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Indonesian Journal of Medicine

theijmed
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Published by Universitas Sebelas Maret

ISSN : - EISSN : 25490265 DOI : -

Core Subject : Health,

Medicine & Pharmacology Public Health

Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.

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Articles 273 Documents

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Relationship between Family History of Diabetes Mellitus and Gestational Diabetes Mellitus: A Meta-Analysis Ammutammima, Ummu Fatihah; Tamtomo, Didik Gunawan; Murti, Bhisma
Indonesian Journal of Medicine Vol. 6 No. 1 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Gestational Diabetes Mellitus (GDM) is the most common metabolic disorder first diagnosed during pregnancy. According to the American Diabetes Association (ADA) in 2006, GDM occurred in 7% of pregnancies each year. Family history of diabetes is an important risk factor for GDM. The relationshipbetween family history of DM and GDM has been investigated in several primary studies with several contradictions in the outcome. Therefore, this study aimed to determine the relationship between family history of diabetes and GDM using a meta-analysis method.Subjects and Method: The meta-analysis was conducted by systematically reviewing articles published from 2007 to 2020 from the Pubmed, Google Scholar, Science Direct, and ResearchGate databases. The keywords were "Risk factor" OR "family history" OR "family history DM") AND "GDM" AND "cross sectional". The article search was carried out using PICO: the study population was pregnant women, the intervention/exposure was family history of DM, the comparison was no family history of DM, and the outcome was GDM. The article search was carried out for one month. The articles included in this study were full-text articles with a cross-sectional design. The articles were reviewed using the PRISMA flow diagram guidelines. This study used Revman 5.3 Software to analyze the articles.Results: Family history of DM increased the risk of Gestational Diabetes Mellitus (aOR= 2.02; 95% CI= 1.54 - 2.67; p<0.001). This study used 11 articles from Ethiopia, Cameroon, Peru, Iran, Pakistan, Malaysia, Kuwait, Saudi Arabia, and India.Conclusion: Family history of diabetes mellitus increases the risk of gestational diabetes mellitus.Keywords: Gestational diabetes mellitus, Family history of diabetesCorrespondence: Ummu fatihah Ammutammima. Masters Program in Public Health, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: ummuftha64@gmail.com. Mobile: 081717252573.Indonesian Journal of Medicine (2021), 06(01): 71-81https://doi.org/10.26911/theijmed.2021.06.01.08.

The Effect of Scoliosis Orthosis on the Reduction of Cobb Angle in Scoliosis Patients: A Meta-Analysis Suprayogi, Dody; Kristiyanto, Agus; Prasetya, Hanung
Indonesian Journal of Medicine Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Scoliosis is a spinal deformity that often occurs in adolescents with a prevalence of 0.47% -5.2% worldwide. The prevalence of scoliosis in Asia was about 2.25% of the population. In Surabaya, Indonesia, 6.37% of students from 784 schools who conducted scoliosis screening tests positively had scoliosis. In addition, 9 out of 300 students in Surakarta positively had scoliosis. This study aimed to estimate the effect of using scoliosis orthosis in reducingcobb angle in scoliosis patients by conducting a meta-analysis on theseveral similar articles.Subjects and Method: This study used a meta-analysis by systematically reviewing the several similar articles from PubMed, ScienceDirect, and Google Scholar. The keywords were "scoliosis" AND "scoliosis orthosis" OR "scoliosis brace" AND "cobb angle" OR "curve" AND "randomized control trial". The intervention was the use of a scoliosis orthosis with a comparison of non-scoliosis orthosis and the scoliosis patients as the study subjects. The outcome of the study was a reduction of cobb angle. The included articles were full-text articles with a randomized controlled trial design that showed the effect size (mean and standard deviations). The articles were collected using PRISMA flow diagrams and analyzed using the Review Manager 5.3 application.Results: Based on a meta-analysis result of 9 randomized controlled trial articles from the United States, Canada, Germany, Sweden, Denmark, Poland, and Hong Kong, scoliosis orthosis reduced cobb angle in scoliosis patients (SMD= -0.67; 95% CI= -1.02 to -0.33; p <0.001). The heterogeneity I2=75%.Conclusion: Scoliosis orthosis affects the reduction of cobb angle in scoliosis patients.Keywords: scoliosis, cobb angle, scoliosis orthosisCorrespondence: Dody Suprayogi. Masters Program in Public Health. Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: 23dhodik.yogi@gmail.com. Mobile: 08562772052.Indonesian Journal of Medicine (2020), 05(04): 356-367https://doi.org/10.26911/theijmed.2020.05.04.11.

