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Indonesian Journal of Medicine

theijmed
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Published by Universitas Sebelas Maret

ISSN : - EISSN : 25490265 DOI : -

Core Subject : Health,

Medicine & Pharmacology Public Health

Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.

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Articles 273 Documents

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Relationship between Formula Milk and the Incidence Obesity in Children Under Five: Meta-Analysis Yopiana, Elma; Dewi, Yulia Lanti Retno; Murti, Bhisma
Indonesian Journal of Medicine Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Obesity is a nutritional disorder that most often occurs in children. Obesity is associated with worse health outcomes in children, including asthma and sleep apnea. This study aimed to examine the relationship between formula feeding and obesity in children under five.Subjects and Method: This was a meta-analysis study conducted by systematically reviewing articles from PubMed, Science Direct, Springer Link, and Google Scholar. The articles used in this research are articles that have been published from 2008-2016. The search for articles was carried out by considering the eligibility criteria using the PICO model, P: toddlers, I: formula feeding, C: breastfeeding, O: obesity. The key words for finding articles were as follows: "OR" Formula milk "OR" Infant Formula") AND" Breast Feeding "AND (Obesity OR" Body Mass Index"). The inclusion criteria used were full paper, used English, cohort and cross-sectional observational study design and the results reported were adjusted odds ratio. Articles were collected using PRISMA diagrams, and analyzed using the Review Manager 5.3 application.Results: A total of 9 articles were conducted meta-analysis in this study with a sample size of 26,119. The results of the meta-analysis of the cohort study showed that formula feeding increased the incidence of obesity in children under five (aOR= 1.10; 95% CI= 0.78 to 1.56; p= 0.570). The results of the meta-analysis of cross-sectional studies showed that formula feeding increased the incidence of obesity in children under five (aOR= 1.25; 95% CI= 0.59 to 2.63; p= 0.560).Conclusion: Formula feeding increases the incidence of obesity in children under five.Keywords: Obesity, formula, toddlers, meta-analysisCorrespondence: Elma Yopiana. Masters Program in Public Health. Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Jawa Tengah, Indonesia. Email: elmayopiana@gmail.com.Indonesian Journal of Medicine (2020), 05(04): 299-307https://doi.org/10.26911/theijmed.2020.05.04.05.

The Effect of Mesenchymal Secretome Stem Cell Therapy toward Caspase-3 Expression in Pregnant Mice with Pristan-Induced Lupus Model Adiyana, Febrian Andhika; Bachnas, M Adrianes; Sulistyowati, Sri; Anggraini, Nutria Widya Purna; Respati, Supriyadi Hari
Indonesian Journal of Medicine Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Systemic lupus erythematosus (SLE) is one of the pregnancy complications which cause an increase in fetal and maternal complications which are mainly caused by placental damage due to chronic inflammation and apoptosis. The rate of apoptosis can be assessed by the high expression of caspase-3 which is the majorexecutioner caspases of apoptosis. The use of Mesenchymal Secretome Stem Cell for SLE therapy has an anti-inflammatory and anti-apoptotic role. This study aimed to examine the effect of mesenchymal secretome stem cell therapy toward caspase-3 expression in pregnant mice with pristan-induced lupus model.Subjects and Method: This study was a randomized controlled trial. This study was conducted at the Prodia ProStem Laboratory, Laboratory of the Faculty of Veterinary Medicine of Airlangga University, and Anatomical Pathology Laboratory, Faculty of Medicine, Airlangga University. A total of 14 healthy BALB/C female mice strain aged 6-8 weeks, with a bodyweight of 20-30 grams, were divided into two groups, (1) 7 pregnant mice who received pristan therapy only, and (2) 7 pregnant mice who received pristan therapy and mesenchymal secretome stem cell.The dependent variable was the caspase-3 expression. The independent variable was the administration of mesenchymal secretome stem cell therapy. The caspase-3 expression was measured by an immunoreactive score. The data were analyzed using independent t-test.Results: After giving mesenchymal secretome stem cell therapy, the mean of the caspase-3 expression in the treatment group (Mean=1.86; SD=0.66) was lower than the control group (Mean=3.30; SD = 1.42), with p=0.031.Conclusion: Mesenchymal secretome stem cell therapy is effective for reducing caspase-3 expression in the placenta of pregnant mice with pristan-induced lupus model.Keywords: Caspase-3 expression, lupus, placentaCorrespondence: Febrian Andhika Adiyana. Department of Obstetrics and Gynecology, Faculty of Medicine, Univesitas Sebelas Maret/Moewardi Surakarta, Indonesia. Email: FebrianAndhika@gmail.com. Mobile: 081215897960.Indonesian Journal of Medicine (2020), 05(03): 224-229https://doi.org/10.26911/theijmed.2020.05.03.07

