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Rachmat Kosman
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As-syifaa Jurnal Farmasi
Published by Universitas Muslim Indonesia
ISSN : 20854714     EISSN : 25029444     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
As-Syifaa Jurnal Farmasi receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmacology and Toxicology, Pharmaceutical Microbiology and Biotechnology, Herbal Medicines, Pharmaceutics, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 397 Documents
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UJI AKTIVITAS EKSTRAK ETIL ASETAT DAUN KAYU JAWA (Lannea coromandelic (Houtt.) Merr.) TERHADAP PENYEMBUHAN LUKA BAKAR PADA TIKUS PUTIH (Rattus norvegicus) Bayu Putra; Safriani Rahman
As-Syifaa Jurnal Farmasi Vol 12, No 2 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v12i2.720

Abstract

Wound healing is a process of repairing skin and soft tissue when these organs are injured. One of the plants that are presumed to affect wound healing is Kayu Jawa (Lannea coromandelic (Houtt.) Merr.). This research aims to determine the healing effect of burns and the effective dose of ethyl acetate extract of Kayu Jawa’s leaves. The animal test that has been induced using a hot plate with temperature 100oC stuck at the back of mice were divided into 5 (five) groups. Group 1 Na.CMC as Negative control, Group 2 Lanakeloid-E as Positive control, Group III, IV, and V were extract ethyl acetate of Kayu Jawa’s leaves (Lannea coromandelic (Houtt.) Merr) with 3 dosage variations namely, 75 mg/kg, 150 mg/kg, and 300 mg/kg were given topically 2 times a day for 21 days. Then wound area measure using calipers. The group with 300 mg/kg dosage has the best effect for reducing wound area of burns, with statistical value not significantly different from the comparison group (Lanakeloid-E) with a percentage value of 84%.
PROFIL KADAR GLUKOSA DARAH PASIEN DIABETES MELLITUS TIPE 2 YANG MENGGUNAKAN ATORVASTATIN 20 MG DI RUMAH SAKIT MADANI, ANUTAPURA DAN UNDATA PERIODE 2015-2019 Lestari, Widya; Mukaddas, Alwiyah
Jurnal Ilmiah As-Syifaa Vol 12, No 2 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v12i2.607

Abstract

Atorvastatin is one of the lipophilic statins that can cause diabetes through some mechanisms, such as liphophilic properties, it’s activities to insulin secretion, insulin signaling, and adiponectin levels. The purpose of this research is to know demographic data, profile of when blood sugar levels, and the time needed for atorvastatin to increase blood sugar when type 2 diabetes mellitus patients use atorvastatin for 20 mg. This research is observational descriptive research with retrospective data collection approach by looking at the usage of atorvastatin, with total samples 22 patients obtained from medical record data at Madani hospital, Anutapura and Undata in Palu in the period of 2015-2019. This research result shows that the demographic data of the average age of type 2 diabetes mellitus patients in which complications of dysplidemia that uses atorvastatin for 20 mg are in the age of 45-56 years old, female gender (57.14%), with the last education of Senior High School (38.09%) and occupation as Government Employees (33.33%), the time needed for atorvastatin 20 mg to increase blood sugar is 2 months (the difference is 26.38 mg/dl; percentage 19.52%) and the percentage of highest blood sugar increase is one year, which is 93.91%.
UJI EFEKTIVITAS EKSTRAK ETANOL KULIT PISANG MAS (Musa acuminata Colla) TERHADAP PENURUNAN KADAR KOLESTEROL TIKUS (Rattus norvegicus) HIPERLIPIDEMIA Sukmawati, Sukmawati; Wati, Aulia; Asmaliani, Ira; Meilinda, Mega
Jurnal Ilmiah As-Syifaa Vol 12, No 2 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v12i2.645

Abstract

Hyperlipidemia is the escalation level of cholesterol and triglyceride in blood. Lady finger banana peel had chemical flavonoid, tanin, and saponin contents having the activity to reduce cholesterol level. The research aimed to determine the effect of cholesterol level reduction of ethanol exctract of lady finger peel on hyperlipidemia rat. The research used twenty rats divided into five groups. Group I (negative control) was given Na. CMC of 1% b/v, group II (positive control) was given simvastatin of 1,023 mg/kgBW, group III, IV, V groups were given the extract of 500 mg/kgBW 1000 mg/kgBW, and 1500 mg/kgBW. The rats were fed a high dietary fat during treatment and induces with pristine cholesterol for twenty one days. The measurement of rat cholesterol level was conducted on day 0, 22 and 36. The result were statistically processed using One Way Anova proceeded to Post Hoc Bonferroni. The result of the research showed that the positive control group had no different tangible effect to ethanol extract of lady finger banana groups (p>0,5). In conclusion, the ethanol extract of lady finger banana had the activity in reducing cholesterol level with effective doses of 500 mg/kgBW, 1000 mg/kgBW, and 1500 mg/kgBW.
EVALUASI PENGGUNAAN ANTIBIOTIK DENGAN METODE ATC/DDD DAN DU 90% DI PUSKESMAS AUR DURI KOTA JAMBI PERIODE 2016-2018 Andriani, Yuni; Martua, Aris Sahat; Andriani, Medi
Jurnal Ilmiah As-Syifaa Vol 12, No 2 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v12i2.628

