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Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)

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Published by Perkumpulan Obstetri dan Ginekologi Indonesia

ISSN : 23386401 EISSN : 23387335 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.

Arjuna Subject : -

Articles 1,760 Documents

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Mesothelin versus Ca125 in Screening the Ovarian Malignancy Jayasaputra, Meliana; Wagey, Freddy W; Rarung, Max R
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 2, April 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the sensitivity and specificity of mesothelin compared with Ca-125 as a tumor marker in predicting ovarian malignancy. Method: The cross sectional study design with diagnostic tests was conducted in 30 samples of patients undergoing elective laparotomy due to ovarian tumor. We compared the sensitivity and specificity between mesothelin and Ca-125, then the data were analyzed using SPSS software version 22.0. Result: According to the ROC curve analysis, optimal sensitivity and specificity value of mesothelin was 63.2% and 54.5% at a cut-off point of 0.45 pg/ml; or 42.1% and 72.7% at a cut-off point of 0.55 pg/ml. While the value of both optimal sensitivity and specificity of Ca-125 was 73.7% and 63.6% at a cut-off point of 46.63 U/ml. Conclusion: Mesothelin and Ca-125 are not different significantly for the AUC value of 50%. Due to higher sensitivity and specificity of Ca-125 than mesothelin, Ca-125 is still used as tumor marker for screening the ovarian malignancy. [Indones J Obstet Gynecol 2016; 4-2: 107-110] Keywords: Ca-125, mesothelin, ovarian malignancy

Fetal Biometry Nomogram Based on Normal Population : an Observational Study Wibawa, Aria; Rumondang, Amanda
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 July 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

  Objective: To establish fetal biometry nomogram using percentilemethod based on normal population.   Methods: A descriptive retrospective study in order to establishfetal biometry nomogram using percentile method basedon normal population. Four fetal biometry measurement (BPD,HC, AC and FL) was collected from ultrasonography examinationresult in Fetomaternal Division Ultrasound Unit - AnggrekClinic and from medical record unit Dr. Cipto MangunkusumoGeneral Hospital, from January 2015 until April 2016. Databeing documented using case report form and being tabulatedusing Microsoft Excell 2011 Version 14.7.0 (161029). All datawere analyzed using SPSS 20.0 dan Matlab R2016a.   Results: There were 6169 pregnant women underwent fetalbiometry ultrasound within January 2015 - April 2016. Basedon inclusion criteria, 2798 (45%) were eligible as researchsample distributed from 12 until 42 wga. Due to evenly distributiondata, 2205 (78%) were distributed from 20 until 40 wgato develop fetal biometry nomogram. Most pregnant womenwere 28.9 years old (SD  5.74) in range of 21-30 (55%) yearsold. The youngest was 13 years old and the oldest was 45years old. Four fetal biometry were collected and distributedevenly using percentile method to establish fetal biometrynomogram. As for estimated fetal weight curve was developedby Hadlock C formula. Each biometry was calculated the 10th,50th and 90th centile curves according to gestational age. Thus,representing the fetal biometry and modified Hadlock C estimatedfetal weight nomogram based on normal population inJakarta.   Conclusion: Each biometry and modified Hadlock C estimated fetalweight were calculated in 10th, 50th and 90th centile curves accordingto gestational age represent fetal biometry nomogram based onnormal population in Jakarta. Keywords: biometry, estimated fetal weight formula, nomogram

Progesterone Serum Level in-Labor Women does not Differ with not in-Labor Women Hutomo, Caroline
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 4, October 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Objectives: To find out the relation of serum progesterone level between patients in-labor and pregnant patients not in-labor. Methods: This was an analytic cross-sectional study, comparing serum progesterone level between in-labor gravida and not in-labor gravida. Subjects were in-labor gravida (n=21) and not in-labor gravida (n=24) admitted to Sanglah Hospital from April to August 2011. The data were analyzed by SPSS 16.0. Independent sample ttest and Fisherâs exact test were used. Results: Mean serum progesterone level were 214.90Â±92.06 inlabor gravida and 190.69Â±76.02 not in-labor gravida (t = 0.966 and p = 0.399). Conclusions: There is no difference in serum progesterone level between in-labor and not in-labor pregnant women. [Indones J Obstet Gynecol 2012; 36-4: 185-7] Keywords: labor, progesterone, progesterone withdrawal

