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Raymond Pranata
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Editorial Office: Heart House, Jalan Katalia Raya No. 5, Kota Bambu Utara West Jakarta, 11430 - Indonesia Telephone: +62 21 5681149, Fax: +62 21 5684220 Email: ijc@inaheart.org
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INDONESIA
Indonesian Journal of Cardiology
Published by Indonesian Heart Association
ISSN : 28303105     EISSN : 29647304     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Indonesian Journal of Cardiology (IJC) is a peer-reviewed and open-access journal established by Indonesian Heart Association (IHA)/Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI) [www.inaheart.org] on the year 1979. This journal is published to meet the needs of physicians and other health professionals for scientific articles in the cardiovascular field. All articles (research, case report, review article, and others) should be original and has never been published in any magazine/journal. Prior to publication, every manuscript will be subjected to double-blind review by peer-reviewers. We consider articles on all aspects of the cardiovascular system including clinical, translational, epidemiological, and basic studies. Subjects suitable for publication include but are not limited to the following fields: Acute Cardiovascular Care Arrhythmia / Cardiac Electrophysiology Cardiovascular Imaging Cardiovascular Pharmacotherapy Cardiovascular Public Health Policy Cardiovascular Rehabilitation Cardiovascular Research General Cardiology Heart Failure Hypertension Interventional Cardiology Pediatric Cardiology Preventive Cardiology Vascular Medicine
Arjuna Subject : Kedokteran - Cardiology and Cardiovascular Medicine
Articles 10 Documents
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Faktor Risiko Pneumonia Paska Operasi Bedah Pintas Arteri Koroner Fadhilah, Vita Karima; Achmad, Chaerul; Afrianti, Rien; Santoso, Prayudi
Jurnal Kardiologi Indonesia Vol 45 No 4 (2024): Online First - Indonesian Journal of Cardiology April-June 2021
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1789

Abstract

Background: Postoperative pneumonia (POP) is a common infectious complication of coronary artery bypass grafting (CABG), leading to significant morbidity, mortality, and increased healthcare costs. This study found that the prevalence of POP was nearly double that reported in previous studies, underscoring the urgent need to identify specific risk factors. These findings emphasize the importance of local data in refining preventive strategies and improving clinical outcomes in CABG patients. Material and Methods: This is a retrospective cohort study. The subjects comprised patients who underwent CABG procedures at a single institution between June 2020 and June 2024. A logistic regression analysis model for evaluating the risk of POP was established. Results: This study observed a POP rate of 41.7%, significantly exceeding the 2–24% range reported in previous studies. Key risk factors included elevated creatinine levels, eGFR <60 ml/min/1.73 m², and low early postoperative albumin. POP strongly correlated with prolonged hospitalization, with an odds ratio of 13.043 (95% CI: 6.130–27.751, p < 0.0001), underscoring its substantial impact on patient outcomes. Conclusions: The present study delineates renal impairment and hypoalbuminemia postoperative as pivotal risk factors for POP following CABG. It emphasizes the importance of tailored interventions, structured institutional practices, and continuous research to enhance preventive strategies and patient outcomes.
Novel Echocardiographic Parameter Assessing Pulmonary Vascular Resistance in Patient with Acyanotic Congenital Heart Disease Natadikarta, Muhammad Raihan Ramadhan; Cool, Charlotte Johanna; Khalid, Achmad Fitrah; Sukmadi, Norman; Martha, Januar Wibawa
Jurnal Kardiologi Indonesia Vol 45 No 4 (2024): Online First - Indonesian Journal of Cardiology April-June 2021
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1790

