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Efek konsumsi yoghurt probiotik terhadap kadar low density lipoprotein pada penyandang diabetes mellitus tipe 2 Yuliani, Kartika; Kertia, Nyoman; Lestari, Lily Arsanti
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 8, No 1 (2019)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background : As one of important markers of cardiovascular complication in patients with type 2 diabetes mellitus, low density lipoprotein (LDL) shall be maintained to be in normal range. Based on previous research, consumption of probiotic yogurt contains Lactobacillus acidophilus and Bifidobacterium animalis subsp. Lactis is presumed can improve LDL in patients with type 2 diabetes mellitus but the scientific evidence is still few.Objectives: To investigate the effect of probiotic yogurt on LDL in patients with type 2 diabetes.Methods: This study was double blinded randomized controlled trial which was conducted on 32 patientss with type 2 diabetes mellitus. Subjects were divided randomly into 2 groups and given 4 weeks intervention. Subjects in control group were given conventional yogurt while subjects in intervention group were given probiotic yogurt contains L. acidophilus LA5 and B. animalis subsp. Lactis Bb12. Food intake data was collected 4 times using 24-hour recall method during intervention period. LDL of subjects was measured before and after intervention.Results: There was no significant difference between LDL before and after intervention in control group (128 â€“ 148.5 mg/dL) and intervention group (130 â€“ 120.5 mg/dL). Meanwhile, LDL after intervention in control group and intervention group were significantly different (p<0.05). LDL between energy and macronutrients intake categories were not significantly different.Conclusion: Probiotic yogurt has a better LDL reduction effect in patients with type 2 diabetes mellitus than conventional yogurt, although the reduction is not significant.

Efek konsumsi yogurt terhadap glukosa darah puasa pada penyandang diabetes melitus tipe 2 Nuriannisa, Farah; Kertia, Nyoman; Lestari, Lily Arsanti
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 8, No 1 (2019)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background: Generally, patients with type 2 diabetes mellitus (T2D) have dysbiosis condition. Dysbiosis can increase oxidative stress that leads to hyperglycemia. Previous researches showed that yogurt consumption can reduce blood glucose in T2D, so it can be used as an alternative healthy snack for T2D patients.Objectives: To investigate the effects of probiotic and conventional yogurt with dosage 100ml/day on fasting blood glucose (FBG) in T2D patientsMethods: Randomized controlled trial, double blind with pre-post group design. The 30 T2D patients from 3 publics health centre in Yogyakarta, were assigned to two groups. Each group, either control or intervention group, received 100 ml/d of yogurt for 4 weeks. FBG samples was assessed before and after intervention periodResults: FBG significantly decreased in both group, which was -27 mg/dL in control group (p<0.05) and -19 mg/dL in intervention group (p<0.05). No significant difference in FBG change between intervention and control group, but control group has greater reduction in FBG compared to intervention group. Conclusion: Conventional yogurt has no significant difference effect in FBG change compared to probiotic yogurt.Â

Correlation between HbA1c level and monocyte percentage in obesity Limijadi, Edward Kurnia Setiawan; Hendrianingtyas, Meita
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 8, No 1 (2019)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background : HbA1c is one of the parameters that can be useful for diagnosing diabetes mellitus that can occur in obesity. Monocyte as an inflammatory cell is widely studied in relation to diabetes mellitus and obesity. The purpose of this study is to analyze the correlation between HbA1c levels and monocyte percentage in obesity.Methods : A Cross-sectional study of 30 medical students at a private laboratory in Semarang on March â€“ April 2017 was done. The monocyte percentage included incomplete blood count was examined with the Sysmex XS-800i hematology analyzer, while HbA1c level was examined with Hemocue HbA1c 501 System. Spearman test was done for analyzing data with p <0.05 was considered statistically significant. Result and discussion : Median of HbA1c level was 5.8 Â± 0.23%. Medians of leukocyte count, lymphocyte percentage, neutrophil percentage, and monocyte percentage were 8,600 Â± 339,77 /Î¼l, lymphocyte percentage 33% Â± 1.19%, neutrophil percentage 56% Â± 1.35%, and monocyte percentage of 9.0% Â± 0.26%, respectively. Spearman test showed that correlation value (r) was 0.131 (p = 0.489).Conclusion and suggestion : There was no correlation between HbA1c levels and monocyte percentage in obesity. The increased of monocyte percentage can be used as monitoring and evaluation parameters in obesity that can lead to diabetes mellitus. Further study can be done in an obese population with older age as well as other parameters related to obesity and diabetes mellitus.