Profile of Policystic Ovarian Syndrome Patients in Dr. Cipto Mangunkusumo General Hospital Jakarta March 2009 - March 2010 Pangastuti, Niken P.
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 1, January 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Objective: To study phenotype profile and correlation between fasting blood glucose-fasting insulin ratio and luteinizing hormonefollicle stimulating hormone ratio with free androgen index in polycycstic ovarian syndrome in Dr. Cipto Mangunkusumo Hospital Jakarta. Method: A descriptive cross-sectional study was carried out at Dr. Cipto Mangunkusumo General Hospital Jakarta in March 2009 - March 2010, using secondary data, were involved 105 reproductive age women who has been diagnosed as PCOs with Rotterdam criteria. History of the subjects was taken from medical record that consist of interview result about menstrual history and clinical manifestations of hyperandrogenemia and clinical, biochemical, and ovarian ultrasound assessment. Result: From 105 women were identified, 100 women with oligo/amenorrhea (94.2%) and 34 women with hirsutism (32.4%). Further evaluation of the 105 cases, it was identified 80% subjects with polycystic ovaries morphology, 34.3% with hyperandrogenemia, 71.4% with insulin resistant, and 66.7% with increasing LH and FSH ratio. While, the most symptom and sign combination is oligo/amenorrhea and polycystic ovaries morphology, that is 44.8%. With Spearman non parametric correlation test, there were a significant correlation between fasting blood glucose-fasting insulin ratio and free androgen index (FAI) with coefficient of correlation -0.342 and and between LH/FSH and FAI with coefficient of correlation 0.386. Conclusion: The most common symptom and sign of PCOs patients in this study were oligo/amenorrhea and polycystic ovaries and insulin resistant. There were significant correlations between fasting blood glucose-fasting insulin ratio and LH/FSH with FAI. [Indones J Obstet Gynecol 2011; 35-1: 8-13] Keywords: polycystic ovarian syndrome, insulin resistance, luteinizing hormone hypersecretion, hyperandrogenemia

Role of Glycated Albumin during Pregnancy Immanuel, Suzanna; Ronald, Thoeng; Sumapradja, Kanadi; Setiawati3, Arini
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 1, January 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the glycated albumin profile during pregnancy with normal glycemic status. Methods: We recruited 60 pregnant women between 21 and 36 weeks of gestation. We conducted several laboratory tests, such as glycated albumin, blood glucose, and albumin. These parameters were compared among four groups of gestational age (21-24 weeks, 25-28 weeks, 29-32 weeks, and 33-36 weeks) using ANOVA or Kruskal-Wallis test continued by Post-hoc test. Results: Glycated albumin was not statistically different among the groups. Albumin level of 33-36 weeks of gestation women (3.6 (SD 0.2) g/dl) was lower than 21-24 weeks of gestation women (3.8 (SD 0.2) g/dl). Conclusion: Glycated albumin level is not affected by gestational age. Therefore, glycated albumin may be used as glycemic status indicator during pregnancy from 21 to 36 weeks. [Indones J Obstet Gynecol 2017; 5-1: 16-18] Keywords: HbA1c, glycated albumin, glycemic status, pregnancy

Perbandingan kadar asam folat pada kehamilan dengan preeklampsia dan kehamilan normal JAYAKUSUMA, A.A. N.; KARKATA, M. K.; DARMAYASA, K.; GUNUNG, K.
Indonesian Journal of Obstetrics and Gynecology Volume. 31, No. 2, April 2007
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (140.177 KB)

