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INDONESIA
Indonesian Journal of Medicine
Published by Universitas Sebelas Maret
ISSN : -     EISSN : 25490265     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.
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Articles 8 Documents
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Search results for , issue "Vol. 10 No. 3 (2025)" : 8 Documents clear
Correlation Between Analgesic Administration, Depression, and Knee Osteoarthritis Severity in Elderly Gutomo, Arthur Marc; Kusumaningrum, Sulistyani; Budiningsih, Fatichati; Werdiningsih, Yulyani
Indonesian Journal of Medicine Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.3.772

Abstract

Background: Chronic diseases in the elderly, including osteoarthritis (OA), impact quality of life and can lead to depression. Pain caused by knee osteoarthritis may trigger stress and depression, while depression can worsen pain perception and disability. This study aimed to analyze the correlation between analgesic use, depression, and the severity of knee osteoarthritis in elderly patients. Subjects and Method: A cross-sectional study was conducted at Dr. Moewardi Hospital, Surakarta, using medical records of 99 elderly patients diagnosed with primary knee osteoarthritis between January 2018 and January 2024. Analgesic administration data were obtained from prescription records. Depression levels were assessed using the Geriatric Depression Scale (GDS), while the severity of osteoarthritis was evaluated using the Kellgren and Lawrence radiological classification. Data were analyzed using the Spearman correlation test. Results: Analgesic administration was negatively associated with depression (OR= 0.09; 95% CI= 0.03 to 0.32; p<0.001) and severity of knee OA (OR= 1.91; 95% CI= 0.60 to 6.08; p<0.001). Severity of knee OA was positively associated with depression (OR= 0.18; 95% CI= 0.05 to 0.62; p<0.001). Conclusion: Analgesic administration is negatively associated with depression and severity of knee OA. Severity of knee OA is positively associated with depression.
Risk Factors Associated with Elderly Diabetes Patients Khuluq, Husnul; Fitri, Dwiki; Miyarso, Condrosuro; Winarno, tunjung
Indonesian Journal of Medicine Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.3.775

Abstract

Background: Diabetes mellitus is a chronic disease with increasing global prevalence, including in Indonesia. Among the elderly, its management is more complex due to age-related physiological changes and comorbidities. This study aimed to identify and analyze risk factors associated with diabetes in the elderly population. Subjects and Method: This retrospective cross-sectional study analyzed medical records of 1,634 inpatients with type 2 diabetes mellitus at PKU Muhammadiyah Hospital Yogyakarta from January 2021 to July 2023. Total sampling was used. Data on demographics, comorbidities, and laboratory values were analyzed using Chi-square test. Results: Of 1,634 patients, 853 (52.52%) were aged >65 years. Significant risk factors associated with elderly diabetes included elevated erythrocytes (OR= 1.60; 95% CI= 1.32–1.96; p <0.001), urea (OR= 1.51; 95% CI= 1.23–1.86; p <0.001), lymphocytes (OR= 1.26; 95% CI = 1.04–1.53; p= 0.020), hemoglobin (OR= 1.38; 95% CI = 1.14–1.68; p <0.001), systolic blood pressure (OR= 1.33; 95% CI= 1.07–1.65; p= 0.009), stroke (OR= 1.59; 95% CI = 1.09–2.32; p= 0.016), creatinine (OR= 1.24; 95% CI= 1.02–1.51; p= 0.028), and hypertension (OR= 1.29; 95% CI = 1.03–1.63; p= 0.028). Conversely, cholesterol (OR= 0.89; 95% CI= 0.65–1.23; p<0.001), and glucose (OR= 0.65; 95% CI= 0.51–0.83; p <0.001) were inversely associated. Conclusion: Elderly diabetes is significantly associated with multiple clinical and laboratory indicators. These findings highlight the importance of comprehensive monitoring to improve elderly diabetes management.
A Rare Case of Newly Acquired Hemophilia Following Diabetic Ketoacidosis in A Male Patient with IL-2 (Rs2069762) Polymorphism Muhammad, Faizal; Arthareza, Adhelia Galuh Permatasari; Marwanta, Sri
Indonesian Journal of Medicine Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.3.832

