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Indonesian Journal of Chemistry

ijc
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Published by Universitas Gadjah Mada

ISSN : 14119420 EISSN : 24601578 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).

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Articles 1,981 Documents

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Structure and Compatibility Study of Modified Polyurethane/Fe3O4 Nanocomposite for Shape Memory Materials Dick Ferieno Firdaus; Masrudin Masrudin; Dessy Ayu Lestari; Mutya Rahmah Arbi; Mochamad Chalid
Indonesian Journal of Chemistry Vol 15, No 2 (2015)
Publisher : Universitas Gadjah Mada

Shape Memory Polymer (SMP) is one of smart materials class that has the ability to recall a given shape before deformation in the transient state. The development of SMP is dominated by polyurethane which is currently focused on the optimization of manufacturing-related research (ease of processing), and the extraction of the potential for biomedical applications. In this study, Shape Memory Polyurethane (SMPU) with Polyethylene Glycol-based material (PEG mw: 6000) as soft segment, 4,4'-Methylenebis (Cyclohexyl isocyanate) (HMDI) as a hard segment and 1,1,1-Trimethylol propane (TMP) as a chain extender were used as a candidate for Vascular Stents. Materials used for the fillers were nano particles of magnetite (Fe3O4) which have 20–50 nm diameters. Variations of the composition were used as a variable. Fourier Transform Infrared Spectroscopy (FTIR) and Nuclear Magnetic Resonance (NMR) were conducted to investigate the polymer chains which were formed during polymerization, Field Emission Scanning Electron Microscopy (FE-SEM) was used to analyze the interface between the filler and the composite matrix. Manual physical actuation was conducted to analyze the physical recovery and transition temperature of the SMPU. Composition and fillers effect on the performance of SMPU composite were discussed in detail along with analysis of its structure and molecular design.

Major Anthocyanin Pigments in the Ficus padana Fruits: HPLC-DAD-ESI-MS Identification and Antioxidant Activity Daimon Syukri; Djaswir Darwis; Adlis Santoni
Indonesian Journal of Chemistry Vol 14, No 3 (2014)
Publisher : Universitas Gadjah Mada

The anthocyanins in Ficus padana were extracted and identified by using high-performance liquid chromatography/diode array detection and electrospray ionization/mass spectrometry (HPLC-DAD-ESI-MS). The individual anthocyanins were identified by comparing between their mass spectral data and published data. The first compound (peak 1) was identify as a pelargonidin 3-(6”-p-coumarylglucoside)-5-(4”’-Malonylglucoside) and the second compound was identify as a pelargonidin 3-(6’’-Malonylglucoside). The second one is a major compound that taking up to 91% of the total anthocyanin content in F. padana extract. The antioxidant activity was determined with 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays and results showed that extract possessed high antioxidant capacity.

COMPARATIVE EVALUATION OF CONVENTIONAL VERSUS RAPID METHODS FOR AMPLIFIABLE GENOMIC DNA ISOLATION OF CULTURED Azospirillum sp. JG3 Stalis Norma Ethica; Dilin Rahayu Nataningtyas; Puji Lestari; Istini Istini; Endang Semiarti; Jaka Widada; Tri Joko Raharjo
Indonesian Journal of Chemistry Vol 13, No 3 (2013)
Publisher : Universitas Gadjah Mada

As an initial attempt to reveal genetic information of Azospirillum sp. JG3 strain, which is still absence despite of the strains' ability in producing valued enzymes, two groups of conventional methods: lysis-enzyme and column-kit; and two rapid methods: thermal disruption and intact colony were evaluated. The aim is to determine the most practical method for obtaining high-grade PCR product using degenerate primers as part of routine-basis protocols for studying the molecular genetics of the Azospirillal bacteria. The evaluation includes the assessment of electrophoresis gel visualization, pellet appearance, preparation time, and PCR result of extracted genomic DNA from each method. Our results confirmed that the conventional methods were more superior to the rapid methods in generating genomic DNA isolates visible on electrophoresis gel. However, modification made in the previously developed DNA isolation protocol giving the simplest and most rapid method of all methods used in this study for extracting PCR-amplifiable DNA of Azospirillum sp. JG3. Intact bacterial cells (intact colony) loaded on electrophoresis gel could present genomic DNA band, but could not be completely amplified by PCR without thermal treatment. It can also be inferred from our result that the 3 to 5-min heating in dH2O step is critical for the pre-treatment of colony PCR of Azospirillal cells.

