cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Widya Norma Insani, M.Sc., Apt.
Contact Email
Widya Norma Insani, M.Sc., Apt.
Phone
-
Journal Mail Official
pcpreditorialteam@gmail.com
Editorial Address
-
Location
Kota bandung,
Jawa barat
INDONESIA
Pharmacology and Clinical Pharmacy Research
Published by Universitas Padjadjaran
ISSN : 25277332     EISSN : 26140020     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Pharmacology and Clinical Pharmacy Research (PCPR) is an international, peer-reviewed journal, publishing original research, review, case reports, and commentaries on all aspects of pharmacology and clinical pharmacy. The journal aims to contribute to the scientific committee by publishing the high quality articles. It is published 3 times a year to provide a forum for pharmacologists, pharmacists, and other healthcare professionals to share best practice, encouraging networking, and a more collaborative approach in pharmacology and clinical pharmacy.
Arjuna Subject : -
Articles 207 Documents
 17   18   19   20   21 
An Observational Study to Compare the Anti Anginal Efficacy of Ranolazine versus Nicorandil in Ischemic Heart Disease Patients Attending a Tertiary care Hospital in Kolkata Mallick, Arup R.; Saha, Pradip; Sengupta, Ishita; Sengupta, Gairik; Bhattacharya, Paramartha; Dutta, Soumya K.
Pharmacology and Clinical Pharmacy Research Vol 9, No 1 (2024)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v9i1.51841

Abstract

Ischemic Heart disease (IHD) occurs due to an imbalance between myocardial oxygen supply and demand. In stable IHD, second-line anti-anginal drugs like Ranolazine and Nicorandil are used as add-on therapy with first-line agents like Nitrates and beta-blockers. Our study compared the efficacy of Ranolazine versus Nicorandil utilizing the patient’s responses to the Short Seattle Angina Questionnaire (SAQ7) score. A prospective observational study on stable IHD patients attending the cardiology Outpatient Department (OPD) of IPGME&R and SSKM Hospital, Kolkata, with either Ranolazine or Nicorandil as add-on therapy (50 patients in each group). SAQ7 score was recorded at baseline and three follow-up visits (1.5, 3, and 6 months). Adverse effects and the changes in HbA1C levels in diabetic patients among these patients were also compared. There was a significant increase in SAQ7 score in Ranolazine [median (IQR) - 26.50 (25.00 - 29.25) to 32.00 (30.75 - 34.00), p < 0.0001] and also in Nicorandil [median (IQR) - 27.00 (24.00 - 30.00) to 32.50 (31.00 - 34.00), p < 0.0001] group in third follow up visits from baseline. The comparison between the groups didn’t show any significant changes. There were no significant changes in HbA1C levels between the pre and post-treatment period. Adverse effects were more in the Nicorandil group. Both drugs significantly improved IHD patients’ symptom control and were well tolerated. There were no significant differences in the change of HbA1C level in Diabetic patients. However, a larger study is required to decide whether these drugs can be used as a single agent alone.
The Potency of Polymeric Nanoparticles as New Drug Delivery System: A Narrative Review Ariesaka, Kiky M.; Hidayati, Zulfa; Nurhayati, Siti; Dewi, Ni L.M.N.; Nuryady, Moh M.
Pharmacology and Clinical Pharmacy Research Vol 10, No 1 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i1.56782

Abstract

Polymeric nanoparticles are particles ranging from 1 to 1,000 nm that can be loaded with active compounds. Polymeric nanoparticles can be classified based on their morphological structure into nanocapsules and nanospheres. In addition, polymeric nanoparticles can also be classified based on the compound’s origin into natural and synthetic polymer. The nanoparticle production method is adjusted based on the type of drug that will be loaded. The methods commonly used for the production of polymeric nanoparticles are solvent evaporation, solvent emulsification/ diffusion, nanoprecipitation, emulsification/ reverse-salting out, and nanoprecipitation. This review also provides several examples of clinical applications of nanoparticles in the formulation of several drugs/bioactives including hyperforin, curcumin, and amphotericin B.
Incidence of Metabolic Syndrome from Atypical Antipsychotic Therapy in Schizophrenia Patients Utami, Indah K.
Pharmacology and Clinical Pharmacy Research Vol 10, No 1 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i1.60838

