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INDONESIA
Indonesian Journal of Medicine
Published by Universitas Sebelas Maret
ISSN : -     EISSN : 25490265     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.
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Articles 12 Documents
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Search results for , issue "Vol 4, No 3 (2019)" : 12 Documents clear
Effect of Early Spironolactone on the ST2 Level and Clinical Changes in Acute Decompensated Heart Failure Patients Wasyanto, Trisulo; Mufidah, Atik
Indonesian Journal of Medicine Vol 4, No 3 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: In spite ofmajor advances in therapy, morbidity, and mortality due to acute decom­pen­sated heart failure (ADHF) remain poor. Early initiation of mineralocorticoid antagonist (spironolactone) may increase the suppression of negative effect of renin-angiotensin-aldosterone system (RAAS) activation, even though it already uses ACEI/ARB accompanying ADHF and give a better outcome. This study aims to determine the effect of early spironolactone 100 mg a day for 3 consecutive days on the suppression of tumorigenicity 2 (ST2) level and clinical changes in patients with ADHF.Subjects and Method: This was a randomized single blind controlled trial. Thirty eight conse­cutive patients with ADHF hospitalized at Dr. Moewardi Hospital, Surakarta were randomized into two groups: spironolactone group (standard therapy plus spironolactone 100 mg per day for 3 day, n=19) and control group (standard therapy, n=19). Clinical sign and simptom of ADHF was monitored everyday and the difference of clinical changes was evaluated at the day-3. Venous blood samples were collected from all patients at the first day prior therapy and day-4 after therapy. The dependent variable was ST2 level. The independent variable wasSpironolacton therapy. The data were analyzed by independent t-test.Results: Decreased levels of ST2 in the spironolactone group (mean= 36.96; SD= 21.29) was higher than the control group (mean= 19.73; SD= 16.48) and it was statistically significant (p= 0.008). Spironolacton therapy 100 mg once daily at the first 3 day in patient with ADHF was safe, no hiperkalemia, or worsening renal function. There was decreasing risk of hipokalemia up to 33% (RR= 0.33; 95% CI= 0.1 to 1.0; p= 0.036) and greater proportion patient with improvement clinical simptom and sign of ADHF at day-3 in the spironolactone group vs control group.Conclusion: Administration of spironolactone 100 mg at the first 3 day plus standard therapy decreases levels of ST2, safe, decreases risk of hipokalemia and give greater proportion of clinical improvement patients ADHF.Keywords: Spironolactone, ADHF, ST2Correspondence: Trisulo Wasyanto. Department of Cardiology and Vascular Medicine, Faculty of Medicine, Uni­versitas Sebelas Maret/Dr. Moewardi Hospital. Jl. Kol. Sutarto 132, Surakarta 57126. Indonesia. Email: trisulo.wasyanto@gmail.com. Indonesian Journal of Medicine (2019), 4(3): 232-240https://doi.org/10.26911/theijmed.2019.04.03.06
Yoga Increases the Quality of Sleep in Menopause Women Fara, Yetty Dwi; Pujiastuti, Rr. Sri Endang; Hadisaputro, Suharyo
Indonesian Journal of Medicine Vol 4, No 3 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Menopausal women expe­rience various changes, physical, psycho­logical, and hormonal changes that cause menopausal symptoms. During menopause, women experience sleep disorders and some experience insomnia. Lifestyle changes are one way to reduce menopausal symptoms, such as physical activity. Physical activities such as yoga can stimulate a relaxation response both physically and psychologically that can reduce physical and psychological symptoms in menopausal women. The aim of this study was to examine the effect of yoga interventions on the sleep quality of menopausal women.Subjects and Method: This was a quasi-experiment with a non-equivalent control group design. The study was conducted in the Gedawang-Banyumanik area, Semarang, Central Java. A total of 22 study subjects was collected by purposive sampling. The dependent variable was the quality of sleep. The independent variable was yoga. The quality of sleep was measured using the Pittsburgh Sleep Quality Index (PSQI).Results: Poor quality of sleep score decreased by 10.73 after yoga intervention (95% CI= -4.30 to -0.26; p= 0.029).Conclusion: Yoga interventions improve the quality of sleep in menopausal women.Keywords: quality of sleep, yoga, menopausal womenCorrespondence: Yetty Dwi Fara. Midwifery Program, School of Health Polytechnics Semarang. Jl. Tirto Agung Pedalangan, Banyumanik, Semarang, Central Java, 50239. Email: yettydwifara@gmail.com. Mobile: 085279545189.Indonesian Journal of Medicine (2019), 4(3): 278-284https://doi.org/10.26911/theijmed.2019.04.03.11
