEPITING BAKAU (Scylla serrata) DAN APLIKASINYA TERHADAP PENYERAPAN TRIGLISERIDA Dali, Seniwati; Safitri, Nur Ramadhana Dewi; Fawwaz, Muammar
Jurnal Ilmiah As-Syifaa Vol 8, No 2 (2016): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (206.392 KB) | DOI: 10.33096/jifa.v8i2.200

Abstract

Chitosan is the result of deacetylation process from chitin which it can be found on Crustacean outer shell such as crabs. Chitosan can bind fat if it was consumed by human. The fat-binding ability of chitosan depends on the deacetylation degree. The research have been made into two phases. The first phase, chitosan was made from crab shell using NaOH. The deacetylation degree from chitosan that was made from the earlier process was analyzed with FTIR. The deacetylation degree result of the research was 59.39% using NaOH 50%. The second phase was the process of adsorbing triglycerides using chitosan in 10, 30, 45, and 60 minutes which was analyzed using spectrophotometer UV-Vis. The result of this research showed that the optimum triglycerides with 0.5, 1, 3 gram of chitosan was 2.99%, 3.14%, and 3.36%.
ANALISIS KANDUNGAN ASPARTAM YANG TERDAPAT PADA MINUMAN JAJANAN ANAK SEKOLAH YANG BEREDAR DI MAKASSAR DENGAN METODE HPLC Seniwati Dali; A. Trihadi Kusuma; Afiat Wahyuni Anar
As-Syifaa Jurnal Farmasi Vol 5, No 2 (2013): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (270.273 KB) | DOI: 10.33096/jifa.v5i2.57

Abstract

This research have done of Aspartame compound in seven kinds of beverage of the student which turn in elementary school with tehe mean that to analyze Aspartame compound in beverage and have purpose to determine the concentration of Aspartame in beverage. As a comparison used the main of Aspartame with purity about 98,38%. The sample is weigh about 10 gram in a flask 50 ml, and then diluted with mobile phase is sodium dihydrogen phosphate and acetonitrile (82.5 : 17.5)ml and then it’s filtered by membrane filter 0,45 um. The result are sonicated and to injection about 20 ml to in colomn with rate of flow 1,2 mk/min and λ 210 nm. The sample is analyzed by HPLC method. The analyzed showed that the average concentration of Aspartame by calculating linear regression equation contained in the sample A. 7.5658 mg/kg, B. 198.3445 mg/kg, C. 257.8844 mg/kg, D. 226.5515 mg/kg, E. 0 mg/kg, F. 45.5389 mg/kg, G. 140.3748 mg/kg which is still below the standard of 600 mg/kg. So, sample E is just not contain of Aspartame. Key words : Aspartame, HPLC, Compound, Analyze
AKTIVITAS ANTIMIKROBA EKSTRAK DAUN TEH HIJAU (Camellia sinensis) DAN JATI BELANDA (Guazuma ulmifolia Lamk.)TERHADAP MIKROBA PATOGEN SECARA BIOAUTOGRAPHY-TLC Herwin Herwin; St. Maryam
As-Syifaa Jurnal Farmasi Vol 9, No 1 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (48.868 KB) | DOI: 10.33096/jifa.v9i1.259

Abstract

An investigation has been conducted on the antimicrobial activities of extract teh hijau leaves (Camellia sinensis) and jati belanda leaves (Guazuma ulmifolia Lamk.) using TLC-Bioautography. The aom of this research is to test the antimicrobial activity of extract against some pathogen microbes. The preliminary research conducted screening test using several tipe of microbes including Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Shigella dysentriae, Staphylococcus aureus, Staphylococcus epidermidis, Strepthococcus mutans, and Vibrio cholera. The screening results of extract inhibited almost all of pathogen microbies, except Bacillus subtilis and Staphylococcus aureus for extract teh hijau leaves and Vibrio cholera, Staphylococcus aureus, and Escherichia coli for extract jati belanda leaves. The research was continued with the antimicrobial activity against severeral microbes at different Rf and the result showed that the higher inhibited at Staphylococcus epidermidis Rf 0,02 and Shigella dysentriae Rf 0,49, 0,73 and 0,8 for teh hijau leaves, Pseudomonas aeruginosa Rf 0,02 dan 0,49 for jati belanda leaves. That extracts have antimicrobial activity to several pathogen microbes, so that are can use as one of alternative antimicrobial.
TINGKAT KEPATUHAN TERAPI PASIEN GAGAL GINJAL KRONIK YANG MENGALAMI DEPRESI Rahman, Havizur; Arifin, Helmi; Murni, Arina Widya
Jurnal Ilmiah As-Syifaa Vol 11, No 2 (2019): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.22 KB)

Abstract

Depression is known to be one of the causes of noncompliance therapy. This study aims to determine the correlation between depression with compliance of chronic renal failure patients. The method in this study is cross-sectional. Data is collected by judgment sampling. Depression level is assessed by using the Beck Depression Inventory-II (BDI- II). Compliance level is assessed by using the morisky scale. The result shows an average compliance level of chronic renal failure patients is included in high compliance category (53.03%). It is found that there is not a correlation between depression and compliance of chronic renal failure patients (p> 0.05). it is concluded that there is no correlation between depression and compliance of chronic renal failure patients.

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