Abstract

Schizophrenia is a psychiatric disorder impacting behavior, emotions, and communication. Atypical antipsychotics are increasingly prescribed due to their significant reduction of both positive and negative symptoms and low risk of extrapyramidal side effects (EPS) in schizophrenia patients. However, long-term effects of atypicals may include weight gain, insulin resistance, and hyperglycemia. This study was conducted in Palu, Madani General Hospital, and Anutapura General Hospital. It used a prospective cross-sectional design with a sample of 40 outpatient participants who received monotherapy or combination therapy with clozapine, olanzapine, and risperidone for more than three months. Blood samples were collected to determine the presence of metabolic syndrome, defined as meeting at least three of the following five criteria: BMI > 30 kg/m², blood pressure ≥ 130/85 mmHg, triglycerides ≥ 150 mg/dL, HDL ≤ 40 mg/dL, and fasting blood glucose ≥ 110 mg/dL. The prevalence of metabolic syndrome was (25%), pre-metabolic syndrome (37,5%), and non-metabolic syndrome (37,5%) with a significance value of 0,5 > 0,05. The percentage of schizophrenia patients by gender was dominated by males (58%). Age-wise, adults dominated the sample (77.5%). Risperidone was the most frequently used atypical antipsychotic (56%). The most common concomitant medications were antimuscarinics (29.6%). The use of atypical antipsychotics did not significantly impact the side effects associated with metabolic syndrome with a p-value 0,5 > 0,05. However, there was an increase in the values for one or two of the five criteria for metabolic syndrome in schizophrenia patients. Future research should consider using only olanzapine or clozapine monotherapy for medication criteria. 
The Influence of Macrovascular and Microvascular Complications on the Quality of Life of Diabetes Mellitus Patients at Mardi Rahayu Kudus Hospital Caesary, Clara D.
Pharmacology and Clinical Pharmacy Research Vol 10, No 1 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i1.56842

Abstract

Diabetes Mellitus, also known as diabetes, is a chronic disease characterized by blood sugar levels that exceed normal limits. Poor management of diabetes mellitus patients can cause various macrovascular and microvascular complications. Complications in diabetes mellitus sufferers are one of the factors that can affect quality of life. This study aims to determine the effect of macrovascular and microvascular complications on the quality of life of diabetes mellitus patients at Mardi Rahayu Kudus Hospital. The method used in this research is prospective, quantitative research using a cross-sectional approach. Data for quality of life researchers used the WHOQOL-BREF questionnaire. The respondents involved and meeting the inclusion criteria were 104 patients. The results of the study showed that there were macrovascular and microvascular complications. The highest incidence of complications was macrovascular (37.5%), followed by microvascular complications (26.0%), and macrovascular + microvascular complications (36.5%).  Meanwhile, the highest quality of life category with complications was the high category at (52.9%) and the moderate category at (47.1%). DM and complications are mostly suffered by women (58.7%), with an average age of 45-65 years. The highest use of antidiabetic therapy includes metformin (53.1%), metformin + glimepiride (31.8%) and glimepiride + metformin + sansulin log-g (21.4%), as well as medication for comorbidities given according to the complications suffered by the patient. patient. Research shows that macrovascular and microvascular complications have no influence on quality of life due to the results of the binary logistic regression test (Sig. > 0.05).
Comparison of Random Blood Sugar, Uric Acid, and Cholesterol Levels in Krangkeng Village with Karangjaladri Village, West Java, Indonesia Hendriani, Rini
Pharmacology and Clinical Pharmacy Research Vol 10, No 1 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i1.61595

Abstract

The prevalence of metabolic diseases has increased over time, especially in Indonesia where 17.5% of the population suffers from metabolic syndrome. Metabolic diseases themselves are related to each other such as diabetes mellitus, gout, and dyslipidemia. One of the causes of metabolic diseases is environmental factors so this research aims to examine whether there was a relationship between metabolic diseases between two villages with different environmental conditions (Krangkeng Village and Karangjaladri Village). Data analysis used IBM SPSS Statistics 25 with random blood glucose, total cholesterol, and uric acid data taken using the Multi-Monitoring System Autocheck 3 in 1. The results of the analysis showed that random blood glucose and uric acid levels in men were greater in Karangjaladri village compared to Krangkeng village with statistically significantly different results. Meanwhile, uric acid in women was also greater in Karangjaladri village compared to Krangkeng village but not statistically different. Total cholesterol levels in Krangkeng village were greater than those in Karangjaladri village with statistically significantly different results. This difference could be caused by differences in daily consumption due to differences in geographic location and the main livelihoods of the two villages, where the majority of the residents of Krangkeng village work as farmers and Karangjaladri village as fishermen. The conclusion appears to be that there was a relationship between metabolic diseases and the environmental factors in the two villages studied.
Retrospective Observational Analysis in a Cohort Patients in Treatment with Alirocumab and Evolocumab: Focus on C-LDL Values Coppolino, Salvatore
Pharmacology and Clinical Pharmacy Research Vol 10, No 1 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i1.51899

