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INDONESIA
Indonesian Journal of Medicine
Published by Universitas Sebelas Maret
ISSN : -     EISSN : 25490265     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.
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Articles 407 Documents
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Meta-Analysis the Effectiveness of Ivermectin Use on the Length of Stay in Inpatients of COVID-19 Wijayanto, Masromi Hendria; Tamtomo, Didik; Murti, Bhisma
Indonesian Journal of Medicine Vol. 7 No. 2 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: COVID-19 is a common problem in global health. COVID-19 is a disease that infects the respiratory tract caused by the Coronavirus virus. Symptoms range from mild to severe and life-threatening pneumonia can occur. At the beginning of the PSBB, information circulated that Ivemectin could treat COVID-19 infections. Ivermectin is an antiparasitic drug that can be used as prophylaxis and therapy for coronavirus disease 2019. Ivermectin is an alternative therapy for COVID-19 because there is a previous drug, chloroquine, which can be used to treat COVID-19. This study aims to estimate the effectiveness of Ivermectin on the duration of hospitalization of patients with COVID-19 based on the results of previous similar studies.Subjects and Method: This study is a meta-analysis with the following PICO, population: COVID-19 patients. Intervention: ivermectin. Comparison: standard therapy. Outcome: shorter duration of hospital stay. Meta-analyses and systematic studies using the PubMed, Scopus, Scholar, Springlink, Cochrane, Clinical Key, and Science Direct databases. Keywords using Ivermectin AND RCT AND COVID-19 AND “Coronavirus Disease” AND “NCOV disease” AND “COVID-19 treatment”. The article under study is a full-text article with a randomized controlled clinical trial (RCT) study design. Articles were collected using PRISMA diagrams and analyzed using Review Manager 5.3.Results A total of 9 Randomized Control Trial (RCT) studies from Europe, America, Asia and Africa were selected for systematic review and meta-analysis. COVID-19 patients receiving Ivermectin therapy decreased the duration of hospital stay by 1.52 units compared to standard therapy and this result was statistically significant (SMD= -1.52; 95% CI= -2.34 to -0.70; p= 0.003).Conclusion: Ivermectin can reduce the duration of hospital stay for COVID-19 patients.Keywords: COVID-19, ivermectin, duration hospital stayCorrespondence: Masromi Hendria Wijayanto. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Jawa Tengah. Email: masromi­hendria@gmail.com. Mobile: 0895402471549.Indonesian Journal of Medicine (2022), 07(02): 200-208https://doi.org/10.26911/theijmed.2022.07.02.08
The Effects of Diabetes Mellitus Comorbidities on the Risk of Treatment Failure in Tuberculosis Patients: A Meta-Analysis Iswahyuni, Sri; Fauziah, Ani Nur; Indarto, Indarto; Atmojo, Joko Tri; Widiyanto, Aris
Indonesian Journal of Medicine Vol. 7 No. 4 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.643 KB) | DOI: 10.26911/theijmed.2022.7.4.597

Abstract

Background: Tuberculosis or TB is a disease caused by the Mycobacterium tuberculosis complex. There are several comorbidities that experience severity and death when infected with tuberculosis or TB, namely hypertension, diabetes mellitus, cardiovascular disease, chronic kidney disease, cerebrovascular disease, and other diseases. This study aims to estimate the magnitude of the risk of treatment failure in Tuberculosis patients with Diabetes Mellitus comorbidity, with a meta-analysis of primary studies conducted by previous authors.Subjects and Method: This was a systematic review and meta-analysis with the following PICO, population: tuberculosis patients. Intervention: chronic comorbid diabetes mellitus. Comparison: without comorbid diabetes mellitus. Outcome: treatment failure. The articles used in this study were obtained from three databases, namely Google Scholar, PubMed, and Science Direct. Keywords to search for articles “Tuberculosis” OR “TBC” AND “Diabetes Mellitus” OR “DM” AND “Treatment failure”. The included article is a full-text English cohort study design from 2007 to 2021 and reports the adjusted odds ratio (aOR) in multivariate analysis. The selection of articles is done using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application.Results: A total of 7 cohort studies involving TB patients undergoing treatment from America, Europe, Africa and Asia were selected for systematic review and meta-analysis. The data collected showed that tuberculosis patients undergoing treatment with comorbid diabetes mellitus had a 1.57 time the risk of treatment failure compared to patients without comorbid diabetes mellitus (aOR= 1.57; 95% CI= 1.08 to 2.30; p= 0.002).Conclusion: Comorbidity Diabetes mellitus increases the risk of experiencing treatment failure in tuberculosis patients.Keywords: diabetes mellitus, tuberculosis, mortality.Correspondence: Sri Iswahyuni. School of Health Sciences Mamba’ul Ulum Surakarta. Jl. Ringroad Utara, Mojosongo, Jebres, Surakarta, Central Java, Indonesia. Email: iswahyunisri@yahoo.co.id. Mobile: +62 815-6720-715.Indonesian Journal of Medicine (2022), 07(04): 417-427https://doi.org/10.26911/theijmed.2022.07.04.07 
