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INDONESIA
Indonesian Journal of Medicine
Published by Universitas Sebelas Maret
ISSN : -     EISSN : 25490265     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.
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Articles 407 Documents
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Relationship between Family Support and Family Burden in Families With Cancer: Meta-Analysis Adyani, Sang Ayu Made; Jadmiko, Arief Wahyudi
Indonesian Journal of Medicine Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.2.613

Abstract

Background: Cancer is a chronic disease caused by abnormal cell growth with special care needs that cause a burden on the family. Family support can have a significant impact on family burden. Adequate support from family members can lighten the burden on individuals or families and improve their overall well-being. This study aimed to estimate the relationship between family support on family burden in families with cancer obtained from several previous similar studies.Subjects and Method: This research was conducted using a systematic review and meta-analysis with PICO namely, Population: family with cancer; Intervention: good family support; Comparison: Lack of family support; Outcome: family burden. By searching articles in 4 databases namely PubMed, Google Scholar, Science Direct, and ProQuest published from 2014 to 2022, entering the following keywords “Family support” OR “Supportive Family” AND “Family Burden” OR “Family depresssion” AND “Chronic Disease” AND “Cancer” AND “Multivariate Analysis”. Articles were selected using PRISMA flow and data analysis using the Review Manager 5.3 application.Results: There 9 articles using the Cross-Sectional study design with a total sample of 2,832 subjects from India, Japan, USA, Swiss, Austria, Yunani, Germany, and Mexico which have been subject to systematic review and meta-analysis. The results showed that good family support are effective in decreasing family burden, and the results are statistically significant. Families with cancer who receive good family support are decrease family burden 0.57 times than families with cancer receive lack family support (aOR= 0.57; 95% CI= 0.38 to 0.85; p= 0.006).Conclusion: Good family support are effective in decreasing family burden.Keywords: family support, family burden, chronic disease, cancer.Correspondence: Sang Ayu Made Adyani. Nursing Department, Faculty of Health, Universitas Pembangunan Nasional Veteran Jakarta. Jl. RS. Fatmawati Raya, Pd. Labu, Cilandak, Depok, West Java. Email: adyani.sangayu@upnvj.ac.id. Mobile: +62 819-3206-5946.Indonesian Journal of Medicine (2023), 08(02): 169-178https://doi.org/10.26911/theijmed.2023.08.02.06
Intrafracture Recombinant Platelet-Derived Growth Factor Improves Fracture Healing Process on Wistar Rat Aryana, I Gusti Ngurah Wien; Giri, Kadek Gede Bakta; Suyasa, I Ketut; Lestari, Anak Agung Wiradewi
Indonesian Journal of Medicine Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.2.615

Abstract

Background: Femoral fracture is associated with high morbidity and mortality, especially in young adults with high-energy injuries. Abnormal fracture healing presents as a significant matter in management of femoral fracture. Platelet Derived Growth Factor (PDGFBB) is proposed as potential agent in fracture healing. Up to this point, PDGF has been scientifically studied improve wound healing by enhancing fibroblast proliferation, extracellular matrix synthesis, and revascularization. This study aims to evaluate role of PDGF on fractured bone healing.Subjects and Method: This was a randomized controlled trial conducted at Animal and Biomedical Laboratory of Udayana University, from March to September 2022. 36 male and healthy Wistar Rats at 34 months old and weighs 140160 grams were selected for this study. The dependent variables were Allen score, type I and type III collagen levels. The independent variable was administration of 10 mcg PDGFBB following femoral osteotomy and intramedullary wire fixation. Type I and III collagen levels are assessed using ELISA methods. Statistical analysis is performed using independent T-test in SPSS ver 25.0 software.Results: Allen score in the PDGFBB group (Mean= 3.89; SD= 1.40) was higher than control group (Mean= 2.28; SD= 1.48), with p=0.002. Type I collagen in the PDGFBB group (Mean= 4.97; SD= 0.54) was higher than control group (Mean= 4.41; SD= 0.74), with p=0.014. Type III collagen in the PDGFBB group (Mean= 12.1; SD= 2.49) was higher than control group (Mean= 10.01; SD= 1.61), with p=0.005.Conclusion: In comparison to the nonPDGFBB group, Wistar rats that had their femurs osteotomized and joined with intramedullary wire in the PDGFBB group has higher mean of Allen score, type I and type III collagen levels.Keywords: femoral fracture, allen score, type I collagen, type III collagen, PDGFBBCorrespondence: IGN Wien Aryana, Consultant of Sports Medicine, Dept. Orthopaedic and Traumatology, Prof IGNG Ngoerah General Hospital, Faculty of Medicine, Udayana University. Jl. Diponegoro, Dauh Puri Klod. Denpasar City, Bali 80113. Email: wienaryanaortho@gmail.com. Mobile: +62811385263.Indonesian Journal of Medicine (2023), 08(02): 136141https://doi.org/10.26911/theijmed.2023.08.02.02
Correlations between Age and Hypertension on Diabetic Foot Ulcer Marsya, Vitania; Mahmuda, Iin Novita Nurhidayati; Lestari, Nining; Jatmiko, Safari Wahyu
Indonesian Journal of Medicine Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.2.622

