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Meta-Analysis: The Effectiveness of Acupucture in Reducing Pain and Improving Quality of Life in Patients with Low Back Pain Winahyu, Frannesty Estu; Prasetya, Hanung; Murti, Bhisma
Indonesian Journal of Medicine Vol. 7 No. 3 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: In Indonesia, low back pain is a common health problem that can interfere with a person's productivity in carrying out activities due to the manifestations of the pain it causes. Acupuncture therapy is one of the complementary treatments that is quite effective in reducing the intensity of low back pain. This study aims to estimate the effectiveness of acupuncture therapy to reduce pain and improve quality of life in patients with low back pain.Subjects and Method: This study is a systematic review and meta-analysis with PICO, Population: Low back pain patients, Intervention: Acupuncture therapy, Comparison: No acupuncture therapy, Outcome: Pain reduction and quality of life improvement. It was measured using the Oswestry Disability Index. The article search process was carried out between 2006-2022 using 3 databases, including Google Scholar, PubMed, and Science Direct. The keywords used in the database search were “acupuncture” AND “oswestry disability index” AND “quality of life” AND “low back pain”. The inclusion criteria for full text articles using a Randomized Controlled Trial (RCT) study design by including the results of the study in the form of the number of respondents, the mean and standard deviation (SD) values, for articles using English and Indonesian. Articles that have met the requirements are analyzed using the RevMan 5.3 application.Results: There are 9 articles that meet quantitative requirements and are divided into 2 categories according to independent variables with a Randomized Controlled Trial (RCT) study design originating from Spain, Australia, South Korea, Brazil, Germany and England, which were carried out in a meta-analysis in this study. Meta-analysis of 7 articles showed estimates that acupuncture therapy was effective in reducing pain in LBP patients. Patients experienced a decrease in pain 0.32 units higher than those who were not given acupuncture therapy (SMD = 0.32; 95% CI= -0.46 to -0.17; p <0.001). Meanwhile, a meta-analysis of 9 articles showed the estimation of the effect of effective acupuncture therapy on improving the quality of life in LBP patients. Patients experienced an improvement in quality of life 0.52 units higher than those who were not given acupuncture therapy (SMD = 0.52; 95% CI= 0.22 to 0.81; p= 0.006).Conclusion: Acupuncture therapy is effective in reducing pain and improving the quality of life of LBP patients. Keywords: acupuncture, low back pain, quality of life, oswestry disability index, meta-analysisCorrespondence: Frannesty Estu Winahyu. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: frannestyestuwinahyu@gmail.com. Mobile: +6285228783882.Indonesian Journal of Medicine (2022), 07(03): 313-325https://doi.org/10.26911/theijmed.2022.07.03.08

The Use of Modified Cervical Colar in Reducing Neck Pain Zubaidi, Alfan; Fadli, Arif
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: One of the conditions of pain in the neck area where there is a stiff neck, so sometimes there is pain radiating from the shoulder to the hand, the symptom is often called cervical syndrome. This condition occurs because the vertebral root is compressed for a long time in the use of activities. In the long term, the pain can even radiate to both shoulders and even to the arms of the arch, this situation will result in abnormal and rapid fatigue. According to studies conducted by researchers, this situation may be prevented by giving a special cervical collar design to Tafidz Ouran students. In this study, it will be investigated how effective the special collar model is to overcome the problems/prevention of cervical syndrome for Tafidz Ouran students in Karanganyar. The purpose of this study was to determine how effective a special cervical collar design is to reduce pain in cervical syndrome.Subjects and Method: This research is a Randomized Controll Trial (RCT) where in this study before being randomized in determining the control and treatment groups, matching was done first. In the control group in this study were students who used regular collars (collars sold in the market) and in the intervention group were given special collars. The sample in this study was the students of the Tahfidz boarding school in the Karanganyar area as many as 160 students who experienced cervical syndrome. Each group in this study amounted to 80 students. The sampling technique was simple random sampling. The variables in this study, the dependent variable is the cervical syndrome condition of the Tafidz Quran students and the use of a special cervical collar model as the independent variable. Analysis of the data using the Independent samples t test if the data is normal, and using the Mann Whitney test if the data is not normal.Results: After the intervention, it was shown that pain in the special cervical collar group (mean = 2.51; SD = 0.50) was lower than that in the regular collar group (mean = 5.50; SD = 0.59) and was statistically significant (p value = 0.000).Conclusion: The use of a special cervical collar is better than a regular cervical collar to reduce neck pain.Keywords: cervical syndrome, cervical collar, special cervical collarCorrespondence: Alfan Zubaidi. Department of Orthotic Prosthetic, Ministry of Health Surakarta. Jl. Letjen Sutoyo, Mojosongo, Surakarta, Central Java, Indonesia. Email: drsalfanzubaidi@gmail.com.Indonesian Journal of Medicine (2021), 06(04): 460-464https://doi.org/10.26911/theijmed.2021.06.04.12

