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INDONESIA
Indonesian Journal of Medicine
Published by Universitas Sebelas Maret
ISSN : -     EISSN : 25490265     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.
Arjuna Subject : -
Articles 273 Documents
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Effectiveness of Combined Acupuncture Therapy and Turmeric (Curcuma longa Linn) on Blood Protein Profile in Osteoarthritis Patients Kusumawati, Heni Nur; Prasetya, Hanung; Nugraha, Nurtama Aditya
Indonesian Journal of Medicine Vol. 10 No. 2 (2025)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.2.838

Abstract

Background: Osteoarthritis (OA) is a degenerative disease of the joints that commonly occurs in the hands, waist, a. nd knees. One of the efforts to control OA is with acupuncture. This study aims to analyze the effectiveness of the combination of acupuncture and turmeric herbs on reducing the levels of total protein, albumin, and globulin in OA patients. Subjects and Method: The Randomized Controlled Trial (RCT) study was conducted at Redy Clinical Laboratory in August 2024. A total of 50 patients with OA were divided into two groups: (1) Intervention group of combination of acupuncture and turmeric herbs (n= 25); and (2) The control group was given acupuncture (n=25). The dependent variables are total protein, albumin, and globulin. The independent variable was a combination of acupuncture and turmeric herbs. The difference in the average increase in protein, albumin, and globulin levels in each group was analyzed using the Independent test. Results: The average protein level in the combination group of acupuncture therapy and turmeric herbs (Mean= 8.40; SD= 0.27) was higher than the control group (Mean= 7.74; SD= 0.33), and this result was statistically significant (p <0.001). The average albumin level in the combination group of acupuncture therapy and turmeric herbs (Mean= 5.07; SD= 0.49) was higher than the control group (Mean= 4.84; SD= 0.66), but this result was statistically insignificant (p= 0.156). The average globulin levels in the combination group of acupuncture therapy and turmeric herbs (Mean= 3.41; SD= 0.88) were higher than the control group (Mean= 3.17; SD= 0.65), but this result was statistically insignificant (p = 0.280). Conclusion: The combination of acupuncture therapy and turmeric herbs is effective in increasing total protein, albumin, and globulin levels in OA patients.
Paraspinal Abscess Secondary to Spondylodiscitis: A Rare Presentation with Progressive Neurological Deficits and Systemic Infection Putra, I Gusti Ngurah Paramartha Wijaya; Wijaya, I Gusti Ngurah Paramartha; Febyan, Febyan; Yulian, Kenny
Indonesian Journal of Medicine Vol. 10 No. 2 (2025)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.2.842

Abstract

Background: Spondylodiscitis is a rare but serious spinal infection that may result in neuro-logical and systemic complications, especially when associated with paraspinal abscess formation. This case highlights its clinical severity and the importance of early intervention. This study aims to highlight the clinical importance and potential severity of spondylodiscitis, particularly when complicated by paraspinal abscess formation. Case Presentation: A patient presented with progressive lower back pain, bilateral lower limb weakness, and systemic symptoms including fever and night sweats. Laboratory tests revealed hypoalbuminemia, leukocytosis, and anemia. MRI imaging identified a paraspinal abscess at the L3–L5 levels, resulting in lumbar canal stenosis and worsening neurological deficits. Emergency surgical intervention was undertaken, consisting of abscess drainage, laminectomy for neural decompression, and posterior spinal stabilization. Intraoperative findings included a substantial purulent collection, necessitating extensive debridement. Postoperatively, the patient demonstra¬ted clinical improvement with ongoing antibiotic therapy, nutritional support, and rehabilitation. Discussion: Spondylodiscitis with paraspinal abscess is a diagnostic challenge due to its insidious onset and non-specific presentation. Delayed recognition increases the risk of severe neurological impairment and systemic sepsis. MRI is the gold standard for early detection, while micro¬biological confirmation is crucial for targeted treatment. A multidisciplinary approach is essential. Surgical intervention is indicated for progressive neurological deficits, extensive abscess formation, or spinal instability, with timely antibiotic therapy playing a critical role in infection control. Conclusion: This case illustrates the importance of early diagnosis and timely surgical manage-ment in spondylodiscitis with paraspinal abscess. Multimodal treatment improves outcomes and helps prevent long-term disability.
Impact of Dental Restoration and Extraction Treatments on Oral Health–Related Quality of Life (OHRQoL) Sulistyawati, Tri; Novika, Revi Gama Hatta; Murti, Bhisma; Cahyanto, Erindra Budi; Demartoto, Argyo
Indonesian Journal of Medicine Vol. 10 No. 4 (2025)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.2.843