Abstract

Background:  Diabetic foot ulcer is a wound located on the foot of a diabetic patient, which is related to peripheral neuropathy or arterial disease. Hypertension can be related to diabetic foot ulcer by its mechanism that caused peripheral artery disease. Age also can be the one of risk factors for diabetic foot ulcers, because aging occurs a reduction of insulin secretion, even insulin resistance. Insulin resistance occurs in macroangiopathy. The purpose of this study is to determine the correlation between age and hypertension with diabetic foot ulcers.Subjects and Method:  This was a cross-sectional study conducted at Arafah Islamic Hospital Rembang, Central Java. The dependent variable is diabetic ulcers. The independent variables were age and hypertension. A sample of diabetic patients using medical records from January 2022-June 2022. Data were collected using purposive sampling and analyzed using the Chi-Square test, and regression logistic test.Results:  Significant correlation was found between age (OR= 3.80; 95% CI= 1.38 to 10.57; p<0.001) and hypertension (OR= 8.12; 95% CI= 2.70 to 24.40; p<0.001) with a diabetic foot ulcer.Conclusion:  There is a significant correlation between age and hypertension with diabetic foot ulcers.Keywords:  age, hypertension, diabetes, diabetic foot ulcers.Correspondence:  Nining Lestari. Bachelor of Medicine, Muhammadiyah University of Surakarta. Jl. A. Yani, Mendungan, Pabelan, Kartasura, Sukoharjo 57162, Central Jawa, Indonesia. Email: nl209@ums.ac.id. Mobile: +62852-2939-0353Indonesian Journal of Medicine (2023), 08(02): 179-185https://doi.org/10.26911/theijmed.2023.08.02.07 
Green Synthesis of Silver Nanoparticles as a Wound Healing Agent: a Systematic Review of the Biological Activities Priambodo, Galih; Samekto, Widiastuti; Subagio, Agus; Susanto, Hardhono; Dwiantoro, Luky
Indonesian Journal of Medicine Vol. 8 No. 1 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.1.612

Abstract

Background:  The implication of nanotechnology includes silver nanoparticles to medical sciences, and has a revolutionary impact on therapeutic and diagnostics management. Many studies reported that silver nanoparticle (AgNPs) application can accelerate the wound healing process. This study aimed to systematically review the biological activities of silver nanoparticles as a wound-healing agent.Subjects and Method:  This article was a systematic review study conducted by searching for articles from online databases such as EBSCO, PubMed, Science Direct, and World Scientific. Populations: laboratory animals; Intervention: green synthesis of silver nanoparticles; Comparison: a standard ointment for wounds such as povidone-iodine, etc; Outcome: wound healing. The independent variable is the green synthesis of silver nanoparticles, and the dependent variable is wound healing. The inclusion criteria for this study were full articles using an experimental study, with the publication year until 2022. The data extraction was focused on the biological activities of silver nanoparticles and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations for systematic reviews.Results:  A total of 8 articles reviewed in this study were from countries: Egypt, India, Saudi Arabia, Singapore, and China. The green synthesis of AgNPs was accomplished using a natural aqueous extract from leaves such as Azadirachta indica, Tridax procumbens, the combinations of Catharanthus roseus and Azadirachta indica, Scutellaria barbata, the fungus Fusarium verticillioides, or cyanobacterial platforms (ex: Phormidium sp., Synechocystis sp, and arthrospira sp polysaccharides). All studies were animal-based experimental with wounds infected with bacteria and inflicted in regards to the experiment. All trials resulted in favor of the AgNPs ointment treated group compared to the untreated group or the standard ointment group.Conclusion:  Our review suggested that all studies about the efficacy of AgNPs as wound-healing therapy showed positive results.Keywords:  biological activities, silver nanoparticles, wound healing.Correspondence: Galih Priambodo. Faculty of Medicine, Universitas Diponegoro. Jl. Prof. Sudarto, Tembalang, Kec. Tembalang, Kota Semarang, Central Java. Email: g2_37@yahoo.co.id. Mobile: 085229998999.Indonesian Journal of Medicine (2023), 08(01): 100-113https://doi.org/10.26911/theijmed.2023.08.01.10
Meta-Analysis: Effectiveness of Scoliosis Brace to Reduce Scoliosis Curve Degree in Adolescent Idiopathic Scoliosis Marsim, Etanaulia; Prasetya, Hanung; Murti, Bhisma
Indonesian Journal of Medicine Vol. 8 No. 1 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.1.598