Meta-Analysis of the Effect of High-Intensity Interval Training in Increasing High-Density Lipoprotein Levels in Type 2 Diabetes Mellitus Patients Adelita, Sela Putri; Pamungkasari, Eti Poncorini; Murti, Bhisma
Indonesian Journal of Medicine Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Diabetes mellitus is one of the second biggest health problems. The International Diabetes Federation said that diabetes currently affects 382 million people worldwide, with type 2 diabetes mellitus (DM) being the largest prevalence of 85-95% of the diabetes population. This study aimed to estimate the effect of high-intensity interval training (hiit) on increasing levels of high-density lipoprotein in patients with type 2 diabetes mellitus based on the results of several previous studies.Subjects and Method: This study was a meta-analysis and systematic study, with the following PICO Population =type 2 diabetes mellitus patients aged 35-65 years. Intervention=HIIT. Comparison = No HIIT. Outcome = increased levels of high-density lipoprotein. The articles used in this study were obtained from several databases, including PubMed, ScienceDirect, and Google Scholar. The keywords for finding articles were: "HIIT" OR "High-Intensity interval Training" OR "Diabetes Mellitus" OR "High-Density Lipoprotein" AND "Randomized Controlled Trial". The articles included in this study were full-text with a randomized controlled trial. Articles were analyzed by PRISMA flow chart and RevMan 5.3.Results: A total of 9 articles reviewed in this meta-analysis study originated from New York, Canada, France, Thailand, Berlin, Denmark, Australia, and the United Kingdom. Studies showed that high intensity interval training increased the levels of high density lipoproteins (Mean Difference= 0.01; 95% CI= 0.31 to 0.30; p= 0.970).Conclusion: High-intensity interval training increases high-density lipoprotein levels.Keywords: High-intensity interval training, type 2 diabetes mellitus, high-density lipoproteinCorrespondence: Sela Putri Adelita, Masters Program In Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: Selaadelita558@gmail.com.Indonesian Journal of Medicine (2020), 05(04): 272-281https://doi.org/10.26911/theijmed.2020.05.04.02.

Association between Serum Calcidiol Levels and Cognitive Function in Geriatric Patients Anandhita, Sandy; Budiningsih, Fatichati; Nurrudhin, Arief
Indonesian Journal of Medicine Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: The role of vitamin D toward cognitive function is as neuroprotective in which vitamin D will increase neurotrophic factor production which contributes to supporting neuron life sustainability, development, and function. The study aims to analyze the association between calcidiol serum level and cognitive functions of geriatric patients.Subjects and Method: A cross-sectional study was conducted at Geriatric Polyclinic of dr. Moewardi Hospital, Surakarta. A sample of 30 geriatric patients was selected randomly. The dependent variable was cognitive functions (MMSE score). The Independent variable was calcidiol serum level. The data were analyzed by Spearman test.Results: There was no difference of calcidiol serum level with MMSE score (OR= 1.00; p= 0.478).Conclusion: There was no difference in calcidiol serum level with MMSE score.Keywords: cognitive functions, calcidiolCorrespondence: Sandy Anandhita. Masters Program in Family Medicine, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta, Central Java. Email: anandhitasandy3@gmail.com. Mobile: 082227940410Indonesian Journal of Medicine (2020), 05(03): 185-190https://doi.org/10.26911/theijmed.2020.05.03.02

