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Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
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Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
Arjuna Subject : -
Articles 429 Documents
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The Association Between Smartphone Addiction, Learning Motivation Levels, and Cumulative Grade Point Average Among Students at the Faculty of Medicine, Pelita Harapan University Purushotama, Nyoman Bagus Satcitta Ananda; Nainggolan, Julita Dortua Laurentina
Medicinus Vol. 14 No. 2 (2025): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v14i2.9552

Abstract

Background: Cumulative Grade Point Average (CGPA) is a crucial metric in higher education. Achieving a good CGPA increases students' opportunities for career advancement or further education. Smartphones can aid learning by boosting motivation and academic achievement but may also cause addiction when used primarily for entertainment. Objective: To examine the relationship between smartphone addiction, learning motivation levels, and CGPA among preclinical students at the Faculty of Medicine, Pelita Harapan University. Methodology: This cross-sectional analytical study involved 103 students with a minimum sample size of 95. Data were analyzed using SPSS version 23 through bivariate analysis. Results: Among the respondents, 70 students were addicted to smartphone use, 94 achieved satisfactory CGPA scores, and 65 had high learning motivation. A significant relationship was found between smartphone addiction and CGPA (p = 0.029), smartphone addiction and learning motivation (p = 0.013), and learning motivation with CGPA (p = 0.000). Conclusion: There is a significant association between smartphone addiction, learning motivation levels, and CGPA among students at the Faculty of Medicine, Pelita Harapan University.
Addressing Uncontrolled Symptoms and Communication Gaps in a Patient with Metastatic Cholangiocarcinoma: Lessons from a Palliative Care Case Huang, Ian
Medicinus Vol. 14 No. 2 (2025): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v14i2.9553

Abstract

Background : Timely integration of palliative care is essential in managing advanced cancer patients, addressing both physical symptoms and psychosocial distress. Delayed communication of prognosis and inadequate symptom control can result in unnecessary suffering for patients and emotional distress for their families. Case Presentation : We report a 49-year-old male with metastatic cholangiocarcinoma, admitted with severe abdominal pain, nausea, and vomiting. He had undergone a Longmire procedure and gastrojejunostomy three weeks prior. Despite surgical intervention, his symptoms remained poorly controlled. Upon assessment, he expressed fear of death, while his wife struggled with the emotional burden of his prognosis, indicating a lack of prior communication regarding his terminal condition. Symptom management included oral morphine for pain and a combination of ondansetron, omeprazole, and haloperidol for nausea and vomiting, leading to improved symptom control. However, his condition deteriorated with pneumonia and respiratory failure, marking the transition to end-of-life care. He passed away peacefully 15 days after admission. Discussion : This case highlights the consequences of delayed prognosis disclosure and inadequate early symptom management. The absence of structured communication contributed to family distress, underscoring the importance of models like SPIKES in breaking bad news. The need for a multidisciplinary palliative care approach, including psychological support and optimized opioid management, was evident. Conclusions : Early palliative care involvement, proactive symptom control, and clear communication of prognosis are crucial in advanced cancer care. Establishing a dedicated palliative care team can improve quality of life, facilitate shared decision-making, and enhance end-of-life experiences for patients and families.
Exploring Joubert Syndrome: A Rare Case Study from Indonesia Siswanto, Johanes Edy; Tasmina; Prayudijanto, Muhammad I.; Daniswara, Boromeus A.; Pamungkas, Christophorus A. S.; Pratanu, Lydia
Medicinus Vol. 14 No. 2 (2025): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v14i2.9554

Abstract

Background: Joubert Syndrome is a rare autosomal recessive disorder characterized by midbrain-hindbrain malformation and multisystem involvement. This study aims to present a detailed case of Joubert Syndrome from Indonesia, emphasizing clinical presentation, diagnostic challenges, and management strategies in a resource-limited setting. Methods: This descriptive case study examines a newborn female referred for breathing difficulties and a skull tumor present since birth. Data were collected through clinical evaluations, imaging studies, laboratory tests, genetic analysis, and multidisciplinary consultations. A literature review was conducted to compare the findings with global data. Result: The first case involved a female infant with hydrocephalus, a posterior skull mass, and microcornea. Echocardiography showed a patent foramen ovale, while genetic analysis confirmed a normal 46,XX karyotype. The second case featured a male infant with posterior meningocele, seizures, and retinal dystrophy. EEG confirmed subclinical seizures, and genetic testing identified pathogenic TMEM237 mutations consistent with Joubert Syndrome type 14. Both infants received respiratory support, antibiotics, and targeted treatments, resulting in significant clinical improvement. Conclusions: These cases highlight the importance of multidisciplinary care and genetic testing in Joubert Syndrome diagnosis and management. Early recognition, advanced diagnostics, and consistent follow-up are crucial for optimizing outcomes, particularly in resource-limited settings.
Multifactorial Dermatitis in an Elderly Patient with Chronic Actinic Dermatitis: A Case Report Sunardi, Hendry Purnomo; Sutedja, Gina Triana
Medicinus Vol. 14 No. 2 (2025): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v14i2.9555