Abstract

Background: Adolescent Idiopathic Scoliosis (AIS) is a disorder of the spine that is curved laterally which includes rotation of the spine so that there is humpback on the ribs, which occurs in children aged 10-18 years. The use of a brace is an attempt to modify the mechanical shape and control the development of curves in the curvature of the spine by applying certain pressure points on the body. The purpose of this study was to determine the magnitude of the effect of using the scoliosis brace to reduce the degree of scoliosis in adolescents with idiopathic scoliosis.Subjects and Method: This study was conducted using a systematic review and meta-analysis study design using PICO, population: adolescent idiopathic scoliosis, intervention: using a scoliosis brace. comparison: not using a scoliosis brace, outcome: degree of scoliosis. The articles used in this study come from 3 databases, namely Google Scholar, PubMed, and Science Direct. With keywords including "Adolescent scoliosis" OR "scoliosis" AND "scoliosis brace" OR "brace" AND "degree of scoliosis" OR "Cobb Angle" AND "randomized control trial". The articles included in this study are full paper articles with experimental studies, research subjects of adolescent patients with scoliosis, articles published in the 2011-2021 period.Results: A meta-analysis was conducted on 10 primary randomized control trials conducted from Turkey, China, Canada, Switzerland, the United States, and Hong Kong, with a total sample size of 558. The meta-analysis concluded that adolescent patients with idiopathic scoliosis who received intervention The scoliosis brace had a lower grade of scoliosis 0.27 compared to adolescents who did not use the scoliosis brace, and the difference was statistically significant (SMD= -0.27; 95% CI= -0.45 to –0.09; p= 0.003).Conclusion: The use of a scoliosis brace can reduce the degree of scoliosis in adolescents with idiopathic scoliosis.Keywords: adolescent idiopathic scoliosis, scoliosis brace, cobb angleCorespondence: Etanaulia Marsim. Master’s Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: etanaulia@gmail.com. Mobile: +6285840530580.Indonesian Journal of Medicine (2023), 08(01): 12-22https://doi.org/10.26911/theijmed.2023.08.01.02
Effect of Hypnobreastfeeding on Fatigue and Motivation to Breastfeed in Post Partum Mothers Starting on Day 3 Watna, Ida; Ambarika, Rahmania; Peristiowati, Yuly
Indonesian Journal of Medicine Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.2.625

Abstract

Background: Fatigue is a condition in which individuals feel tired and reduce their physical and mental abilities and will not go away with rest. Mothers with postpartum fatigue have a higher risk of stopping breastfeeding. This study aimed to analyze the effect of hypno-breastfeeding on maternal fatigue and motivation for breastfeeding post-partum mothers starting on the 3rd day in the working area of the Arjasa Health Center.Subjects and Method: Research with a Pre-Experimental design was conducted at the Arjasa Health Center, Jember, East Java in January 2023. A total of 33 mothers were selected by cluster sampling. The dependent variable is the fatigue of the postpartum mother and the motivation for breastfeeding. The independent variable is the provision of hypno-breastfeeding. Data was collected using the PFS and BMIMS questionnaires. Data were analyzed using paired sample T-test.Results: Mother's fatigue before (Mean= 51.60; SD= 16.73) was higher than after (Mean= 36.06; SD= 7.45) given hypno-breastfeeding and was statistically significant (p<0.001). Mothers' motivation in breastfeeding after being given hypno-breastfeeding treatment (Mean= 85.96; SD= 4.64) was higher than before (Mean= 68.80; SD= 14.66), and statistically significant (p<0.001).Conclusion: Hypno-breastfeeding is effective in reducing fatigue and increasing motivation in breastfeeding post-partum mothers.Keywords: hypno-breastfeeding, postpartum mothers, fatigue, breastfeeding motivation.Correspondence: Ida Watna. Master's Program of Public Health, Strada Institute of Health Sciences, Indonesia. Jl. Manila No. 37, Tosaren, Kec. Islamic Boarding School, City of Kediri, East Java 64123. Email: danandeso79@gmail.com. Mobile: +62 823-3423-6376.Indonesian Journal of Medicine (2023), 08(02): 150-156https://doi.org/10.26911/theijmed.2023.08.02.04  
Epidemiological Analysis of Mental Health Disorders in Patients at Psychiatric Hospitals in the Special Region of Yogyakarta, Indonesia Rokhmayanti, Rokhmayanti; Rulianawati, Viandika; Astuti, Fardhiasih Dwi; Hastuti, Siti Kunia Widi; Rosyidah, Rosyidah; Desvita, Widea Rossi
Indonesian Journal of Medicine Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.2.640