Abstract

Background Pulmonary vascular resistance (PVR) is an important variable in management of acyanotic congenital heart disease. Right heart catheterization (RHC) using impedance catheter remains gold standard for pulmonary vascular resistance (PVR) measurement. The ratio of peak tricuspid regurgitant velocity to the right ventricular outflow tract time-velocity integral (TRVmax/RVOTVTI) was presented as a reliable non-invasive method of estimating PVR. Recently, right ventricular 2-dimensional speckle tracking strain (RVGLS) was proven as a new promising parameter to evaluate PVR. This study performed to examine whether this new non-invasive variable ratio (TRVmax/RVGLS) provides clinically reliable method to determine pulmonary vascular resistance (PVR) obtained by echocardiography. Methods Right-heart catheterization and echocardiographic examination were performed in 56 patients with congenital heart disease. The ratio of TRVmax/RVOTVTI and TRVmax/RVGLS analysis performed using receiver-operating characteristic curve analysis, a cutoff value for the ratio was generated to determine PVR more than 5 WU. Results A TRVmax/RVOTVTI cutoff value of 0.21 provided a sensitivity of 77.1% and a specificity of 81% (CI 81% to 97.5%) and TRVmax/RVGLS cutoff value of -23.16 provided sensitivity of 74.3% and a specificity of 90.5% to determine PVR > 5 WU (CI 79.6% to 98.2%). Conclusions The echocardiography parameter (TRVmax/RVGLS) could serve as a dependable noninvasive method to predict PVR greater than 5 WU in acyanotic congenital heart disease patients.
Collagen-Based Hydrogel Encapsulated Cardiosphere-Derived Cell (CDC): Potential of Stem Cells as Tissue Repair Therapy Post-Acute Myocardial Infarction Evananda, Maria Pramesthi Sabrina; Salim, Albert; Surya, Stevanus Christian; Suastika, Luh Olivia Saraswati
Jurnal Kardiologi Indonesia Vol 45 No 4 (2024): Online First - Indonesian Journal of Cardiology April-June 2021
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1281

Abstract

Acute myocardial infarction (AMI) is a global health issue that is the leading cause of morbidity and mortality. Post-AMI management currently has therapeutic and side effect limitations, and has not been able to repair damage to myocardial tissue caused by AMI. The development and discovery of therapeutic modalities with the potential for a more optimal therapeutic effect remains a challenge in this post-AMI treatment. The purpose of this literature review is to collect and analyze various sources related to collagen-based hydrogel encapsulated cardiosphere-derived cell (CDC). This literature review is written systematically by gathering library sources from various search engines, such as Google Scholar, PubMed, and Research Gate. According to the findings of the study, CDC has the potential to be used as a post-AMI therapy because it can promote regeneration of the heart, which has lost function as a result of the AMI. To achieve the greatest effect, this modality is administered intracoronary. This modality will be encapsulated with collagen hydrogel, which has a cardioprotective effect, in order to increase the survival and effectiveness of CDC. The use of collagen-based hydrogel encapsulated CDC can provide post-AMI cell regeneration effects comparable to existing modalities while having minimal side effects. Further investigation in larger and more definitive trials is needed to elucidate the potential use of CDC therapy in AMI.
Outcome Analysis and Determinants of Major Adverse Cardiac Events in Young Adults After Coronary Artery Bypass Graft Surgery Who Participated in Early Phase II Cardiac Rehabilitation Program: A single-centre study Radi, Basuni Radi; Intan, Ryan Enast; Dwiputra, Bambang; Desandri, Dwita R; Ambari, Ade Meidian
Jurnal Kardiologi Indonesia Vol 45 No 4 (2024): Online First - Indonesian Journal of Cardiology April-June 2021
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1727