Abstract

Background : Chronic actinic dermatitis (CAD) is a rare, persistent photodermatosis triggered by UV and visible light, primarily affecting elderly individuals. With multifactorial etiologies, including genetic predisposition, environmental exposure, and comorbidities, CAD significantly impacts quality of life. This case report presents an elderly farmer with CAD, emphasizing the complexities of diagnosis and management in individuals exposed to high levels of sunlight due to occupational factors. Methods : A 70-year-old male farmer presented with a two-week history of pruritus and burning sensations on his face, exacerbated by sun exposure. He had a history of seborrheic dermatitis and hypertension. Physical examination revealed erythematous, hyperpigmented plaques on sun-exposed areas, with macular erythema, erosion, and lichenification. The working diagnosis was CAD, with actinic prurigo and cutaneous T-cell lymphoma as differentials. Management included methylprednisolone, cetirizine, and a compounded cream containing clobetasol propionate and gentamicin. Preventive measures, such as the use of moisturizers, sunblock, and UV avoidance, were also emphasized. The prognosis was favorable for life and function but uncertain for complete remission due to CAD's chronic nature. Conclusions : This case underscores the importance of an integrated approach combining pharmacological treatment and preventive strategies to manage CAD effectively. Tailored interventions addressing occupational and environmental risk factors are vital. Diagnostic limitations highlight the necessity for follow-up and the development of enhanced diagnostic tools. CAD management requires multidisciplinary collaboration to optimize patient outcomes.
The Palliative Role of Colchicine on Advanced Hilar Cholangiocarcinoma Patient with Socio-Economic Challenges: A Case Report Yanto, Theo Audi; Mulia, Nathania Raphaeli; Kusuma, Yordan
Medicinus Vol. 14 No. 2 (2025): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v14i2.9556

Abstract

Cholangiocarcinoma is a rare, slow-growing tumor that commonly presents beyond the point of resectability. Current guidelines recommend chemotherapy and radiotherapy for inoperable cases. However, palliative resources are not always accessible for patients with socio-economic barriers. Meanwhile, colchicine is a cost-effective drug and possesses anticancer effects. Here, we present a 53-year-old man with a 6-month history of painless jaundice, severe pruritus, recurrent fever, progressively growing abdominal mass, loss of appetite, and significant weight loss. He was incapable to perform adequate self-care and remained bedridden. Courvoisier sign was noted. Liver function tests show hyperbilirubinemia with elevated CA 19-9 level. Abdominal MRI 3T and MRCP showed hilar cholangiocarcinoma and obliteration of the hepatic vein. The patient and his family did not have health insurance and lived on a minimum income. Considered inoperable, the patient received daily colchicine 1 mg. Within four months, his symptoms have subsided, and he could perform several house chores. Bilirubin also showed a decreasing trend. In neoplastic cells, colchicine inhibits cell mitosis by perturbing tubulin formation. Being widely available, colchicine can be a palliative drug for terminally ill patients with socio-economic challenges. Although it improves patient performance status, we recommend further studies and close monitoring for the use of colchicine in advanced cholangiocarcinoma cases.
Gambaran Dermal-Epidermal Junction Pada Bullous Pemphigoid Dan Epidermolysis Bullosa Acquisita Budiman, Caroline; Devi, Mutia; Thaha, HM Athuf
Medicinus Vol. 6 No. 3 (2017): June 2017 - September 2017
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v6i3.1151

Abstract

Epidermis and dermis of the skin attach each other because of the role of a structure which is called dermal-epidermal junction. The dermal-epidermal junction can be divided into three distinct zones named hemidesmosome-keratin intermediate filament complex, basement membrane, and anchoring fibril. Each part of the distinct zone has significant components for the integrity of the skin. Bullous pemphigoid is an autoimmune disorder caused by autoantibody against a 180-kDa molecule now called Bullous Pemphigoid Antigen 2 (BPAG2) or type XVII collagen within basement membrane. To date, the slot deposit 5000 patophysiology and the components of dermal-epidermal junction that induce the blister formation remain unclear. Epidermolysis bullosa acquisita is an autoimmune disease with sub-epidermal blistering associated with autoimmunity to the collagen within anchoring fibrils. The pathophysiology and etiology””again””remain unknown.
Poor Sleep Quality of Hospitalized Geriatric Patients in General Hospital in Karawaci, Tangerang, Banten Province, Indonesia Hardjo Lugito, Nata Pratama; Yanto, Theo Audi; Kurniawan, Andree; Wijaya, Indra; Tjiang, Margaret Merlyn; Setiadinata, Resa; Sumantri, Stevent; Seto, Euphemia
Medicinus Vol. 6 No. 1 (2016): October 2016 - January 2017
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v6i1.1136

