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Rachmat Kosman
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As-syifaa Jurnal Farmasi
Published by Universitas Muslim Indonesia
ISSN : 20854714     EISSN : 25029444     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
As-Syifaa Jurnal Farmasi receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmacology and Toxicology, Pharmaceutical Microbiology and Biotechnology, Herbal Medicines, Pharmaceutics, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 397 Documents
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POTENSI DAUN PURING (Codiaeum variegatum) DALAM MENYERAP LOGAM TIMBAL (PB) DENGAN METODE SPEKTROFOTOMETRI SERAPAN ATOM (SSA) Asriani Suhaenah; St. Maryam; Gusmiati Gusmiati
As-Syifaa Jurnal Farmasi Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.666 KB) | DOI: 10.33096/jifa.v12i1.613

Abstract

One type of pollution that must be taken into concern is lead metal (Pb) as an element that is harmful to humans. Croton leaves contain tannin chemical compounds that able to bind lead (Pb). The research aimed to determine to potency of croton leaves as an adsorbent of lead (Pb). The research used a metal content measurement method based on the adsorption of croton leaves by atomic absorption spectrophotometry (AAS). The results showed that the absorption of lead was based on 3 gram concentrations in the samples, namely sample (1) 0.1181 gram of 1.9991 µg/g, sample (2) 0.3179 gram    of 0.0871 µg/g and sample (3) 0.5117 gram of 0.2171 µg/g. in the use of parameter of the sample concentration it is indicated that at mass 0.1181 gram, the lead metal content showed a maximum absorption of 1.9991 µg/g sample.
EVALUASI POTENSI INTERAKSI OBAT ANTIBIOTIKA PADA PENYAKIT INFEKSI GASTROINTESTINAL PASIEN RAWAT INAP PERIODE JANUARI – JUNI 2016 DI RUMAH SAKIT IBNU SINA MAKASSAR Irma Santi; Hendra Herman; Andi Afifatun Nisa Al Ishak
As-Syifaa Jurnal Farmasi Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (135.879 KB) | DOI: 10.33096/jifa.v12i1.623

Abstract

Infective gastrointestinal is gastrointestinal tract inflammation (GIT), which is caused by microorganisms. The symptoms include diarrhea, vomit, abdominal pain, and fever. This study aimed to determine the antibiotic drug interaction potential based on the interaction mechanisms of gastrointestinal infectious diseases of in patients in the period of January to June 2016 at IbnuSina Hospital Makassar and to determine the severity of antibiotic drug interaction using the website www.drugs.com on the gastrointestinal infectious diseases. This research is non experiments conducted by dekskriptif method retrospectively. The results showed that the drug interaction in the therapeutic use along with less potential antibiotics to interact. This was shown that pharmacokinetic interaction mechanism is 3.80% cases and pharmacodynamics interactions is 6.33% cases, while the pharmacokinetic interaction instead of antibiotics is 40.51% cases, and pharmacodynamics interactions is 7.60% cases. Based on the minor or moderate severity levels, the drug interactions between antibiotics and other drugs are 11.39% cases while the drugs which is not the antibiotics of drug interaction case is 32.91% cases.
EVALUASI POTENSI INTERAKSI OBAT ANTIBIOTIKA PADA PENYAKIT INFEKSI GASTROINTESTINAL PASIEN RAWAT INAP PERIODE JANUARI – JUNI 2016 DI RUMAH SAKIT IBNU SINA MAKASSAR Santi, Irma; Herman, Hendra; Al Ishak, Andi Afifatun Nisa
Jurnal Ilmiah As-Syifaa Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (135.879 KB)

Abstract

Infective gastrointestinal is gastrointestinal tract inflammation (GIT), which is caused by microorganisms. The symptoms include diarrhea, vomit, abdominal pain, and fever. This study aimed to determine the antibiotic drug interaction potential based on the interaction mechanisms of gastrointestinal infectious diseases of in patients in the period of January to June 2016 at IbnuSina Hospital Makassar and to determine the severity of antibiotic drug interaction using the website www.drugs.com on the gastrointestinal infectious diseases. This research is non experiments conducted by dekskriptif method retrospectively. The results showed that the drug interaction in the therapeutic use along with less potential antibiotics to interact. This was shown that pharmacokinetic interaction mechanism is 3.80% cases and pharmacodynamics interactions is 6.33% cases, while the pharmacokinetic interaction instead of antibiotics is 40.51% cases, and pharmacodynamics interactions is 7.60% cases. Based on the minor or moderate severity levels, the drug interactions between antibiotics and other drugs are 11.39% cases while the drugs which is not the antibiotics of drug interaction case is 32.91% cases.
UJI STABILITAS DAN KEAMANAN GRANUL EKSTRAK BATANG SELEDRI (AVIUM GRAVEOLENS) SEBAGAI BIOLARVASIDA AEDES AEGYPTI Dian Kartikasari; Dani Suryaningrat
As-Syifaa Jurnal Farmasi Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (160.527 KB) | DOI: 10.33096/jifa.v12i1.578

