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INDONESIA
Indonesian Journal of Medicine
ISSN : -     EISSN : 25490265     DOI : -
Core Subject : Health,
Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.
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Articles 407 Documents
Path Analysis on the Effects of Bio-psychosocial Factors and Calorie Intake in Blood Glucose Control in Patients with Type 2 Diabetes Mellitus -, Isfaizah; Murti, Bhisma; Indarto, Dono
Indonesian Journal of Medicine Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Diabetes mellitus (DM) is a serious chronic disease with its tendency to deteriorate. The DM cases worldwide in 2015 was 415 million people and it is estimated to increase as many as 642 million cases in 2040. Indonesia ranked 7 in the world with 10 million cases of DM in 2015, about 90% of which were Type 2 Diabetes Mellitus. This study aimed to determine the effect of biopsychosocial factors and calorie intake on the blood glucose control in patients with Type 2 DM.Subjects and Method: This was an analytic and observational study with case control design. This study was carried out at Internal Medicine Polyclinic, Department of Endocrinology, Dr. Moewardi Hospital, Surakarta, Central Java, from October to November 2016. A total sample of 135 cases of Type 2 DM were selected for this study by fixed disease sampling. As many as 106 of these study subjects at  HbA1c ≥6.5% and 29 cases of Type 2 DM had HbA1c <6.5%. The dependent variable was HbA1c level. The independent variables were educational level, family income, psychological stress, calorie intake, and Body Mass Index (BMI). The data were collected by a set of questionnaire. HbA1c was measured by High Performance Liquid Chromatography (HPLC), which was recorded in the medical record. Calorie intake was measured by 24 hour food recall. Psychological stress was measured by International Physical Activity Questionnaire (IPAQ). The data was analyzed by path analysis on STATA 13.Results: Psychological stress (b=0.99, 95%CI=0.07 to 1.92, p=0.034), calorie intake (b= 1.84, 95%CI= -0.24 to 3.92, p=0.083), and BMI (b= 1.15, 95%CI= 0.22 to 2.08, p=0.016), had positive and statistically significant effect on HbA1c. Calorie intake increased BMI (b= 2.35, 95%CI=0.31 to 4.39, p=0.024), education decreased calorie intake (b=-2.26, 95%CI= -3.38 to -1.14, p<0.001), and family income increased calorie intake (b= 1.23, 95%CI= 0.26 to 2.21, p= 0.013).Conclusion: Calorie intake, BMI, psychologi stress, and family income are associated with increase in HbA1c level. Education decreases HbA1c level via decreased calorie intake. Type 2 DM patients need to pay attention to these biopsychosocial factors and calorie intake in order to control blood sugar.Keywords: biopsychosocial factors, calorie intake, HbA1cCorrespondence: Isfaizah. Ngudi WaluyoUniversity, Ungaran, Central Java. Email: is.faizah84@yahoo.com. Mobile: +6281228570003.Indonesian Journal of Medicine (2016), 1(2): 90-99https://doi.org/10.26911/theijmed.2016.01.02.02
Serum Ferritin as a Predictor of Shock in Children with Dengue Infection Evalda, Putri; Soebagyo, Bambang; Riza, Muhammad
Indonesian Journal of Medicine Vol 2, No 3 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Dengue shock syndrome causes high morbidity and mortality among children worldwide. Several laboratory monitoring can be used to evaluate the progressivity of dengue virus infection. This study aimed to analyze ferritin serum as a predictor of shock in children with dengue infection, and to determine the cut off point that can be used to diagnose dengue shock.Subjects and Method: This was a cross sectional study conducted at pediatric ward, Dr. Moewardi hospital Surakarta Dr. Soetrasno hospital Rembang, Central Java. Study population was children aged less than 18 years old with dengue infection. Study subjects were selected by consecutive sampling. Tha dependent variable was dengue shock. The independent variable was serum ferritin concentration. Mann Whitney test was used to compare mean ferritin concentration between children with and without dengue shock. Cut off point of serum ferritin concentration was determined by ROC curve.Results: Mean serum ferritin concentration in children with dengue shock (mean= 3628.8; SD= 1582.4) was higher than in children without dengue shock (mean= 717.8; SD= 695.8), with p<0.001. Therefore, there was a statistically significant asssociation between serum ferritin concentration and dengue shock .  