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As-syifaa Jurnal Farmasi
Published by Universitas Muslim Indonesia
ISSN : 20854714     EISSN : 25029444     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
As-Syifaa Jurnal Farmasi receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmacology and Toxicology, Pharmaceutical Microbiology and Biotechnology, Herbal Medicines, Pharmaceutics, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 397 Documents
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AKTIVITAS ANTIOKSIDAN DAUN BAWANG MEKAH (Eleutherine americana Merr.) DENGAN METODE DPPH (2,2-difenil-1-pikrilhidrazil) Isnindar Isnindar
As-Syifaa Jurnal Farmasi Vol 6, No 1 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (158.434 KB) | DOI: 10.33096/jifa.v6i1.35

Abstract

Antioxidant is a substance which in small concentrations can significantly inhibit or prevent the oxidation of the substrate. Antioxidant has an important part in health. One of plants that have antioxidant activity is bawang mekah (Eleutherine americana Merr.). This research aims to determine the antioxidant activity of bawang mekah leaves. Antioxidant activity assays performed using DPPH (2,2-diphenyl-1-picrylhydrazyl) method, begins with the extraction using ethanol 70% by maseration. Ethanol fraction performed phytochemical screening with tube test method and preliminary test with DPPH method by silica gel 60 F254 Thin Layer Chromatography (TLC) eluted by chloroform p.a mobile phase. The antioxidant activity of fraction measured using UV-Vis Spectrophotometer with 10, 20, 30, 40 μg/mL variation concentration and vitamin C with 2; 2,5; 3; 3,5 μg/mL as a positive control. The results of phytochemical screening showed the fraction contained flavonoids, phenols and saponins. The result of preliminary test gained 1 spot with 12,50 hRf visualized with 366nm UV light. The fraction spot showed positive result of antioxidant test was signed by changed color to yellow with purple background after sprayed with DPPH 0,2%. The results of UV-Vis Spectrophotometer measurements showed the ethanol fraction had antioxidant activity with IC50 45,33694μg/mL and vitamin C had IC50 0,62147 μg/mL.
PENGARUH VARIASI KONSENTRASI CAIRAN PENYARI ETANOL TERHADAP KADAR POLIFENOL PADA DAUN BIDURI (Calotropis gigantea L.) Asriani Suhaenah
As-Syifaa Jurnal Farmasi Vol 8, No 2 (2016): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.315 KB) | DOI: 10.33096/jifa.v8i2.202

Abstract

Effect of ethanol concentration variations on levels of polyphenols in the Biduri leaves extract (Calotropis gigantea L.), with the aim to determine the concentration of ethanol that produce high levels of polyphenols maximum on Biduri leaves extract (Calotropis gigantea L.). The method used in the form of laboratory experimental method, which leaves Biduri (Calotropis gigantea L.) is made in the form of extracts by using a variation of ethanol that is 50% ethanol, 70% and 96%, then the variation of the extract polyphenols quantitative test conducted using standard gallat acid  and Folin -ciocalteau reagen with UV-VIS spectrophotometry method. The results of quantitative analysis by UV-VIS spectrophotometry method at the maximum wavelength 730 nm, obtained polyphenol content of 50% ethanol to extract mgGAE 11.14 / gram extract, 70% ethanol extract mg GAE 16.20 / gram extract, and 96% ethanol extract 11 , 72 mgGAE / gram of extract. Maximum levels of polyphenols contained in the ethanol extract with a concentration of 70%. Based on statistical analysis, the results obtained polyphenol content of ethanol Biduri leaves extract (Calotropis gigantea L.) with the third variation of the concentration that is 50%, 70%, and 96% were significantly different.
UJI TOKSISITAS TERATOGENIK EKSTRAK ETANOL DAUN ASAM JAWA (Tamarindus indica Linn) TERHADAP TIKUS (Rattus norvegicus) Rahimah, Sitti; Salampe, Mirnawati; Rahmania, Nurbaiti
Jurnal Ilmiah As-Syifaa Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.058 KB) | DOI: 10.33096/jifa.v12i1.588

Abstract

In this study of teratogenic toxicity tests was carried out on the ethanol extract of tamarindus leaves (Tamarindus Indica Linn) on rats (Rattus norvegicus) during the organogenesis period. This study aims to know the safety and toxicity of the administration of ethanol extract of tamarind leaves (Tamarindus indica L.) to fetus rats (Rattus norvegicus) with macroscopic parameters including number, resorption, weight, and skeleton of the fetus. 15 animals were divided into 3 groups, each group consisted of 5 rats. Group I was treated with 0.5% Na CMC as normal control,  group II was treated with ethanol extract of tamarind leaves with a dose of 14 mg / 200 g BW for 10 days and group III was given a simvastatin tab at a dose of 10 mg / kg BW. Treatment was given orally during the organogenesis period on the 5th to 15th day of pregnancy. On the 16th day, laparatomy of the rat and fetus was removed from the uterus. The results showed that the suspension of ethanolic extract of tamarind leaves did not cause teratogenic occurrence in fetal rats, and the control of simvastatin caused teratogenic due to resorption, less fetal weight, hand and foot defect, and death in the fetus, compared to the normal control group.
BARKOD DNA PADA TANAMAN GAMBIR (Uncaria gambir(Hunter) Roxb.) BERDASARKAN GEN matK DAN rbcL Wardi, Epi Supri; Jamsari, Jamsari; Irwandi, Irwandi; Sartika, Diza; Ningsih, Azma Risilvia
Jurnal Ilmiah As-Syifaa Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (435.864 KB) | DOI: 10.33096/jifa.v12i1.587