Computer Aided Design of Molecular Imprinted Polymer for Selective Recognition of Capsaicin Iqmal Tahir; Karna Wijaya; Shafiqul Islam; Mohd Noor Ahmad
Indonesian Journal of Chemistry Vol 14, No 1 (2014)
Publisher : Universitas Gadjah Mada

Searching capsaicin-like molecule as an alternative dummy template has been conducted for the synthesis of Molecularly Imprinted Polymer (MIP) of capsaicin. Dummy template should be applied because synthesis of capsaicin practically has a problem due to its structure containing double bond at the aliphatic chains. Virtual searching was done using an online chemical database of ChemDB containing 5 million commercial molecules. Capsaicin structure was converted into SMILES code and then it was run on ChemDB with molecular similarity threshold of 0.5. There were 69 chemical structures obtained as the output and pseudocapsaicin was practically selected as the dummy template. Experimental result from the prediction evaluation showed that the use of capsaicin as template and pseudocapsaicin as dummy template produced MIPs that have separation factor of 1.28 and 1.25 respectively. It is suggested to choose pseudocapsaicin as dummy template for the synthesis MIP of capsaicin instead of using capsaicin molecule.

PyPLIF-ASSISTED REDOCKING INDOMETHACIN-(R)-ALPHA-ETHYL-ETHANOLAMIDE INTO CYCLOOXYGENASE-1 Muhammad Radifar; Nunung Yuniarti; Enade Perdana Istyastono
Indonesian Journal of Chemistry Vol 13, No 3 (2013)
Publisher : Universitas Gadjah Mada

Identification of Protein-Ligand Interaction Fingerprints (PLIF) has been performed as the rescoring strategy to identify the best pose for the docked poses of indomethacin-(R)-α-ethyl-etanolamide (IMM) in the binding site of cyclooxygenase-1 (COX-1) from simulations using PLANTS molecular docking software version 1.2 (PLANTS1.2). Instead of using the scoring functions included in the docking software, the strategy presented in this article used external software called PyPLIF that could identify the interactions of the ligand to the amino acid residues in the binding pocket and presents them as binary bitstrings, which subsequently were compared to the interaction bitstrings of the co-crystal ligand pose. The results show that PyPLIF-assisted redocking strategy could select the correct pose much better compared to the pose selection without rescoring. Out of 1000 iterative attempts, PyPLIF-assisted redocking simulations could identify 971 correct poses (more than 95%), while the redocking simulations without PyPLIF could only identify 500 correct poses (50%).These works have also provided us with the initial step of the construction of a valid Structure-Based Virtual Screening (SBVS) protocol to identify COX-1 inhibitors.

Analytical Method Validation and Determination of Pyridoxine, Nicotinamide, and Caffeine in Energy Drinks Using Thin Layer Chromatography-Densitometry Florentinus Dika Octa Riswanto; RR. Endang Lukitaningsih; Sudibyo Martono
Indonesian Journal of Chemistry Vol 15, No 1 (2015)
Publisher : Universitas Gadjah Mada

Food supplement which contains vitamins and stimulants such as caffeine were classified as energy drink. TLC-densitometry method was chosen to determine the pyridoxine, nicotinamide, and caffeine in the energy drink sample. TLC plates of silica gel 60 F254 was used as the stationary phase and methanol : ethyl acetate : ammonia 25% (134:77:10) was used as the mobile phase. The correlation coefficient for each pyridoxine, nicotinamide, and caffeine were 0.9982, 0.9997, and 0.9966, respectively. Detection and quantitation limits of from the three analytes were 4.05 and 13.51 µg/mL; 13.15 and 43.83 µg/mL; 5.43 and 18.11 µg/mL, respectively. The recovery of pyridoxine, nicotinamide, and caffeine were within the required limit range of 95-105%. The percent of RSD were below the limit value of 5.7% for caffeine and nicotinamide and 8% for pyridoxine. The content amount of pyridoxine in the sample 1 and 2 were 33.59 ± 0.981 and 30.29 ± 2.061 µg/mL, respectively. The content amount of nicotinamide in the sample 1 and 2 were 106.53 ± 3.521 and 98.20 ± 3.648 µg/mL, respectively. The content amount of caffeine in the sample 1 and 2 were 249.50 ± 5.080 and 252.80 ± 2.640 µg/mL, respectively. Robustness test results showed that the most optimal method conditions should be applied for the analysis.

Synthesis of Fe Ionic-Imprinted Polyeugenol Using Polyethylene Glycol Diglycidilether as Cross-Linking Agent for Sorption of Fe(III) Muhammad Cholid Djunaidi; Jumina Jumina; Dwi Siswanta; Mathias Ulbricht
Indonesian Journal of Chemistry Vol 15, No 3 (2015)
Publisher : Universitas Gadjah Mada