The Effect of the Use of Cervical Collar on the Reduction of Neck Pain: Meta-Analysis Syafiâ€™ie, Hisyam; Prasetya, Hanung; Murti, Bhisma
Indonesian Journal of Medicine Vol. 6 No. 1 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Neck pain is the fourth leading cause of disability, with an annual prevalence rate exceeding 30%. Nearly 50% of individuals will continue to experience pain or it often occurs to some degree. This study aimed to analyze the magnitude of the effect of using a cervical collar on reducing the degree of pain in neck pain patients compared to manual therapy (exercises).Subjects and Method: This research is a systematic review and meta-analysis carried out by following the PRISM diagram flow. The process of searching for articles through a journal database that includes: PubMed, Google Scholar and Science Direct by selecting articles published in 2000-2020. The keywords used include: “cervical collar” OR “neck collar” OR “soft collar” OR “hard collar” AND “neck pain” AND “cervical pain” AND “cervical radiculopathy” AND “cervical syndrome” AND “randomized controlled trial”. The inclusion criteria were full paper articles with a randomized controlled trial study design, articles using English and Indonesian, and bivariate analysis with adjusted odds ratio. Articles that meet the requirements are analyzed using the Revman 5.3 application.Results: A total of 6 articles were reviewed in this study with a randomized controlled trial study design. Meta-analysis of 6 randomized controlled trial (RCT) studies showed that there was no difference in effectiveness in using cervical collars compared to manual therapy (exercises) in reducing neck pain (ES = 0.04; 95% CI -0.31 to 0.39; p = 0.083).Conclusion: This meta-analysis concluded that there was no difference in effectiveness between the use of cervical collars and manual therapy (exercises) in reducing the degree of pain in neck pain.Keywords: neck pain, cervical collar, exercises,meta-analisisCorrespondence: Hisyam Syafi’ie. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: bunghifi@gmail.com. Mobile: 081326002006.Indonesian Journal of Medicine (2021), 06(01): 112-118https://doi.org/10.26911/theijmed.2021.06.01.12

Meta Analysis the Effect of Physical Activity on Survival Life in Breast Cancer Patients Ketaren, Enge Surabina; Murti, Bhisma; Widyaningsih, Vitri
Indonesian Journal of Medicine Vol. 6 No. 1 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Physical activity has a positive role in breast cancer risk. Physical activity intensity is often expressed as metabolic equivalents (METs) and the analytic guidelines for international physical activity questionnaires define low activity as 4 METs and high activity as 8 METs. This study aims to estimate the effect of physical activity on the survival of breast cancer survivors based on a number of previous similar studies.Subjects and Method: This study is a systematic review and meta-analysis study. The articles used in this study were obtained from several databases including PubMed, Science Direct, Google Scholar, and Springer Link. The articles used in this study were those published from 2000-2020. The population in the study were breast cancer survivors with an intervention in the form of high physical activity. Comparison, namely low physical activity, and an outcome in the form of survival. Keywords for searching articles are as follows: "physical activity" AND "breast cancer survivors" AND "lifesustainability" OR "survival" AND "breast cancer" AND "adjusted hazard ratio" AND "cohort". The articles included in this study are full text articles with a cohort study design. Articles were collected using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application.Results: There were 8 articles originating from Denmark, Norway, Canada, Germany and the United States. The results of the meta-analysis showed that physical activity was statistically significant in increasing the survival of breast cancer survivors (HR= 0.74 95% CI= 0.63 to 0.87; p= 0.0003) and I² = 0%.Conclusion: High physical activity increases the survival of breast cancer survivors.Keywords: High physical activity, survival, breast cancer survivorsCorrespondence: Enge Surabina Ketaren. Masters Progam in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: ketarenenge3@gmail.com. Mobile: 087838583646.Indonesian Journal of Medicine (2021), 06(01): 32-41https://doi.org/10.26911/theijmed.2021.06.01.04.

