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Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
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Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
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Articles 10 Documents
 1 
Search results for , issue "Vol. 13 No. 1 (2023): October" : 10 Documents clear
Role of Light Physical Activity Towards Stress in the Elderly in Nursing Homes Nesia, Waynhena Sarawa; Atmodjo, Wahyuni Lukita; Moningkey, Shirley Ivonne
Medicinus Vol. 13 No. 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i2.7526

Abstract

Introduction: It was reported that one in five adults and four out of five adolescents around the world did not do enough physical activity, especially the elderly tend not to do physical activity that is classified as active. Less physical activity can inhibit the release of ACTH and decrease cortisol secretion so that it can cause stress. Although it has been reported about the relationship between physical activity and stress levels at the age of 23-54 years, there has not been much research on the relationship in the elderly. Many elderly people aged over 60 years, especially those living in nursing homes experience stress due to lack of physical activity. Thus, further research is needed regarding the relationship between light physical activity and stress levels in the elderly at the Nursing Home.Methods: It was an unpaired categorical comparative analytic study. Elderly respondents at the Nursing Home aged 60-74 years will fill out the PASE questionnaire to assess physical activity and the PSS-10 to assess stress levels. The data obtained will be processed using Microsoft Excel and analyzed with the Pearson Chi-Square test using the SPSS-25 program.Result: Of the 40 respondents, 30 did light physical activity and 10 did heavy physical activity. It was also found that 14 experienced mild stress and 26 experienced severe stress. The results from Pearson ChiSquare show p-value <0.001 and OR = 16.000.Conclusions: The results of this study states that there is a significant relationship between light physical activity and stress levels in the elderly aged 60-74 years who live in nursing homes.
Association Between Body Mass Index and Low Back Pain Among Students at the Faculty of Medicine, Pelita Harapan University Thiono, Jeskry; Suryadinata, Neneng
Medicinus Vol. 13 No. 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i2.7527

Abstract

Background: Low back pain (LBP) is the most common musculoskeletal complaint and the largest contributor to the burden of disability in the world. One of the risk factors for LBP is having a higher body mass index (BMI). Although the relationship between BMI and LBP in the age group susceptible to LBP has been widely studied, the relationship in the young adult age group is still under-researched. Meanwhile, several studies report that lifestyle changes that occur during the COVID-19 pandemic might lead to an increasing number of overweight obese sufferers, including in the young adult age group. Given the context, this research aims to determine the relationship between BMI and LBP in UPH Medical Faculty (FK UPH) students during the COVID-19 pandemic.Method: A cross-sectional method of unpaired categorical comparative analytical study design was conducted with a population of 414 medical students. Data were collected by an online survey of BMI measurement and the Nordic Musculoskeletal Questionnaire. Statistical analysis was done using SPSS Statistics with Chi-squared or Fischer's exact method.Result: The study involved a sample of 372 people with 188 people (50.5%) being LBP sufferers. Most of the sample belongs to the category of BMI < 23 kg/m2, which is 215 people (57.8%).Conclusion: The result from this research concludes that there is no significant relationship between BMI and LBP in FK UPH students during the COVID-19 pandemic (P = 0.420); significant relationships were found between LBP with gender (P = <0.001) and smoking habit (P = 0.022).  
The Role of Classical Music Therapy on Dysmenorrhea Pain and Anxiety in Pelita Harapan University Medical Students Godjali, Handriani Almira; Haryanto, Hori; Sungono, Veli
Medicinus Vol. 13 No. 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i2.7529

Abstract

Introduction: Dysmenorrhea is menstrual pain that often occurs in young women. The pain felt in every women can be different from one another. Anxiety experienced by each women can also worsen the menstrual pain. Efforts to treat dysmenorrhea can be in the form of non-pharmacological therapy, one of which is music therapy.Aim: This study uses an experimental method with random allocation to divide 122 respondents who are medical students of Pelita Harapan University into a control group and an intervention group.Methodology: The intervention group has been given anexperiment of random allocationin the form of classical music therapy for 20 minutes on the first day of the respondent getting menstruation. As for the control group given 40Hz sound for 20 minutes. The data analyzed using chi-square and wilcoxon test.Results: The results of the study found that the average menstrual pain in the control group before the intervention was 6.11 and after the intervention was 6.07. Meanwhile, in the intervention group, the average menstrual pain before being given classical music therapy was 6.46 and after the intervention was 3.39.Conclusion: So that classical music therapy is effective for reducing anxiety by 0.77 and the menstrual pain scale is 3.07 in the group given classical music therapy with P value <0.001.
WNT-Activated Medulloblastoma in A 6-Year-Old Boy Prasetyo, Patricia Diana; Wahjoepramono, Eka Julianta
Medicinus Vol. 13 No. 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i2.7530