Abstract

Background: Diabetes is commonly linked to autoimmune processes, but acquired hemophilia A (AH)—a rare bleeding disorder due to factor VIII (FVIII) inhibitors—remains uncommon, particularly during diabetic ketoacidosis (DKA). Recent studies have suggested a role of IL-2 (rs2069762) polymorphism in FVIII inhibitor development. This study aims to highlight a rare case of newly acquired hemophilia coinciding with DKA and the presence of IL-2 gene polymorphism. Case Presentation: A 40-year-old male presented with dyspnea, abdominal pain, and signs of DKA. He had a history of drug-induced rash due to sulfasalazine. Initial management with IV fluids and insulin resolved the metabolic crisis. However, on day two, he developed spontaneous bruising and gross hematuria. Laboratory tests revealed a low FVIII inhibitor titer (1.2 BU) and positive insulin antibodies. Genetic testing showed TT homozygous polymorphism of IL-2 (rs2069762), potentially contributing to FVIII inhibitor formation. Results: The patient was treated with low-dose cyclophosphamide and methylprednisolone, followed by rituximab due to poor initial response. Intensive insulin therapy was also administered. After five weeks, clinical remission of AH was achieved, although the patient remains at risk for relapse due to the IL-2 polymorphism. Conclusion: This case illustrates a rare interplay between DKA and acquired hemophilia, potentially mediated by IL-2 (rs2069762) polymorphism. Prompt diagnosis and individualized immunosuppressive therapy are essential. The findings support further investigation into genetic predispositions in AH pathogenesis during autoimmune or metabolic stress events like DKA.
Effect of Preoperating Maltodextrin 12.5% Carbohydrate Drink on High Sensitive C Reactive Protein Levels Post-Brachytherapy Purwoko, Purwoko; Arianto, Ardana Tri; Putra, Eka Satrio; Purnomo, Frederick Johan
Indonesian Journal of Medicine Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.3.853

Abstract

Background: Brachytherapy is radiation therapy that will cause inflammation and tissue damage that leads to inflammation, characterized by the release of pro-inflammatory cytokines, including hs-CRP levels in the plasma. Preoperative administration of glucose solution is known to reduce the increase in cortisol, and is thought to reduce postoperative hs-CRP levels. So far there has been no research that specifically examines the effect of preoperative carbohydrate administration on hs-CRP values after brachytherapy. This study aims to determine the effect of preoperative carbohydrate administration on post-brachytherapy hs-CRP values. Subjects and Method: This study was designed a double-blind randomized controlled trial was conducted at the Radiotherapy Unit of Dr. Moewardi General Hospital, Surakarta, from April to September 2022. Sixty-four cervical cancer patients with ASA physical status I or II undergoing brachytherapy under general anesthesia were recruited using consecutive sampling. Participants were randomly assigned into two groups: an intervention group receiving 12.5% maltodextrin solution and a control group receiving mineral water. The independent variable was preoperative carbohydrate administration, and the dependent variable was hs-CRP level measured 2 hours before and 4 hours after brachytherapy. Data were analyzed using paired t-test Results: Post-brachytherapy hs-CRP levels were significantly lower in the treatment group (mean = 2.565 ± 2.0 mg/dL) compared to the control group (mean = 3.69 ± 2.58 mg/dL; p = 0.019). Both groups showed significant increases in hs-CRP from pre- to postoperative values (p < 0.001). The change in hs-CRP (Δhs-CRP) was also significantly lower in the treatment group (p = 0.025). Conclusion: The administration of maltodextrin was able to significantly reduce post-brachytherapy hs-CRP levels compared to placebo.
Giant Cell Tumor of the Metacarpal and Its Intervention to Preserve Joint Function: A Case Report Ericsen Tiondi Putra; Kusuma, Yudha Eka; Calvin, Calvin
Indonesian Journal of Medicine Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.3.854

Abstract

Background: Giant cell tumor (GCT) is one of the most common benign bone tumors, but it has a high recurrence rate and is aggressive. It can occur elsewhere, but frequently in the distal femur and proximal tibia. The goal of treatment is to remove the tumor cells and maintain the metacarpophalangeal function. Various modalities exist to remove the tumor cells from curettage, wide excision, radical excision, or amputation. Reconstruction following the removal of tumor cells also varied by using graft, bone cement, prosthesis, or arthrodesis. There are no definitive guidelines to determine which modalities are the best, especially in unusual sites. In this case report, we present an unusual site of GCT in the second metacarpal, and clinical outcomes after the 1-year final follow-up were nearly normal. Case Presentation: A 22-year-old female presented to the hospital with a history of a lump and intermittent pain in the right hand for 2 years. Physical examination and radiograph suspected an unusual site of GCT and no cartilage involvement. A core biopsy was taken, and a GCT was confirmed. Wide excision, preserving the native joint of the metacarpal, and reconstruction using autologous non-vascularized fibular graft with the help of K-wire and adjuvant of hydrogen peroxide. Results: Constant improvement of clinical outcomes post-operatively with Michigan Hand Outcomes Questionnaire (MHQ) score was nearly normal, and there was no sign of recurrence at 6-month follow-up. Conclusion: Our report suggests that wide excision and reconstruction by fibular struts with a preserved native metacarpal joint, followed by hydrogen peroxide as an adjuvant and K-wire as a fixator, could be used as a combination therapy with good results.
Analysis Factor Which Relate With Complaint Musculoskeletal disorders (MSDs) At the Asahan Regency Education Office Employees Hasibuan, Arini Salsabila; Harahap, Reni Agustina; Utami, Tri Niswati
Indonesian Journal of Medicine Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.3.868