Abstract

Introduction: Since 23 years ago, WHO transferred ATC (Chemical Therapeutic Chemical) and DDD (Defined Daily Dose) as a global standard for the study of drug use, one of which is antibiotics. Drug Use Method 90% (DU 90%) method that shows the grouping of drugs that fall into the 90% category of use that is often used in conjunction with an analysis of the use of ATC / DDD drugs. Research Objectives: determine the use of antibiotics in Aur Duri Health Center in Jambi City based on the ATC / DDD method and DU 90% for the 2016-2018 period. Research Methods: Retrospective data collection using ATC / DDD and DU 90% methods. Results: Of the four types of antibiotics, the highest DDD value was obtained at Aur Duri Health Center for the period of 2016-2018, namely amoxicillin antibiotics. Antibiotics that entered the DU 90% segment at Aur Duri Health Center based on data for the 2016-2018 period were amoxicillin, ciprofloxacin and tetracycline. The most quantitative data using the ATC / DDD method is amoxicillin with the highest number of 39.39 DDD / 1000 KPRJ / Year in Aur Duri Puskesmas in 2017.
ANALISIS KADAR FENOLIK FRAKSI ETIL ASETAT DAUN PETAI CINA (Leucaena leucocephala) (Lam.) de Wit) SECARA SPEKTROFOTOMETRI Uv-Vis Sari, Intan Purnama; Abidin, Zainal; Maryam, St
Jurnal Ilmiah As-Syifaa Vol 12, No 2 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v12i2.681

Abstract

Traditionally, river tamarind leaves (Leucaena leucocephala (Lam.) De Wit.) can be used as medicine for injuries, swollen, diarrhea and also as antiseptic. The river tamarind leaves contains several main compounds such as alkaloids, saponins, flavonoids, phenols, mimosine, lectin, protein, oil, calcium, phosphorus, iron, vitamin A and vitamin B. The research aimed to determine the phenolic levels found in the ethyl acetate fraction of the leaves. The extraction was done by maceration method using ethanol 96% then fractionated with ethyl acetate solvent. The obtained fraction was analysed by UV-Vis spectrophotometry method at the maximum wavelength of 761 nm using gallic acid as a standard. Based on the qualitative test, river tamarind leaves positively contained phenolic. The phenolic compound contained in the ethyl acetate fraction was 0.176 mgGAE/g in that every gram of ethyl acetate fraction had phenolic of 0.176 mg equivalent to garlic acid.
IDENTIFIKASI MEDICATION ERROR PADA RESEP PASIEN PEDIATRI di PALU INDONESIA Firdayanti Firdayanti; Amelia Rumi
As-Syifaa Jurnal Farmasi Vol 12, No 2 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v12i2.635

Abstract

 Medication error is an event that is detrimental to the patient and can also endanger the safety of the patient, occurring as long as the patient is in a preventable health care workforce. This research aims to determine the form and percentage of medication error on prescription pediatric patients aged 2 months – 18 years in one of the hospitals in the city of Palu, Indoenesia. This research is a descriptive cross-sectional research with data retrieval conducted prospectively with the total sampling method. The sample of this study has 118 prescription paediatric patients in the period of September to October 2019. With the results of the research medication error in the prescribing  phase ie no SIP doctor 92.37%, no high patients 92.37%, no weight 90.67%, no age of the patient 72.88%, no medical record number 64.40%, no dosage form 58.47. Phase of transcribing error is no patient status 81.65%, no age of the patient 72.88%, no apparent medical record number 59.32%, not clear the dosage form of 53.38%. The dispensing error is a 61.86% incorrect or incomplete tag. The administration error phase of the patient is not given an explanation about the cure 66.10%%, it can be concluded that it has been medication error in one of the hospitals in the city of Palu, Indonesia
ISOLASI DAN IDENTIFIKASI FUNGI ENDOFIT BATANG SESURU (Euphorbia antiquorum L.) SEBAGAI PENGHASIL ANTIBAKTERI DENGAN METODE KLT-BIOAUTOGRAFI Asnita Asnita; Herwin Herwin; Rachmat Kosman; Ayyub Harly Nurung
As-Syifaa Jurnal Farmasi Vol 12, No 2 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v12i2.718