Abstract

Background: Cardiac rehabilitation (CR) program is proven to reduce mortality risk after coronary artery bypass surgery (CABG). Our study aimed to investigate the determinants of survival in young adult patients after CABG. Method: This was a single-centre, longitudinal study with a survival analysis method from MACE of consecutive patients under 55 years old who underwent CABG and participated in the early phase II CR program between January 2017 and December 2018. The major adverse cardiac events (MACE) rates were determined over a 2-year follow-up time. Cox regression and Kaplan-Meier analysis were used to determine the predictors of the events based on the data registry. Result: 279 patients who fulfilled the inclusion criteria were recruited in this study. MACE happened to 23 (8.45%) of them (3 patients died, 20 patients were hospitalised). Patients who dropped out (12%) from the CR program had a higher risk of developing events (HR 3.86, 95% CI 1.36-10.99). Of those who completed the CR program (245 patients), beta-blocker usage, chronotropic index, resting heart rate, and functional capacity after the CR program independently correlated with MACE. Six-minute walk distance (6-MWD) 376 meters was a significant predictor (p=0.001), with a shorter mean survival time of 6 months. Conclusion: The early phase II CR program after CABG in young adult patients reduced the risk for cardiovascular mortality, major adverse events, and related readmission. It also increased the survival rate and mean survival time for participants who completed the CR program compared to dropouts. Optimum beta blocker medication, chronotropic index, resting heart rate, and functional capacity after the CR program are essential predictors of survival after CABG in young adults.
Effects of High-Intensity Interval Training on Cardiovascular Function and Risk Factors, Functional Impairments, and the Quality of Life in Coronary Artery Disease Patients: A Narrative Review Nazir, Arnengsih; Biben, Vitriana; Gunanegara, Aggi; Clementius, Brandon
Jurnal Kardiologi Indonesia Vol 45 No 4 (2024): Online First - Indonesian Journal of Cardiology April-June 2021
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1751

Abstract

Background: Coronary artery disease (CAD) causes damage to the cardiovascular system that leads to functional and quality of life (QoL) deterrence. Cardiac rehabilitation (CR) aims to improve cardiorespiratory fitness (CRF) to prevent disease progression and its risk factors. Aerobic exercise (AE) causes different physiological effects depending on the applied intensity. High-intensity interval training (HIIT) is being developed because of better effectivity than moderate-intensity continuous training (MICT). Even so, HIIT has not been prescribed generally. This review aimed to describe the effects of HIIT on cardiovascular function and risk factors, functional impairments, and the QoL. Methods: Articles were searched using PubMed and CINAHL databases with the keywords “high-intensity interval training”, “cardiac rehabilitation”, “exercise-based cardiac rehabilitation”, and “coronary artery disease”. Results: Twenty-two articles were found and used to explain sub-topics. Discussion: HIIT improves ventricular function, LVEF, heart contractility, and endothelial function which further improve systolic and diastolic blood pressure. Improvement in cardiovascular risk factors was better in HIIT compared to AE in lower intensities. Studies recommend HIIT for CAD patients due to significant cardiovascular adaptation in this exercise. Compared to MICT, most studies found that HIIT is better at improving CRF. HIIT also positively affects cognitive and affective functions. Research on the impact of HIIT on functional activity and QoL is still limited. However, one study found no differences in physical activity level and QoL in groups given HIIT or MICT. Conclusion: In CAD patients, HIIT is considered an alternative exercise that is more time-efficient than continuous exercise.
HUBUNGAN ANTARA DIABETES MELITUS TIPE 2 DAN SKOR LESI KALSIFIKASI BERDASARKAN PEMERIKSAAN INTRAVASCULAR ULTRASOUND (IVUS) PADA PASIEN PENYAKIT ARTERI KORONER Saboe, Aninka; Wahyudi, Dendi Pudji; Fattima, Eliza Techa; Yahya, Achmad Fauzi
Jurnal Kardiologi Indonesia Online First
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1449

