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Majalah Kedokteran Nusantara The Journal Of Medical School
Published by Universitas Sumatera Utara
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Arjuna Subject : -
Articles 181 Documents
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Manfaat pemberian gabungan selenium dan probiotik pada pengobatan konstipasi fungsional pada anak Wahyu Ningsih Lestari; Atan Baas Sinuhaji; Supriatmo dr
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 45, No 2 (2012): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Constipation is a common health problem in children and can cause serious problems. The prevalence of constipation in childrenvaries from 0.7% to 29.6% and most of constipation in children (> 90%) is functional in the absence of organic abnormalities.Probiotics are living microorganisms when administered in sufficient quantities will benefit the host. Probiotic bacteria in thegut can increase intestinal motility, improve stool consistency and increase the frequency of defecation so effective in thetreatment of constipation. Selenium is an essential micronutrient required by the majority of the body's organ systems to functionproperly. Oxidative stress thought to be involved as one of the factors causing constipation. Selenium as an antioxidant cantreat functional constipation in children, because the main function of selenium is a cofactor of glutathione peroxidase, whichprotects membranes from oxidative damage.Keywords : functional constipation; selenium; probiotic
Neuropsychiatric systemic lupus erythematosus Kiki Mohammad Iqbal
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 45, No 2 (2012): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Systemic lupus erythematosus (SLE) is a chronic, heterogenous, autoimmun disease with diverse clinical manifestations, which can include end-organ damage. Neuropsychiatric systemic lupus erythematosus (NP-SLE) is defined as abnormalities of the central, peripheral and autonomic nervous systems and the psychiatric syndromes observed in patients with SLE for which other causes have been excluded.. However, the pathogenic mechanisms that result in primary neuropsychiatric manifestations in NP-SLE are throught to include autoantibodies, vascular abnormalities, and the local production of inflammatory mediators. Diagnosis is typically achieved throught careful analysis of clinical, laboatory, and imaging data on a case-by-case basis. A better approach to management of NP-SLE may be achieved by : 1) the recognition of the antiphospholipid syndrome and its treatment with anticoagulants; 2) the use of steroids, especially in patients with mild manifestations; and 3) the use of pulse cyclophosphamide in diffuse / nonthrombotic CNS lupus.Keywords : neuropsychiatric; systemic lupus erythematosus
Management of schneiderian papilloma with midfacial degloving Farhat dr
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 45, No 2 (2012): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Schneiderian Papilloma is a rare and benign sinonasal tumor. The symptoms include unilateral nasal obstruction, epistaxis, nasal drainage, bilateral nasal obstruction, nasal mass and sinusitis. The exact location, extension and the histological evaluation of the tumour is very important in order to decide the surgical modality. Here, we are reporting a case of Schneiderian Papilloma of the left nasal cavity and left maxillary sinus in a 62 years old man managed with midfacial degloving.Keywords : schneiderian papilloma; midfacial degloving
Pengaruh modifikasi pola hidup dengan atau tanpa metformin terhadap kadar C-reactive protein pada penderita obesitas Muhammad Budiman; Mardianto dr; Dharma Lindarto
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 45, No 3 (2012): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Background : Obesity is a multifactorial disease caused by accumulation of excessive adipose tissue that can cause metabolic syndrome and increase cardiovascular event. Adipose tissue secretes adipokine that induces the formation of CRP. Metformin as an antidiabetic agent has anti inflammatory effect.Aim of the study : Find out whether combination of medical life style and metformin in obesity subjects can improve CRP level. Method : This study was a clinical trial held for 12 weeks on obesity subjects which divided in to two groups. Group was subjects with medical life style without metformin and group was subjects with combinationof medical life style and metformin. Results : After 12 weeks of intervention in group without metformin (n= 19) there was significant improvement in body weight 78.01 (SD 11.33) compared to 75.68 (SD 11.02), P= 0.0001); waist circumference 95.47 (SD 7.12) compared to 90.07 (SD 7.63), P = 0.001; body mass index 32.35 (SD 4.13) compared to 31.26 (SD 4.15), P = 0.0001; and hs-CRP 3.03 (SD 2.20) compared to 3.22 (SD 2.40), P = 0.445. While metformin group (n= 19) the body weight was 76.07 (SD 13.06) compared to 72.33 (SD 12.97), P = 0.0001; waist circumference 93.97 (SD 9.70) compared to 87.80 (SD 9.42), P = 0.0001; body mass index 32.49 (SD 4.88) compared to 30.70 (SD 4.72), P= 0.0001; and hs-CRP 3.02 (SD 2.25) compared to 2.63 (SD 1.93), P = 0.292. There was significant difference in body weight and body mass index.Conclusion : Implementation of medical life style in 12 weeks improved spesific antropometric parameter and metformin complementation did not improve the CRP level significantly in obesity subjects.Keywords : obesity; lifestyle; modification; metformin; CRPBackground : Obesity is a multifactorial disease caused by accumulation of excessive adipose tissue that can cause metabolic syndrome and increase cardiovascular event. Adipose tissue secretes adipokine that induces the formation of CRP. Metformin as an antidiabetic agent has anti inflammatory effect.Aim of the study : Find out whether combination of medical life style and metformin in obesity subjects can improve CRP level. Method : This study was a clinical trial held for 12 weeks on obesity subjects which divided in to two groups. Group was subjects with medical life style without metformin and group was subjects with combinationof medical life style and metformin. Results : After 12 weeks of intervention in group without metformin (n= 19) there was significant improvement in body weight 78.01 (SD 11.33) compared to 75.68 (SD 11.02), P= 0.0001); waist circumference 95.47 (SD 7.12) compared to 90.07 (SD 7.63), P = 0.001; body mass index 32.35 (SD 4.13) compared to 31.26 (SD 4.15), P = 0.0001; and hs-CRP 3.03 (SD 2.20) compared to 3.22 (SD 2.40), P = 0.445. While metformin group (n= 19) the body weight was 76.07 (SD 13.06) compared to 72.33 (SD 12.97), P = 0.0001; waist circumference 93.97 (SD 9.70) compared to 87.80 (SD 9.42), P = 0.0001; body mass index 32.49 (SD 4.88) compared to 30.70 (SD 4.72), P= 0.0001; and hs-CRP 3.02 (SD 2.25) compared to 2.63 (SD 1.93), P = 0.292. There was significant difference in body weight and body mass index.Conclusion : Implementation of medical life style in 12 weeks improved spesific antropometric parameter and metformin complementation did not improve the CRP level significantly in obesity subjects.Keywords : obesity; lifestyle; modification; metformin; CRP
Profil penderita rinosinusitis kronik yang menjalani bedah sinus endoskopik fungsional di Rumah Sakit H. Adam Malik Medan 2008-2011 Emilda Dewi; Mangain Hasibuan; Aliandri dr
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 45, No 3 (2012): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Background : Prevalens of chronic rhinosinusitis in Indonesia is high and many research explain about chronic rhinosinusitis that had performed functional endoscopic sinus surgery. This study is aimed to know profile of patient with chronic rinosinucitis that had performed functional endoscopic sinus surgery.Purpose : To know the profile of patient with chronic rhinosinusitis in Adam Malik General Hospital since 2008-2011. Methods : This research is a descriptive with case series design. The research use secondary data obtained from medical records of patients in Adam Malik General Hospital since 2008 untill 2011.Result : Out of 111 patients, the most common gender are men (52.3%), the most prevalent in age group 15-24 years, the most common symptom is nasal obstruction (98.7%), the most common symptom period is under one year (43.2%); the most common nasoendoscopy is oedema/mucosa obstructive in middle meatus (88.3%) and maxilla sinus is the most common sinus that attached infection (95.5%).Conclusion : Profile of patient with chronic rhinosinusitis in Adam Malik General Hospital, the most common gender are men with the most prevalent in age group 15-24 years, and the most common symptom is nasal obstruction. Keywords : chronic rhinosinusitis; functional endoscopic sinus; rhinosinusiti
Perubahan tingkat kekerasan ereksi pada pasien BPH paska pemberian α1A- adrenoreceptors antagonis di RSUP H. Adam Malik Medan Muhammad Eka Agusfansyah; Syah Mirsya Warli; Bungaran Sihombing
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 45, No 3 (2012): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Background : Lower urinary tract infection (LUTS) at benign prostate hyperplasia (BPH) patient commonly followed by sexual dysfunction which include erectile dysfunction, at last study there was relation between LUTS/BPH and erectile dysfunction.1a-adrenoceptors antagonists (Tamsulosin) is very selective adrenoceptor •1 antagonist. These drugs block a adrenaceptor1a the prostate which further led to improvement of LUTS symptoms and also blocked the action of noradrenaline at the level1a receptors on smooth muscle of the corpus cavernosum to enhance and improve erectile function. The purpose of this study was to determine changes in the level of erection hardness in patients with BPH after administration •1a-adrenoceptors antagonists for 1 month.Methods : This research is an experimental study. Anamnesis directly performed on 50 subjects who met the inclusion criteria and did not meet the exclusion criteria. To assess the degree of erection hardness using a special instrument that used erection hardness score (EHS), where EHS is a diagram of the quality of erection hardness which consisted of grade 1 to 4. Patients will be assessed level of erection hardness using EHS before and after the intervention for 1 month with •1a-adrenoceptors antagonistsResult : Based on statistical analysis, after administration of •1a-adrenoceptors antagonists found there was a significant increase in the value of EHS compared with before intervention, with P value = 0.001 (• = 0.005 CI = 95%). 