Effect of Acupressure on Blood Glucose Level in Diabetes Mellitus Patients: Meta-Analysis Muslihatin Khuril Rosyida; Didik Tamtomo; Hanung Prasetya
Indonesian Journal of Medicine Vol. 8 No. 1 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Diabetes Mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia resulting from abnormalities in insulin secretion that affect blood sugar levels. Chronic hyperglycemia in DM is associated with long-term damage to several organs of the body. One of the interventions that can be given to lower blood sugar levels is acupressure therapy. The purpose of this study was to determine the effect of acupressure therapy on blood sugar levels in patients with diabetes mellitus.Subjects and Method: This study is a systematic review and meta-analysis with PICO, P: Diabetes mellitus patients, I: Acupressure, C: No acupressure, O: Blood sugar levels. The process of searching for articles is done through a database of journals including: Pubmed, Google Scholar, Science Direct, Scopus, Spinger Link, CNKI and Hindawi. The keywords used in the literature search were: “acupressure” AND “diabetes” AND “blood sugar” AND “blood glucose” AND “standard controlled trial”, “acupressure for diabetes”, “diabetes standardized controlled trial”, “acupressure randomized controlled trial”. trial”, diabetes acupoint, “diabetes and placebo”, “acupressure” AND “diabetes”. The articles included in the study were full text articles with a randomized controlled trial study design and the results were reported with the effect size, mean standard deviations (SMD). Articles were collected using PRISMA flow diagrams and analyzed using the Review Manager 5.3 application.Results: A meta-analysis of 9 articles reviewed in this study came from Taiwan, China, Indonesia, Egypt and Iran with a sample size of 451. The study results showed that acupressure therapy was able to reduce blood sugar levels in diabetes mellitus patients with SMD blood sugar values. acupressure was 0.56 units lower than no acupressure and was statistically significant with a significance value of (SMD=-0.56; 95% CI= -0.76 to -0.37; p<0.001).Conclusion: Acupressure therapy has the effect of lowering blood sugar levels in diabetes mellitus patients.Keywords: acupressure, blood sugar, diabetes mellitus.Correspondence: Muslihatin Khuril Rosyida. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Jawa Tengah, Indonesia. Email: khurilrosyida@gmail.com. Mobile: 08564713149.Indonesian Journal of Medicine (2023), 08(01): 68-78https://doi.org/10.26911/theijmed.2023.08.01.07