Differences in Age Estimated by the Kvaal Method on Right and Left Mandibular Canines Kusumaningrum, Sulistyani; Wasita, Brian; Wujoso, Hari; Rahayu, Rachmi Fauziah; Hermansyah, Muhamad Lukman; Lawei, Tharina
Indonesian Journal of Medicine Vol. 6 No. 2 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: The radiographic method for deter­mining the estimated age has the advantage of being non-invasive and the orthopantomogram images are digitally processed. Canines have a strong corre­la­tion with chronological age and have good resistance and large pulp space. This study aimed to determine the difference in age estimates using the Kvaal method on the right and left mandibular canines.Subjects and Method: There were 80 ortho­pantomogram samples from dental and oral clinic patients who had undergone orthopantomography at the Radiology Installation of Dr. Moewardi Hos­pital, from January 2019 to December 2020. The estimated age of right and left canines was calcu­lated based on the Kvaal method and performed a T-test.Results: At the estimated age of the right and left mandibular canines determined by the Kvaal formula, the T-test was performed showing a mean of 38.3 years for the right mandibular canine (Mean= 38.3; SD= 6.7) and 38.2 year the left mandi­bular canine (Mean= 38.2; SD= 8.9), with p = 0.910. Data analysis showed that there was no difference in age estimation using the Kvaal method on the right and left mandibular canines.Conclusion: There was no difference in age estimates by the Kvaal method on the right and left mandibular canines.Keywords: Oratopantomogram, Metoday Qual, Kaninus MandibulaCorrespondence: Sulistyani Kusumaningrum. Department of Radiology Dr. Moewardi Hospital / Faculty of Medicine Universitas Sebelas Maret, Surakarta. Email: kusumasulis1@gmail.com.Indonesian Journal of Medicine (2021), 06(02): 206-211https://doi.org/10.26911/theijmed.2021.06.02.09
Osteochondroma of the Distal Femur in Young Patient: An Oncology Case Report Sandiwidayat, Komang Septian
Indonesian Journal of Medicine Vol. 7 No. 1 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Osteochondroma is the most common primary bone tumor manifested as a painless, slow-growing mass. Apart from its asymptomatic manifestations, the tumor is malignant potential so appropriate management needs to be acknowledged. The aim of this study is to discuss the possible clinical findings for diagnosing with managing this rare case properly, which may provide a good outcome for this patient.Case Presentation: A 17-year-old male presented with a chief complaint of a slow-growing lump on the back of his right thigh. On physical examination, a 7 cm x 6 cm mass with mild tenderness was found during palpation. Based on these clinical and imaging findings, we informed and gained consent from the patient for surgery followed by a histopathology examination. The histopathology examination confirmed osteochondroma in the right distal femur.Results: Surgery was performed to curatively remove the tumor, followed by a histopathological examination which confirmed the diagnosis of osteochondroma. One week after the surgery, the post-surgical wound care was performed showing an excellent result, without any signs of infection or complications.Conclusion: Typical manifestation of painful osteochondromas may be associated with mechanical compression to the surrounding nerve and vascular structures. Surgical excision is an appropriate management approach to provide consistent relief of pain and deformity in osteochondroma case.Keywords: arteriovenous malformations, CT scan, rare case, embolizationCorrespondence: Komang Septian Sandiwidayat. Oncology Division, Department of Orthopaedic & Traumatology, Sanglah General Hospital, Faculty of Medicine, Udayana University, Bali, Indonesia. Email: drseptianortho@gmail.com. +62-821-4725-2042.Indonesian Journal of Medicine (2022), 07(01): 82-88https://doi.org/10.26911/theijmed.2022.07.01.09
Effect of Ethanolic Extract in Moringa oleifera, Lam. Leaf on Uric Acid Levels and Body Surface Area of Kidney Glomerulus in Wistar Rats (Rattus novergicus) Induced Metabolic Syndrome Model Darmawan, Muhammad Dzaki; Subandono, Jarot; Setyawan, Novan Adi; Budiani, Dyah Ratna