Correlation between Family Support and Self Care in Type 2 Diabetes Mellitus: Meta-Analysis Islami, Dian Dini; Tamtomo, Didik Gunawan; Prasetya, Hanung
Indonesian Journal of Medicine Vol. 6 No. 1 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Patients with Type 2 Diabetes Mellitus have a high risk of serious complications. Complications resulting from diabetes can be minimized and prevented by implementing self-care behavior. The study revealed that one of the factors that affect self-care activity is family support. The correlation of family support with self-care activity has been extensively investigated in several primary studies with several contradictions in the results. This study aimed to determine the correlation between family support and self-care activity in people with type 2 diabetes mellitus using the meta-analysis method.Subjects and Method: This study was a systematic review and meta-analysis. The meta-analysis was carried out by systematically reviewing articles published from 2010 to 2020 from the Pubmed, Google Scholar, DOAJ, and Springer Link databases using search keywords, namely ("Family Support" OR "Social Support") AND ("Self Management "OR" Self Care ") AND" Diabetes Mellitus Type 2". Article searches were carried out using PICO. The study population was people with type 2 diabetes mellitus. Intervention/exposure was getting family support compared to not getting family support, and the outcome was diabetes mellitus self-care. The search for articles was carried out for one month. The articles included in this study were full-text articles with a cross-sectional design. Articles were reviewed using the PRISMA flow diagram guidelines. Articles analyzed using Revman 5.3 Software.Conclusion: People with type 2 diabetes mellitus with good family support will increase self-care activity 2.22 times compared to people with type 2 diabetes mellitus who do not get family support. (aOR = 2.22 (95% CI = 1.84-2.68; p <0.001) The study of 7 articles originated from Africa.Keywords: family support, self-care, diabetes mellitus type 2Correspondence: Dian Dini Islami. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: dian.dinii94@gmail.co. Mobile: 085729483960.Indonesian Journal of Medicine (2021), 06(01): 62-70https://doi.org/10.26911/theijmed.2021.06.01.07.

Meta-Analysis of Risk Factors for Lower Extremity Amputation in Diabetes Mellitus Patients with Foot Ulcers Septiani, Anissa Eka; Rahardjo, Setyo Sri; Prasetya, Hanung
Indonesian Journal of Medicine Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Diabetic foot ulcer is a complication of diabetes mellitus which costs high, takes long wound care, increases mortality, morbidity and causes non-traumatic amputation. There are risk factors that are thought to be the cause of lower limb amputation in diabetic foot ulcers, namely peripheral artery disease, hypertension and gender. This study aims to estimate the influence of peripheral artery disease, hypertension and gender on the risk of lower limb amputation in diabetes mellitus patients with leg ulcers.Subjects and Method: Meta-analysis studies and systematic reviews were applied to this study using electronic databases of Pubmed, Scopus, Google Scholar, and Springer Link. The keywords to search for articles are as follows: "diabetic foot", "lower limb amputation", "lower extremity amputation", "risk factor", "predictor", "cohort", "retrospective", "adjusted odds ratio". Articles were collected using PRISMA diagrams, and analyzed using the Review Manager 5.3 application.Results: Meta-analysis of 9 cohort articles of diabetic foot ulcer patients with peripheral artery disease (aOR= 2.46; 95% CI= 1.70 - 3.55; p<0.01); Meta-analysis of 8 cohort articles, diabetic foot ulcer patients with hypertension (aOR= 1.05; 95% CI= 0.66 - 1.68; p= 0.83); Meta-analysis of 9 cohort articles of male diabetic foot ulcer patients (aOR= 1.60; 95% CI= 1.32 - 1.94; p<0.01); Peripheral artery disease, hypertension and male gender are risk factors that can increase the incidence of lower limb amputation.Conclusion: Peripheral artery disease, hypertension and male gender are risk factors that can increase the incidence of lower limb amputation.Keywords: Peripheral artery disease, diabetic foot ulcer, lower limb amputationCorrespondence: Anissa Eka Septiani. Masters Program in Public Health. Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java,. Email: sanissaeka@gmail.com. Mobile: 089514646458.Indonesian Journal of Medicine (2020), 05(04): 343-355https://doi.org/10.26911/theijmed.2020.05.04.10.