Abstract

Background: Cavities or dental caries is one of the most common diseases as the main cause of pain in the oral cavity which can have a significant impact on quality of life. Cavities have several treatment modalities available such as restoration and tooth extraction. These treatment options not only affect the patient's clinical condition, but can also affect the psychological, social, and functional aspects reflected in the Oral Health Related Quality of Life (OHRQoL). The study aimed to determine the effect of restoration treatment and tooth extraction on Oral Health Related Quality of Life (OHRQoL). Subjects and Method: This research was conducted in December 2024 with a total of 200 samples in Surakarta, This study uses a quantitative design with a cross-sectional approach. Data were collected from patients who had undergone restoration treatment and/or tooth extraction on cavities. Dependent variables are in the form of Oral Health Related Quality of Life (OHRQoL) and independent variables in the form of restorative treatments, tooth extraction, age and gender. Data were analyzed by double linear regression. Results: Multiple linear regression analysis showed a significant negative association between the type of dental treatment and OHRQoL. Patients who underwent tooth extraction had OHRQoL scores that were 26.89 units lower than those who received restorative treatment (b = -26.89; 95% CI = -29.39 to -24.39; p < 0.001). No significant association was found between age or sex and OHRQoL. Conclusion: Dental restoration treatments have a significant influence on improving Oral Health Related Quality of Life (OHRQoL), while tooth extraction shows a positive but insignificant relationship. Age and sex variables had no statistical effect on OHRQoL.
The Application of the Health Belief Model in the Selection of Acupuncture Therapy for Low Back Pain Patients Ningrum, Anis Lupita; Prasetya, Hanung; Murti, Bhisma; Demartoto, Argyo
Indonesian Journal of Medicine Vol. 10 No. 2 (2025)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.2.844

Abstract

Background: Low back pain (LBP) is one of the health problems experienced by 50–80% of adults. LBP affects individual, physical, social, and psychological aspects. Individuals suffering from LBP require comprehensive treatment to ensure the success of therapy. The study aims to determine the patient's perception of the choice of LBP therapy using the Health Belief Model theory. Subjects and Method: This research was conducted using a cross-sectional study conducted in Surakarta, from September to October 2024. A total of 200 acupuncture patients and physiotherapy patients were selected using fixed disease sampling. The independent variables were vulnerability perception, severity perception, benefit perception, obstacle perception, cues to action perception, self-efficacy. The bound variable is the choice of therapy. The data using questionnaires were analyzed using multiple logistic regression. Results: Perceived susceptibility was less likely to use acupuncture therapy (OR= 0.51; 95% CI= 0.14 to 1.79; p=0.293). Perceived severity was more likely to use acupuncture therapy (OR=3.99; 95% CI= 1.17 to 13.54; p= 0.027). Perceived benefits were more likely to use acupuncture therapy (OR=43.90; 95% CI= 9.45 to 203.99; p<0.001). Perceived barriers were less likely to use acupuncture therapy (OR=0.03; 95% CI p< 0.01 to 0.20; p< 0.001). Cues to action were more likely to use acupuncture therapy (OR=7.10; 95% CI p= 2.20 to 22.91; p< 0.001). High self-efficacy has a greater likelihood of using acupuncture therapy (OR=142.49; 95% CI= 14.17 to 1432.86; p<0.001). Conclusion: The Health Belief Model for the selection of acupuncture therapy increased with the perception of severity, perception of benefits, action signals, and self-efficacy. The choice of acupuncture therapy decreased with a high perception of resistance. Perception of vulnerability was statistically not significantly associated with therapy selection. The independent variables in the model were able to explain the variation in therapy selection (acupuncture vs physiotherapy) by 68.69%.
The Social Face of Stigma: A Meta-Analysis of Gender, Support, and Living Environment in HIV/AIDS Perception Utami, Indri Nur; Dewi, Rachael Saraswaty; Amalia, Rizky Nur Aprilianti; Murti, Bhisma; Veibiani, Nindita Arum
Indonesian Journal of Medicine Vol. 10 No. 2 (2025)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.2.845