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: There has been an increasing prevalence of metabolic syndrome (MS) caused by life style such as sedentary behavior and western diet. Metabolic syndrome causes degeneration in ren’s structure and processes the elimination of by product in metabolism, which is uric acid. Moringa oleifera Lam. leaves contain antioxidant that can repair damages caused by MS. Studies about improvement of ren’s structure and uric acid level related to Moringa oleifera Lam. leaves’ consumption has not been found yet. Therefore, this study was intended to examine the effects of ethanolic extract in Moringa oleifera Lam. leaves to uric acid and glomerular surface area in male wistar rat (Rattus norvegicus) with induced metabolic syndrome model.Method: This study is an experimental laboratory study. The subjects of this study consisted of 30 rats which were divided into 5 groups with 6 in each group. K1 is control group, K2 is MS group, and K3, K4, and K5 are MS groups given variety of ethanolic extract doses. The induction of MS was done by giving high-fat diet in 28 days and injection of streptozotocin-nicotinamide (STZ-NA) in the 25th day. Rats in group K3, K4, and K5 were given doses of 150, 250, and 350 mg/kgBW in 28 days.Results: The administration of high-fat diet for 28 days and injection of STZ-NA caused MS condition in rats.  Repeated ANOVA and One-Way Anova test showed that the administration of ethanolic extract in Moringa oleifera Lam. leaves with doses of 150, 250, and 350 mg/kgBW in 28 days decreased uric acid significantly (p= 0.001; p=0.001; p= 0.001). Another result also found that ethanolic extract from Moringa oleifera Lam. leaves with doses of 250 and 350 mg/kgBW increased area of glomerular surface area in rats significantly.Conclusion: The administration of ethanolic extract from Moringa oleifera Lam. leaves with doses of 150, 250, and 350 mg/kgBW for 28 days decreased uric acid level in rats. Ethanolic extract of Moringa oleifera Lam. leaves 250 and 350 mg/kgBw doses increase glomerular surface area.Keywords: Moringa Oleifera, uric acid, glomerular cross-sectional area, metabolic syndrome, kidneyCorrespondence: Muhammad Dzaki Darmawan. Study Program of Medical Doctor Education, Faculty of Medicine, Universitas Sebelas Maret. Email: mdddzaki@student.uns.ac.id.Indonesian Journal of Medicine (2021), 06(04): 412-422https://doi.org/10.26911/theijmed.2021.06.04.07
Effectiveness of Acupuncture Therapy to Reduce Pain in Patients with Upper Trapezius Myofascial Pain Syndrome: A Meta-Analysis Saraspuri, Niken Putri Eka; Tamtomo, Didik; Murti, Bhisma
Indonesian Journal of Medicine Vol. 7 No. 3 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Upper trapezius myofascial pain syndrome is a muscle pain condition associated with sensory, motoric, or autonomic functions and generated by trigger point arising from hardened and stiff taut band of muscle fiber while being touched as well as palpated. One of the interventions to reduce the pain is by using acupuncture therapy. The study aims to analyze and estimate the effectiveness magnitude of acupuncture therapy toward the pain reduction in patients with upper trapezius myofascial pain syndrome.Subjects and Method: This was a systematic review and meta-analysis study using PRISMA diagrams. The article search was conducted based on the eligibility criteria using the PICO Model. population: patients with upper trapezius myofascial pain syndrome. Intervention: acupuncture therapy. Comparison: placebo acupuncture. Outcome: reduced pain. The articles used were from 6 databases, namely Pubmed, Google Scholar, Science Direct, Scopus, Spinger Link, and Hindawi Key words for article search were “acupuncture” OR “acupuncture therapy” AND “upper trapezius pain” OR “upper trapezius myofascial pain syndrome” OR “upper trapezius MPS” AND “Randomized Con¬trolled Trial” OR “RCT”. Inclusion criteria used of the study were full text articles with Randomized Controlled Trial study design, measure of association used was Mean SD. Articles were analyzed using the Review Manager 5.3 application.Results: The 9 articles reviewed were from Taiwan, China, UK, Turkey, Brazil, and Iran. The study result indicated that acupuncture therapy was effective in reducing pain in upper trapezius myofascial pain syndrome. Upper trapezius myofascial pain syndrome that obtained acupuncture therapy had average score of pain -1.16 units lower than placebo acupuncture (SMD= -1.16; CI 95%= -1.93 to -0.39; p= 0.003).Conclusion: Acupuncture therapy was effective in reducing pain in upper trapezius myofascial pain syndrome.Keywords: acupuncture, pain, upper trapezius myofascial pain syndrome, randomized controlled trial, meta-analysis.Correspondence: Niken Putri Eka Saraspuri. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: nikenputri54@gmail.com. Mobile: 081327372766.Indonesian Journal of Medicine (2022), 07(03): 326-336https://doi.org/10.26911/theijmed.2022.07.03.09