Effect of Curcuma Longa Rhizome Extract on Fasting Blood Sugar Levels and HbA1C in Type 2 Diabetes Mellitus: A Meta-Analysis Fatony, Riska Fajar; Tamtomo, Didik Gunawan; Prasetya, Hanung
Indonesian Journal of Medicine Vol. 6 No. 2 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Diabetes mellitus (DM) is a metabolic disease that is developing into a serious global problem. Diabetes mellitus is characterized by an increase in blood levels that are more than the normal reference. In type 2 DM generally occurs due to reduced insulin secretion and sensitivity over time. Control of blood sugar levels can improve the patient's quality of life. This study aimed to analyze the effect of curcuma longa rhizome extract on fasting blood sugar levels and HbA1C in patients with type 2 diabetes.Subjects and Method: This was a meta-analysis of a number of randomized controlled trials. The articles were obtained from PubMed, Google Scholar, Springerlink, BMJ, and Sciencedirect databases, published from 2010-2020. The article search was carried out by considering the eligibility criteria defined using the PICO model. P: Type 2 diabetes patients, I: Curcuma longa rhizome extract, C: Placebo, and O: Fasting blood sugar levels and HbA1C. The keywords to find articles are as follows: "Curcuma longa", OR "Curcumin" OR "Tumeric" OR "Curcuma" AND "Fasting blood glucose" AND "HbA1C" OR "Glicemic" OR "Diabetes Mellitus" AND "Randomized Controll Trials". Articles were collected using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application.Results: A total of 14 articles were reviewed in this study. Meta-analysis of 12 articles showed that the curcuma longa rhizome extract reduced fasting blood sugar levels (Standardized Mean Difference= -0.48; 95% CI= -0.61 to -0.34; p <0.001). The meta-analysis of 11 articles showed that administration of curcuma longa rhizome extract decreased HbA1C levels (Standardized Mean Difference= -0.40; 95% CI= -0.59 to -0.20; p <0.001). This meta-analysis combines primary studies from Iran, Japan, Thailand, China, Mexico, Brazil, and AustraliaConclusion: Curcuma longa rhizome extract reduces fasting blood sugar and HbA1C levels in patients with type 2 diabetes.Keywords: Curcuma longa, Fasting blood sugar levels, HbA1C, diabetes mellitus type 2, randomized controlled trialCorrespondence: Riska Fajar Fatony. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: respatieka10@gmail.com.Indonesian Journal of Medicine (2021), 06(02): 119-134https://doi.org/10.26911/theijmed.2021.06.02.01

Secondary Knee Osteoarthritis with Medial Instability and Tibial Defect due to Chronic Abscess Treated by Total Knee Arthroplasty with Metal Augmentation - Case Report Soetjahjo, Bintang; Hancoro, Udi Herunefi; Ermawan, Rieva; Saputra, Rhyan Darma; Akbar, Hillan
Indonesian Journal of Medicine Vol. 6 No. 2 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background:Knee osteoarthritis (OA), known as degenerative joint disease, is typically the result of wear and tear and progressive loss of articular cartilage, most common in elderly women and men. Knee OA is a leading cause of disability and increase with an aging and overweight population. Total Knee Arthroplasty (TKA) is a common surgical treatment of OA knee that highly cost-effective procedure. Stable placement of components is difficult and thus it presents technical challenges for the surgeon but various options are available for managing these defects.Case Report: A 58 years-old housewife came to our clinic due to chronic left knee pain with associated instability since two years ago and getting worse in last three months. She already had knee joint supplementation injections and physical therapy but no improvements. Based on our clinical and radiological findings, our assessment was secondary left knee osteo-arthritis with medial instability and tibial defect due to chronic abscess. Patient underwent TKA to correct this condition. A revised implant was used to close the defect in the medial part of the tibia and soft tissue reconstruction procedure was used to correct the instability.Result: On the first postoperative month, the patient underwent rehabilitation and physical therapy to strengthen her lower limb muscles. On the second month, she started to walk using walking assisted device. On the ninth months follow-up, the patient was able to walk normally without assisted device, the pain disappeared and the symptoms of knee instability were reduced.Conclusion:Bone defects are commonly encountered during TKA, which still has no standard treatment to cure. In this case, the use of metal augmentation with revision implant give satisfactory results with good clinical outcome.Keywords: Osteoarthritis, Total Knee Arthro¬plasty, knee instability, tibial defect, metal augmentationCorrespondence:Bintang Soetjahjo. Dr. Moewardi Hospital. Jl. Kolonel Sutarto 132, Jebres, Surakarta, Central Java 57126, Indonesia. Mobile: +628122987359. Email: bjortho@yahoo.comIndonesian Journal of Medicine (2021), 06(02): 168-176https://doi.org/10.26911/theijmed.2021.06.02.06