Abstract

Hypercholesterolemia is the main risk factor for cardiovascular disease. Statins are the drugs of first choice, but many patients fail to reach the recommended levels of LDL cholesterol, or are intolerant. The PCSK9 inhibitor drugs (Alirocumab and Evolocumab) are anti-PCSK9 antibodies: represent a new pharmacological approach, and have been approved as an adjunct to Statins or in intolerant patients. The aim of the work was to carry out a retrospective analysis of a cohort of patients treated with anti-PCSK9 antibodies. The AIFA Therapeutic Plans were received by the Pharmacy from 01/01/2021 to 06/30/2023 by extrapolating data such as: sex, age, prescribed PCSK-9, adverse reactions, LDL cholesterol values before treatment and at the first re-evaluation. Out of 329 patients on treatment, 215 (65.3%) were treated with Evolocumab, 114 (34.7%) with Alirocumab. The 329 patients analyzed , have an average age of 64 years (minimum 30 - maximum 87). Our analysis has highlighted that in post-treatment patients the percentage change in LDL cholesterol values compared to baseline is equal to 59.8% in line with what was observed in the ODISSEY and FOURIER studies. PCSK9 inhibitors are state-of-the-art therapies and are well tolerated and effective in the management of the statin-intolerant patient, or as an adjunct to existing lipid-lowering therapies. Furthermore, statins increase serum PCSK9 levels; therefore, the best effect of these inhibitors is seen in combination with them
Factors associated with men’s skincare sales at Shopee Indonesia e-commerce Effendi, Muhamad H.; Mulyono, Lalu E.H
Pharmacology and Clinical Pharmacy Research Vol 10, No 1 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i1.61742

Abstract

Men's skincare use is increasing, along with the awareness of its importance. Shopee, as one of the largest e-commerce platforms in Indonesia, has become the main place for purchasing men's skincare products. However, study on the factors influencing men's skincare sales at e-commerce is still limited. This research aims to identify the factors associated with men's skincare sales at Shopee Indonesia e-commerce. A cross-sectional study, utilizing data from the 100 best-selling men's skincare products on Shopee until September 2024, was conducted. The dependent variable is the number of men's skincare sales, and the independent variables are the number of reviews, type of store, type of product, active ingredients, brand ambassador, number of products in one package, rating, price, free shipping feature, and discount. We analyzed the data using univariate descriptive, bivariate chi-square, and multivariate logistic regression analysis. SPSS 25 was used for all statistical analyses. The bivariate analysis results indicate that the number of reviews, product type, and rating have a significant relationship with men's skincare sales (p-values of p=0.000, p=0.076, and p=0.020). The logistic regression test showed that the variable number of reviews is the only variable that has a significant value with men's skincare sales (OR value of 132.021; CI=28.076-620.801; p=0.000). Thus, it can be concluded that the most associated factor with men's skincare sales at Shopee Indonesia's e-commerce until September 2024 is the number of reviews. Products with 376 or more reviews tend to have 132 times higher sales than products with fewer than 376 reviews.
Rationality Analysis of Antibiotics for Community-Acquired Pneumonia in Adult Inpatients at X Hospital Sukoharjo Rahardjoputro, Rolando; Amrullah, Adhi W.; Rizky, Wahyu; Ernawati, Ernawati; Wahyudi, Andrey; Widyaningrum, Nova R.
Pharmacology and Clinical Pharmacy Research Vol 10, No 1 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i1.53198

Abstract

Community-acquired pneumonia in adult patients contributes to high morbidity and mortality rates. The rationality of antibiotics for community-acquired pneumonia pharmacotherapy can determine the result of patient clinical outcomes. The aim of this study was to determine antibiotics rationality for community-acquired pneumonia in adult inpatients at X Hospital Sukoharjo and relationship between antibiotics rationality and its clinical outcomes.This study was analytical cohort design with retrospective data in the form of patient medical records for the period 2022. Sampling method was carried out using total sampling with inclusion criteria being patients aged ≥ 18 years, male or female, diagnosed with community-acquired pneumonia and receiving antibiotic therapy. The total samples was 102 who met the inclusion criteria which 52% was female gender and predominantly aged ≥ 65. The rationality analysis using Gyssens method showed that 29.51% of antibiotics were given rationally with the highest number of irrationalities due to another more effective antibiotics (category IVA) at 54.90%. There was no significant relationship between antibiotic rationality and its clinical outcomes.
Effect of Yellow Root Ethanol Extract (Fibraurea tinctoria Lour.) on Liver Histopathology of Paracetamol-Induced Male Swiss Webster Mice Safari, Astina; Ramadhani, Juwita; Fauzi, Muhammad; Pratama, Rizki R.
Pharmacology and Clinical Pharmacy Research Vol 10, No 1 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i1.55680