Transcutaneous Electrical Nerve Stimulation Uptake in Lowering Low Back Pain Salsabil, Husna Arwa; Prasetya, Hanung; Murti, Bhisma
Indonesian Journal of Medicine Vol. 7 No. 1 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Low Back Pain (LBP) is a generalized pain from the second lumbar vertebra to the sacroiliac joint, and is generally a lifelong health disorder. LBP is often the cause of people feeling a decrease in ability in daily functional activities. Patients often complain of symptoms of pain, muscle spasms and impaired function. One of the interventions that can be used to reduce LBP is therapy using transcutaneous electrical nerve stimulation (TENS). TENS is a device used to relieve pain by stimulating nerves through electrodes transcutaneously. TENS is one of the modalities that can improve neuromuscular function or reduce pain and is very useful for patients with complaints of low back pain who experience pain and muscle weakness around the pelvis, trunk, and lower legs. LBP patient.Subject and Method: This study was a meta-analysis with the following PICO, population: low back pain patients. Intervention: administration of TENS. Comparison: not given TENS. Result: decreased pain. The articles used in this study were obtained from three databases, namely Google Scholar, Pubmed, and Science Direct. Keywords to search for articles “transcutaneous electrical nerve stimulation” OR “TENS” AND “reduction pain” OR “pain relief” AND “low back pain”. The articles included are full-text English with a randomized control trial study design from 2007 to 2022. Article selection was carried out using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 . application.Results: A total of 12 case studies from continental Europe, America and Asia were selected for systematic review and meta-analysis. It was found that giving TENS -0.67 times reduced pain in complaints of low back pain compared to not given TENS significantly (SMD = -0.67; 95% CI = -1.03 to -0.32; p = 0.002).Conclusion: Transcutaneous Electrical Nerve Stimulation reduces pain in low back pain patients.Keywords: Transcutaneous Electrical Nerve Stimulation, reduction pain, low back painCorrespondence: Husna Arwa Salsabil, Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Mobile: +6289611006503. Email: husna0105­@gmail.com.Indonesian Journal of Medicine (2022), 07(01): 9-18https://doi.org/10.26911/theijmed.2022.07.01.02 
Meta-Analysis Correlation between Dementia and the Risk of Mortality in COVID-19 Patients Atin, Ulya Khoirunnisa’; Murti, Bhisma; Prasetya, Hanung
Indonesian Journal of Medicine Vol. 7 No. 3 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Dementia is a common cause of morbidity and mortality in the elderly population. The elderly have a higher risk when exposed to COVID-19, especially if they have serious medical conditions such as dementia (senility). The purpose of this study was to determine the effect of dementia on the risk of mortality in COVID-19 patients based on previous primary studies.Subject and Method: This research is a systematic review and meta-analysis study using PRISMA diagrams. The article search was conducted based on the eligibility criteria using the PICO Model. P: COVID-19 patients, I: dementia, C: no dementia, O: mortality. The articles used were from 3 databases, namely Pubmed, Google Scholar and Science Direct. The search keywords for articles were as follows: dementia AND (death OR Mortality) AND COVID-19 OR Sars-Cov-2. The inclusion criteria in this study include full text articles with cohort study designs, full text available articles, the size of the relationship used is the adjusted Odds Ratio or Risk Ratio, the year the article used is in the 2019-2022 range and the research outcome is mortality. Articles were analyzed using the Review Manager 5.3 application.Results: There are 9 articles in this study from New York, United States, Spain, Korea with 2 articles, and England with 4 articles. The article was analyzed using the PRISMA flow diagram. The results of the study show that COVID-19 patients with dementia have a mortality risk of 2.02 times greater than COVID-19 patients without dementia. These results were statistically significant (aOR= 2.19; 95% CI = 1.48 to 2.75; p<0.001).Conclusion: Dementia increases the risk of mortality from COVID-19Keywords: Dementia, mortality, COVID-19, SARS-COV-2Correspondence: Ulya Khoirunnisa’ Atin. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: ulyakhns9@gmail.com. Mobile: +62823259186864.Indonesian Journal of Medicine (2022), 07(03): 251-261https://doi.org/10.26911/theijmed.2022.07.03.01 