Abstract

Background: The stigma of society towards ODHA itself is influenced by various factors, where there are three factors that can be used as a benchmark, namely gender, place of residence, and social support. This study aims to estimate the magnitude of the influence of gender, social support and housing on the perception of stigma in people with HIV/AIDS, based on the results of a number of previous primary studies. Subject and Method: This study is a meta-analysis and systematic review study, with PICO, Population: ODHA patients (People with HIV/AIDS), Intervention: Women, low social support and village dwelling, Comparison: men, high social support and urban dwelling, Ooucome: HIV/AIDS stigma. Primary study searches used electronic databases: PUBMED, BMC, Scopus and Scient Direct published from 2012 to 2022. The keywords used are "people living with HIV" AND "gender" AND "social support" AND "residence" AND "perceived stigma HIV, cross-sectional"". There are 9 English fulltext arithmetic with effect size using adjusted odds ratio from 2012 to 2022. Articles selected with PRISMA Flow and analyzed using RevMan 5.3. Result: This meta-analysis was conducted on 9 primary studies from India and Ethiopia with a sample = 14,191 HIV/AIDS patients. This study showed that the risk of stigma perception increased with female sex (aOR=1.35, CI 95%=0.75 to 2.46; p=0.320; I²=91%) and rural housing (aOR=1.49; CI 95%=0.89 to 2.47; p=0.130), but it is not statistically significant. The risk of stigma perception decreased with high social support (aOR=0.53; CI 95%=0.32 to 0.90; p=0.020), and the results are statistically significant. Conclusion: The risk of stigma perception increases with female gender, rural housing and high social support.
Correlation Between Analgesic Administration, Depression, and Knee Osteoarthritis Severity in Elderly Gutomo, Arthur Marc; Kusumaningrum, Sulistyani; Budiningsih, Fatichati; Werdiningsih, Yulyani
Indonesian Journal of Medicine Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.3.772

Abstract

Background: Chronic diseases in the elderly, including osteoarthritis (OA), impact quality of life and can lead to depression. Pain caused by knee osteoarthritis may trigger stress and depression, while depression can worsen pain perception and disability. This study aimed to analyze the correlation between analgesic use, depression, and the severity of knee osteoarthritis in elderly patients. Subjects and Method: A cross-sectional study was conducted at Dr. Moewardi Hospital, Surakarta, using medical records of 99 elderly patients diagnosed with primary knee osteoarthritis between January 2018 and January 2024. Analgesic administration data were obtained from prescription records. Depression levels were assessed using the Geriatric Depression Scale (GDS), while the severity of osteoarthritis was evaluated using the Kellgren and Lawrence radiological classification. Data were analyzed using the Spearman correlation test. Results: Analgesic administration was negatively associated with depression (OR= 0.09; 95% CI= 0.03 to 0.32; p<0.001) and severity of knee OA (OR= 1.91; 95% CI= 0.60 to 6.08; p<0.001). Severity of knee OA was positively associated with depression (OR= 0.18; 95% CI= 0.05 to 0.62; p<0.001). Conclusion: Analgesic administration is negatively associated with depression and severity of knee OA. Severity of knee OA is positively associated with depression.
Risk Factors Associated with Elderly Diabetes Patients Khuluq, Husnul; Fitri, Dwiki; Miyarso, Condrosuro; Winarno, tunjung
Indonesian Journal of Medicine Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.3.775