Abstract

Background: One of the major occupational health problems that can arise due to ergonomic risk is musculoskeletal disorders (MSDs). Office workers are among those most susceptible to chronic musculoskeletal health issues. This study aimed to identify factors associated with MSDs among employees of the Asahan District Education Office. Subjects and Method: This study was conducted at the Asahan District Education Office from December to January 2025. A descriptive quantitative analysis using a cross-sectional design was applied. The total population was 71 employees, and total sampling was used. Data were analyzed statistically using the Chi-square test. Results: There were significant associations between age (Mean=1.86; SD=0.350; p=0.004), work duration (Mean=1.65; SD=0.481; p=0.001), BMI (Mean=1.46; SD=0.502; p=0.001), and exercise habits (Mean=1.35; SD=0.481; p=0.001) with MSD complaints. However, gender (Mean=1.39; SD=0.492; p=0.683) was not significantly associated with MSDs. Conclusion: Four factors were significantly associated with MSD complaints. These findings can serve as a reference for institutions to improve ergonomic intervention and prevention efforts, such as mandating employees to participate in morning exercise activities every Friday.
Antidiabetic and Anti-inflammatory Effects of Peperomia pellucida Leaf Extract: Modulation of Blood Glucose, IL-1β, and Pancreatic Histopathology in STZ-Induced Diabetic Rats Oktavia, Ria; Anto, Endy Juli; Siahaan, Jekson Martiar
Indonesian Journal of Medicine Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.3.870

Abstract

Background: Diabetes mellitus (DM) is a significant global health challenge with a rapidly increasing prevalence. Although synthetic antidiabetic drugs remain the standard treatment, long-term use often leads to adverse side effects, prompting exploration of natural alternatives. This study investigated the therapeutic potential of ethanol extract of Peperomia pellucida (L.) Kunth leaves in diabetes management through comprehensive assessment of glycemic control, inflammatory marker (IL-1β), and pancreatic tissue histopathology. Subjects and Method: Thirty male Wistar rats were randomized into five groups (n=6): normal control, negative control (STZ-induced), positive control (STZ+metformin 50 mg/kg BW), and two treatment groups receiving Peperomia pellucida extract at doses of 40 mg/kg BW and 80 mg/kg BW, respectively. After 7 days of treatment, blood glucose levels, serum IL-1β concentrations, and pancreatic histopathology were evaluated. Phytochemical screening was conducted to identify bioactive compounds in the extract. Results: Phytochemical analysis confirmed the presence of alkaloids, flavonoids, tannins, saponins, and phenolics. Blood glucose measurements showed significant intergroup differences on day 0 (p<0.001) and day 7 (p<0.001). The 80 mg/kg BW extract group showed a reduction in blood glucose from day 0 (Mean=312.83; SD=40.92) to day 7 (Mean=281.00; SD=34.86). IL-1β serum analysis revealed significant differences among groups (p<0.001), with lower IL-1β levels observed in extract-treated groups compared to the negative control. Histopathological examination demonstrated improved pancreatic tissue structure in extract-treated groups, especially at higher doses. Conclusion: Ethanol extract of Peperomia pellucida (L.) Kunth leaves exhibits promising antidiabetic and anti-inflammatory properties in STZ-induced diabetic rats, as evidenced by reduced blood glucose, decreased IL-1β levels, and improved pancreatic histology. These findings suggest that Peperomia pellucida (L.) Kunth is a potential candidate for the development of natural therapies for diabetes management.  
Factors Influencing Events Dysfunction Cognitive Post Operation on Patient Elderly: Systematic Review Kusuma, Ratna; Veibiani, Nindita Arum
Indonesian Journal of Medicine Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.3.871

Abstract

Background: : Improvements in global life expectancy have led to a significant increase in the elderly population, which in turn results in a growing number of elderly patients undergoing surgery. This condition raises the risk of postoperative complications, such as postoperative cognitive dysfunction (POCD). POCD can reduce quality of life, prolong the length of hospital stay, and increase mortality. This study aims to identify and synthesize the factors that influence the occurrence of POCD in elderly patients. Subjects and Method: This study is a Systematic review with PICO. The article used in research were obtained from several databased including Google Scolar, Scopus, and PubMed Keywords to find articles are "postoperative cognitive dysfunction," "elderly patients," and "geriatrics". This articles used are failing to directly discuss risk factors for postoperative cognitive dysfunction in elderly patients, or identified as opinion pieces, conference abstracts without full text, or narrative reviews, will be excluded. Articles were selected using PRISMA flow diagram. Results: a total 8 articles reviewed in Systematic Review showed that The incidence of POCD in the elderly shows significant variation between studies, ranging from 8.33% to 37.7% . Risk factors that have been consistently identified as having a significant influence on the incidence of POCD include advancing age, low level of education, number of comorbidities, high ASA score, long duration of anesthesia, intraoperative hypotension, history of cerebral infarction, and low oxygen saturation at induction. The use of certain anesthetic agents such as sevoflurane and midazolam has also been shown to increase the risk of POCD. Instead, use dexmedetomidine preoperative, analgesia preemptive and the combination of general anesthesia with epidural block were identified as protective factors. Conclusion: The main risk factors advanced age, education level, comorbidities, and type and duration of anesthesia.

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