The cut off point of serum ferritin concentration that could be used to show dengue shock with high sensitivity (0.92) and specificity (0.97) was 2304.5.Conclusion: High serum ferritin concentration is a predictor of dengue shock.Keywords: ferritin, dengue shock syndrome, childrenCorrespondence: Putri Evalda. Dr. Moewardi Hospital, Jl. Kolonel Sutarto No.132 Jebres, Surakarta, Central Java 57126. Email: dr. putri.evalda@gmail.com. Mobile: 081227970440Indonesian Journal of Medicine (2017), 2(3): 154-160https://doi.org/10.26911/theijmed.2017.02.03.02
Effect of Lawsonia inermis Linn. Ethanol Extract on the Superoxyde Dismutase Activity in Hyperglycemic Rattus norvegicus Antika, Maya Anjelir; Ilyas, Syafruddin; Sari, Mutiara Indah
Indonesian Journal of Medicine Vol 2, No 2 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Alloxan causes experimental diabetic conditions (hyperglycemia) in experi­mental animals through oxidation and the formation of free radicals (oxidative stress) that damage pancreatic β cells. The ethanol extract of the henna leaves can decrease oxidative stress. The purpose of this study is to know the effect of ethanol extract of henna leaves to decrease blood sugar level and increase superoksida enzyme activity.Subjects and Methods: This study is an experimental study. The study design of posttest only control group design, using mice (Rattus norvegicus) strains of wistar, was randomized in five groups: negative control, positive control, group obtaining ethanol extract of henna leaves 200 mg/kg BW, 400 mg/kg BW and 600 mg/kg BW.Results: This study showed a significant reduction in blood glucose levels when compared to the control group. Superoxide dismutase enzyme activity increased but was not statistically significant.Conclusion: Ethanol extract of henna leaves 400 mg/kg BW significantly decreased mice blood glucose level, there was no significant difference in the increase of superoxide dis­mutase enzyme activity.Keywords: Alloxan, antioxidant, flavonoids, hyperglycemia, oxidative stress.Correspondence: Maya Anjelir Antika. Masters Program of Biomedic, Faculty of Medicine, University of North Sumatera.Indonesian Journal of Medicine (2017), 2(2): 79-85https://doi.org/10.26911/theijmed.2017.02.02.01
MicroRNA-155 Tissue Expression in Patients with Breast Cancer at Dr Haji Adam Malik Hospital, Medan Ompusunggu, Henny Erina Saurmauli; -, Juwita; Nauphar, Donny; Pardede, Sumondang M.; Lim, Hadyanto; Siregar, Yahwardiah
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: MicroRNA (miRNA) is noncoding-RNA that comprises 18-22 nucleotides. miRNA binds its gene targets in the 3-untranslated region (3-UTR), causing direct degradation of mRNA and repressed translation of RNA. MicroRNA regulates various biological processes, including cell proliferation, apoptosis, cell growth, cell differentiation, and metabolism. Various changes have been identified miRNA expression in different types of cancers. This study aimed to describe the expression of miR-155 in patients with breast cancer tissue in Haji Adam Malik Hospital in Medan.Subjects and Method: This was a descriptive study. A total sample was 64 paraffin tissue blocks was taken from female patients with breast cancer at the surgical oncology unit, Haji Adam Malik Hospital in 2013-2014. RNA sample were isolated and checked using a spectrophotometer followed by cDNA synthesis. Then this sample was analyzed for miR-155 expression by using Real Time qPCR. Histopathological grade data were obtained from the medical record.Results: The miR-155 expression in the breast cancer patients is higher than that in the UniSp6 RNA Spike-in (internal controls). miR-155 expression was 29.64, 