Abstract

Background: Coronary artery calcification reflects the chronic burden of atherosclerosis and contributes to procedural complexity during Percutaneous Coronary Intervention (PCI). While coronary calcium has been extensively studied using Computed Tomography (CT), data on Intravascular Ultrasound (IVUS)-derived calcium characteristics in Southeast Asian populations remain limited. The Southeast Asian population, particularly Indonesians, may exhibit distinct patterns of atherosclerosis influenced by genetic, lifestyle, and metabolic factors. Therefore, we sought to investigate the association between cardiovascular risk factors and IVUS-derived total coronary calcium score in an Indonesian population. Methods: This single-center, retrospective observational study included consecutive patients who underwent IVUS-guided PCI between January 2020 and December 2021. Data on patient demographics and cardiovascular risk factors were obtained from medical records. The IVUS calcium scores recorded in the database were independently reanalyzed and validated by an experienced interventional cardiologist to ensure consistency and accuracy. Associations between cardiovascular risk factors and total IVUS calcium score were assessed using Spearman's rank correlation and the Kruskal–Wallis test.Results: A total of 111 patients were included in this study with a mean age of 61.3 ± 10.2 years; 72.1% were male. Hypertension was present in 60.4%, DM in 45.0%, dyslipidemia in 38.7%, and active smoking in 40.5%. The mean IVUS total calcium score was 1.93 ± 1.41. Among individual risk factors, dyslipidemia (ρ = 0.22, p = 0.021) and smoking (ρ = −0.24, p = 0.009) were significantly associated with calcium score. Patients with ≥2 risk factors had higher mean calcium scores (2.15 ± 1.35) compared with those with ≤1 risk factor (1.15 ± 1.33; p = 0.028). Conclusion: The total IVUS calcium score correlated significantly with the presence of dyslipidemia in this Indonesian population. A cumulative increase in cardiovascular risk factors was associated with greater coronary calcium burden, suggesting that multifactorial risk exposure plays an important role in coronary calcification in this population.
Cardiac Resynchronization Therapy (CRT) Optimization: A Way Out for Non-Responders - A Case Report Damaiati, Nabila Edhiningtyas; Hermanto, Dony Yugo
Jurnal Kardiologi Indonesia Online First
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1469

Abstract

Background Non-responders account for 30% of patients receiving Cardiac Resynchronization Therapy (CRT). Optimization of CRT using Electrocardiographic (ECG) and Transthoracic Echocardiographic (TTE) guidance has been proposed as a strategy to enhance therapeutic efficacy in this subset. This case report presents a young female patient with advanced heart failure secondary to ischemic cardiomyopathy, highlighting the role of ECG- and TTE-guided CRT optimization in improving clinical and hemodynamic outcomes. Case Illustration A 37-year-old female presented with advanced heart failure. Her medical history was notable for recurrent episodes of acute coronary syndrome, multiple Percutaneous Coronary Interventions (PCIs), and Cardiac Resynchronization Therapy with Pacemaker (CRT-P) implantation, despite adherence to Guideline-Directed Medical Therapy (GDMT). On admission, the ECG demonstrated atrial sensing with consistent biventricular pacing. Laboratory evaluation revealed an elevated N-terminal pro–B-type natriuretic peptide (NT-proBNP) level of 5.462 pg/mL. TTE showed a severely reduced Left Ventricular Ejection Fraction (LVEF) of 20% and an absent A wave on mitral inflow Doppler, indicating impaired diastolic filling. Additionally, the Left Ventricular Outflow Tract (LVOT) Velocity Time Integral (VTI) was reduced to 7.4 cm, consistent with low forward stroke volume.Six months after the implantation, CRT optimization was performed using ECG and TTE guidance. Optimization resulted in a reduction of QRS duration to 129 ms, distinct separation of the mitral inflow E and A waves, an increase in LVOT VTI to 10.9 cm, and an improvement in functional capacity to New York Heart Association (NYHA) class III. Conclusion CRT optimization, guided by ECG or TTE, is critical in managing non-responders. In this case, it led to improved QRS duration, hemodynamics, and NYHA functional class. Routine reassessment should be considered in patients with persistent symptoms despite optimal GDMT to enhance clinical response.
Myocardial Remission in High Burden Outflow Tract Premature Ventricular Complex-Induced Cardiomyopathy after Radiofrequency Catheter Ablation: Case Report Hendiperdana, Mochamad Rizky; Maharani, Erika
Jurnal Kardiologi Indonesia Online First
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1844