Abstract

Long-term use of synthetic insecticides or larvicides can cause undesirable things, so plant-based biolarvacides need to be developed that do not cause harm and are more environmentally friendly. The aim of this study was to determine the total phenolic value of Avium graveolens  extract granules as well as to determine the temperature stability of good storage for larvicidal granules of Avium graveolens extract and to know the safe limits of the use of larvicide granules of Avium graveolens extract based on LC50 values. Total phenol test of Avium graveolens extract was carried out using Folin Cetaceau reagent, then the stability test of Avium graveolens extract granules was carried out by storing Avium graveolens extract granules at several different temperatures for the next 28 days based on physical properties and total phenol values on Avium graveolens extract granules before being saved and after being stored. Then the safety test was carried out by the BSLT method (Brine Shrimp Lethality Test) by looking at the number of deaths of Artemia saline larvae and then LC50 values were calculated.The results showed that the total phenol content of Avium graveolens extract was 0.23605% b / b. And the results of the stability test showed that the granules did not change physically even though they were stored at 60oC for 28 days. The results of the toxicity test obtained LC50 values of 608,98 mcg/g, meaning that Avium graveolens extract granules are safe to use
ISOLASI BAKTERI PENGHASIL SELULOSA DARI BUAH-BUAHAN DIPASAR TRADISIONAL MAKASSAR Herwin Herwin; Fitriana Fitriana; Ayyub Harly Nurung
As-Syifaa Jurnal Farmasi Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (96.237 KB) | DOI: 10.33096/jifa.v12i1.618

Abstract

Isolation of bacterial cellulose from fruits in traditional market of Makassar have been done. The objective of this research is to adding diversity of microorganism that can producing cellulose and observe it’s both optimum temperature and pH. First step is isolation of bacteria from Watermelon, Papaya, Cantaloupe, Mango, Dragon fruit, and Banana that found in traditional market in Makassar using Hestrin-Schramm (HS) agar. Each colony bacteria have been separated to making pure culture using HS agar then the colony was screening in HS broth to obtain colony bacteria that producing cellulose. Screening test found that 10 isolate that can produce cellulose which is MB-B02, MS-B01, MS-B03, NB-B03, PB-B01, PB-B02, PB-B03, PB-B04, PS-B01, and PS-B03. Then the colony that producing cellulose was optimize its temperature and pH. Cellulose obtained from optimization was measure it’s weight to determine optimum temperature and pH. Based from optimization found that 250C was optimum temperature for MS-B01, MS-B03, NB-B03, dan PB-B04, and 370 was optimum temperature for MB-B02, PB-B01, PB-B03, PS-B01, dan PS-B03, meanwhile for isolate PB-B02 optimum both in 250C dan 370C dan pH optimum for all isolate is pH 6
ISOLASI BAKTERI PENGHASIL SELULOSA DARI BUAH-BUAHAN DIPASAR TRADISIONAL MAKASSAR Herwin, Herwin; Fitriana, Fitriana; Nurung, Ayyub Harly
Jurnal Ilmiah As-Syifaa Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (96.237 KB)

Abstract

Isolation of bacterial cellulose from fruits in traditional market of Makassar have been done. The objective of this research is to adding diversity of microorganism that can producing cellulose and observe it?s both optimum temperature and pH. First step is isolation of bacteria from Watermelon, Papaya, Cantaloupe, Mango, Dragon fruit, and Banana that found in traditional market in Makassar using Hestrin-Schramm (HS) agar. Each colony bacteria have been separated to making pure culture using HS agar then the colony was screening in HS broth to obtain colony bacteria that producing cellulose. Screening test found that 10 isolate that can produce cellulose which is MB-B02, MS-B01, MS-B03, NB-B03, PB-B01, PB-B02, PB-B03, PB-B04, PS-B01, and PS-B03. Then the colony that producing cellulose was optimize its temperature and pH. Cellulose obtained from optimization was measure it?s weight to determine optimum temperature and pH. Based from optimization found that 250C was optimum temperature for MS-B01, MS-B03, NB-B03, dan PB-B04, and 370 was optimum temperature for MB-B02, PB-B01, PB-B03, PS-B01, dan PS-B03, meanwhile for isolate PB-B02 optimum both in 250C dan 370C dan pH optimum for all isolate is pH 6
UJI AKTIVITAS ANTIOKSIDAN ISOLAT FUNGI ENDOFIT DAUN GALING-GALING (Cayratia trifolia L.) DENGAN METODE 1,1-DIPHENYL-2-PICRYLHYDRAZIL (DPPH) Magfirah Abdullah; Fitriana Fitriana; St. Maryam
As-Syifaa Jurnal Farmasi Vol 12, No 2 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v12i2.617