28.44, 29.22, in grade-I, grade-II, grade-III breast cancer, respectively. UniSp6 RNA Spike-in was 22.30, 22.89, 23.10, respectively in the control groups. Thus, increased of miR-155 expression was the highest in grade I breast cancer patients.Conclusion: Increased miR-155 expression can be used as a biomarker for early diagnosis and prognosis of breast cancer.Keywords: miRNA, miR-155, breast cancer.Correspondence: Henny Erina Saurmauli Ompusunggu. Department of Cellular and Molecular Biology, Faculty of Medicine, HKBP Nommensen University, Medan. Email: ompusunggu.henny@gmail.comIndonesian Journal of Medicine (2016), 1(1): 20-25https://doi.org/10.26911/theijmed.2016.01.01.03
Path Analysis of Factors which Correlated with Dysmenorrhea Ertiana, Dwi; Akhyar, Muhammad; Budihastuti, Uki Retno
Indonesian Journal of Medicine Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: All women menstruate every month. There are some disorders suffered by women associated with menstruation, dysmenorrhea is among them. It interferes the women activities, even often requires the sufferers to take a rest and leave classes. The research was purposed to analyze the factors associated with dysmenorrhea.Subjects and Method: This research is an analytical research with cross-sectional approach. The research was conducted on February 23 to March 23, 2016 at Senior High School of Pare, Kediri district. The population study were 452 senior high school students in the Pare who had dysmenorrhea. The samples of research were 198 students by using proportional random sampling technique. The technique for collecting the data was questionnaires. The data were analyzed using path analysis of IBM SPSS AMOS 22.Results: The results showed that the fit model with CMIN = 0.77 (p= 0258); GFI= 0.99; NFI= 0.95; CFI= 0.99; RMSEA= 0.038. The five variables were associated by dysmenorrhea obtained three variables associated indirectly with dysmenorrheal, i.e. physical activity/exercise, BMI and family support and two variables associated with dysmenorrheal directly, i.e. psychological stress (b= 0:36; p <0.001) and the coping mechanisms (b= -0.39; p= 0.002). Obtained of relationships, i.e; family support with coping mechanisms (b= 0:31; p= 0.008); coping mechanisms with psychological stress (b= - 0:13; p= 0.007); BMI with psychological stress (b= -0.43; p= 0.025).Conclusion: Dysmenorrhea is directly related to coping mechanisms and psychological stress. Physical activity / exercise, BMI and family support are related indirectly. It is expected to improve the coping mechanisms and family support so that the sufferers can avoid the stress that can reduce the occurrence of dysmenorrhea. It is expected to improve the coping mechanisms and family support so the sufferers can avoid the stress that can reduce the occurrence of dysmenorrhea.Keywords: path analysis, dysmenorrhea, coping mechanisms, psychological stressCorrespondence: Dwi Ertiana. Masters Program in Public Health, Sebelas Maret University, Surakarta.Journal of Medicine (2016), 1 (2): 136-145https://doi.org/10.26911/theijmed.2016.01.02.08
Association between Left Ventricular Global Longitudinal Strain and Functional Capacity Measured with Six-Minutes Walk Test in Patients after Acute Myocardial Infarction. Wasyanto, Trisulo; Wulandari, Pipiet; Purwaningtyas, Niniek; Murti, Bhisma
Indonesian Journal of Medicine Vol 2, No 3 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: The ischemia resulting from critical coronary narrowing or total occlusion first affects the subendocardialmyofibers. Thus, abnormalities in longitudinal function can be detected before reductions in LVEF and reflects infarct size. The 6MWT provides information that may be a better index of the patients ability to perform daily activities. This study was to assess the relationship between left ventricular (LV) global longitudinal strain (GLS) and functional capacity measured with 6 minute walk test (6MWT) after AMI.Subjects and Method: This is a cross sectional study of patients with STEMI and NSTEMI, at Moewardi Hospital, Surakarta. Eligible patients underwent