Para-aortic and Meningitis Tuberculosis: A Case Report Reviono, Reviono; R, Sari Apriliana; Sutanto, Yusup Subagio; Soetejo, FX; Subandrio, Subandrio
Indonesian Journal of Medicine Vol 4, No 3 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: In 2018, Indonesia was in third place as the country with the highest incidence of tuberculosis (TB) in the world. In addition to pulmonary TB, extrapulmonary TB cases are also quite large. Lymphadenitis of the aortic TB can cause a fatal risk if not treated immediately. This study aimed to explore the para-aortic and meningitis tuberculosis case in Klaten Hospital, Central Java.Case presentation: There was a 24-year-old woman with complaints of missing chest pain for 2 months, fear of seeing light (photophobia), and decreased consciousness. The patient was a referral from Klaten Hospital with a diagnosis of a mediastinal tumor. The chest radiograph shows a picture of homogeneous opacity in the anterior mediastinum. Bronchoscopy results show compression stenosis in 1/3 distal and blunt carina. After a sternotomy, it was obtained pus (pus) and tissue granuloma in the area of the aorta. After the rapid molecular test was carried out, the results showed that M tuberculosis detected. The results of histopathology of anatomical pathology show epitheloid tubercle and Datia Langhans cells that suggest an infection with M. tuberculosis. Therapy was done by giving a standard anti-tuberculosis drug, namely Rifampicin 450 mg, INH 300 mg, Ethambutol 1000 mg, and Pyrazinamide 1000 mg. The patient's condition improved marked by weight gain in 2 months.Conclusion: In the case of pulmonary masses (mediastinal tumors), we need to be aware of the possibility of cases of TB lymphadenitis because Indonesia is a country with a high prevalence of TB. This is because a slow diagnosis can lead to life-threatening conditions Keywords: Tuberculosis, para aorta lymphadenitis, meningitis TB, tumor mediastinum, sternotomyCorrespondence: Reviono. Department of Pulmonology and Medical Respiration, Universitas Sebelas Maret Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: reviono@staff.uns.ac.id. Mobile: +6281­8474671.Indonesian Journal of Medicine (2019), 4(3): 201-210https://doi.org/10.26911/theijmed.2019.04.03.02
Blood Urea Nitrogen as a Predictor of In-Hospital Mortality in Acute Coronary Syndrome Patients Wasyanto, Trisulo; Tridamayanti, Annisa
Indonesian Journal of Medicine Vol 4, No 3 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Acute coronary syndrome (ACS) is one of the major causes of morbidity and mortality worldwide. Thus, it is important to effectively diagnose and determine prognosis and mortality risk. While criteria such as Thrombolysis in Myocardial Infarction (TIMI) and Global Registry of Acute Coronary Events (GRACE) score are clinically used to work out the prognosis of patients with ACS, the examination of Blood Urea Nitrogen (BUN) and creatinine alongside in predicting outcome may prove favorable as well. This study aimed to determine the efficacy of BUN and creatinine in mortality risk assessment of patients with ACS and to find which one is better.Subjects and Method: This was an analytical study with a cohort retrospective design included 1463 ACS patients in Dr. Moewardi hospital from January 2014 to July 2018. The relationship between admission BUN, creatinine level, and in-hospital mortality was analyzed with chi-square and logistic regression. Receiver Operating Characteristic (ROC) curve to determine which one better as a predictor of in-hospital mortality.Results: The mean age of patients was 60 years old (mean= 60.08; SD= 11.04), which 72.9% were men. From all sample, 232 (15.9%) patients were died. In binary log regression models, elevated BUN (>50 mg/dL) at admission was an independent predictor of in-hospital mortality (OR= 4.01; 95% CI= 1.0 to 7.0; p= 0.001). Similar results were obtained for elevated creatinine (>1.3 mg/dL) at admission (OR= 3.6; 95% CI= 2.2 to 5.8; p= 0.031). ROC curves showed that area under the curve (AUC) of BUN (0.87) was higher than AUC of creatinine (0.61).Conclusion: Elevated BUN and creatinine are independent predictors of in-hospital mortality in ACS patients. A high-level of BUN at admission is a more accurate predictor of in-hospital mortality than creatinine.Keywords: blood urea nitrogen, creatinine, acute coronary syndromeCorrespondence: Trisulo Wasyanto. Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi Hospital. Jl. Kol. Sutarto 132, Surakarta 57126. Indonesia. Email: trisulo.wasyanto@gmail.com.Indonesian Journal of Medicine (2019), 4(3): 241-251https://doi.org/10.26911/theijmed.2019.04.03.07