Abstract

Background:  Mental disorder is a condition of decreasing all psychiatric conditions that result in deviant behavior. WHO estimates that one in eight people in the world lives with a mental disorder in the world. The COVID-19 pandemic that has occurred since 2019 has had an impact and has had a major impact on the mental health of people in the world and in Indonesia. The Special Region of Yogyakarta is the province with the highest cases of mental disorders in Indonesia based on the results of the 2013 and 2018 Basic Health Research (Riskesdas) surveys. The purpose of this study was to determine the epidemiological description of mental disorders per classification in inpatients at Mental Hospitals in the Special Region of Yogyakarta in 2019-2021.Subjects and Method:  This study used a quantitative descriptive method, sourced from secondary data from Mental Hospitals in the Special Region of Yogyakarta for the period 2019 - 2021. The population in this study was 4,413, with a total sample of 3,919. The inclusion criteria are data of inpatients with mental disorders recorded in the recapitulation of medical records of inpatients at the Mental Hospital for the period 2019 to 2021. Exclusion criteria are incomplete data. The sampling technique used is total sampling. The person variable consists of a classification of mental disorders, age, gender, education level, occupation, marital status, health insurance, and end of care. The instrument used in this research is a dummy table. Data from this study were analyzed descriptively by looking at the frequency and proportion of each variable studied.Results:  The results showed that the highest disease classification was F20-F29 (schizophrenia, schizotypal disorder, and delusional disorder) 76.72%. Most of them were aged 25-44 years (55.60%), male (61.55%), graduated from high school or equivalent (46.54%), did not work (66.90%), and were not married (57.29%). Most of them use national health insurance (62.95%), end of treatment with doctor's approval (97.86%), and length of stay ≤ 42 days (95.1%). Most of the patients came from Sleman Regency (37.25%) and from urban areas (71.37%).Conclusion:  Most patients with mental disorders are in productive age. People with mental disorders are an economic burden that must be borne by their families and the government. So there is a need for comprehensive prevention efforts to reduce the incidence of mental disorders in the community.Keywords:  mental disorders, epidemiological studies, schizophreniaCorrespondence: Siti Kurnia Widi Hastuti, Faculty of Public Health Universitas Ahmad Dahlan. Jl Prof Dr Soepomo Warungboto Umbulharjo, Special Region of Yogyakarta, Indonesia. Email: kurnia.widihastuti@ikm.uad.ac.id. Mobile: +62813-2843-3256.Indonesian Journal of Medicine (2023), 08(02): 204-218https://doi.org/10.26911/theijmed.2023.08.02.10
Effect of Cryotherapy Combined with William Flexion Exercise in Reducing Myogenic Low Back Pain Windiastoni, Yoga Handita; Basuki, Nur; Haritsah, Nurul Fithriati
Indonesian Journal of Medicine Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.2.641

Abstract

Background: Health problems related to daily activities can be experienced by individuals or groups. The most common complaint in the musculoskeletal system is low back pain. Low Back Pain according to the Ministry of Health of the Republic of Indonesia in 2018 means pain that is felt in the lower back area, between the lowest costal angle to the sacrum. The purpose of this study was to determine the effect of adding cold pack therapy to the William flexion exercise on reducing pain in myogenic LBP patients. Subjects and Method: This was an experiment study conducted at Dr. Moewardi Hospital, Surakarta, Central Java, in September 2022. A sample of 22 patients with myogenic low back pain was allocated into two groups. The dependent variable was pain. The independent variable was cryotherapy combined with William flexion exercise. Pain was measured using quadripel visual analogue scale. Mean between groups after intervention was analyzed using independent t test. Results: Mean of pain in the intervention group (Mean= 6.27; SD= 1.00) was lower than control group (Mean= 7.09; SD= 0.94), and it was statistically significant (p<0.001). Conclusion: Cryotherapy combined with William flexion exercise is better to reduce pain in patients with myogenic low back pain. Keywords: low back pain myogenic, cryotherapy, William flexion exercise. Correspondence: Yoga Handita Windiastoni. Study Program of Physiotherapy, Health Polytechnic, Ministry of Health Surakarta, Karanganyar, Central Java. Email: handitayoga@gmail.com. Mobile: 081329036114.    
Factors Influencing Nursing Student's Satisfaction in the Clinical Practice Education Program: A Systematic Review Jadmiko, Arief Wahyudi; Felaza, Estivana
Indonesian Journal of Medicine Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.2.623