Comparison Neutrophil to Lymphocyte Count Ratio with C-Reactive Protein as a Predictor for Neonatal Sepsis Nugroho, Irfan Dzakir; Hidayah, Dwi; Salimo, Harsono
Indonesian Journal of Medicine Vol. 6 No. 2 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Accurate early detection of bacteriemia plays an important role in the treatment and prognosis of infected neonates, but is constrained by the limitations of specific sepsis markers for detecting bacteriemia. NLCR or neutrophil to lymphocyte count ratio in adult population shows a more sensitive parameter in predicting infection and has the advantage of being economical and widely available. The role of NLCR in the neonatal population has not been widely studied. The purpose of this study was to analyze NLCR versus CRP as a predictor of neonatal sepsis.Subjects and Method: This study take analytic observatinal with diagnostic test approach to subject with sepsis risk factor and neonatal sepsis at dr. Moewardi hospital from April until May 2017. Characteristics data as gestational age, gender, birth weight, IT ratio, leucocyte count, neutrophil and lymphocyte count, NLCR, CRP and blood culture. Data presented descriptively and statistical analysis was performed.Results: No significant correlation between subject’s characteristics and neonatal sepsis. NLCR with cutoff point for 2.22 has sensitivity, specificity, positive and negative predictive value for 87.5%, 75%, 70% and 90%, respectively. CRP with cutoff point for 0.25 has sensitivity, specificity, positive and negative predictive value for 83.3%, 55.6%, 55.6% and 83.3% respectively. While IT-rasio has sensitivity, specificity, positive and negative predictive value for 29.2%, 91.7%, 70% and 66%, respectively.Conclusion: NLCR has a satisfactory predictive value for neonatal sepsis that widely available and economic predictor alternative with cutoff point for 2.22.Keywords: NLCR, CRP, predictor, neonatal sepsisCorrespondence: Irfan Dzakir Nugroho. Masters Program in Family Medicine, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta, Central Java.Indonesian Journal of Medicine (2021), 06(01): 112-118https://doi.org/10.26911/theijmed.2021.06.02.02

Effectivity Biopsychosocial intervention with Cognitive Behavioral Therapy and Exercise Therapy Program in Chronic Low Back Pain: Meta-analysis Fadli, Arif; Prasetya, Hanung; Kristyanto, Agus
Indonesian Journal of Medicine Vol. 6 No. 2 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Pain is a common complaint that causes decreased work productivity and a cause of disability. Biomedical interventions failed to inhibit the increase in chronic low back pain (CLBP) treatment costs. The pain perception of CLBP patients is influenced by emotional psychological and cognitive factors that require biopsychosocial intervention. This study aimed to summarize the existing literature data regarding the effectiveness of biopsychosocial interventions with Cognitive Behavioral Therapy (CBT) and Exercise Therapy Program (ETP) in CLBP.Subjects and Method: This research was systematic review and meta-analysis of the Randomized Control Trial study on the electronic database Pubmed, Google scholar, Willey Online Library, Research Gate, Science Direct. Data analysis was performed using the Revman 5.3 program with Cohen's effect size d.Results: There are 7 articles included in this research. The results of the analysis of studies on the effectiveness of biopsychosocial interventions for CBT and ETP in reducing the intensity of CLBP pain were very large with the effect size (d= -1.31; 95% CI= -2.39 to -0.23; p <0.001), while the effect size of the disability index was very large (d= -1.62; 95% CI= -2.70 to -0.54; p<0.001).Conclusion: Biopsychosocial interventions for CBT and ETP are effective in reducing the pain and disability index of CLBP. The effectiveness of biopsychosocial interventions with CBT and ETP methods is due to the patient's efficacy in completing the rehabilitation program.Keywords: biopysichosocial, CBT, ETP, CLBPCorrespondence: Arif Fadli. Masters Program in Public Health Sciences, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: Ariffadli950@gmail.com. Mobile: +6281355377050.Indonesian Journal of Medicine (2021), 06(02): 177-193https://doi.org/10.26911/theijmed.2021.06.02.07

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