Abstract

Background: In Indonesia, geriatric population in the year 2005 was 15.8 million (7.2 % population), and expected to reach 11.34% in the year 2020. There was growing evidence for poor sleep as an independent risk factor for poor physical and mental health. Geriatric population may be particularly vulnerable to effects of sleep disturbance due to significant age-related changes in both sleep and inflammatory regulationObjective: To study the epidemiological (gender, age group) and health status (co-morbidities), sleep quality according to Pittsburgh Sleep Quality Index (PSQI) and its associations in geriatric population hospitalized in General Hospital in Karawaci, Tangerang, Banten Province, Indonesia.Materials and Methods: A hospital based cross sectional study was conducted from January to June 2014. A total of 92 subjects aged 60 years and above were selected consecutively from hospitalized geriatric patients for this study. The data was analyzed by means and proportions.Results: The male and female subjects were 51.1% and 48.9%. Mean age was 66.79 + 5.448 years. The age group of 60 - 75 years and above 75 years was 92.4% and 7.6% consecutively. Subjects with diabetes, hypertension, allergy, asthma, cardiac failure and chronic kidney disease were 30.4%, 62.0%, 18.5%, 21.7%, 21.7%, 20.7% consecutively and 63.0% with more than 2 co-morbidities. According to PSQI 72.8% subjects have poor sleep quality. Associations between poor sleep quality to epidemiological and health status were not significant except for diabetes (RR= 3.208 [95% CI: 1.045 - 9.848], p = 0.022) and chronic kidney disease (RR= 6.247 [95% CI: 0.902 - 43.279], p = 0.017)Conclusions: Seventy two percents of subjects have poor sleep quality, and associations between poor sleep quality to epidemiological and health status were not significant except for diabetes.
Pendekatan Diagnostik Terhadap Leukemia Akut Hartoyo, Vinson; Kurniawan, Andree
Medicinus Vol. 6 No. 1 (2016): October 2016 - January 2017
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v6i1.1138

Abstract

Acute leukemia is the most common form of cancer in children, comprises approximately 30 percents of all childhood malignancies, with acute lymphoblastic leukemia (ALL) being five times more common than acute myeloid leukemia (AML)1. Despite the advance in the treatment of acute lymphobalstic leukemia, five-year event free survival rate still remain quite low in group of patient with advanced age of onset (40% or below in later age)2,3,4. A case of 17 year old girl presented with 3 day onset of profuse bleeding from her nostril, ear, gums and gastrointestinal tract (melena and hematemesis). Blood count and peripheral blood smear revealed a pancytopenia with 26% blast count lymphocyte dominant, and reticulocyte percentage of 0.26% which is signalling a bone marrow failure. The patient was planned to undergo a bone marrow transplant before finally died on third day of care.
Tatalaksana Penurunan Kesadaran Pada Penderita Diabetes Mellitus Huang, Ian
Medicinus Vol. 6 No. 1 (2016): October 2016 - January 2017
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v6i1.1139

Abstract

Hyperglycemic crisis (diabetic ketoacidosis or hyperosmolar hyperglycemic state), lactic acidosis, hypoglycemia, and uremic encephalopathy are life-threatening complications of diabetes mellitus (DM). Specific therapies of each condition are essential in reducing mortality rate of the complications.
Hemofilia Susanto, Michael; Kurniawan, Andree
Medicinus Vol. 6 No. 1 (2016): October 2016 - January 2017
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v6i1.1140

Abstract

Hemophilia A and B are X-linked recessive diseases that are caused by gene mutations in factors VIII adan IX of the blood clotting cycle. Hemophilia C is an autosomal recessive disease caused by a mutation in factor XI, and acquired hemophilia is largely is an autoimmune process. Hemophilia A and B cannot be distinguished clinically, and severe cases can cause bleeding in the joints and lead to chronic hemophilic arthropathy. The main treatment of hemophilia is infusions of factor VIII and IX, and DDAVP in less severe cases. The main complication that can rise from the use of clotting factors is the appearance of specific inhibitor antibodies that can neutralize the work of the factors. Severe cases of hemophilia A and B by itself carries a poor prognosis, but proper treatment throught the use of clotting factors can give a very good prognosis

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