Abstract

The public most commonly uses paracetamol, an analgesic antipyretic drug available over-the-counter without a doctor's prescription. The use of toxic doses can cause centrilobular necrosis, where paracetamol will form excessive N-acetyl-p-benzoquinone-imine (NAPQI), causing there to be insufficient glutathione to convert NAPQI into non-toxic compounds. The antioxidant activity of yellow root (Fibraurea tinctoria Lour.) can shield the liver from paracetamol-induced liver damage. This study aims to determine the hepatoprotective effect of an ethanol extract of yellow root (Fibraurea tinctoria Lour.) on the liver histopathology picture of mice (Mus muscular) induced by paracetamol. The study used 30 mice divided into six groups, namely healthy control (s), negative control (Nacmc), positive control (curcuma), treatment 1 given (75 mg/kg BW), treatment 2 (150 mg/Kg BW), and treatment 3 (300 mg/kg BW). Following a 7-day administration period, we initiated induction on the 8th day, and 24 hours later, we executed necropsy on all mice. Subsequently, we extracted their liver organs for histopathological preparations using hematoxylin eosin (HE) staining. The results showed that an ethanol extract of yellow roots (Fibraurea tinctoria Lour.) at a dose of 300 mg/kg BW had an effect on the histopathological picture of the liver of male Swiss Webster mice (Mus musculus) because it was able to maintain liver condition when given a dose of 300 mg/Kg BW.    
QTc Interval Prolongation in Drug-Resistant Tuberculosis Treated with Bedaquiline and Delamanid Under Programmatic Conditions Putra, Oki Nugraha
Pharmacology and Clinical Pharmacy Research Vol 10, No 2 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i2.60987

Abstract

Background: The cardiac safety of regimens containing bedaquiline and delamanid is not well-established, especially in Indonesia.  This study aimed to analyze QTc interval during six months of treatment and factors associated with QTc interval prolongation. Methods: A prospective cohort of drug-resistant tuberculosis (DR-TB) patients received regimens containing bedaquiline and delamanid between September 2022 and May 2023 at the outpatient department of MDR-TB of the Dr. Soetomo Hospital. Patients were divided into bedaquiline and bedaquiline-delamanid-containing regimens groups, respectively. QTc interval was evaluated before and until the sixth month of treatment using ECG. QTc interval prolongation was categorized as clinically significant if ≥ 500 ms or QTc difference ≥ 60 ms. Results: Sixty-three (63) DR-TB patients enrolled in this cohort consisting of 51 and 12 patients in the bedaquiline and the bedaquilin-delamanid group, respectively. Grade II and III of QTc interval prolongation was higher in the bedaquiline-delamanid than in the bedaquiline group, 41.7% vs. 8.3%; 15.7% vs. 1.9%, respectively, P-value 0.084. However, the mean difference in QTc interval was < 60 ms between the two groups during six months of treatment, with a P-value ≥ 0.05.  Maximum QTc interval was observed after four months of treatment. No patients had serious cardiac events during the study period. Potassium and calcium levels were associated with QTc interval prolongation. Conclusion: Regimens containing bedaquiline-delamanid provide a good safety profile without serious signs of QTc interval prolongation in patients with DR-TB. These regimens should be considered as a programmatic treatment in a clinical setting.Keywords: Bedaquiline; Delamanid; DR-TB; QTc Interval

Page 20 of 21 | Total Record : 207

 17   18   19   20   21 

Filter by Year

2018 2025


Reset
Filter By Issues
All Issue Vol 10, No 2 (2025) Vol 10, No 1 (2025) Vol 9, No 3 (2024) Vol 9, No 2 (2024) Vol 9, No 1 (2024) Vol 8, No 3 (2023) Vol 8, No 2 (2023) Vol 8, No 1 (2023) Vol 7, No 3 (2022) Vol 7, No 2 (2022) Vol 7, No 1 (2022) Vol 6, No 3 (2021) Vol 6, No 2 (2021) Vol 6, No 1 (2021) Vol 5, No 3 (2020) Vol 3, No 2 (2018) Vol 5, No 2 Vol 5, No 1 Vol 4, No 3 Vol 4, No 2 Vol 4, No 1 Vol 3, No 3 Vol 3, No 2 Vol 3, No 1 Vol 3, No 1 Vol 2, No 3 Vol 2, No 3 Vol 2, No 2 Vol 2, No 2 Vol 2, No 1 Vol 2, No 1 Vol 1, No 3 Vol 1, No 3 Vol 1, No 2 Vol 1, No 2 Vol 1, No 1 Vol 1, No 1 More Issue