High Energy Injury Ankle Fracture-Dislocation without Neurovascular Involvement Utomo, Pamudji; Arimuqti, Zarkasyi; Santoso, Asep; Sibarani, Tangkas SMHS; Anwar, Iwan Budiwan
Indonesian Journal of Medicine Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Open tibiotalar joint dislocation associated with medial malleolus and distal fibular fracture without neurovascular damage are rarely reported.Case presentation: This study present a case of 55-year-old female with open tibiotalar joint dislocation associated with medial malleolus and distal fibular fracture without neurovascular injury treated with emergent debridement, open reduction, and internal fixation.Results: Six months follow-up showed complete bone and soft tissue healing with excellent functional outcome.Conclusion: Emergent debridement, open reduction, and internal fixation is needed to treat tibiotalar joint dislocation associated with medial malleolus and distal fibular fracture.Keywords: high energy injury, ankle joint, fracture dislocationCorrespondence: Asep Santoso. Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: asepsantoso@gmail.com.Indonesian Journal of Medicine (2020), 05(03): 259-264https://doi.org/10.26911/theijmed.2020.05.03.12

Aminoglycocides as An Alternative Antibiotic Therapy Against Urinary Tract Infection in Children due to Extended-Spectrum Β-Lactamase (ESBL) Producing Escherichia Coli in Carbapenem Trends Mapindra, Muhammad Pradhika; Mahindra, Muhammad Pradhiki; Ramadhan, Muhammad; Putri, Apriska Mega Sutowo
Indonesian Journal of Medicine Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Extended-spectrum β-lactamase (ESBL) is an enzyme produced by certain Escherichia coli and Klebsiella pneumoniae. ESBL can induce theantibiotic resistance for betalactam antibiotics such as penicillin, cephalosporin, etc. Frequent utilization of carbapenem may induce the risk for carbapenem resistant against ESBLs producing microorganisms. This stud aimed to communicate Aminoglycocides as an alternative antibiotic therapy against urinary tract infection in children.Case Presentation: We present a case of 4 years child who was admitted to the state hospital of Madiun with main complaint of 10 days high fever accompanied by phimosis appearance. Laboratory results based on urine culture show the ESBL positive Escherichia coli. Results: We have used aminoglycoside for treating the patient. Clinical presentation in this patient start showing an improved clinical response and negative bacteriuria in the second urine test after the aminoglycoside therapy.Conclusion: Aminoglycosides such as gentamicin can be considered to be one of the best options for treating an ESBL infection beside carbapenem in order to reduce the carbapenem trend In clinical setting of the urinary tract infection caused by ESBL Eschericia coli.Keywords: Aminoglycosides, Carbapenem, Extended-spectrum β-lactamase, Gentamicin, urinary tract infectionCorrespondence: Muhammad Pradhika Mapindra. General Practitioner in State Hospital of Madiun, Easy Java. Email: mpradhika57@gmail.com.Indonesian Journal of Medicine (2020), 05(03): 200-205https://doi.org/10.26911/theijmed.2020.05.03.04