36 subjects with EHS 2 before intervention, 16 subjects turned into EHS 3 after the intervention. 13 subjects with EHS 3 before the intervention, after the intervention did not change the value of EHS. One subject with EHS 4 before intervention also did not change after the intervention.Conclusion : This study proved that •1a-adrenoceptors antagonists can improve erectile dysfunction in patients with BPH. Keywords : BPH; erectile dysfunction; •1a-adrenoceptors antagonists; LUTS; EHS
Korelasi kadar β-hCG serum terhadap kadar TSH, T3 dan T4 pada molahidatdosa di RSUP. H. Adam Malik dan RSUD. Dr. Pirngadi Medan periode tahun 2008-2012 Novrial DR; Rusda M; Sidabutar ER; Siregar MFG; Perangin-angin M; Tobing JL
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 45, No 3 (2012): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Latar belakang: Secara klinis bukti dari hipertiroidisme terdeteksi pada 7% pasien molahidatidosa komplit, tetapi, secara laboratorium lebih sering terjadi. Hiperfungsi tiroid pada kehamilan molahidatidosa dikaitkan dengan berlebihnya hCG, yang mempunyai aktivitas pemicu tiroid. Tingginya kadar hCG akan merangsang kelenjar tiroid dengan menekan pelepasan TSH dari kelenjar hipofisis sehingga akan mempengaruhi juga sekresi hormon T3 dan T4.Tujuan: Menganalisa korelasi kadar •-hCG serum terhadap kadar TSH, T3 dan T4 pada molahidatidosa di RSUP. H. Adam Malik dan RSUD dr. Pirngadi Medan periode tahun 2008–2012.Metode: Penelitian ini bersifat analitik korelatif dengan studi retrospektif dan menggunakan data sekunder dari catatan rekam medis RSUP.H. Adam Malik dan RSUD. dr. Pirngadi Medan.Hasil: Dari data rekam medis didapatkan 45 kasus molahidatidosa yang memenuhi kriteria inklusi. Karakteristik pasien berdasarkan usia yang terbanyak adalah usia 31-35 tahun (20%), paritas <3 sebanyak 28 kasus (62.2%), mayoritas keluhan yang paling sering adalah perdarahan pervaginam sebanyak 84.4%, usia kehamilan saat di diagnosa yang paling banyak pada usia kehamilan >10 minggu pada 38 kasus, tinggi fundus uteri yang lebih besar dari usia kehamilan terdapat pada 29 kasus (64.4%), dan nilai rerata tekanan darah sistole adalah 130.2 (SD 20.50) mmHg dan diastole 80.2 (SD 11.58) mmHg. Nilai rerata dari masing–masing •-hCG adalah 344,561 (SD 327135.07) mIU/mL, TSH 0.38 (SD 0.60) μIU/mL, T3 2.06 (SD 1.53) mg/dL dan T4 13.7 (SD 6.40) μg/mL. Korelasi antara •-hCG dengan TSH adalah dengan nilai r = -0.321 (P = 0.031), •-hCG dengan T3 dengan nilai r = 0.574 (P = 0.0001), dan •-hCG dengan T4 dengan nilai r = 0.606 (P = 0.0001). Kesimpulan: Terdapat korelasi negatif yang bermakna antara •-hCG dengan TSH dengan kekuatan korelasi yang lemah serta korelasi positif yang bermakna antara •-hCG dengan T3 dan antara •-hCG dengan T4 dengan kekuatan korelasi sedang. Kata kunci: molahidatidosa; •-hCG; TSH; T3; T4
Karakteristik penderita katarak senilis yang dilakukan tindakan pembedahan katarak di RSUP H. Adam Malik Medan tahun 2012 Safriati Eka; Delfi dr; D Sihotang Aslim
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 45, No 3 (2012): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Background : Cataracts are a cloudiness in the lens. The WHO defines cataracts as a keen eyesight is less than 3/60 which is a cause of blindness worldwide. Cataract surgery is one of the important management against a significant lens cloudiness affects vision.1,2Objective : To know the characteristics of the patients with senile cataract who performed cataract surgery based on age and gender of the most incisive, sharp vision cataract the average pre operation, sharp vision average post surgery, systemic disease history, the use of companion planting and lens power lens planting an average of cataract surgery, the type most used on patients with cataract surgery is performed by 2012.Methods: This is a descriptive retrospective observational study on senile cataract sufferers who performed cataract surgery in the Hospital of Haji Adam Malik, Medan from January 2011 to December 2012 and control routine post-operative week VIII until 2012.Results : Of the total samples there are 152 samples sufferers cataract senilis done surgically, age most be found at age 60- 69 year namely 73 people (48%). Man 89 people (58.5% ), women 63 (41.4%), sharp of sight average pre operation most 1/300 for 48 people (31.5%), systemic disease history companion most is diabetes mellitus that is, (43.4%), discharging lens cropping (92.1%) and strength lens cropping average is 20.00D (23.5%), sharp of sight after operation <6/18-6/60 60 samples (39.4%), type surgically cataract most used is ECCE, 118 samples (77.6%).Conclusion : From an examination of the senile cataract sufferers sample 152 performed cataract surgery in 2012 found the largest age group 60-69 years of age, male gender more than women and sharp vision on average pre-operation is 1/300 and have a history of systemic disease of most Companion is diabetes mellitus. Sufferers who performed surgery on average using the lens with the lens power plant the largest planting was 20 D. Sharp vision under average operating <6/18-6/60, the type of cataract surgery is the most used is the ECCE.Keywords : senile cataract; cataract surgery; sharp vision pre operation; sharp vision post surgery; systemic diseas
