cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kab. banyumas,
Jawa tengah
INDONESIA
Acta Pharmaciae Indonesia : Acta Pharm Indo
Published by Universitas Jenderal Soedirman
ISSN : 23378433     EISSN : 26214520     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Journal of Acta Pharmaciae Indonesia is a journal published twice a year by Pharmacy Department, Jenderal Soedirman University, Purwokerto with the Number of ISSN 2337-8433 and E-ISSN 2621-4520. Our journal discusses various pharmaceutical fields in terms of Pharmaceutics & Pharmaceutical Technology, Pharmaceutical Biology, Pharmaceutical Chemistry, and Pharmacology & Clinical Pharmacy.
Arjuna Subject : -
Articles 6 Documents
 1 
Search results for , issue "Vol 11 No 2 (2023): Acta Pharmaciae Indonesia: Acta Pharm Indo" : 6 Documents clear
Characterization and tyrosinase activities of a mixture of β-sitosterol and stigmasterol from Bauhinia rufescens Lam Muhammad, Aminu; Idris, Musa Maikudi; Ali, Umar; Umar, Abdulganiyu; Sirat, Hasnah Mohd
Acta Pharmaciae Indonesia Vol 11 No 2 (2023): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.2.6284

Abstract

Background: Phytosterols are steroid compounds present in plants that are similar to cholesterol in structure and functions. In this work, stem bark of Bauhinia rufescens was extracted with petroleum ether. Objective: This work aims to determine anti-tyrosinase activities of a mixture of β-sitosterol and stigmasterol from the stem bark B, rufescens for the treatment of dermatological disorders. Methods: This work is presenting isolation, characterization and anti-tyrosinase activities of a mixture of β-sitosterol and stigmasterol from the stem bark B. rufescens. The extract was subjected to chromatographic techniques to afford a phytosterol identified as a mixture of β-sitosterol and stigmasterol based on GC-MS, IR, 1HNMR and 13CNMR data. Results: The phytosterol isolated showed inhibition of tyrosinase activity at 57.1%±0.03 as compared to kojic acid with 85.0% ± 0.01 (sample concentrations of 0.1 mg/mL). Conclusion: The finding of this study revealed that, the mixture of β-sitosterol and stigmasterol has potential to be developed as tyrosinase inhibitors for the treatment of dermatological disorders.
Cost-effectiveness analysis of lopinavir, ritonavir, and nevirapine toward HIV AIDS patients as antiretroviral: a systematic review Pratama, Anggara Martha; Pramestutie, Hananditia Rachma; Krisnadewi, Kadek Ida; Pratiwi, Hening
Acta Pharmaciae Indonesia Vol 11 No 2 (2023): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.2.6916

Abstract

Background: The mobilization of resources to prevent and treat human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) is unparalleled in the history of public health. Nevirapine resistance may decrease the effectiveness of viral suppression with nevirapine-based HIV in women infected with human immunodeficiency virus (HIV) with previous exposure to single-dose nevirapine. However, the alternative lopinavir/ritonavir–based antiretroviral therapy (ART) regimen is more expensive. Objective: Our objectives were to project the tradeoffs regarding the cost-effectiveness of ART regimens for nevirapine-exposed and lopinavir/ritonavir. Methods: A thorough literature search was conducted using PubMed and SAGE databases, employing search terms such as “cost-effectiveness analysis,” AND “HIV AIDS,” AND “lopinavir,” OR “ritonavir,” AND “nevirapine.” Additionally, hand searches were carried out on Google Scholar with various combinations of these terms to ensure comprehensive coverage of relevant studies. Results: Six studies met the our inclusion criteria and were reviewed. The analysis confirms that both nevirapine and lopinavir/ritonavir-based ART regimens are cost effective in a range of settings, despite differences in their relative efficacy and contexts in which they are used. Conclusion: This systematic review collates recent studies on the cost-effectiveness of nevirapine and lopinavir/ritonavir in ART. It showed that in this finding, there are cost effective but this article had wide variation with comparison therapy. Cost-effectiveness results depended on the relative efficacy of lopinavir/ritonavir and nevirapine in both first-line and second-line ART.
Biolarvicide activity of extract and essential oil of culantro (Eryngium foetidum L.) on Culex quinquefasciatus larvae in silico and in vitro Winarti, Sri Ayu; Khumaisah, Lela Lailatul; Anwar, Devi Indah
Acta Pharmaciae Indonesia Vol 11 No 2 (2023): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.2.8925