Association between Myeloperoxidase and High Sensitive Troponin I on Myocardial Contractility in Acute Myocardial Infarction Patients Wasyanto, Trisulo; Meilus, Budi Patria; Yasa, Ahmad
Indonesian Journal of Medicine Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Myeloperoxidase (MPO) levels have been shown to have prognostic values for death events in acute myocardial infarction (AMI) patients. Increased levels of high sensitive troponin I (hs Trop I) are associated with poorer prognosis in AMI patients. This study aimed to determine the association between levels of MPO and hs troponin I at admisson on myocardial contractility in AMI patients.Subjects and Method: This was a prospective observational analytic study, conducted at Dr. Moewardi General Hospital, Surakarta, from November1, 2018 to January 31, 2019. The study subjects were patients who were diagnosed with AMI. A total of 23 patients were included in this study; 15 patients with ST elevation myocardial infarction (STEMI) and 8 with non ST elevation myocardial infarction (NSTEMI). The dependent variable was myocardial contractility. The independent variables were MPO and hs Trop I. Blood tests for MPO and hs Trop I was measured at admission and the left ventricular ejection fraction (LVEF) was measured when predischarge by the Simpson method to examine myocardial contractility. The data were analyzed by Pearson correlation run on SPSS 22. Results: hs Trop I (r= -0.53; p= 0.009) and MPO (r= -0.15; p=0.487) decreased LVEF.Conclusion: Hs Trop I at admission has a correlation with myocardial contractility, and no correlation of MPO at admission with myocardial contractility in AMI patients.Keywords: Myeloperoxidase, High sensitive Troponin I, Acute myocardial infarctionCorrespondence: Trisulo Wasyanto. Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi Hospital. Jl. Kol. Sutarto 132, Surakarta 57126, Central Java, Indonesia. Email: trisulo.wasyanto@gmail.com.Indonesian Journal of Medicine (2020), 05(04): 265-271https://doi.org/10.26911/theijmed.2020.05.04.01.

The Effect of Ear Acupuncture in Reducing Body Weight in Obesity Patients: A Meta-Analysis Pangestu, Utami; Dewi, Yulia Lanti Retno; Prasetya, Hanung
Indonesian Journal of Medicine Vol. 6 No. 1 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Obesity is now no longer considered a health problem in developed countries, but has also been faced by developing countries such as Indonesia. According to WHO, obesity worldwide has increased by more than two times from 1980. In 2016, there were 1.9 billion adults who were overweight and more than 600 million of them were obese or overweight. This study aims to analyze the effect of ear acupuncture therapy on weight loss.Subjects and Method: This study was a systematic review and meta-analysis using the Randomized Controlled Trial design. The articles used in this study were obtained from several databases including PubMed, Google Scholar, Springerlink, Hindawi, and Sciencedirect. The articles used in this study were those published from 2008-2020. The article search was carried out by considering the eligibility criteria defined using the PICO model. P: obese patients (BMI ≥25), I: ear acupuncture therapy, C: no ear acupuncture therapy O: weight loss. The keywords for searching articles are as follows: "auricular acupuncture", AND "obesity", "auricular acupuncture for obesity" and "acupuncture obesity randomized controlled trial". The articles included in this study are full text articles with a Randomized Controlled Trial. Articles were collected using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application.Results: A total of 7 articles were reviewed in this study. The meta-analysis showed the results that ear acupuncture therapy was effective for weight loss in obese people (SMD= -0.74; 95% CI= -1.31 to-0.16; p<0.001). This meta-analysis combined primary research from Korea, Taiwan and Iran.Conclusion: Ear acupuncture therapy affects weight loss in obese people.Keywords: auricular acupuncture, obesity, randomized controlled trialCorrespondence: Utami Pangestu. Masters Program in Public Health, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: utamipangestu@gmail.comIndonesian Journal of Medicine (2021), 06(01): 23-31https://doi.org/10.26911/theijmed.2021.06.01.03.