Tujuan: Membandingkan konsentrasi asam folat pada kehamilan dengan preeklampsia dan kehamilan normal dan hubungannya dengan peningkatan konsentrasi homosistein dan tekanan darah. Bahan dan cara kerja: Penelitian kasus-kontrol mengikutsertakan 30 pasien preeklampsia sebagai kasus dan 30 pasien dengan kehamilan normal sebagai kontrol. Imx Folate Reagent Pack dari Abbott Laboratories digunakan untuk mengukur konsentrasi asam folat plasma, sedang konsentrasi homosistein diukur dengan Fluorescent Polarization Immunology Assay. Analisis dilakukan dengan tes Kai-kuadrat atau Fishserâs Exact, T test dan korelasi Pearson. Hasil: Rerata konsentrasi asam folat plasma pada pasien preeklampsia (12,32 ng/mL) lebih rendah dibanding dengan yang didapat pada kehamilan normal (14,22 ng/mL), namun secara statistik tidak berbeda bermakna (p=0,275). Didapatkan perbedaan bermakna (p=0,027) antara rerata konsentrasi homosistein pasien preeklampsia (9,71 Î¼mol/L) dan pasien dengan kehamilan normal (6,13 Î¼mol/L). Tidak terbukti korelasi negatif konsentrasi asam folat plasma (r=-0,3; p=0,123) dan homosistein (r=-0,1; p=0,551) antara pasien preeklampsia dengan kehamilan normal. Namun didapatkan korelasi negatif yang bermakna dari konsentrasi asam folat plasma dengan tekanan sistolik (r=-0,4; p=0,030) dan tekanan diastolik (r=-0,4; p=0,030) pada pasien preeklampsia. Kesimpulan: Berdasarkan penelitian ini tidak didapatkan perbedaan bermakna antara konsentrasi asam folat plasma pasien preeklampsia dengan kehamilan normal. Didapatkan hubungan bermakna antara asam folat plasma dengan tekanan sistolik dan diastolik pada pasien preeklampsia. [Maj Obstet Ginekol Indones 2007; 31-2: 61-5] Kata kunci: preeklampsia, asam folat, homosistein, tekanan darah sistolik/diastolik

Risantoâs Formulas is more Accurate in Determining Estimated Fetal Weight Based on Maternal Fundal Height Siswosudarmo, Risanto
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Objectives: To compare the accuracy of Johnsonâs and Risantoâs formulas in determining estimated fetal weight based on maternal fundal height (FH). Methods: This was a cross sectional study, consisting of 655 pregnant women from Dr. Sardjito Hospital and affiliated hospital sat 37-42 weeks of gestation. Fundal height was measured from the symphisis to the top of uterine fundus, using inverted unelastic flexible tape. EFW based on Johnsonâs and Risantoâs formulas were compared with the actualbirth weight. Wilcox on analysis was used for statistical analysis. Results: Mean EFW of Johnsonâs formula was 3136 Â± 392.2 grams and EFW of Risantoâs formula was 3056 Â± 322.5 grams and mean actual birth weight was 3021 Â± 341.1 grams. The mean difference between EFW of Johnsonâs formula and the actual birth weight was 156.1 Â± 107.3 grams, and mean difference between EFW of Risantoâs formula and the actual birth weight was 100.8 Â± 86.1 grams. Those two differences was statistically significant (p=0.001). Conclusion: This study showed that Risantoâs formula was more accurate than Johnsonâs in predicting birth weight based on the maternalâs fundal height. [Indones J Obstet Gynecol 2013; 1-3: 149-51] Keywords: actual birth weight, fundal height, Johnsonâs formula, Risantoâs formula