echocardiography global longitudinal 2D-STE that performed within 48 hour of admission and 6MWT pre- discharge or at the first follow-up visits (day 4-9). Patients were divided into 2 groups according to the LV GLS value, patients with substantial infarction (LV GLS > -13.8%) and non-substantial infarction (LV GLS < -13.8%).Results: There were 50 patients with 42 STEMI and 8 NSTEMI. Compared to patients in group LV GLS < -13.8% (n=18), patients in group LV GLS > -13.8% (n=32) were more likely to be older (57.6 y.ovs 55 y.o), less in functional capacity (10.17 1.3 ml/kg/min vs 11.04 0.98 ml/kg/min; p= 0.018) and less in 6 MWT distance (347.97 65.49 m vs392.39 49.44 m; p=0.016). Using ROC curves, the 6 MWT distance cutoff value of 375 m identified patients with LV GLS >-13.8%, sensitivity of 72.2% and specificity 65.6%, respectively with AUC= 0.70 (CI 95%; 0.559-0.852; p= 0.017). However, LV GLS >-13.8% and age >60 y.o remained the independent predictor in a multivariate logistic regression analysis to identify 6 MWT distance < 375 m in patients after AMI with GLS >-13.8%, (OR =7.967; CI 95%= 1.669-38.030; p=0.009) and age >60 y.o, (OR=10.898; CI95%= 2.201-53.971; p=0.003).Conclusions: In patients after AMI with substantial infarction (LV GLS >-13.8%) had less in functional capacity. The 6 MWT distance cutoff value of 375 m identified patients with LV GLS >-13.8% and could be used in rehabilitation program after AMI.Keywords: Acute Myocardial Infarction, LV Global longitudinal strain, functional capacity, 6 MWT.Correspondence:Trisulo Wasyanto. Department of Cardiology and Vascular Medicine, Faculty of Medicine, Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami No. 36 A, 57126, Surakarta, Central Java.Indonesian Journal of Medicine (2017), 2(3): 192-206https://doi.org/10.26911/theijmed.2017.02.03.07
Anthrax Seroprevalence in Central Java, Indonesia Redhono, Dhani; Dirgahayu, Paramasari
Indonesian Journal of Medicine Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Anthrax is a zoonotic disease that is caused by Bacillus Anthracis is transmitted to humans through infected animal. The transmission to humans occurs when there is a contact to animals or animal products contracting anthrax. Clinical skin manifestations and anthrax serum Ig G antibody can be used to diagnose infected anthrax animals. This study aimed to determine the prevalence of anthrax based on ELISA serum Ig G antibody and clinical skin manifestations occurring in patients with anthrax.Subjects and Method: This was a descriptive study with cross sectional design conducted in Sragen district, Central, Indonesia, in 2015. A sample of 101 patients infected with anthrax was examined based on clinical skin manifestations and anthrax serum Ig G antibody.Results: 39.6% of the sample was 21 to 40 years of age. 57.4% of the sample was female. 74% of the sample completed primary school. 21% worked as farmers. 30.5% of the sample who cooked and consumed meat showed positive Ig G. Test results showed serum Ig G antibody negative 50%, 15.8% and 33.7% borderline positive. Clinical manifestations in the skin as much as 11.9%, which is the eschar on all respondents and 92.8% showed positive Ig  G. While 88.1% did not show any clinical signs of anthrax.Conclusion: The increase in serum antibody titer Ig G anthrax is not all respondents were exposed, in an area that otherwise outbreak of anthrax, which is only a third of all respondents, and when it comes up eschar will be followed by an increase in Ig G antibody titer.Keywords: cutaneous anthrax, Ig G antibody ELISA, escharCorrespondence: Dhani Redhon. Sub Division Tropical Medicine and Infectious Disease, Internal Medicine.Indonesian Journal of Medicine (2016), 1(2): 129-135https://doi.org/10.26911/theijmed.2016.01.02.07
Association between hsCRP Levels, Glycemic Control and Total Interatrial Conduction Time in Patients with Type 2 Diabetes Mellitus K, Isyana Miranti; Wasyanto, Trisulo; Murti, Bhisma