The Potential Effect of Thymol from Black Seed Extract (Nigella Sativa) on Inhibiting the Growth of Candida albicans (Laboratory Studies in Leucorrhea Culture) Thaariq, Nurul Aziza Ath; Hadisaputro, Suharyo; Supriyana, Supriyana
Indonesian Journal of Medicine Vol 4, No 3 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Leucorrhea is a complaint of reproductive health problems that are often expe­rienced, 83% of cases are caused by Candida albicans. Candida albicans resistance to fluconazole (2.9%) and itraconazole (5.4%), so that antifungals from plant screening are safer and able to inhibit the growth of Candida albicans. This study aimed to explain the potential of thymol compounds in black cumin seed extract (Nigella sativa) various concentrations can inhibit the growth of Candida albicans.Subject and Method: This was a randomized controlled trial. The study sample was Candida albicans culture divided into 5 groups. The dependent variable was the growth of Candida albicans. The independent variable was thymol compounds of black cumin seed extract. The growth of Candida albicans was measured by calipers. The data were analyzed by one way ANOVA and post hoct.Results: Thymol 12.5% lowered the growth of Candida albicans 9.20 (mean= -9.20; p<0.001).Conclusion: Thymol compounds of black cumin seed extract has the potential as an alternative treatment for leucorrhea.Keywords: thymol, black seeds, Candida albicansCorrespondence:Nurul Aziza Ath Thaariq. Master of Applied of Midwifery, Health Polytechnics Ministry of Health Semarang. Jl. Tirto Agung, Pedalangan, Banyumanik, Semarang 50239, Central Java. Email: naziza.aththaariq@gmail.com. Mobile: +6285869522220Indonesian Journal of Medicine (2019), 4(3): 285-292https://doi.org/10.26911/theijmed.2019.04.03.12 
Metformin/Glimepiride and Metformin/Glibenclamide, Which is Better?: A Systematic Review and Meta-Analysis Sukmawan, Yedy Purwandi
Indonesian Journal of Medicine Vol 4, No 3 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Type 2 diabetes mellitus (DM) is associated with the microvascular and macrovascular complication. Metformin and sulphonylurea (glimepiride and glibenclamide) combination is widely used for the treatment of type 2 DM. This study aimed to examine the difference of Metformin/Glimepiride and Metformin/Glibenclamide administrations in reducing HbA1C among type 2 DM patients.Subjects and Method: This was a systematic review and meta-analysis according to PRISMA guideline with PICO construction using MeSH and text-word. 214 article were identified from PubMed, Cochrane, other source databases. Two articles with 183 type 2 DM  patients were selected for this study.Results: No significant difference on HbA1C level, fasting plasma glucose, and hypoglycemia adverse events between glimepiride/metformin and glibenclamide/metformin combinations. However, glimepiride/metformin combination demonstrated lower HbA1C (-0.11; 95% CI= -0.41 to 0.18; p= 0.450) and lower hypoglycemia adverse events (OR= 0.52; 95% CI= -1.02 to 3.05; p= 0.450), while glibenclamide/metformin combination demonstrated lower fasting plasma glucose concentration (1.01; 95% CI= -1.02 to 3.05; p= 0.450).Conclusion: Glimepiride/metformin combination is preferable in HbA1C lowering and hypoglycemia risk than glibenclamide/metformin combination.Keywords: Glimepiride-metformin, Glibenclamide-metformin, type 2 diabetes mellitusCorrespondence: Yedy Purwandi Sukmawan. Department of Clinical Pharmacy and Pharmacology, Institute of Health Science of Bakti Tunas Husada Tasikmalaya, West Java, Indonesia. Email: yedipur@­gmail.comIndonesian Journal of Medicine (2019), 4(3): 211-218https://doi.org/10.26911/theijmed.2019.04.03.03
Path Analysis of the Effect of Waist-Pelvic Circumference, Body Mass Index, and Abdominal Circumference on the Occurrence of Prediabetes Loekito, Cindy Lestyani; Murti, Bhisma; Pamungkasari, Eti Poncorini