Abstract

Background: Medulloblastoma is the most common malignant brain tumor of childhood. Prognosis is mostly favorable, but may be affected by histological and molecular subtypes. Long-term therapy-related morbidity also remains a significant concern.Case Presentation: A 6-year-old boy with brainstem/midline cerebellum tumor. Histopathology found area of necrosis, sheets of malignant undifferentiated round cells with hyperchromatic nuclei and scanty cytoplasm, no nodule and no anaplasia. Immunohistochemistry found p53 wild-type staining pattern along with b-catenin diffuse cytoplasmic and focal nuclear staining. This indicated a diagnosis of WNT-activated medulloblastoma, World Health Organization (WHO) grade IV, with classic histological features.Discussion: WNT-activated medulloblastomas with classic histological features and no anaplasia were reported to have the most favorable prognosis. The current patient showed negative staining for GFAP, Olig2, EMA, H3K27M, EZHIP, and LIN28A, with retained staining for INI1 and BRG1, thus excluding several differential diagnosis such as atypical teratoid/rhabdoid tumor, embryonal tumor with multilayered rosettes, small cell glioblastoma, Ewing sarcoma, high-grade neuroepithelial tumor with BCOR alteration or diffuse midline glioma. Histopathology in combination with immunohistochemical and molecular subtyping of medulloblastoma can help to refine diagnosis, exclude differential diagnosis, and improve counseling in regards to overall prognosis.
Ultrasound-guided Genicular Nerve Ablation with Alcohol Solution for Knee Osteoarthritis: A Case Series Butarbutar, John; Phandu, Mirna; Lee, Kevin; Tasya, Earlene; Sulaeman, Wendell Sebastian
Medicinus Vol. 13 No. 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i2.7531

Abstract

Genicular nerve ablation using radiofrequency (RF) is a common minimally invasive procedure for painful osteoarthritic knees. However, the high cost and unavailability of equipment in many healthcare centers made this inconvenient for some patients. Some case reports tried the cheaper and newer method, using an alcohol solution to ablate the genicular nerves, showing considerable improvement in the patient's pain, functional knee score, and quality of life. We have attempted the ultrasound-guided genicular nerve ablation using alcohol solution in 6 patients with knee osteoarthritis to complement the body of evidence. We found that the genicular nerve ablation using alcohol solution is an excellent method for relieving symptoms of knee osteoarthritis if knee pain is the main symptom.
Strangulated Left Lateral Inguinal Hernia in a 54-Year-Old Woman: A Case Report Sudirman, Taufik; Surya, Clarissa; Marina, Sinta
Medicinus Vol. 13 No. 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i2.7532

Abstract

Introduction: Around 20 millions of hernia repairs were done annually with women presenting least cases. The occurrence of inguinal hernia in female patients is 3-6%, which is lower than men (27-43%). Inguinal hernia itself may present as a bulge in the groin in which the definitive treatment is through surgery. Although many research were done for hernia repair in men, guidelines for women are still currently observed with less favourable outcomes.Case illustration: A 54-year-old woman came to the ED complaining of pain of protruding bulge in the groin area for two hours. The patient has had a history of bulging for three years, which was previously reducible. Examination of the inguinal region revealed a lump with a diameter of +/- 4 cm and painful when palpated. Abdominal USG showed a left inguinal hernia consisting intestinal tissues. Open herniotomy with mesh grafting was performed and the patient got discharged after 4 days of hospitalisation.Conclusion: Lifetime risk for development of inguinal hernia is higher in men compared to women, but the rate of emergency procedures in women is 3 to 4-fold higher than in men. Guidelines for hernia repair in women show less favourable results than in men. Therefore, special steps must be taken in the repair of inguinal hernia in women.
Intramedullary Spinal Cord Cavernoma: A Case Report and Literature Review Widjaya, Ingrid A; Yunus, Yesaya; Wahjoepramono, Eka Julianta; July, Julius
Medicinus Vol. 13 No. 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i2.7533

Abstract

Background: Spinal cord intramedullary cavernous malformation (SICM) is kind of rare vascular disease, and the therapeutic strategy is still under debate. Cavernous malformation (CM) can be found throughout the central nervous system (CNS) but only rarely occur within the spinal cord. The purpose of this article is to describe natural history, clinical presentation and outcome of SICM case which treated surgicallyCase Presentation: A 70-year-old healthy woman presented with lower extremity weakness. A posterior laminectomy was performed, and a diagnosis of intramedullary spinal cord cavernous malformation was established. Neurological improvement was seen in one month after surgeryConclusion: Intramedullary CM is a rare disease but one with significant consequences if not managed appropriately. whenever safely feasible, gross total resection is suggested, to prevent rebleeding and further worsened of neurological deficit.
Applications of Artificial Intelligence in Peripheral Neuropathy: A Systematic Review Sutha, Anak Agung Ngurah Agung Bayu; Sharon; Rahman, Dea Nabila; Amanah, Salma Rizqi; Wicaksono, Teguh Budi; Sofiana, Dina; Hermawan, Galih Muchlis
Medicinus Vol. 13 No. 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i1.10778