Fe-Ionic Imprinted Polymer (IIP) from polyeugenol as base polymer and polyethylene glycol diglycidyl ether (PEGDE) as cross-linking agent had been synthesized to adsorb Fe(III) from aqueous media. The non-imprinting material (NIP) and polyeugenol were used in the adsorption study as control. Synthesis work included polymerization, template uploading, crosslinking and template removal, optimized for different template ion upload pH and concentrations. The polymers were characterized by FTIR spectroscopy, XRD and SEM-EDX, followed by adsorption test to study the adsorption kinetics and isotherms for all adsorbents. Selective adsorption study of IIP was carried out using binary mixtures of Fe(III) and Cr(III), Pb(II), Cd(II). Experimental results showed that the optimum conditions for the synthesis was template upload pH of 3, Fe/polyeugenol ratio of 1 mg/g, while the optimum adsorption pH was 3. The adsorption mechanism of Fe(III) on all adsorbents was dominated by hydrogen bond formation. The adsorption kinetics followed the pseudo-second-order model while the equilibrium data was best explained by the Langmuir isotherm model. The adsorption capacity of Fe(III) on the IIP was 12.73 mg/g, higher than that of the other adsorbents. Results also show that IIP-Fe was more selective toward Fe than NIP by 2.69 (Cd), 1.66 (Cr) and 1.6 (Pb) fold, respectively.

Method Development for the Analysis of Pharmaceuticals with Acethylcholinesterase Activity in Water Using HPLC-DAD and Solid Phase Extraction Samuel Budi Wardhana; Marit Kolb; Müfit Bahadir; Bambang Purwono; Tutik Dwi Wahyuningsih
Indonesian Journal of Chemistry Vol 14, No 1 (2014)
Publisher : Universitas Gadjah Mada

An SPE followed by HPLC-DAD method with ion pair chromatography technique to analyze pharmaceuticals with acethylcholinesterase activity including pyridostigmine (PYR), galathamine (GAL), neostigmine (NEO), eserine (ESE), and donepezil (DON) in water samples was developed. Acetylcholinesterase (AChE) inhibitors have been used to treat less severe dementias such as Alzheimer’s disease. Chromatographic separation was achieved using reversed-phase SymmetryShield column using gradient system with mobile phase consisting of H2O/ACN (99:1, v/v) as mobile phase A with 10 mM sodium 1-hexanesulfonate and 0.1% acetic acid (HAc). The HPLC/DAD method was linear between concentrations of 5 to 100 ng/μL. The IDL and IQL ranged from 0.50 to 1.25 ng/μL and 1.5 to 3.0 ng/μL, respectively. SPE was used to extract and clean up the target substances in spiked pure water, tap water, and wastewater samples. The application of extraction method of 5 target substances in wastewater sample was divided into 2 parts: Oasis WCX (6 mL, 500 mg) for PYR and Oasis HLB (6 mL, 200 mg) for GAL, NEO, ESE and DON. The developed SPE and HPLC/DAD method is applicable for quantification of the 5 target substances in water samples in a concentration range > 50 µg/L and assumable lower for DON (> 25 µg/L).

Synthesis Methyl Nitrophenyl Acrylate and Cytotoxic Activity Test against P388 Leukemia Cells Teni Ernawati; Zulfa Khoirunni’mah
Indonesian Journal of Chemistry Vol 15, No 1 (2015)
Publisher : Universitas Gadjah Mada

Synthesis of methyl nitrophenyl acrylate via modification of methyl trans-cinnamate had been done to improve its biological activity. The reaction of methyl trans-cinnamate with nitrating agent gave methyl 3-(2-nitrophenyl)acrylate and methyl 3-(4-nitrophenyl)acrylate with an ortho/para ratio of 1:8. Its structure was confirmed with 1H-NMR, 13C-NMR, FTIR, GC-MS. Biological activity of methyl 3-(4-nitrophenyl)acrylate and methyl 3-(2-nitrophenyl)acrylate assays was performed on Cancer cells against P388 Murine Leukemia with IC50= 7.98 μg/mL, IC50 = 27.78 μg/mL.

Preparation and Pb(II) Adsorption Properties of Crosslinked Pectin-Carboxymethyl Chitosan Film Budi Hastuti; Mudasir Mudasir; Dwi Siswanta; Triyono Triyono
Indonesian Journal of Chemistry Vol 15, No 3 (2015)
Publisher : Universitas Gadjah Mada

A modified pectin has been synthesized by reacting/combining -OH group among pectin and chitosan with BADGE (Bisphenol A diglycidyl ether) crosslinker agent. The structure and morphology of the new material were characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and X-ray Diffraction (XRD) analysis. Thermogravimetric studies showed an improvement in thermal characteristic. Adsorption experiments were performed in batch processes; sorption isotherms and kinetics were also studied. The Langmuir and Freundlich adsorption isotherm models were applied to describe the isotherms and isotherm constants for the adsorption of Pb(II) ion onto adsorbent pectin-carboxymethyl chitosan-BADGE (pec-CMC-BADGE). The dynamic study showed that the sorption process followed the second-order kinetic equation. Result indicated also that Pb(II) ion uptake could be well described by the Langmuir and Freundlich adsorption model of pec-CMC-BADGE and CMC with DG° of 25.3 and 23.1 kJ mol-1,respectively, while that of pectin followed Freundlich isotherm with DG° of 16.6 kJ mol-1.

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