Kualitas diet, kurang energi kronis (KEK), dan anemia pada pengantin wanita di Kabupaten Semarang Dieny, Fillah Fithra; Jauharany, Firdananda Fikri; Fitranti, Deny Yudi; Tsani, A Fahmy Arif; Rahadiyanti, Ayu; Kurniawati, Dewi Marfuâ€™ah; Wijayanti, Hartanti Sandi
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 8, No 1 (2019)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Introduction: Pre-conception women are potential mothers or vulnerable groups who need special attention. The less of nutrients Intake than necessary can lead to nutritional problems such as Chronic Energy Deficiencyand nutritional anemia that have an impact on the next phase of life such as the risk of giving birth to babies with low birth weight (LBW), babies stunting, and growth disruption and development of the fetus / baby during pregnancy or after that. Objective: To analyze the relationship between diet quality, chronic energy malnutrition status with anemia in the bride.Methods: A cross-sectional study with 70 subjects who were brides aged 16-30 years. Selection of subjects with consecutive sampling method. Dietary quality data was measured through the Semi Quantitative Food Frequency Questionnaire (SQ-FFQ) and Diet Quality Index - International (DQI-I) forms, SEZ status assessed from body mass index (BMI) and upper arm circumference (LiLA). Anemia status was measured from hemoglobin levels, MCV, MCH, and MCHC. To examine the relationship between diet quality, chronic energy malnutrition, and anemia using a linear regression test.Results: The subject aged 16-30 years, and 41.4% are still <20 years old. A total of 10 subjects (14.3%) belonged to Chronic Energy Deficiency. Haemoglobin level measurements showed there were 8 subjects (11.4%) who had low Hb levels, and 4 of them had anemia with microcytic hypychromic type which was characterized by low MCV, MCH and MCHC values. Based on the calculation of intake was known that 55 subjects (78.6%) had a low quality diet. This study showed no relationship between diet quality and anemia, but the sub-components of diet quality were adequacy of protein intake (p = 0.007), iron intake (p = 0.009) and upper arm circumference (p = 0.018) indicating a significant relationship with anemia (hemoglobin level) in the bride. Conclusion: the less protein and iron intake and lower upper arm circumference associated with a decrease in the bride's hemoglobin level

Pengaruh pemberian ubi jalar ungu (Ipomoea batatas L.Poir) terhadap kadar superoksida dismutase (SOD) tikus wistar jantan (Rattus Norvegicus) yang dipapar asap rokok Widyanti, Alfreda Sabrina; Ardiaria, Martha; Widyastuti, Nurmasari
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 8, No 1 (2019)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background: Cigarette smoke exposure is one of the source of free radicals that causes oxidative stress and decreases superoxide dismutase (SOD) level. Purple fleshed sweet potato is a type of food that contains antioxidants to neutralize oxidative stress.Objectives: To study the effect of purple fleshed sweet potato on superoxide dismutase (sod) level on rats exposed to cigarette smoke.Methods: This was a true experimental study with a post-test randomized control group design. The rats were randomized into 4 groups (6 rats in each group). The negative control group (K-) was treated with standard diet; the positive control group (K+) was treated with cigarette smoke exposure and standard diet; the treatment 1 (P1) group was treated with standard diet and purple fleshed sweet potato with the dose of 8 g / 200 g bw/day, and the treatment 2 (P2) group was treated with cigarette smoke exposure and purple fleshed sweet potato with the dose of 8 g /200 g bw/day.Results: There was a significant difference of SOD levels in each group (p=0.00) except between group K- and P1. Giving purple fleshed sweet potatoes increased SOD levels as much as 85.81Â±4.59 (P1). The K+ group had the lowest SOD level 22.34Â±3.98. The SOD level for K- group and P2 group was 82.27Â±4.59 and 67.73Â±6.68 respectively.Conclusion: The highest SOD level is on the treatment 1 group which is administered with purple fleshed sweet potato.