Abstract

Gambir (Uncaria gambir (Hunter) Roxb.) is a superior commodity of West Sumatra that has many benefits and has been used as a drug. Plant identification carried out morphologically has many weaknesses, with the development of electronic and genetic technology now a new method of species identification has been developed. plants and animals, namely DNA barcoding technology that uses standard short pieces of DNA Species identification methods have been agreed to using standard DNA barcodes are rbcL genes and matK genes. The purpose of this study is to find out DNA Barkoding candidates between matK and rbcL which can identify gambier (Uncaria gambir (Hunter) Roxb.) Which is good. Polymerase Chain Reaction (PCR) technique is used to amplify rbcL and matK gene sequences through universal primers. The DNA sequences of the MATC sequence in the GR sample (Riau Gambir) produced a similarity rate of 98.79% with Nauclea diderrichii, for the rbcL sequence GC (Cubadak Gambir) samples produced a similarity rate of 99.81% with Uncaria macrophylla, and GR (Gambir Riau) samples produced the similarity rate was 96.84% with Uncaria macrophylla based on analysis with BOLD Systems. This similarity indicates the low variation in intraspecific genetics for the identification or confirmation of gambir species
STUDI KOMPARASI AKTIVITAS ANTIOKSIDAN DAUN JERUK PURUT (Citrus hystrix DC) DAN DAUN JERUK NIPIS (Citrus aurantifolia (christm) Swingle) ASAL KOTA TERNATE MENGGUNAKAN METODE PEREDAMAN RADIKAL BEBAS DPPH Handayani, Virsa; Naid, Tadjuddin; Umasangaji, Ria Fitriani
Jurnal Ilmiah As-Syifaa Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (102.36 KB) | DOI: 10.33096/jifa.v12i1.621

Abstract

Citrus (Citrus hystrix DC) and lime leaves (Citrus aurantifolia (christm) Swingle) are a Rutaceae family which contain flavonoids with antioxidant activity. The aim of this study is to compare the antioxidant activity of the citrus and lime leaves using DPPH free radical suppression method. The extraction of citrus and lime leaves by maceration method using ethanol 96 %. The antioxidant assay qualitatively by Thin Layer Chromatography (TLC) used the eluent n-hexane : ethyl acetat (7:3). The antioxidant assay quantitatively used DPPH free radical suppression method measured the absorption at the wavelength 515 nm. The results showed that the IC50 value of the citrus is 228.695 µg/mL. This showed that the potential of the antioxidant activity of the sample is weak; however, the IC50 value of the lime leaves is 335.064 µg/mL. this showed that the antioxidant activity of thev sample is not active.
UJI AKTIVITAS PENGHAMBATAN ENZIM α-GLUKOSIDASE EKSTRAK ETANOL BIJI BUAH ALPUKAT SANGRAI (Persea americana Mill.) SECARA IN VITRO St. Maryam Maryam; Asriani Suhaenah; Nurul Fadhillah Amrullah
As-Syifaa Jurnal Farmasi Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (179.199 KB) | DOI: 10.33096/jifa.v12i1.619

Abstract

It is known that the seeds of avocado (Persea americana Mill.) are one part of the avocado widely used to treat various diseases, including diabetes. Based on the previous research, avocado seeds contain flavonoids with the potency as inhibitors of the enzyme α-glucosidase. The research aimed to determine the potency of ethanol extracted by meceration using 96% ethanol. The inhibitory activity was assayed using ELISA (Enzyme-Linked Immunosorbant Assay) reader measured at the wavelength of 405 with an acarbose comparator. The results showed that the ethanol extract of avocado seeds had an inhibitory activity included in the active category based on IC50 value of 34.300 µg/mL. Meanwhile, the acarbose had inhibition activity included in the very active category with an IC50 value of 0.253 µg/mL.
PEMANFATAN LIMBAH RAMBUT JAGUNG BAKAR (Zea Mays L. sacharata) SEBAGAI KRIM ANTIOKSIDAN DAN TABIR SURYA Sony Andika Saputra; Munifatul Lailiyah
As-Syifaa Jurnal Farmasi Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (134.066 KB) | DOI: 10.33096/jifa.v12i1.541

