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Rachmat Kosman
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As-syifaa Jurnal Farmasi
Published by Universitas Muslim Indonesia
ISSN : 20854714     EISSN : 25029444     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
As-Syifaa Jurnal Farmasi receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmacology and Toxicology, Pharmaceutical Microbiology and Biotechnology, Herbal Medicines, Pharmaceutics, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 397 Documents
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PENETAPAN KADAR FLAVONOID FRAKSI ETIL ASETAT DAUN KARET KEBO (Ficus elastica) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Suhaenah, Asriani; Pratama, Mamat; Amir, A. Hesti Wulandasari
Jurnal Ilmiah As-Syifaa Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.761

Abstract

Rubber plant (Ficus elastica) is a plant that has been widely used as traditional medicine. The leaves of this plant are used as medicine for coughing up blood, laxative urine, relieving pain and improving blood circulation. Various kinds of properties and benefits of the rubber plant (Ficus elastica) cannot be separated from  the compounds contained in it such as saponins, polyphenols, and flavonoids.  The aims of this research is to determine the flavonoid total content in the ethyl acetate fraction of the rubber leaves (Ficus elastica). Simplicia was extracted by maceration method, using 96% ethanol solvent for 3x24 hours and partitioned with a mixture of 96% ethanol - aquadest (2:3) and ethyl acetate as a solvent. Determination of flavonoid content using UV-Vis spectrophotometry method , with a maximum wavelength of 438 nm, using quercetin as a comparison. The results of this research obtained that the total flavonoid content in the ethyl acetate fraction of  rubber leaves (Ficus elastica) was an average of 74,345 mgQE/g fraction
EVALUASI TINGKAT PENGETAHUAN OBAT ANTIDIABETES PADA MASYARAKAT DI DESA BONTOKASSI GOWA Putra, Bayu; Kosman, Rachmat; Kamri, Andi Maulana
Jurnal Ilmiah As-Syifaa Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.760

Abstract

Diabetes mellitus is one of disease caused by changes individual's lifestyle and is not in accordance with a healthy lifestyle. In addition, this is also caused by factors that cannot be ignored. Knowledge of the general public in rural areas is very minimal because of their ignorance about diabetes mellitus. The method used in this study is descriptive observational prospectively by providing a questionnaire to assess the level of knowledge of respondents and the use of diabetes medication. Data collection was carried out in two stages. As a result of this service activity, respondents who were given counseling actually experienced an increase in their understanding of diabetes. The data obtained were analyzed by statistical program with t-test analysis. This can be seen from the statistical results that there is an effect of p <0.05 on knowledge about diabetes, the use of antidiabetic drugs, the effectiveness of antidiabetic drugs, the quality of antidiabetic drugs, and adherence to taking antidiabetic drugs. With these changes, the importance of information on patients by pharmacists in the area is very important.
EVALUASI TINGKAT PENGETAHUAN OBAT ANTIDIABETES PADA MASYARAKAT DI DESA BONTOKASSI GOWA Bayu Putra; Rachmat Kosman; Andi Maulana Kamri Petta Lolo
As-Syifaa Jurnal Farmasi Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.764

Abstract

Diabetes mellitus is one of disease caused by changes individual's lifestyle and is not in accordance with a healthy lifestyle. In addition, this is also caused by factors that cannot be ignored. Knowledge of the general public in rural areas is very minimal because of their ignorance about diabetes mellitus. The method used in this study is descriptive observational prospectively by providing a questionnaire to assess the level of knowledge of respondents and the use of diabetes medication. Data collection was carried out in two stages. As a result of this service activity, respondents who were given counseling actually experienced an increase in their understanding of diabetes. The data obtained were analyzed by statistical program with t-test analysis. This can be seen from the statistical results that there is an effect of p <0.05 on knowledge about diabetes, the use of antidiabetic drugs, the effectiveness of antidiabetic drugs, the quality of antidiabetic drugs, and adherence to taking antidiabetic drugs. With these changes, the importance of information on patients by pharmacists in the area is very important.
AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN KELOR (Moringa oleifera L.) DAN PENGEMBANGANNYA MENJADI BENTUK SEDIAAN GEL Asisi, Nur; Uliyah, Uliyah; Amaliyah, Nurul Fitrah; Hasrawati, A
Jurnal Ilmiah As-Syifaa Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.682