Abstract

Background:  Nursing education programs' major success is arguably linked to students' practical clinical practice. The practical clinical practice provides a realistic setting in which students can safely integrate theoretical nursing knowledge into practical nursing care while also developing the attitudes and abilities required for the profession. This study aimed to examine the factors influencing nursing students' satisfaction in the clinical practice education program.Subjects and Method: A systematic review were conducted by searching articles from PubMed, ResearchGate, Science Direct, Google Scholar, and EBSCO is an article published from 2012 to 2022. The keywords were “clinical practice” AND “education” AND “students, nursing” AND “satisfaction”. The inclusion criteria were cross-sectional study. The articles were selected by PRISMA flow diagram.Results: A total of 8 studies was included in this review. Individualized supervision model, the pedagogical atmosphere on the ward, the relationship with the clinical nurse supervisors, the relationship with the nurse teachers, leadership style, clinical nurse commitment, patient relationships, higher age, grade point average (GPA), completion of several clinical courses, type of service and center, the type of management, the preference in the choice of the practice center, the number of students per period per clinical educator, being a woman and being in the second-grade year group, unhealthy placement environments.Conclusion: Factors influencing the satisfaction of student nurses in the clinical practice education program are the type of management, service, and center; the premises of nursing in the ward; the pedagogical atmosphere on the ward; the Ward/ Nurse Manager’s leadership style; individualized supervision model; unhealthy placement environments, clinical tutors and nurse teacher.Keywords: clinical practice, learning, education, students, nursing, satisfaction.Correspondence: Arief Wahyudi Jadmiko. Nursing Department, Faculty of Health, Universitas Pembangunan Nasional Veteran Jakarta. Jl. RS. Fatmawati Raya, Pd. Labu, Cilandak, Depok, West Java. Email: ariefwjadmiko@gmail.com. Mobile: +62 856-4721-3628.Indonesian Journal of Medicine (2023), 08(02): 225-235https://doi.org/10.26911/theijmed.2023.08.02.12
Meta-Analysis of the Effect of Cognitive Activity Exercise on Independence Ability in Post-Stroke Patients Aktovianta, Lukman; Murti, Bhisma; Adriani, Rita Benya
Indonesian Journal of Medicine Vol. 7 No. 3 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: A stroke is an attack on the brain that occurs when the blood supply to part of the brain is blocked so that part of the brain becomes damaged and dies because it does not get nutritional intake. Cognitive exercise activities can maintain optimal blood flow and improve the delivery of nutrients to the brain. The study aims to analyze the effect of cognitive exercise activity on the independence ability in post-stroke patients.Subject and Method: The study was a meta-analysis with PICO as the following: Population: post-stroke patients. Intervention: cognitive exercise activity. Comparison: no cognitive exercise activity. Result: independence ability. The articles used in this study were obtained from three databases, namely Google Scholar, PubMed, and ScienceDirect. The keywords for searching for the articles were "cognitive exercise activity" AND "cognitive ability" AND "post-stroke". The included articles were full-text English versions with a randomized control trial study design from 2012 to 2022. The article selection was conducted using the PRISMA flow diagram. The articles were analyzed using the Review Manager 5.3 application.Results: A total of 9 case studies from Europe (Oxford, Sweden, United Kingdom), South America (Brazil), North America (Texas, Jamaica), Asia (Korea), and Africa (Egypt) were selected for systematic review and meta-analysis. It was discovered that cognitive exercise activity of 0.36 units increased independence ability in post-stroke patients compared to not obtaining cognitive exercise activities. Result statistically (SMD = 0.36; 95% CI = 0.19 to 0.54; p<0.001).Conclusion: Cognitive exercise activity increased independence ability in post-stroke patientsKeywords: cognitive exercise activity, cognitive ability, post-stroke.Correspondence: Lukman Aktovianta. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: lukman.aktovianta15@gmail.com. Mobile: +6285641434548.Indonesian Journal of Medicine (2022), 07(03): 350-359https://doi.org/10.26911/theijmed.2022.07.03.12

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