Brixia Score as Predictor of D-Dimer Levels of COVID-19 Patients in Intensive Care Unit Adyanata, Yanuareza Totti; Soewondo, Widiastuti; Arifin, Arifin; Redhono, Dhani
Indonesian Journal of Medicine Vol. 8 No. 1 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (30.995 KB) | DOI: 10.26911/theijmed.2023.8.1.570

Abstract

Background:  COVID-19 is caused by a novel virus that can cause lung abnormalities which can be measured with new chest x-ray scoring system named Brixia score. In COVID-19 patients, coagulation disorders are often found that can be seen through D-Dimer levels. This study aimed to prove the Brixia Score as a predictor of D-Dimer levels.Subjects and Method: This study was an observational analytic study with a cross-sectional approach. The subjects were 94 COVID-19 patients which taken from ICU Melati 1 Dr. Moewardi General Hospital, Surakarta from March 2021 to August 2021 who met the exclusion and inclusion criteria. The independent variable is the Brixia score performed by radiologists and the dependent variable is D-Dimer levels taken from laboratory results. Sampling was obtained by purposive sampling and the data were investigated using the receiver operating characteristic (ROC) curve.Results: 94 samples were obtained for analysis. The average Brixia Score of patients with D-Dimer <2 µg/mL was Mean= 15.85; SD= 1.43 and D-Dimer ≥2 µg/mL was Mean= 17.29; SD= 0.96. There was a significant difference between the Brixia Score of patients with D-Dimer <2 µg/mL and D-Dimer ≥2 µg/mL (p<0.001). Analysis with the ROC curve shows an area under the curve (AUC) of 0.793. The optimal cutoff value of the Brixia Score for predicting D-Dimer levels was 16.5 (sensitivity 77.9%, specificity 73.1%).Conclusion: Brixia Score proved to be a predictor of D-Dimer levels of COVID-19 patients in ICU care.Keywords: COVID-19, ICU, brixia score, predictor, D-Dimer.Correspondence: Widiastuti Soewondo, Radiology Department, Faculty of Medicine, Universitas Sebelas Maret. JL. Ir. Soetami No. 36A, Surakarta 57126, Indonesia. E-mail: widiastuti.sprad56@staff.uns.ac.id. Mobile: 082134368592Indonesian Journal of Medicine (2023), 08(01): 92-99https://doi.org/10.26911/theijmed.2023.08.01.09
The Effectiveness of Electro-acupuncture in Reducing Body Weight in Obese Patients: A Meta-Analysis Mutiah, Nurmila; Murti, Bhisma; Prasetya, Hanung
Indonesian Journal of Medicine Vol. 6 No. 3 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Obesity is a problem that is starting to be found, not only in urban areas with high socioeconomic status but also in children living in rural areas, even from middle to lower socio­economic groups. This study aimed to examine the effectiveness of electro-acupuncture in obesity cases.Subjects and Method: Meta-analysis was carried out with PICO: The population in this study were obese patients aged 16-65. The intervention was in the form of electro-acupuncture therapy. Comparison in the form of sham/ placebo acupuncture. The outcome is weight loss. A meta-analysis study was applied with electronic data sources: Clinical Key, Google Scholar, MED­LINE/PubMed, Science Direct, Scopus. The articles included were full-text with a Ran­domized Control Trial (RCT) study design. There were 10 articles used in this study with a sam­ple size of 818 people who were divided into two groups (455 people in the acupuncture group and 363 people in the sham/placebo acupuncture group). Articles were analyzed using the Review Manager 5.4 application. The data were analyzed using Standardized Mean difference (SMD) and the heterogeneity of the research sample.Results: There was high heterogeneity between one experiment and another (I2= 86%; p<0.001), so the Random Effect Model (REM) was used. Electroacupuncture therapy was effective in reducing body weight with a Standardized Mean Different (SMD) of 0.50 compared to false acupuncture (SMD= -0.50; 95% CI= -0.92 to -0.08; p= 0.020).Conclusion: Acupuncture therapy can lose weight in obesity cases with a Standardized Mean Different (SMD) of 0.50 compared to fake acupuncture.Keywords: acupuncture, obesityCorrespondence: Nurmila Mutiah. Masters Program in Public Health, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta, Central Java, Indonesia. Email: nurmilamutiah77@gmail.com.Mobile: +6287730797747.Indonesian Journal of Medicine (2021), 06(03): 325-335https://doi.org/­10.26911/theijmed.­2021.06.03.10 

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