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Type 2 Diabetes Mellitus (T2DM) represents one of the most important risk factors for atrial fibrillation (AF). Numerous studies have shown that T2DM and poor glycemic control reflected by glycated hemoglobin A1c (HbA1c) levels are independently associated with new onset AF. Recent experimental studies reported that the increased susceptibility to AF in the diabetic patients was presumably due to the slowing of conduction associated with increased interstitial fibrosis. Systemic inflammation cam play role in the development of atrial fibrillation. High-sensitivity C-reactive protein (hsCRP) is an inflammatory biomarker that independently predicts the cardiovascular risk. This study aimed to determine the association between hsCRP level and glycemic control with total interatrial conduction time in T2DM patients.Subjects and Methods: This was an analytic study with cross-sectional design. A total of samples were 41 patients with T2DM. Peripheral venous blood samples to measure hsCRP and HbA1c were drawn in all study population. The total interatrial conduction time was measured by tissue Doppler echocardiography. Multivariate analysis was performed using multiple regression analysis. P < 0,050 was considered to indicate a statistically significant difference. Results: The high-sensitivity C-reactive protein level was higher in the T2DM patients with HbA1c≥7% than in the T2DM patients with HbA1c<7%, but not statistically significant (0,44±0,30 vs 0,32±0,22; p = 0,183). The total atrial conduction time was longer in the T2DM patients with HbA1c≥7% than in T2DM patients with HbA1c<7%, but not statistically significant (100,29±28,53 vs 94,88±16,50; p = 0,449). Multiple regression analysis showed that hsCRP levels and glycemic control had significant positive correlation with total interatrial conduction time in T2DM patients (r = 0,51; p = 0,004).Conclusions: The hsCRP levels and glycemic control were significant positively correlated with total interatrium conduction time in patients with type 2 diabetes.Keywords: hsCRP, glycemic control, HbA1c, total interatrial conduction time.Correspondence: Isyana Miranti K. Biomedic, Family Medicine Program, Sebelas Maret University, Surakarta. Indonesian Journal of Medicine (2016), 1(1): 58-70https://doi.org/10.26911/theijmed.2016.01.01.08
Differences in Influence between Intravenous Methylprednisolone and Intramuscular Progesterone toward Erectile Function After Operation Transurethral Resection of the Prostate (TUR-P) in Patients Benign Prostate Hyperplasia (BPH) Yolanda, Monica; Tusarah, Setya Anton; Alifianto, Untung
Indonesian Journal of Medicine Vol 2, No 2 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Erectile function is an important factor for all men in an active sexual condition, as well as to assess the quality of sex life with their partners. Transurethral Resection of the Prostate (TURP) is a gold standard action for Benign Prostate Hyperplasia (BPH). The researcher tried to study to investigate the effect of corticosteroid and progesterone on erectile function in BPH patients who have done TURP surgery by using Erection Hardness Score (EHS). The purpose of this study was to investigate the effect of intra venous methylprednisolone on post-operative erection function of TURP in BPH patients. To investigate the effect of intra-muscular progesterone on postoperative erectile function of TURP in BPH patients. To investigate the different effect between methylprednisolone and progesterone on post-operative erection function of TURP in BPH patients.Subjects and Method: Subjects of all BPH patients who performed TUR-P surgery in the urology sub-section of Dr. Moewardi Hospital, Surakarta. The sampling technique in this study was incidental sampling. This study was a clinical experimental study using Pre and Post-test design-Only Control Design. 