Indonesian Journal of Medicine Vol 4, No 3 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Diabetes mellitus is an important health problem in the world. Pre-diabetes is a state of blood sugar levels above normal but below the criteria for diabetes. American Diabetes Association (ADA) uses criteria for hemoglobin A1C (HbA1C) levels of 5.7% to 6.4% to define pre-diabetes. The prevalence of pre-diabetes was the highest in overweight individuals. In many studies, body fat levels were assessed by indicators of waist-pelvic circumference, abdominal circumference, and BMI. Among the three, it is still a debate which is more influential on the condition of pre-diabetes. The purpose of this study was to determine the effects of waist-pelvic circumference, BMI, and abdominal circumference in pre-diabetes.Subjects and Method: A cross-sectional study was conducted at Prodia Clinic, Surakarta, Central Java, from January to March 2019. A sample of 200 study subjects was selected by fixed disease sampling. The dependent variable was pre-diabetes. The independent variables were the waist-pelvic circumference, BMI, and abdominal circumference. The data on HbA1C was measured by NGSP standardized ion-exchange HPLC method. The data were analyzed by path analysis.Results: Abdominal circumference >90 cm in men and >80 cm in women (b= 0.87; 95% CI= 0.23 to 1.51; p= 0.008) and age ?45 years old (b = 1.70; 95% CI = 0.93 to 2.46; p <0.001) were directly increased pre-diabetes. Pre-diabetes was indirectly affected by waist?pelvic circumference, gender, and obesity.Conclusions: Abdominal circumference >90 cm in men and >80 cm in women and age ?45 years old are directly increased pre-diabetes. Pre-diabetes is indirectly affected by waist?pelvic circum­ference, gender, and obesity.Keywords: prediabetes, abdominal circumference, waist-pelvic circumference, body mass indexCorrespondence: Cindy Lestyani Loekito. Masters Program in Nutrition, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: cindy.l.l@student.uns.ac.id. Mobile:082134424950.Indonesian Journal of Medicine (2019), 4(3): 252-258https://doi.org/10.26911/theijmed.2019.04.03.08
Association between Carbohydrate, Vitamin C, Vitamin E, and HBA1C Level Andarwati, Dwi Astuti Dian; Murti, Bhisma; Sulaeman, Endang Sutisna
Indonesian Journal of Medicine Vol 4, No 3 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Diabetes is now a disease that is a major concern both globally and regionally and is the leading cause of death in most countries. HbA1c levels are used to measure long-term glucose levels in patients with type 1 and 2 Diabetes Mellitus (DM). Restrictions on carbohydrate diets have the greatest effect on decreasing blood glucose levels. Nutritional interventions with the provision of vitamin C and vitamin E can reduce inflammation and oxidative stress as a strategy to prevent the occurrence of DM. The purpose of this study was to determine the relationship of carbohydrate intake, vitamin C and vitamin E with HbA1c levels.Subjects and Method: This was a cross-sectional study conducted at Prodia Surakarta Clinic, Surakarta, Central Java, Indonesia. A sample of 150 study subjects was selected by fixed disease sampling. The dependent variable was HbA1c level. The independent variables were carbohydrate and vitamin E. The data were collected by questionnaire and 24-hour food recall. The data were analyzed by multiple logistic regression.Results: High carbohydrate intake increased HbA1c level (OR= 2.84; 95% CI= 0.72 to 11.12; p= 0.133), while high intake of vitamin E lowered HbA1c level (OR= 0.12; 95% CI= 0.02 to 0.64; p = 0.012).Conclusion: High carbohydrate intake increases HbA1c level, while high intake of vitamin E decreases HbA1c level.Keywords: diabetes, HbA1c, karbohidrat,  vitamin C.Vitamin ECorrespondence: Dwi Astuti Dian Andarwati. Masters Program in Nutrition, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: dianandarwati@yahoo.com. Mobile: 0813­29588344.Indonesian Journal of Medicine (2019), 4(3): 219-227https://doi.org/10.26911/theijmed.2019.04.03.04  
Correlation between Obesity and Contraceptive Method on Estrogen and Progesterone Receptors and Human Epidermal Growth Factor Receptor–2 Expression among Breast Cancer Patients in Dr. Moewardi Hospital, Surakarta Agustina, Silvia Ari; Barokah, Liberty
Indonesian Journal of Medicine Vol 4, No 3 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Breast cancer is the number 2 cancer in Indonesia after cervical cancer. Breast cancer increases every year. The formation of breast cancer is stimulated by various factors such as obesity and a history of family planning. In breast cancer, there are three important receptors, namely estrogen (ER) receptors, progesterone receptors (PR), and HER-2/Neu. The purpose of this study was to determine the association of obesity and history of family planning with the estrogen hormone receptor (ER), progesterone hormone receptor (PR), and HER-2/Neu expression in breast cancer patients in the dr. Moewardi Hospital in Surakarta, Central Java.Subjects and Method: This was an analytic observational study carried out at Dr. Moewardi Hospital, Surakarta, Central Java. A sample of 117 pre- and post-menopausal women who performed examinations at the oncology surgical clinic at Dr. Moewardi hospital, Surakarta was selected by total sampling. The dependent variables were estrogen and progesterone