Abstract

Endophytic fungi generally produce secondary metabolites that have beneficial biological activities such as anticancer, antiviral, antibacterial or antioxidant compounds. The aim of this study was to examine the antioxidant activity of galling-galing leaf endophytic fungi isolate (Cayratia trifolia L.) by 1,1-diphenyl-2-picrylhydrazil (DPPH) method. This study used IDGG-03 endophytic fungi isolate fermented for 21 days using MYB medium then extracted and evaporation was carried out. The fermentate extract obtained was then tested qualitatively and quantitatively for antioxidant activity. Qualitative results using TLC plates indicate that galling-leaf fungi isolates have antioxidant activity which is characterized by the presence of yellow spots on a purple background. And in the quantitative test IC50 68,133 µg / mL was obtained, which indicated the antioxidant activity of galling-vane leaf endophytic fungi isolate (Cayratia trifolia L.) classified as a strong antioxidant.
FORMULASI DAN EVALUASI FISIK SEDIAAN KAPSUL EKSTRAK DAUN CINCAU HIJAU (Cyclea barbata Miers ) SEBAGAI ANTI INFLAMASI Fitria Wulandari; Fitri Wahyu Widyawati; Khusnul Rizaldi; Fauzia Ningrum Syaputri
As-Syifaa Jurnal Farmasi Vol 12, No 2 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v12i2.638

Abstract

One of the Indonesian plants that can be used is green grass jelly leaf (Cyclea barbata Miers) because it contains alkaloids, polyphenols, saponins and flavonoids that can prevent inflammation. Inflammation is an environmental physiological response caused by damage or damage to the tissue that functions, reduces, or confines an injuring agent or injured tissue. The purpose of this study was to formulate green grass jelly leaf extract into anti-inflammatory capsules. This research begins with the maceration of the simplicia extraction process of green grass jelly leaves using ethanol 96% solvent. Granule preparation used dry granulation method with vivapur 101 which varied in 3 formulas, namely (1: 1, 1: 1,5, 1: 2). The next step was a physical evaluation test of granules including moisture content, flow properties, angle of rest, carcass index, compressible density and true density and a physical evaluation test including organoleptic test, weight uniformity and disintegration time. The results of the evaluation test that have been carried out show that formula 3 with a thick extract concentration: vivapur 101 (1: 2) is the most optimal, because it meets the evaluation test requirements with a moisture content value of dry extract granules 1.5% and a water content value of granule capsules. green grass jelly leaves 1.1%.
PROFIL SOSIODEMOGRAFI DAN TERAPI ANTIRETROVIRAL PADA PASIEN HIV/AIDS RAWAT JALAN RSUD RADEN MATTAHER JAMBI PERIODE TAHUN 2017-2018 Jelly Permatasari; Muhammad Budi; Indri Meirista
As-Syifaa Jurnal Farmasi Vol 12, No 2 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v12i2.627

Abstract

As a result of the decline in the immune system it is very susceptible to various diseases (opportunistic Infections) that can be prevented by the presence of antiretroviral therapy with various complications. Sociodemographic Profile is a human picture related to the purpose of the study, Sociodemographic research in HIV / AIDS patients is still rarely found, therefore Sociodemographic Profile is important to know as a basis for information that can be used to prevent transmission of HIV / AIDS. The purpose of this study was to determine the Sociodemographic Profile and ARV therapy in outpatient HIV / AIDS patients at Raden Mattaher Jambi Hospital in the 2017-2018 period. This research method is descriptive by retrospectively collecting data from medical record data. The results showed in the Age group 26-35 years (41.94%), Male sex (70.97%), the last high school education (61.29%), Employee / Private employment history (54.84%) , based on the highest transmission Heterosexual (84.95%), with Marital marital status (83.87%), based on the highest HIV / AIDS status namely HIV (94.62%). Based on ARV therapy, most combinations of Efavirens + Lamivudin + Tenofovir (59.14%).
EVALUASI PENGGUNAAN ANTIBIOTIK PADA PASIEN INFEKSI SALURAN PERNAFASAN DI PUSKESMAS RAWAT JALAN KECAMATAN SIULAK MUKAI KABUPATEN KERINCI TAHUN 2018 Rasmala Dewi; Deny Sutrisno; Andral Pramirta
As-Syifaa Jurnal Farmasi Vol 12, No 2 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v12i2.626

Abstract

Respiratory infections a major health problem that is commonly found in Indonesia. The height prevalence of respiratory tract infections and their effects have consequences high consumption of over the counter medicines and antibiotics. This research aims to evaluating the use of antibiotics which includes the right patient, the right indication of the drug, the right dose, and the interaction of the drug in patients with respiratory infections in outpatien health centers in the district of Siulak Mukai in Kerinci District in 2018. This study is a observational research is descriptive in nature by collecting data on records medical outpatients retrospectively according to age inclusion criteria 25 years, patients with a diagnosis of respiratory tract infections in outpatient health centers in the district of Siulak Mukai, Kerinci Regency in 2018, complete medical record data and analyzed with the guidelines of Pharmaceutucal Care 2005 with descriptive methods. The results of evaluating the use of antibiotics in patients with respiratory tract infections in outpatient clinics in the district of Siulak Mukai in Kerinci Regency in 2018, showed that 100 % apporopriate treaments, as well as the incidence of antibiotic drug interactions by 2 events.

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