3 groups were divided to get different treatment, the first group was given methylprednisolone, the second group was given progesterone and the third group was given TURP therapy protocol only.Results: After 1 month of TURP treatment in BPH patients, the result obtained for the EHS which on a scale of 2 and 3. EHS on scale 2 for the methylprednisolone group was 9 patients (69.2%), the progesterone group had 6 patients (46.2%), and the control group had 8 of patients (66.7%). Meanwhile, EHS on scale 3 for the methylprednisolone group was 4 patients (30.8%), there were 7 patients (53.8%) of the progesterone group, and the control group had 4 patients (33.3%). After 3 months of TURP treatment in BPH patients, EHS on scale 2 in the methylprednisolone group there were 2 patients (15.4%), the progesterone group there were 0 patients (0.0%), and the control group there were 6 patients (50.0%). The methylprednisolone group had 9 patients (69.2%) on EHS 3 scale, the progesterone group had 4 patients (30.8%), and there were 6 patients (50.0%) in the control group. While, EHS scale of 4 the total of the patients in the methylprednisolone group was 2 patients (15.4%), the progesterone group had 9 patients (69.2%), and the control group had 0 patients (0.0%).Conclusion: the methylprednisolone improved the erectile function in post-operative TURP patients. Progesterone improved erectile function in post-operative TURP patients. Therefore, it can be concluded that progesterone was better than methylprednisolone. Keywords: Erectile dysfunction, Methylprednisolone, ProgesteroneCorrespondence: Monica Yolanda. Masters Program in Family Medicine, Sebelas Maret University, Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java. Email: monica_mail83@yahoo.co.id.Indonesian Journal of Medicine (2017), 2(2): 116-124https://doi.org/10.26911/theijmed.2017.02.02.06 
Effectiveness of Acupuncture and Infrared Therapies for Reducing Musculoskeletal Pain in the Elderly Widowati, Risna; Murti, Bhisma; Pamungkasari, Eti Poncorini
Indonesian Journal of Medicine Vol 2, No 1 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: According to the World Health Organization, the most frequent health problems experienced by the elderly is musculoskeletal pain. The common treatment for musculoskeletal pain is Non-Steroidal Anti-Inflammatory Drugs (NSAID) drugs. These drugs, however, give undesireable side effects such as disorders in digestion, renal function, and increased blood pressure. Acupuncture and infrared therapies have been widely known as cheap and safe for musculoskeletal pain. However, their relative effectiveness are not yet clear. This study aimed to determine the effectiveness of acupuncture and infrared therapies for reducing musculoskeletal pain in the elderly.Subjects and Method: This was an experiment study with randomized controlled trials design. The study was conducted at the elderly integrated health post Klodran, Karanganyar, Central Java, in May, 2016. A total sample of 60 elderlies was selected for this study using random sampling technique. This sample was randomized into 4 groups, each consisting of 15 study subjects: (1) acupressure; (2) acupuncture; (3) infrared; (4) acupuncture and infrared. The dependent variable was musculoskeletal pain. The independent variable was type of  pain relief therapy. The data was analyzed by Kruskall Wallis Test, and post-hoc test using Mann-Whitney.Results: Kruskall Wallis Test showed mean differences in the reduction of musculosceletal pain between the four groups, and they were statistically significant, as follows: acupressure (mean= 1.3; SD= 0.5), acupunture (mean= 2.3; SD= 0.5), infrared (mean= 1.6; SD= 0.6), and acupuncture and infrared (mean= 3.9; SD= 0.4). Mann-Whitney test showed the most effective treatment for reducing musculoskeletal pain was acupunture and infrared combination therapy (mean difference= 2.53; p<0.001).Conclusion: Acupunture and infrared combination is the most effective treatment for reducing musculoskeletal pain in the elderly.Keywords: musculoskeletal pain, acupressure, acupuncture, infrared, elderlyCorrespondence: Risna Widowati. Acupuncture Unit, School of Health Polytechnics, Ministry of Health, Surakarta, Central Java. Email: risna.widowati@gmail.com. HP +6281555742729.Indonesian Journal of Medicine (2017), 2(1): 41-51https://doi.org/10.26911/theijmed.2017.02.01.05

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