receptors and HER-2/Neu expressions. The independent variables were obesity and history of contraceptive method. Data were obtained from the medical record and analyzed by multiple logistic regression.Results: Obesity (OR= 0.29; 95% CI= 0.13 to 0.68; p= 0.004) reduced estrogen hormone receptors and it was statistically significant. History of contraceptive method (OR= 1.18; 95% CI= 0.55 to 2.52; p= 0.680) increased estrogen hormone receptors but it was not statistically signi­ficant. Obesity (OR=0.41; 95% CI= 0.18 to 0.96; p= 0.040) and history of contraceptive method (OR= 0.41; 95% CI= 0.19 to 0.88; p= 0.022) reduced progesterone hormone receptors. Obesity and history of contraceptive method increased Her-2/Neu expression.Conclusion: Obesity reduces estrogen hormone receptors. History of the contraceptive method increases estrogen hormone receptors. Obesity and history of contraceptive method reduce pro­gesterone hormone receptors. Obesity and history of contraceptive method increase Her-2/Neu expression.Keywords: Obesity, contraceptive method, estrogen, progesterone hormones, Her-2/neuCorrespondence: Silvia Ari Agustina. Study Program in Midwifery, School of Health Sciences Achmad Yani, Yogya­karta. Jl. Ringroad Barat Ambarketawang, Gamping, Sleman, Yogyakarta. Phone: (0274) 4342000. Email: silvia_ari99@yahoo.com. Indonesian Journal of Medicine (2019), 4(3): 259-265https://doi.org/10.26911/theijmed.2019.04.03.09
Factors Affecting Ankle Functional Scores at Spastic Diplegia Cerebral Palsy Patients that Have Been Performed Single Event Multi Level Surgery Andryanto, Aryo Budiyogo; Satriadi, Anung Budi; Idulhaq, Mujaddid
Indonesian Journal of Medicine Vol 4, No 3 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Single Event Multi Level Surgery (SEMLS) is the treatment most often used to correct deformities and functional in children with Spastic Diplegic Cerebral Palsy. There is no research in Indonesia that assesses the ankle function in patients with Spastic CP Diplegic has done SEMLS. The purpose of this study was to determine the influence of age, gender and time period after surgery with functional ankle patients with CP Spastic Diplegic that has been done SEMLS in the RSO. Prof. Dr. R. Soeharso Surakarta (RSO).Subjects and Method: This study was a cross sectional study in 43 patients (25 male and 18 female) patients with Spastic Cerebral Palsy Diplegia that has been done SEMLS in pediatric orthopedics clinic RSO. Prof.dr.R.Soeharso Surakarta at least 3 months postoperatively, since January 1st 2013 to December 31st 2014. We assessed ankle function using the Oxford Ankle Foot Questionnaire for Children. From the results of the questionnaire we value outcomes as a percentage and we regrouped into 4 groups: value of 91% - 100% for excellent value, 81% - 90% for good, 71% - 80% for fair and if less than 70% for poor. Then we did impact assessment for age, sex and time of the postoperative with functional ankle score of patients with examination of linear regression model analysis.Results: There were 52 patients with Spastic CP Diplegi have done SEMLS but only 43 patients who qualified the inclusion criteria, the youngest patient was 5 years old and the oldest 15 years old with a mean age of 8.3 years. From the 43 patients, 25 are men and 18 were women. Postoperative time with the fastest time of observation was 5 months and the longest was 26 months with a mean of 14.3 months postoperatively SEMLS. From the 43 patients there are 11 patients (25%) function are excellent, 21 patients (49%) are good, 8 patients (19%) are fair, and 3 (7%) are poor. Age factor significantly influence the functional ankle score (p = 0.013) and postoperative time factors also significantly influence the functional score Ankle with (p = 0.04). While gender has no effect on the functional ankle score (p= 0.266).Conclusion: Paediatri Orthopaedic clinic at RSO. Prof. Dr. R. Soeharso has succed treated patients with CP Spastic Diplegic that have performed SEMLS. Age and time of postoperative significantly influence the functional ankle score in patients with CP Spatik Diplegic that have been done SEMLS. While the sex of the patients had no effect on the functional ankle score in patients with CP Spastic Diplegic that have been done SEMLS.Keywords: RSO Prof. Dr. R. Soeharso, CP Spastic Diplegic, SEMLS, Ankle Functional ScoreCorrespondence: Aryo Budiyogo Andryanto. Student of Orthopaedic and Traumatology school of Medicine, Sebelas Maret University, Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java.Indonesian Journal of Medicine (2019), 4(3): 228-231https://doi.org/10.26911/theijmed.2019.04.03.05

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