Snack bar berbahan pati sagu (Metroxylon sp.), tempe, dan beras hitam sebagai pangan fungsional berindeks glikemik rendah Puspita, Winny; Sulaeman, Ahmad; Damayanthi, Evy
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 8, No 1 (2019)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background: High calories intake from snacks with low nutritional value will contribute to increase the prevalence of obesity and diabetes. Nutritional strategies to prevent hyperglycemia are controlling blood glucose levels, restrict calories and carbohydrate intake. Sago starch (Metroxylon sp.), tempe and black rice contains ingredients such as dietary fiber, resistant starch, amylose and low glycemic index. Modified snack bar using these ingredients can produce attractive products and provide the beneficial nutrients.Objectives: To determine a snack bar formulation made from sago starch, tempe and black rice and analyze physicochemical characteristics and glycemic index value of the product.Methods: This study used a completely randomized design analyzing three different proportions of sago starch and tempe, namely F1 (2:1), F2 (1.5:1), and F3 (1:1) with two replications for each formula. The Selected formula was determined based on consumer acceptability by semi-trained panelists using 9-point hedonic scale, physicochemical properties, nutrient content, and glycemic index value. Results: The Selected formula (F3) was potentially used as functional food as indicated by high level of dietary fiber (11.05%), 8.8 % resistant starch, in vitro starch digestibility (14.02%), the highest amylose-amylopectin ratio (60.1% : 39.9%), low glycemic index (40) and low glycemic load (5.4). The F3 formula produced a slow increase and peak point of blood glucose response of 107.5 mg/dl at minute 30th lower than the administration of anhydrous glucose with peak point of blood glucose levels of 143.4 mg/dl.Conclusion: The F3 formula with the proportion of sago starch and tempe (1:1) had low glycemic index and was categorized as high-fiber food with high level of resistant starch. Therefore, this product has the potency as functional snack alternative for diabetes patients.

Korelasi kadar hepcidin dan asupan makanan dengan serum transferrin reseptor dan hemoglobin pada remaja stunted overweight Mani, La; Fatimah-Muis, Siti; Kartini, Apoina
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 8, No 1 (2019)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background: Stunted overweight is associated with mild chronic inflammation. The state of inflammation will increase the expression of hepcidin, which affects the iron status of the body, besides the intake of protein, iron, and vitamin C.Objective: To analyze the correlation of hepcidin levels and food intake (protein, iron, vitamin C) with serum transferrin receptors (sTfR) and hemoglobin in stunted overweight adolescents.Method: The design of research was cross-sectional. The subjects were 64 adolescents stunted overweight aged 15-18 years in four high/vocational schools in the Banyumanik District, Semarang City. Measurement the level of hepcidin and sTfR was using the ELISA method and haemoglobin was using Cyanomethemoglobin method. Data on protein, iron, vitamin C intake was using the SQ-FFQ method. Bivariate analysis was using Pearson and Spearman correlation test then followed by multiple linear regression analysis.Results: The result showed that 89.1% subjects had adequate intake of protein, 54.7% subjects had low intake of vitamin C, 76.6% subjects had low intake of iron. Hepcidin levels in all subjects were 100% normal. There were 7.8% subjects with a low sTfR and 7.8% with a low haemoglobin level. Statistic test showed there was correlation between hepcidin with haemoglobin and sTfR (p1 = 0,010 r1 = -0,319, p2 = 0,001, r2 = 0,569). From food intake, only intake iron was correlated with haemoglobin but not with sTfR. There was significant difference between the mean of haemoglobin and sTfR among girls and boys. Further analysis, showed that only hepcidin was a weak negative determinant for sTfR (R2 = 0,120). The determinant factors for haemoglobin were gender (p=0,001) and hepcidin (p =0,004) with the value of R2 = 0,577.Conclusion: Hepcidin correlated with sTfR and haemoglobin while iron intake only correlated with hemoglobin.

Pengaruh lama mengunyah terhadap kadar glukosa postprandial dewasa obesitas Wulansari, Arin; Luthfinnisa, Fryta Ameilia; Uyun, Fuadah; Retnoningrum, Dwi; Rahmi, Fifin Luthfia; Wildan, Arief
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 8, No 1 (2019)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background: Obesity cause various physiological changes in the body, one of which is insulin resistance causes high blood glucose levels. Chewing is a stimulus of cephalic phase responses and sensory stimulation that can increase hormones releasing such as insulin, ghrelin, cholecystokinin (CCK) and glucagon like peptide-1 (GLP-1). Chewing plays important role in determining postprandial plasma glucose concentration.Objective: Investigate the effect of chewing on postprandial blood glucose in obese adults.Method: This was true experimental research. Research subjects were treated in the form of chewing 22 times and 40 times each mouthful. Blood glucose levels were measured using glucometer on fasting blood glucose and postprandial blood glucose 15 minutes, 30 minutes, 60 minutes, and 120 minutes. Statistical test using Independent t-test.Results: The mean postprandial glucose levels in the 22 chews group at 15 minutes, 30 minutes, 60 minutes, and 120 minutes were 112.11 Â± 14.3328, 126.11 Â± 15.667, 116.94 Â± 15.539, and 89.67 Â± 11.668 . While the mean postprandial blood glucose levels in the 40 chews group at 15 minutes, 30 minutes, 60 minutes, and 120 minutes were 122.22 Â± 14.381, 129.61 Â± 15.112, 109.50 Â± 14.995, and 85.83 Â± 13.963. There were statistically significant differences between chewing groups 22 times and chewing 40 times on fasting blood glucose and 15 minutes postprandial blood glucose (p = 0.041 and p = 0.042), while on 30 minutes postprandial glucose testing, 60 minutes , and 120 minutes there was no significant difference (p> 0.05).Conclusion: There was significant differences in 15 minutes postprandial blood glucose level between group 22 times chewing and 40 times chewing each mouthful.