Abstract

Background: Filariasis, a priority tropical disease in Indonesia, is transmitted by the Culex quinquefasciatus mosquito. The use of conventional synthetic larvicides can lead to environmental and health issues, including poisoning and resistance in target insect populations. Objective: This study explores the utilization of biolarvicides derived from culantro (Eryngium foetidum) to mitigate these adverse efects, focusing on analyzing the components and evaluating the larvicidal eficacy of both the extract and essential oil of E. foetidum. Method: This study employed a molecular docking approach to examine in silico biolarvicidal activity against the odorant binding protein (OBP) receptor and conducted in vitro experiments on Cx. quinquefasciatus larvae using varying concentrations of E. foetidum extract (100, 250, and 500 ppm) and essential oil (10, 50, and 100 ppm). Results: The in silico study identified hynokiflavone and longifenaldehyde as the compounds with the most potent activity, demonstrating binding a inities of -10.2 and -9.5 kcal/mol, respectively. The in vitro assays revealed that the E. foetidum extract achieved 75% larval mortality at an LC50 of 78.59 ppm, while the essential oil resulted in 88% mortality with an LC50 of 10.13 ppm. Conclusion:The extract and essential oil of E. foetidum exhibit significant biolarvicidal activity against Culex quinquefasciatus, offering promising plant-based alternatives to traditional larvicides, with implications for safer and more sustainable vector control strategies.
Evaluation of physical and chemical stability of semi-solid preparations towards beyond-use date Sukamdi, Dyani Primasari; Dewinda, Zulfa Sekar; Damarwati, Vella Lailli; Maziyyah, Nurul; Ningrum, Dhecella Winy Cintya
Acta Pharmaciae Indonesia Vol 11 No 2 (2023): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.2.9260

Abstract

Background: Semi-solid formulations require careful consideration due to potential drug interactions and incompatibilities. The stability of these compounds is crucial for determining the quality of a preparation, often assessed by its designated shelf life. Objective: This research synthesizes previous studies to provide a comprehensive assessment of the quality and stability of semi-solid drugs, focusing on evaluating their physical and chemical stability in relation to the Beyond Use Date (BUD). Methods: A literature review was conducted using the Google Scholar database, yielding eight articles that met the established inclusion and exclusion criteria and were pertinent to the research topic. Results: The evaluations of physical stability indicated that preparations are stable when stored under standard conditions, away from light, and when formulated with suitable bases. The chemical stability assessments revealed a decline in potency or concentration at elevated temperatures. Conclusion: The study concludes that, within the parameters of stability evaluated, semi-solid drug preparations remain viable for use.
Anti-inflammatory activity of combination of ethanol extracts of ginger (Zingiber officinale) and bangle (Zingiber cassumunar) in carrageenan-induced rats Hasyim, Bellia; Yudhawan, Indra; Ekowati, Heny; Rachmani, Eka Prasasti Nur
Acta Pharmaciae Indonesia Vol 11 No 2 (2023): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.2.11548