Abstract

Background: Peripheral neuropathy (PN) is a common complication of metabolic and systemic diseases, particularly diabetes mellitus, resulting in sensory loss, pain, and motor impairment. Conventional diagnostic tools often detect PN only after irreversible nerve injury. Artificial intelligence (AI), especially machine learning (ML), has emerged as a promising tool for early diagnosis and risk prediction by integrating clinical, imaging, and genetic data. Methods: Following PRISMA 2020 guidelines, PubMed, EMBASE, IEEE Xplore, and Scopus were systematically searched up to September 2025. Studies applying ML or deep learning algorithms to PN were included, while reviews, grey literature, and studies lacking methodological details or performance metrics were excluded. Result: Our study included participants with diabetic, chemotherapy-induced, or pain-related neuropathies. Deep learning models, such as multilayer perceptrons and neural networks, achieved diagnostic accuracies of 87–93%, while classical algorithms including random forest, XGBoost, and SVM reported AUCs of 0.80–0.93. Radiomics-based SVMs using ultrasound showed external validation AUCs of 0.70–0.90. Key predictors included HbA1c, diabetes duration, lipid profile, and BMI. Conclusions: Machine learning demonstrates strong potential for improving the prediction, diagnosis, and phenotypic classification of PN. However, heterogeneity in datasets and limited external validation restrict clinical translation. Future work should focus on standardized data, multicenter validation, and interpretable AI models to facilitate integration into clinical practice.
Recent Therapies for Endometriosis: A Systematic Review Putra, Ananda; Winata, Raymond Malvin; Berlianzsa, El-Varel Baby; Chandra, Angelica Isabella Monica; Manubulu, Charles Pauris; Tarigan, Tiara Namora; Ellyamurti, Devanti Octavia; Firdaus, Najmarani Devi; Risdiana, Dilla Alfinda
Medicinus Vol. 13 No. 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i1.10779

Abstract

Background: Endometriosis is a chronic gynecological disorder characterized by the growth of endometrial tissue outside the uterine cavity. It commonly affects women of reproductive age and is associated with chronic pelvic pain, dysmenorrhea, dyspareunia, and infertility. The disease significantly impacts productivity, social functioning, and sexual health, making it one of the leading causes of disability and reduced quality of life among women. Methods: This review was conducted through a literature search using databases such as PubMed, ScienceDirect, Google Scholar, and ResearchGate. Articles published between 2016 and 2025 were selected using the keywords endometriosis, hormonal therapy, and non-hormonal therapy. Relevant studies were analyzed, cross-referenced, and evaluated to identify current therapeutic strategies for endometriosis management. Result: The management of endometriosis currently includes both hormonal and non-hormonal therapies. Hormonal treatments involve the use of aromatase inhibitors, gonadotropin-releasing hormone (GnRH) analogues, selective estrogen receptor modulators (SERMs), selective progesterone receptor modulators (SPRMs), and dienogest, all aimed at suppressing estrogen production and endometrial growth. Non-hormonal therapies, on the other hand, utilize anti-inflammatory, anti-angiogenic, and pro-apoptotic mechanisms to target the inflammatory cascade that contributes to the pathogenesis of endometriosis. These therapies aim to reduce chronic inflammation, cell proliferation, and pain without interfering with ovulation or fertility. Conclusions: Both hormonal and non-hormonal therapies play a crucial role in managing endometriosis. While hormonal therapy remains the mainstay of treatment, non-hormonal approaches show promising results with fewer side effects and greater patient tolerability. However, further clinical studies are required to evaluate their long-term efficacy and safety before they can be widely implemented in clinical settings.
The Role of Dermatovenereology in the Diagnosis and Management of Bacterial Vaginosis: A Systematic Review Eldy; Amalia, Shania Rizky; Wardianti, Flora Asri; Sitanggang, Mega Rahmani; Hakiki, Nadhira Permata
Medicinus Vol. 13 No. 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i1.10784

Abstract

Background: Bacterial vaginosis (BV) is a prevalent, recurrent cause of abnormal vaginal discharge with important sexual and reproductive health implications. Because symptoms overlap with candidiasis, trichomoniasis, cervicitis/STIs, and vulvar dermatoses, dermatovenereology services are central to accurate diagnosis and comprehensive care. Methods: A PRISMA-compliant systematic review searched PubMed, EMBASE, and Scopus from inception to September 1, 2023, using controlled vocabulary and keywords related to BV, diagnostic modalities (Amsel, Nugent/Gram stain, microscopy, molecular assays), and dermatovenereology/sexual health services. Screening, full-text eligibility, and narrative synthesis were performed; risk of bias was assessed using the Newcastle–Ottawa Scale. Result: From 729 records, 8 studies were included after deduplication, screening, and eligibility assessment. Studies consistently highlighted the value of objective diagnosis particularly in recurrent, atypical, or post-treatment presentations. NAAT-based testing was used mainly in referral settings and facilitated concurrent STI testing. First-line antibiotics (metronidazole or clindamycin) achieved short-term response, but recurrence was common; suppressive intravaginal metronidazole and newer recurrence-prevention approaches (e.g., astodrimer gel, Lactin-V) reduced relapse in selected populations. Conclusions: Dermatovenereology-led pathways that integrate objective testing, careful differential diagnosis, STI screening, and counseling can improve diagnostic precision and reduce BV recurrence.

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