Changes of the calcium ions (Ca++) level and platelet count among donor in plateletpheresis Salomo Fajar Siahaan; Zulfikar Lubis; Ratna A Ganie
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 45, No 3 (2012): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Background : Application technology for apheresis blood donation appears as part of progress towards therapeutic blood components. Apheresis developed from the desire to get a certain fraction of blood to meet the needs of the patient. Therapeutic apheresis comes from the perception that the ability to separate blood into its components quickly and directly can be given to patients to help the healing process of disease.Methods : Blood taken from a vein into a tube just as regular blood donors which the tube directly connected to a machine. This machine has the ability to turn the blood very quickly. Because the blood cells have different types of specific gravity so it will be divided into several components by specific gravity of erythrocytes, leukocytes, platelets and blood plasma is composed of protein and electrolytes. Retrieval of component blood donor in accordance with the needs and the rest is returned to the donor.Results : The number of subjects is 36 donors. The mean value for variable calcium ions levels that prior to apheresis obtained 1155 (SD 0.088) and after apheresis procedure the mean value obtained 1030 (SD 0.122). From these data found significant difference decrease in levels of calcium ions before and after plateletpheresis (P <0.0001). For a variable platelets count prior to apheresis procedure the mean value obtained 302.74 (SD 44.228) and after apheresis procedures the mean value obtained 209.33 (SD 46,717). From these data found differences significant decrease in the number of platelets before and after plateletpheresis (P <0.0001). For variable haemoglobin the mean value prior the procedure apheresis obtained 15.80 (SD 1214) and after procedure apheresis the mean value obtained 14,957 (SD 1538). Have significant differences between decrease of haemoglobin before and after plateletpheresis (P <0.0001).Conclusion : This research obtained meaningful decline in the levels of Ca++, platelets count and haemoglobin levels after plateletpheresis, the cycles of plateletpheresis is tied to platelets count prior to plateletpheresis. Eleveted platelets count before plateletpheresis, then the less of cycles performed on apheresis.Keywords : Apheresis; calcium Ions; platelets; haemoglobin.
Perbandingan faktor resiko aorta abdominal dilatasi pada penderita penyakit jantung koroner dengan menggunakan ekokardiografi Yuke Sarastri; Andre Pasha Ketaren; Nizam Akbar; Sutomo Kasiman; Zulfikri Mukhtar; Tengku Winda Ardini; Rosmaliana dr; Abdullah Afif Siregar
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 45, No 3 (2012): The Journal of Medical School
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Background : Patients with coronary artery disease share common risk factors as abdominal aortic aneurysm (AAA), in which screening for AA dilatation is recommended. Transthoracic echocardiography (TTE) may offer the opportunity to evaluate the cardiac function and to screen for AA dilatation during the same examination.Aims : This study aimed to compare risk factors for abdominal aortic dilatation with abdominal aorta index in patients with coronary artery disease, and to evaluate the feasibility of AA dilatation screening at bedside using TTE in population with CAD. Methods : This is a cross-sectional study of patients with CAD. The abdominal aortic was measured at the end of a regular TTE performed in consecutive patients admitted in coronary care unit of Haji Adam Malik Hospital Medan using an echocardiography machine.Results : We enrolled 75 patients with mean age 56 (SD 10) years. Dilatation of abdominal aortic was observed in 21 patients (28%). From the analysis obtained a significant relationship between history of acute myocardial infarction with dilatation abdominal aorta (P = 0.04).Conclusion : Overall, the prevalence of dilatation of abdominal aortic increased with age and history of AMI. In regard to the simplicity, screening for AA dilatation during TTE may be of value for patients with CAD, especially in elder patients. Keywords : echocardiography; dilatation of abdominal aortic; coronary artery disease

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