Abstract

Background: Premature Ventricular Complex (PVC)-induced Cardiomyopathy (PVC-CMP) is a spectrum of dilated cardiomyopathy. Case Illustration: A 51-year-old female patient who was diagnosed with high suspicion of PVC-CMP underwent successful 3D mapping radiofrequency catheter ablation with a good result. Post-ablation 24-hour ECG-Holter evaluation showed a significant reduction of PVC burden. Echocardiographic evaluation 5 months post-ablation showed improvement in left ventricular systolic function parameters. The presence of high-burden PVC with a typical outflow tract origin could raise suspicion of a specific PVC-CMP aetiology. PVC burden emerged as a major predictor of the development of CMP. Several criteria can be used to identify PVC-CMP. Our case met those descriptive criteria, increasing the likelihood of PVC-CMP. Conclusion: PVC-CMP should be considered in patients with dilated cardiomyopathy who are accompanied by frequent outflow tract origin PVC (> 10 % burden). Early recognition of PVC-CMP is essential, as removal of the primary aetiology improves ventricular structure and function.
Predictive Value of Bazett-Corrected QTc for Chemotherapy-Induced Cardiotoxicity in Breast Cancer: A Retrospective Cohort Study Lerista, Maria; Soniya, Firinda; Salsabila, Zeta Reihan; Putra, Justian Ananda; Agustine, Vania; Banun, Syahri; Felani, Muhammad Rizky; Puspita, Indah; Tondas, Alexander Edo
Jurnal Kardiologi Indonesia Online First
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1896

Abstract

Background : Cardiotoxicity remains a major concern in breast cancer patients receiving anthracycline-based chemotherapy. Meanwhile, prolongation of the QTc interval has been associated with an increased risk of torsades de pointes; however, the clinical evidence for its role as a predictor of subclinical cardiotoxicity remains limited. This study aims to evaluate the association between Bazett-corrected QTc and the incidence of subclinical left ventricular dysfunction, as measured by strain echocardiography. Methods : This single-center retrospective cohort study was conducted at Dr. Mohammad Hoesin General Hospital, Indonesia (January 2022–December 2023). Female breast cancer patients aged ≥18 years who received anthracycline or non-anthracycline chemotherapy and completed baseline and third-cycle echocardiography were included. QTc was measured from 12-lead ECGs before and after chemotherapy using Bazett’s formula. Subclinical cardiotoxicity was defined as a >15% relative reduction in global longitudinal strain (GLS) from baseline. Logistic regression and ROC analyses assessed the predictive value of baseline QTcB. Result : In 32 breast cancer patients on anthracycline therapy (mean age 49.5 ± 9.0 years) were analyzed; 59.4% developed subclinical cardiotoxicity. Prolonged baseline QTcB, older age, and obesity were significantly associated with subclinical cardiotoxicity (p < 0.05). In multivariate analysis, QTcB remained an independent predictor (OR = 21.09; 95% CI: 0.979–454.4; p = 0.05). ROC analysis showed moderate discrimination (AUC = 0.717; 95% CI: 0.50–0.92; p = 0.04). Conclusion : Prolonged QTc appears to be a promising predictor of subclinical cardiotoxicity with fair diagnostic accuracy. However, it should be considered alongside other modalities. Further studies with larger populations are needed to control for other risk factors.
The Role of Coronary Artery Calcium Score as a Systemic Marker of Atherosclerosis: A Cross-sectional Imaging Study Aulia, Mohammad Sidqi; Pranata, Raymond; Hidayat, Syarief; Kusumawardhani, Nuraini Yasmin
Jurnal Kardiologi Indonesia Online First
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.2130

Abstract

Following publication of this article, the authors notified the Editorial Office of an error in the order of authorship. The order of the author is wrong and should have been:Mohammad Sidqi Aulia, Raymond Pranata, Syarief Hidayat, Nuraini Yasmin KusumawardhaniAll authors have provided written consent to approve the revised authorship order. The authorship order has now been corrected in the published article. The authors apologize for any inconvenience caused by this error.

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