Abstract

Background: Diabetes mellitus is a chronic disease with increasing global prevalence, including in Indonesia. Among the elderly, its management is more complex due to age-related physiological changes and comorbidities. This study aimed to identify and analyze risk factors associated with diabetes in the elderly population. Subjects and Method: This retrospective cross-sectional study analyzed medical records of 1,634 inpatients with type 2 diabetes mellitus at PKU Muhammadiyah Hospital Yogyakarta from January 2021 to July 2023. Total sampling was used. Data on demographics, comorbidities, and laboratory values were analyzed using Chi-square test. Results: Of 1,634 patients, 853 (52.52%) were aged >65 years. Significant risk factors associated with elderly diabetes included elevated erythrocytes (OR= 1.60; 95% CI= 1.32–1.96; p <0.001), urea (OR= 1.51; 95% CI= 1.23–1.86; p <0.001), lymphocytes (OR= 1.26; 95% CI = 1.04–1.53; p= 0.020), hemoglobin (OR= 1.38; 95% CI = 1.14–1.68; p <0.001), systolic blood pressure (OR= 1.33; 95% CI= 1.07–1.65; p= 0.009), stroke (OR= 1.59; 95% CI = 1.09–2.32; p= 0.016), creatinine (OR= 1.24; 95% CI= 1.02–1.51; p= 0.028), and hypertension (OR= 1.29; 95% CI = 1.03–1.63; p= 0.028). Conversely, cholesterol (OR= 0.89; 95% CI= 0.65–1.23; p<0.001), and glucose (OR= 0.65; 95% CI= 0.51–0.83; p <0.001) were inversely associated. Conclusion: Elderly diabetes is significantly associated with multiple clinical and laboratory indicators. These findings highlight the importance of comprehensive monitoring to improve elderly diabetes management.
A Rare Case of Newly Acquired Hemophilia Following Diabetic Ketoacidosis in A Male Patient with IL-2 (Rs2069762) Polymorphism Muhammad, Faizal; Arthareza, Adhelia Galuh Permatasari; Marwanta, Sri
Indonesian Journal of Medicine Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.3.832

Abstract

Background: Diabetes is commonly linked to autoimmune processes, but acquired hemophilia A (AH)—a rare bleeding disorder due to factor VIII (FVIII) inhibitors—remains uncommon, particularly during diabetic ketoacidosis (DKA). Recent studies have suggested a role of IL-2 (rs2069762) polymorphism in FVIII inhibitor development. This study aims to highlight a rare case of newly acquired hemophilia coinciding with DKA and the presence of IL-2 gene polymorphism. Case Presentation: A 40-year-old male presented with dyspnea, abdominal pain, and signs of DKA. He had a history of drug-induced rash due to sulfasalazine. Initial management with IV fluids and insulin resolved the metabolic crisis. However, on day two, he developed spontaneous bruising and gross hematuria. Laboratory tests revealed a low FVIII inhibitor titer (1.2 BU) and positive insulin antibodies. Genetic testing showed TT homozygous polymorphism of IL-2 (rs2069762), potentially contributing to FVIII inhibitor formation. Results: The patient was treated with low-dose cyclophosphamide and methylprednisolone, followed by rituximab due to poor initial response. Intensive insulin therapy was also administered. After five weeks, clinical remission of AH was achieved, although the patient remains at risk for relapse due to the IL-2 polymorphism. Conclusion: This case illustrates a rare interplay between DKA and acquired hemophilia, potentially mediated by IL-2 (rs2069762) polymorphism. Prompt diagnosis and individualized immunosuppressive therapy are essential. The findings support further investigation into genetic predispositions in AH pathogenesis during autoimmune or metabolic stress events like DKA.
Effect of Preoperating Maltodextrin 12.5% Carbohydrate Drink on High Sensitive C Reactive Protein Levels Post-Brachytherapy Purwoko, Purwoko; Arianto, Ardana Tri; Putra, Eka Satrio; Purnomo, Frederick Johan
Indonesian Journal of Medicine Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.3.853