Abstract

Background: Inflammation is an essential innate immune response aimed at antigen elimination and preventing their spread. Ginger (Zingiber officinale) and bangle (Zingiber cassumunar) rhizomes have been empirically utilized as medicinal components due to their anti-inflammatory potential. However, the combined efficacy of these rhizomes has not been previously explored. Objective: This study aimed to assess the anti-inflammatory activity of a combination of ginger and bangle rhizome extracts. Method: Ginger and bangle rhizomes were individually subjected to extraction through maceration with 96% ethanol, followed by purification with n-hexane. The anti-inflammatory activity was evaluated via motility tests on subjects administered orally with 1% CMC-Na (control), diclofenac sodium (4.5 mg/kg body weight), ginger ethanol extract (200 mg/kg body weight), bangle ethanol extract (400 mg/kg body weight), and a combination of both extracts (100:200 mg/kg body weight). Observations were made over 6 hours, with motility scores subsequently analyzed using ANOVA and the LSD test for statistical significance. Results: Treatments involving ginger extract, bangle extract, and their combination significantly improved motility scores compared to the negative control. Furthermore, these treatments displayed no significant difference in effectiveness compared to the diclofenac sodium group (p > 0.05). Conclusion: The combined ethanol extracts of ginger and bangle rhizomes demonstrate anti-inflammatory activity comparable to diclofenac sodium, as evidenced by motility score evaluations. This suggests their potential as alternative anti-inflammatory agents.
In silico screening of pomegranate (Punica granatum) and celery (Apium graveolens) metabolites for potential anti-type 2 diabetes activity Auli, Winni Nur; Aziz, Syaikhul; Karim, Dewi Damayanti Abdul; Evanggeulista, Arnanda; Jannah, Aryn Fatkhul; Mendrofa, Alexander Yoel Harazachi
Acta Pharmaciae Indonesia Vol 11 No 2 (2023): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.2.11704

Abstract

Background: Alpha (α)-amylase is a popular pharmacological target for controlling postprandial blood glucose levels. The exploration of natural ingredients for drug development is particularly promising. Notably, pomegranate (Punica granatum) and celery (Apium graveolens) are rich in phenols and flavonoids, making them potential candidates for anti-type 2 diabetes treatments. Objective: This study aims to identify the most promising derivatives from pomegranate and celery using a combined metabolomic and in silico approach. Methods: The study began by identifying metabolites from the KnapSack database, selecting based on primary and secondary metabolites also selecting them based on their pharmacokinetic profile. The selected metabolites were then docked with alpha-amylase (PDB ID: 2QV4). Furthermore, the interactions were analyzed using Discovery Studio, and toxicity profiles were assessed in silico using ECOSAR and Toxtree software. Results: The analysis identified punicaflavone and 2-deoxybrassinolide as the compounds with the highest binding affinity, at -10.06 kcal/mol and -10.89 kcal/mol respectively, both surpassing acarbose’s -9.33 kcal/mol. These compounds interacted with 11 common residues in alpha-amylase, mirroring acarbose’s interactions. In silico toxicity analysis revealed that punicaflavone might pose risks to aquatic organisms but does not exhibit potential as a genotoxic or non-genotoxic carcinogen. Conversely, 2-deoxybrassinolide displayed moderate toxicity to aquatic organisms but was also free from genotoxic and non-genotoxic carcinogenic potential. Conclusion: Punicaflavone and 2-deoxybrassinolide emerged as the most promising compounds, demonstrating strong binding affinities and similar interaction patterns with α-amylase as acarbose. Although both compounds may pose risks to aquatic environments, they do not show potential as genotoxic or non-genotoxic carcinogens, supporting their further exploration as anti-diabetic agents.

Page 1 of 1 | Total Record : 6

 1 

Filter by Year

2023 2023


Reset
Filter By Issues
All Issue Vol 13 No 1 (2025): Acta Pharmaciae Indonesia: Acta Pharm Indo Vol 12 No 2 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo Vol 12 No 1 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo Vol 11 No 2 (2023): Acta Pharmaciae Indonesia: Acta Pharm Indo Vol 11 No 1 (2023): Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo (in progress) Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 9 No 2 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 9 No 1 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 8 No 2 (2020): Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 8 No 1 (2020): Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 7 No 2 (2019): Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 7 No 1 (2019): Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 6 No 2 (2018): Acta Pharmaciae Indonesia Volume 6 No.2 Tahun 2018 Vol 6 No 1 (2018): Acta Pharmaciae indonesia Vol.6 No.1 Tahun 2018 Vol 6 No 2 (2018): Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 6 No 1 (2018): Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 4 No 2 (2016): Acta Pharmaciae indonesia Vol.4 No.2 Tahun 2016 Vol 4 No 01 (2016): Actapharmindo Vol 4 No 2 (2016): Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 4 No 1 (2016) Vol 4 No 1 (2016): Acta Pharmaciae Indonesia : Acta Pharm Indo More Issue