Effect of Vitamin D Supplementation and Calcium in Reducing the Risk of Preeclampsia: Meta-Analysis Fajriyani, Fanny Kartika; Pamungkasari, Eti Poncorini; Murti, Bhisma
Indonesian Journal of Medicine Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Preeclampsia (PE) is a major complication in pregnancy and a major cause of maternal and fetal morbidity and mortality. Analysis of risk factors and prevention of preeclampsia are needed to reduce the adverse effects of preeclampsia. Important supplements during pregnancy to prevent the increase in blood pressure of pregnant women are Vitamin D and calcium. This study aimed to analyze the effect of vitamin D and calcium supplementation on reducing the risk of preeclampsia.Subjects and Method: This study is a meta-analysis of a number of randomized controlled trials. The articles used in this study were obtained from several databases including PubMed, Google Scholar, Springerlink, and Sciencedirect. The articles used in this study were those published from 2002-2020. The article search was carried out by considering the eligibility criteria defined using the PICO model. P: Pregnant women, I: vitamin D and calcium, C: placebo, and O: preeclampsia. The keywords to find articles are as follows: "Vitamin D" OR "Calcium" OR "Vitamin D and Calcium" AND "preeclampsia" AND "Randomized Controll Trials". The articles included in this study are full text articles with Cross-sectional study design. Articles were collected using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3.Results: A total of 9 articles were reviewed in this study. The meta-analysis showed that vitamin D supplementation reduced the risk of preeclampsia in pregnant women (RR= 0.45, 95% CI 0.32-0.63, p<0.001). The meta-analysis of 8 articles also showed that calcium supplementation reduced the risk of preeclampsia in pregnant women with calcium (RR= 0.42; 95% CI= 0.31 - 0.57; p<0.001). This meta-analysis combines primary research from Iran, India, Bangladesh, South Africa, Cameroon, and Saudi Arabia.Conclusion: Vitamin D and calcium supplementation reduces the risk of preeclampsia.Keywords: vitamin D, Calcium, preeclampsia, randomized controlled trialCorrespondence: Fanny Kartika Fajriyani. Masters Program in Public Health, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: fannykfa9@gmail.com.Indonesian Journal of Medicine (2020), 05(04): 308-320https://doi.org/10.26911/theijmed.2020.05.04.06.

The Difference of Endometrial Vascular Endothelial Growth Factor (VEGF) Expression between Polycystic Ovarian Syndrome (PCOS) and Normal Women Saputra, Ricky Bernadi; Budihastuti, Uki Retno; Sulistyowati, Sri; Melinawati, Eriana; Respati, Supriyadi Hari
Indonesian Journal of Medicine Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Polycystic Ovarian Syndrome (PCOS) is an endocrine disorder in women characterized by increased levels of androgens, ovulatory dysfunction, and Polycystic Ovarian Morphology (PCOM), as well as a combination of classic clinical features. Women with PCOS experience changes in the endometrium and endometrial receptivity markers such as VEGF (Vascular Endothelial Growth Factor). VEGF increases the permeability and dilation of endometrial blood vessels which play an important role in implantation. This study aimed to analyze the difference of VEGF expression between women with PCOS and normal women.Subjects and Method: This study was a case-control study design conducted at the polyclinic of the Department of Obstetrics and Gynecology, Dr. Moewardi Hospital, Surakarta, Central Java, in July 2020. There were 30 infertile women with PCOS (diagnosis based on Rotterdam criteria, consensus 2003) and 30 women without PCOS as the sample of this study. The dependent variable was VEGF expression. The independent variables were age, BMI, family history with PCOS, menarche, occupation, and education. VEGF expression was obtained from an endometrial biopsy on days 19-24 of periods. The differences in VEGF expression (in %) were analyzed by the Mann-Whitney test. VEGF determinants were analyzed by a multiple linear regression.Results: The mean of VEGF expression in women with PCOS (Mean=64.33; SD=44.43) was higher than in women without PCOS (Mean= 7.90; SD=8.73) and the result was statistically significant (p<0.001). PCOS (b=42.09; 95%CI=64.26 to -19.93; p<0.001) and obese (b=38.63; 95%CI=-63.44 to -13.82; p=0.003) increased VEGF expression.Conclusion: VEGF expression in the endometrium of women with PCOS is higher than normal women.Keywords: VEGF, endometrium, Polycystic Ovarian SyndromeCorrespondence: Ricky Bernadi Saputra. Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi Hospital, Surakarta, Indonesia. Telp: 081221161933 Email: rickysaputradr@gmail.comIndonesian Journal of Medicine (2020), 05(03): 230-239https://doi.org/10.26911/theijmed.2020.05.03.08

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