Abstract

Antioxidants are used to prevent the oxidation of free radical compounds which have a bad impact on the body, including the skin.  One source of antioxidants derived from natural ingredients is Moringa leaves.  Moringa leaves have a number of benefits due to the many active chemical compounds.  The antioxidant activity of Moringa leaves can be optimized by developing Moringa leaves into a gel dosage form.  A literature review regarding the compound content and activity of Moringa leaves was carried out to obtain scientific data that can be used in the development of Moringa leaves as an antioxidant.  Narrative review with data sources from Science Direct, Pubmed, CiterSeerX, and Google Scholars. The Inclusion and exclusion criteria were set to obtain literature according to the scope of the study.  The results of the literature review showed that Moringa leaves contain the main active compounds of polyphenols and flavonoids which have strong antioxidant activity.  Gel dosage form is one of the best choices to optimize the antioxidant activity of Moringa leaves.  HPMC, carbopol and xanthan gum are gelling agent was produced a gel preparation with good pharmaceutical characteristics.
EVALUASI PENGGUNAAN SUPLEMEN KEHAMILAN PADA PASIEN WANITA HAMIL DI PUSKESMAS BULILI KOTA PALU PERIODE APRIL 2018 – DESEMBER 2018 Mukaddas, Alwiyah; Hardani, Ririen; Fandi, Indra Dwi
Jurnal Ilmiah As-Syifaa Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.689

Abstract

Anemia in pregnant women will increase the risk of new born babies with low birth weight, miscarriage, premature, risk of bleeding before and / or during labor can cause death to both of them. This research aims to determine the evaluation before and after pregnancy supplement to pregnant women at Puskesmas Bulili, Palu, April - December 2018. This is a quantitative research with a retrospective approach. There are 44 females without the anemia and 22 at the anemia group. Pregnant women are said to be anemic when their hemoglobin or red blood levels are less than 11.0 gr%. The results, the hemoglobin levels before and after the use of pregnancy supplements in the non-anemia were 11.7 gr / dl and 11.4 gr dl (p = 0.004; p <0.005), the anemia group 9.7 gr / dl and 11 , 3 gr / dl (p = 0.000; p <0.005, there was a significant change in hemoglobin level. The results showed no anemia group difference which smaller (0.3 g / dl) compared to the anemia group (1.6 g / rdl), with values (p = 0.317; p> 0.005) which means no significant difference in hemoglobin levels after pregnancy supplementation
PENGUJIAN AKTIVITAS EKSTRAK ETANOL KULIT BUAH KECOMBRANG (Etlingera elatior (Jack) R.M.Sm) SEBAGAI INHIBITOR TIROSINASE Widiastuti, Harti; Abidin, Zainal
Jurnal Ilmiah As-Syifaa Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.766

Abstract

Healthy skin should have a flat surface, the texture is soft, elastic, and have the same skin color. Skin color is determined by the size, number and distribution of melanin pigment. Pigment brownish pigment melanin is to protect the skin from UV light scattering. An enzyme that plays a role in this browning reaction is tyrosinase. Browning reaction tyrosinase inhibitor can be inhibited by an enzymatic by an enzymatic reaction in the form of ions or molecules called tyrosinase. Inhibition of tyrosinase is one way to prevent skin hyperpigmentation. Tyrosinase enzyme catalyzes two main reactions in the biosynthesis of melanin, the hydroxylation of L-tyrosin into L-dopa and the oxidation of L-dopa becomes dopakuinon. Polyphenol compounds (Flavonoids) the group is basically have the effect cant inhibit melanogenesis as a tyrosinase inhibitor. Kecombrang a wild plant that has many benefits one of them as a source of natural antioxidants. Based on this research is conducted on the fruit skin kecombrang to see the activity of the enzyme tyrosinase barriers and whether rind kecombrang can inhibit tyrosinase enzyme and with the aim to utilize natural materials and waste that can inhibit the enzyme tyrosinase and can be used as a skin whitheter.Research iniated by the extraction of fruit skins kecombrang using etanol. Flavonid content test on the sample using Mg powder and HCl p, the results show a color change from dark brown to yellow. So positive it contains flavonoids. Measurements were contucted on a maximum wavelength of 478,003 nm, using the substrate L-tyrosine and the enzyme tyrosinase. Using comparators hidroquinon. Of the results of this study concluded that kecombrang fruit peel ectract at a concentration of 2 mg/mL could inhibit amounted to 55,92% and a concentration of 2,5 mg/mL could inhibit amounted to 56,58%.
UJI AKTIVITAS GEL LENDIR BEKICOT (ACHATINA FULICA) SEBAGAI PENYEMBUHAN LUKA SAYAT Shoviantari, Fenita; Fajriyah, Shofiatul; Agustin, Ela; Khairani, Shafia
Jurnal Ilmiah As-Syifaa Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.648