Abstract

Continuous sun exposure to the skin will cause skin damage due to the oxidative effects of free radicals. Phenolic compounds in the form of antioxidants can act as sunscreens to prevent adverse effects due to UV radiation. Positive corn silk contains phenols and flavonoids, which are compounds that have the potential to act as sunscreens and anti-oxidants. This research method was carried out by collecting roasted corn hair waste samples to be made dry simplicia, then extraction extraction with 70% ethanol solvent. The extract obtained was then formulated into a cream with a concentration variation of 1, 5 and 10%. Furthermore, an evaluation of the physical quality of the cream preparation and antioxidant activity test using the DPPH method were also tested for the SPF value. The results showed that the evaluation of the quality of the cream preparations met the requirements. The antioxidant activity test of cream preparations is categorized as very weak. Test the SPF value of cream preparations including the maximum protection category in formulation III.
POTENSI EKSTRAK RUMPUT LAUT (Eucheuma cottoni) SEBAGAI ANTIOKSIDAN Aminah Aminah; Hamsinah Hamsinah; Nurmila A. Abiwa; Sulasmi Anggo
As-Syifaa Jurnal Farmasi Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (160.849 KB) | DOI: 10.33096/jifa.v12i1.600

Abstract

Seaweed (Eucheuma cottoni) is a marine biota that is often used as an additive to pharmaceutical products that function as thickener. But seaweed, which is rich in carrageenan, also contains vitamin C which has the potential as an antioxidant. The method used was to test the antioxidant activity of seaweed extract (Eucheuma cottoni) with the DPPH (1,1-Diphenyl-2-Picrylhdrazil) damping method. The test sample was in the form of seaweed ethyl acetate extract, where the standard standard of comparison of quarsetin and seaweed extract samples was made in 5 variations of concentration. The standard curve produced by quarsetin with concentrations of 2, 4, 6, 8, 10 ppm at the maximum wavelength DPPH 514,942 nm. The results obtained by the Kuarsetin standard with regression values y = 6.4765x + 7.567, the correlation value r = 0.99959 and IC50 = 6.48 (very strong antioxidant activity) while the ethyl acetate extract of seaweed with concentrations of 600, 800, 1000, 1200, 1400 ppm % inhibition was obtained with regression values y = 0.0104x + 16.708, the correlation value r = 0.9972 and IC50 = 3201.15 (very weak antioxidants). So it can be concluded that the seaweed ethyl acetate extract has the potential for antioxidant activity.
PENELUSURAN FUNGI ENDOFIT PADA DAUN KOPASANDA (Chromolaena odorata L.) YANG BERPOTENSI SEBAGAI PENGHASIL ANTIBAKTERI TERHADAP BAKTERI PENYEBAB INFEKSI KULIT Rusli, Rusli; Kosman, Rachmat; Melinda, Pina
Jurnal Ilmiah As-Syifaa Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (45.958 KB) | DOI: 10.33096/jifa.v12i1.622

Abstract

The investigation for endophytic fungi of siam weed leaves (Chromolaena odorata L.) was conducted to obtain endophytic fungi potentially produced bioactive compound which were useful as an antibacterial. The research animed to obtain endophytic fungi isolate and determined the antibacterial activity against bacteria causing skin infection. The research was experimentally conducted including isolation of endophytic fungi, earthing, macroscopic examination, screening assay for antibacterial activity against bacteria, fermentation process for 21 days, and TLC separation and antibacterial testing by TLC-Bioautography against Staphylococcus aureus and Bacillus subtilis. The isolation results obtained 7 isolate followed by fermentation process with IFDK 03 isolate. The fermentate isolate of endophytic fungi showed Rf values of 0,2 anda 0,47 against Staphylococcus aureus and Bacillus subtilis. In conclusion, Siam weed leaves had isolate endophytic fungi with the potency as an antibacterial.
KARAKTERISASI DAN SKRINING FITOKIMIA SIMPLISIA BUAH SELUTUI PUKA (Tabernaemontana macracarpa Jack) Fitri Handayani; Anita Apriliana; Ira Novianti
As-Syifaa Jurnal Farmasi Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (125.191 KB) | DOI: 10.33096/jifa.v12i1.577

Abstract

Selutui puka (Tabernaemontana macrocarpa Jack) is a medicinal plant that grows in forests and river banks. This plant can be found in West Kutai, East Kalimantan. Empirically, the use of selutui puka fruit is used as a medicine for toothache and canker sores by boiling it, the cooking water is used by stew. The importance of simplicia characterization is to determine the quality of simplicia which will become the standard for traditional medicine. The purpose of this study was to determine the characteristics of simplicia powder from selutui puka fruit and to determine the class of chemical compounds contained in selutui puka fruit. This research is non experimental. The research starts from sampling, determination, making simplicia, characterization which includes macroscopic test, microscopic test, determination of moisture content, soluble ethanol extract content, water soluble extract content, moisture content, ash content, acid insoluble ash content and phytochemical screening. Data were analyzed using descriptive methods.Macroscopic and organoleptic characterization of simplicia powder has a distinctive aroma (aromatic), bitter fruit flavor, yellowish-brown simplicia powder, white meat, hard and runny meat. Microscopic results of simplicia powder are found in the endocarp, wooden vessels in the form of stairs, trachea, and cork tissue. The level of dissolved ethanol extract was 36%, water juice content was 47%, water content was 8%, ash content was 4.36%, acid insoluble ash content was 0.57%. The results of phytochemical screening contain alkaloids, saponins, and flavonoids.

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