Abstract

The  research  aimed  to  obtain antibacterial  activity  of  isolate  fermentate  of  endophytic  fungi  of  antique spurge stem (Euphorbia antiquorum L.) on Staphylococcus aureus and Escherichia coli by TLC-Bioautography. The methods used in this research were isolation, purification and isolate screening. The  screening results of endophytic  fungi isolate  of  antique  spurge  stem  showed  the  largest  inhibitory  zone  in preventing  both  bacteria  growth  using  code  IFBS-03  and  IFBS-06.  The chromatogram profile  of antibacterial activity isolate fermentate  of the codes IFBS-03  and  IFBS-06  showed  active  spots  using  TLC-Bioautographic method showed that code IFBS-03 isolate obtained Rf 0.87 and 0.27 values, indicating active spots on  Staphylococcus aureus  and  Escherichia coli. The result of code IFBS-06 isolate obtained Rf 0.83 value active spots against Staphylococcus aureus and  values  Rf  0.83  and  0.27  value on  Escherichia  coli.  Based on isolation and identification some chemical components obtained that dietyl ether ekstract of thin layer cromatography obtained chemicals components flavanoid at Rf 0.83 and 0.27 value with reagent Antimo (III) chloride.
KARAKTERISASI EKSTRAK TERPURIFIKASI KELOPAK ROSELLA (Hibiscsus sabdariffa L.) DAN AKTIVITASNYA SEBAGAI ANTIHIPERTENSI PADA TIKUS SPRAGUE DAWLEY Fita Sari; Dyah Aryantini
As-Syifaa Jurnal Farmasi Vol 12, No 2 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v12i2.608

Abstract

The characterization was ensuring quality of traditional raw materials for drug preparations. Purification extract was a part of extract which released from compounds it was more effective for pharmacological activities. The effectivity an antihypertensive was still very rarely proven by use of traditional ingredients, especially from purified rosella. The aim of the study is characterization and knowing of calyx purified extract of rosella which is suspected to have antihypertensive activity in vivo. The method was done by purifying, characterization, determined of quercetin, and antihypertensive activity. Positive control (captopril), negative (CMC Na 0,5%), test of 12,5 dan 25 mg/kg BB. Descriptive data analysis for characterization, linear regression analysis of quercetin and antihypertensive statistical testing. The results for characterization of 1.41% water content, specific gravity 0.63% w / v, drying losses 2.82% and 2.31%. Levels of quersetin of 7.02 ± 0.15. The activity as antihypertensive result decrease in blood pressure which is indicated by a significant difference between the positive control and the test group. The 25 mg / kg body weight ETKR dose is an effective dose in reducing blood pressure. The non-specific character of purified extract of rosella calyx, FHI and through oral administration of ETKR can reduce the blood pressure of test animals with an effective dose of 25mg / kgBB. This research still requires  identification of bioactive compounds responsible for these activities.
AKTIVITAS ANTIDIABETES DARI TANAMAN FAMILI MYRTACEAE DENGAN INDUKSI ALOKSAN Yustika Alfani; Siva Hamdani; Hesti Renggana
As-Syifaa Jurnal Farmasi Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.762

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia. This disease occurs due to abnormalities in insulin secretion, insulin work or both. Plants from the myrtaceae family that have been used traditionally as medicine and scientifically known to have various anti-inflammatory, anti-cancer, anti-diarrheal, antibacterial and antidiabetic activities. This review aims to provide information and efforts in the treatment of diabetes from several plants in the Myrtaceae family. The method used in this review is a literature review from various journals published online and I will discuss 8 plants from the myrtaceae family that are induced by alloxan. From the results it is known that of the 8 plants of the myrtaceae family that have been tested using alloxan induction has antidiabetic activity. Syzygium Polyanthum (Wight) is the most potential candidate in reducing blood glucose levels.
AKTIVITAS ANTIDIABETES DARI TANAMAN FAMILI MYRTACEAE DENGAN INDUKSI ALOKSAN Alfani, Yustika; Hamdani, Siva; Renggana, Hesti
Jurnal Ilmiah As-Syifaa Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.671

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia. This disease occurs due to abnormalities in insulin secretion, insulin work or both. Plants from the myrtaceae family that have been used traditionally as medicine and scientifically known to have various anti-inflammatory, anti-cancer, anti-diarrheal, antibacterial and antidiabetic activities. This review aims to provide information and efforts in the treatment of diabetes from several plants in the Myrtaceae family. The method used in this review is a literature review from various journals published online and I will discuss 8 plants from the myrtaceae family that are induced by alloxan. From the results it is known that of the 8 plants of the myrtaceae family that have been tested using alloxan induction has antidiabetic activity. Syzygium Polyanthum (Wight) is the most potential candidate in reducing blood glucose levels.

Page 28 of 40 | Total Record : 397

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