Abstract

Snail mucus (Achatina fulica) has a high protein content, which includes beta agglutinin, achasin protein, acharan sulfate, and glycoconjugate. The objectives of this study was to determine differences in physical evaluation of the quality of the gel preparation against snail mucus concentration and to determine the efficacy of snail mucus gel as a wound healing. This study used an experimental research method with a sample of 4 male rats (Rattus novergicus) which were divided into 6 groups in each. The results showed that there was no effect of the physical quality of snail slime gel (Achatina fulica) on the concentration of snail slime formulated. It has been proven in the Kruskall wallis statistical test with the Sig. > 0.05. The results of the wound healing activity test showed an average value of K (+) 49.61%, K (-) 17.48%, P1 48.23%, P2 43.63%, P3 43.43%, and P4 23, 97. Values that indicate differences in K (-) and P4 are evidenced in the Post Hoc LSD test with Sig. <0.05. It can be concluded that the concentration of snail mucus does not affect the physical quality of snail mucus gel preparations and snail mucus gel with snail mucus concentration of 10% is effective in the process of wound healing.
UJI EFEK ANTIRHEUMATOID ARTRITIS EKSTRAK n-BUTANOL DAUN PETAI CINA (Leucaena leucocephala (Lam.) de Wit) PADA TIKUS JANTAN YANG DIINDUKSI COMPLETE FREUND`S ADJUVANT Amirah, Sitti; Rahman, Safriani; Hi Amin, Rahmatia S
Jurnal Ilmiah As-Syifaa Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.759

Abstract

Rheumatoid arthritis is an autoimmune disease characterized by chronic inflammation. The research animed to determine the effect of n-butanol extract of Leucaena leucocephala leaves and the effective dose as antirheumatoid arthritis. It used 15 male rats divided into 5 groups: group I (negative control) was given Na-CMC; group II (positive control) was given a suspension of Methylprednisolone; group III, IV dan V were give the extraxt with doses of 83,3 mg/kgBW, 166,6 mg/kgBW and 333,2 mg/kgBW. The treatment was started by inducing Complete Freund`s Adjuvant intraplantary of 0,1 mL and let it remain until day 16. The therapy was conduction for 14 days orally and the foot volume measurements and observation of the arthritis index were performed on day 17 and 31st. The data analyzed using One Way Anova showed the differences among the groups (p 0,05) and continued with LSD test. The measurement of arthritis index using Kruskal-Wallis showed the differences between groups (p 0,05) proceeded to Mann-Whitney test. In conclusion, the n-butanol extract of Leucaena leucocephala  leaves had the effect as antirheumatoid
PERBANDINGAN EFIKASI DAN KEAMANAN PENGGUNAAN FEBUXOSTAT DAN ALLOPURINOL PADA PASIEN GOUT Hendra Herman; Sukmawati Sukmawati; Andi Desiah Pranada
As-Syifaa Jurnal Farmasi Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.768

Abstract

Febuxostat and allopurinol are xanthine oxidase inhibitors to reduce uric acid levels. The research aimed to determine the differences in efficacy and safety of using febuxostat and allopurinol for gout patients. This research was conducted using a narrative review method for articles obtained from the PubMed and Willey databases published in 2010-2021. From the article exploration, 5 articles were reviewed showing that the determination of drug efficacy was seen by monitoring the changes in uric acid levels for 6 months from the beginning of drug use. Febuxostat and allopurinol had good efficacy in achieving target uric acid levels < 6 mg/dL, however, febuxostat was superior to allopurinol in usual doses. Febuxostat 80 mg had superior efficacy to febuxostat 40 mg, while febuxostat 40 mg had superior efficacy to allopurinol 300 mg (p < 0.05). For safety, febuxostat and allopurinol possessed similar side effects in the form of upper respiratory tract infection, diarrhea, headache, nausea and vomiting.
ANALISIS KOMPONEN KIMIA AKTIF ISOLAT DAUN Colocacia esculenta L. IDTK01 SECARA SPEKTROFOTOMETER INRA MERAH Herwin, Herwin; Baits, Muzakkir; Ririn, Ririn; Harly Nurung, Ayyub
Jurnal Ilmiah As-Syifaa Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.746

Abstract

The objective of this research is to analysis chemical coumpounds active isolate of Colocacia esculenta L.’s leaves IDTK01 using infra red spectrophotometer. The fractionation of the ethanolic extract of Colocasia esculenta L’s leaves using liquid vacuum chromatography obtained 7 fractions. Active fraction was B fraction isolated from the active coumpound by TLC-preparative from 3 different isolate, IDTK01, IDTK02 dan IDTK03. IDTK01 isolate was tested its antibacterial activity using TLC-bioautography with eluen n-hexane:ethyl acetate (10:1) and its active against Salmonella thypi with Rf value 0.98. Active isolate IDTK01 was analyze its active bacterial coumpound using infrared spectrophotometer and the results is hydrogen bond, hydroxyl functional group (OH), aryl/ aromatic (C=C), aliphatic (CH2), Ether aldehyde (C-O), and pyridine.

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