Abstract

Background: Brachytherapy is radiation therapy that will cause inflammation and tissue damage that leads to inflammation, characterized by the release of pro-inflammatory cytokines, including hs-CRP levels in the plasma. Preoperative administration of glucose solution is known to reduce the increase in cortisol, and is thought to reduce postoperative hs-CRP levels. So far there has been no research that specifically examines the effect of preoperative carbohydrate administration on hs-CRP values after brachytherapy. This study aims to determine the effect of preoperative carbohydrate administration on post-brachytherapy hs-CRP values. Subjects and Method: This study was designed a double-blind randomized controlled trial was conducted at the Radiotherapy Unit of Dr. Moewardi General Hospital, Surakarta, from April to September 2022. Sixty-four cervical cancer patients with ASA physical status I or II undergoing brachytherapy under general anesthesia were recruited using consecutive sampling. Participants were randomly assigned into two groups: an intervention group receiving 12.5% maltodextrin solution and a control group receiving mineral water. The independent variable was preoperative carbohydrate administration, and the dependent variable was hs-CRP level measured 2 hours before and 4 hours after brachytherapy. Data were analyzed using paired t-test Results: Post-brachytherapy hs-CRP levels were significantly lower in the treatment group (mean = 2.565 ± 2.0 mg/dL) compared to the control group (mean = 3.69 ± 2.58 mg/dL; p = 0.019). Both groups showed significant increases in hs-CRP from pre- to postoperative values (p < 0.001). The change in hs-CRP (Δhs-CRP) was also significantly lower in the treatment group (p = 0.025). Conclusion: The administration of maltodextrin was able to significantly reduce post-brachytherapy hs-CRP levels compared to placebo.
Giant Cell Tumor of the Metacarpal and Its Intervention to Preserve Joint Function: A Case Report Ericsen Tiondi Putra; Kusuma, Yudha Eka; Calvin, Calvin
Indonesian Journal of Medicine Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.3.854

Abstract

Background: Giant cell tumor (GCT) is one of the most common benign bone tumors, but it has a high recurrence rate and is aggressive. It can occur elsewhere, but frequently in the distal femur and proximal tibia. The goal of treatment is to remove the tumor cells and maintain the metacarpophalangeal function. Various modalities exist to remove the tumor cells from curettage, wide excision, radical excision, or amputation. Reconstruction following the removal of tumor cells also varied by using graft, bone cement, prosthesis, or arthrodesis. There are no definitive guidelines to determine which modalities are the best, especially in unusual sites. In this case report, we present an unusual site of GCT in the second metacarpal, and clinical outcomes after the 1-year final follow-up were nearly normal. Case Presentation: A 22-year-old female presented to the hospital with a history of a lump and intermittent pain in the right hand for 2 years. Physical examination and radiograph suspected an unusual site of GCT and no cartilage involvement. A core biopsy was taken, and a GCT was confirmed. Wide excision, preserving the native joint of the metacarpal, and reconstruction using autologous non-vascularized fibular graft with the help of K-wire and adjuvant of hydrogen peroxide. Results: Constant improvement of clinical outcomes post-operatively with Michigan Hand Outcomes Questionnaire (MHQ) score was nearly normal, and there was no sign of recurrence at 6-month follow-up. Conclusion: Our report suggests that wide excision and reconstruction by fibular struts with a preserved native metacarpal joint, followed by hydrogen peroxide as an adjuvant and K-wire as a fixator, could be used as a combination therapy with good results.

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