Difference of Serum MMP9 and TNF ???? Level in Preterm and Term Premature Rupture of Membranes Wibowo, Aji P; Sulistyowati, Sri; Respati, Supriyadi H
Indonesian Journal of Obstetrics and Gynecology Volume. 3, No. 1, January 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To examine the difference between matrix metalloproteinase‐ 9 (MMP‐9) and Tumor Necrosis Factor ???? (TNF‐????) serum levels in preterm and term premature rupture of membranes (PROM). Method: Our study employed an observational cross sectional approach. Seventy samples were divided into two groups, 35 samples with preterm PROM (28‐36 weeks gestational age) and 35 samples with PROM at term pregnancy (37‐42 weeks gestational age). Both groups underwent examination for serum MMP‐9 and TNF‐???? concentration using ELISA method. Statistical analysis was done using ttest. Result: Serum levels of MMP‐9 in the preterm PROM group was 2860.68K627.32 ng/ml, which was significantly higher than in the PROM at term pregnancy group 2549.74K657.15 ng/ml (p=0.04). Likewise, the average serum level of TNF‐???? in subjects with preterm PROM was 12,086.60K5384.51 ng/ml, significantly higher in comparison to PROM at term pregnancy, which was 6422.51K2645.32 ng/ml (p=0.00). Conclusion: Serum levels of MMP‐9 and TNF‐???? in preterm PROM is significantly higher than that in PROM at term pregnancy. Keywords: MMP‐9, premature rupture of membranes, preterm, term, TNF‐????

The Impact of Educational Intervention of HighRisk Pregnancy and HighRisk Childbirth on Knowledge, Attitude, and Behavior in Recognizing Danger Signs in Pregnancy: A Single Blind Clinical Trial Adjie, JM Seno; Malik, Devi M
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 2, April 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To assess the impact of additional educational interventions given to pregnant women in identifying high-risk pregnancy and high-risk childbirth by measuring changes in knowledge, attitudes and behaviors in the pregnancy and after childbirth. Methods: This study was a single blind clinical trial conducted at obstetrics out-patient clinic of Dr. Cipto Mangunkusumo Hospital, Jakarta. Total sample were 52 responders, for the 26 responders to the control group and 26 responders to the intervention group. The research instrument was a questionnaire form, which include knowledge, attitude and behaviour of a number of 48 questions. Analysis was performed using SPSS 20 with bivariate analysis. Results: We did not found significant differences in a range of age (30.65  29.38 with 1.20  0.75), education (both groups showed a high level of education) and employment for both groups. We found significant differences on knowledge, behaviour (p = 0.001 and = 0.042, respectively) on the first antenatal care compared with after childbirth. Conclusion: The educational intervention gives significant impact in attitude and behaviour. [Indones J Obstet Gynecol 2017; 5-2: 69-72] Keywords: attitude, behaviour, educational intervention, knowledge

The Rise of Inhibin A Serum Level in Preterm Labor Haribudiman, Oky
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 3, July 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Objective: The purpose of this study was to measure inhibin A serum level in women with preterm delivery, thus determining any correlation between inhibin A serum and gestational age in preterm delivery. Method: The design of our study was cross sectional with 36 subjects who came to Dr. Hasan Sadikin Hospital, Bandung and six satellite hospitals in July-August 2011 and met inclusion-exclusion criteria. Inhibin A serum level was measured with ELISA. Inhibin A serum level in preterm labor and was compared using independent t test, and correlation between inhibin A serum level and gestational age in patients with preterm labor was calculated using Pearson correlation test. Result: Characteristics test in both groups showed that both are homogeneous and comparable. The mean inhibin A serum level in preterm labor was higher (845.733 pg/ml) compared with preterm gestation (568.203 pg/ml) (p = 0.025). There was a significant correlation between inhibin A serum level and gestational age in preterm labor (p = 0.023) with a correlation coefficient of 0.38, indicating a moderate positive relationship. Conclusion: Inhibin A serum level in preterm labor was higher than preterm pregnancy. In preterm labor, inhibin A serum level increases with gestational age. [Indones J Obstet Gynecol 2011; 35-3: 110-4] Keywords: preterm delivery, inhibin A serum level

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eko subaktiansyah

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