Pengaruh yoghurt dan soyghurt kayu manis (Cinnamomum burmannii) terhadap kadar glukosa darah, insulin serum, dan malondialdehyde tikus pra sindrom metabolik Rustanti, Ninik; Nafsih, Vifin Zakiahtin; Avisha, Rosita Nur; Kurniawati, Dewi Marfuâ€™ah; Purwanti, Rachma; Nissa, Choirun; Wijayanti, Hartanti Sandi; Afifah, Diana Nur
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 8, No 1 (2019)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background: Pre metabolic syndrome is characterized by two of five risk factors: central obesity, dyslipidemia, hypertension, and increased fasting blood glucose. Cinnamon yogurt and soygurt contain antioxidants and fiber which can improve insulin sensitivity and blood glucose homeostasis and prevent cell damage in pre-metabolic syndrome conditionsObjective: This study aimed to determine the effect of cinnamon yogurt and soygurt on fasting blood glucose (FBG), serum insulin, and malondialdehyde (MDA) levels in pre-metabolic syndrome rats.Method: This study was an experimental study with a pre and post-test control group design. The subjects were 15 male Sprague Dawley rats which were divided into 5 normal control mice (K) and 10 pre metabolic syndrome mice with a diet high in fat and fructose for group P1 (yogurt) and P2 (soygurt) each of 5 mice. The yogurt and soygurt were given as much as 3.4 ml / g BW for 28 days. FBG levels were measured by the GOD-PAP method, while serum insulin and MDA levels were by the ELISA method. Different tests before and after treatment using Paired t-test or Wilcoxon. The difference tests between groups using the One-Way ANOVA test or Kruskal Wallis.Results: There were no differences in FBG and MDA levels between groups after intervention (p> 0.05). The highest percentage reduction in FBG in the P2 (-11.59%), then P1 (-4.06%). The decrease in MDA levels in group P1 = 19.17%, and P2 = 15.44% lower than K = 24.43%. After the intervention, the insulin level in group P2 (0.46 ng / ml) was significantly higher than P1 (0.318 ng/ml), but both were not different from K (0.384 ng / ml).Conclusion: There was no significant effect on the administration of cinnamon yogurt and soygurt to FBG, serum insulin, and MDA levels.

Hubungan pola asuh dengan kejadian stunting balita dari keluarga miskin di Kota Palembang Bella, Febriani Dwi; Fajar, Nur Alam; Misnaniarti, Misnaniarti
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 8, No 1 (2019)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background: Nutritional problems do not always occur in poor families, in fact many of under five years in poor families in good nutritional status which have normal height (not stunting) based on the parenting in the family. The positive parenting in poor families are feeding habit, parenting habit, hygiene habit and health services habit. Objectives: This research aim to observe the parenting of feeding habits, parenting habits, hygiene habits and health services habits on the incidence of toddlerâ€™s stunting on poor families in the city of Palembang.Methods: This research was an observational study which using a quantitative approach with a Cross Sectional Study design. It took 100 mothers who have children aged 24-59 months from poor families in the city of Palembang were chosen by proportional random sampling.Data taken regarding feeding habits, parenting habits, hygiene habits, and health services habits obtained through questionnaires, and the incidence of child stunting obtained from measurements of children's height using a toddler's height measurement tool. Data analysis to observe the relationship between variables using the Chi-Square test.Results: The results showed the proportion of toddler stunting in poor families in the city of Palembang was 29%. There was a significant correlation between feeding habits (p-value = 0.000); parenting habits (p-value = 0.001; hygiene habits (p-value = 0.021) and health services habits (p-value = 0.000) on the incidence of toddlerâ€™s stunting.Conclusion: Normal height (not stunting) toddlers have positive deviance of feeding habits, parenting habits, hygiene habits and health services habits better than stunting under five years with same economic backgrounds family

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Kota semarang,

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INDONESIA