Meta-Analysis of the Effectiveness of Using Antiplatelet Drugs Uptake in Decreasing Mortality in COVID-19 Patients Nurhayati, Happy; Pamungkasari, Eti Poncorini; Murti, Bhisma
Indonesian Journal of Medicine Vol. 6 No. 3 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Viscoelastic coagulation testing in COVID-19 patients often found elevated concentrations of D-dimer and fibrinogen. Thrombotic complications can be in the form of Venous Thromboembolism (VTE), where this thrombotic disease is one of the factors associated with increased mortality of COVID-19 patients. This study aims to analyze the effectiveness of antiplatelet drugs in reducing mortality in COVID-19 patients.Subjects and Method: This is a meta-analysis study using PRISMA flowchart guidelines. The article search process was carried out between 2020-2021 using PubMed, Science Direct, Google Scholar, and Scopus databases. The article search was carried out by considering the eligibility criteria defined in the PICO model. Population= COVID-19 patients, Intervention= using antiplatelet drugs, Comparison= not using anticoagulant drugs, Outcome= mortality. The keywords used were "antiplatelet" AND "mortality" AND "COVID-19". The inclusion criteria used were English full-text cohort papers and the relationship measure used as the adjusted odds ratio (aOR). Based on the database, 9 articles fulfilled the inclusion criteria. The analysis was carried out using RevMan 5.3 software.Results: The meta-analysis was carried out on 9 articles from the UK, Spain, Germany, Poland, America, Israel, and China. The results of data processing showed that COVID-19 patients who received antiplatelet drugs had a 0.70 times risk of dying than those without antiplatelet drugs, and it was not statistically significant (aOR= 0.70; CI 95%= 0.46 to 1.07; p= 0.100).Conclusion: The use of anticoagulant drugs reduces the mortality risk of COVID-19 patients, but it is not statistically significant.Keywords: antiplatelet, mortality, COVID-19Correspondence: Happy Nurhayati. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: happyajja3@gmail.com. Phone: +62 81226160538.Indonesian Journal of Medicine (2021), 06(03): 315-324https://doi.org/10.26911/theijmed.2021.06.03.09

Probiotics and Its Effects on the Cognitive Development in Children: A Meta-Analysis Ambarsari, Anggraini; Murti, Bhisma; Rahardjo, Setyo Sri
Indonesian Journal of Medicine Vol. 7 No. 2 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Due to its high morbidity and mortality rate, diarrhea is still a major health problem among children, particularly toddlers, in developing countries. One of the causes of diarrhea in children is the side effect of antibiotics or known as antibiotic-associated diarrhea (AAD). Evidences of studies conducted in several countries indicated the high use of antibiotics among children that put the group at a high risk of enduring AAD. Probiotics has shown efficacy in preventing and curing various medical conditions, especially those involving digestive tract in children.Subject and Method: It was a systematic review and meta- analisis study. Data collection was conducted by obtaining from databases, namely: Google Scholar, PubMed, Scopus and Science Direct. The study was analyzed by using RevMan 5.3 software. Inclusion criteria used were full paper in English with Randomized controlled trial design during the period of 2000-2022. Keywords used were “Probiotic” AND “Antibiotic Associated Antibiotic” AND “Child” AND “Randomized Controlled Trial”.Results: Meta-analisis was conducted to 9 primary studies from several countries such as Poland, Italy, Korea, Iran, and Australia. Mata-analysis concludes that there were effects of probiotics toward antibiotic-associated diarrhea. Children who were given probiotics had one-third time risk of diarrhea episodes compared to those who were not given probiotics (RR= 0.32; 95% CI= 0.23 to 0.44; p<0.001). Heterogeneity of between-study effect estimates of the meta-analysis data was (I2= 0%; p= 0.096) therefore, calculation of effect estimates was written by using fixed effect approach. Funnel plot did not identify the occurrence of publication bias out of the meta-analysis. Therefore, the funnel plot did not identify the occurrence of publication bias.Conclusion: Probiotics have effects in reducing antibiotics-associated diarrhea incidences in children.Keywords: probiotics, diarrhea, antibiotics.Correspondence:Anggraini Ambarsari. Masters Program in Public Health, Sebelas Maret University. Jalan Ir. Sutami 36A, Surakarta 57126, Jawa Tengah, Indonesia. Email: Aanggraini.ambarsari29@gmail.com. Mobile: 085600184363Indonesian Journal of Medicine (2022), 07(02): 232-241https://doi.org/10.26911/theijmed.2022.07.02.11

Differences in the Effect of the Combination of Home-Based Walking Exercise and Pursed Lip Breathing with Pranayama Exercise on Increasing Lung Capacity in COPD Conditions Nurul Fithriati Haritsah; Yoga Handita Windiastoni; Noerdjannah Noerdjannah
Indonesian Journal of Medicine Vol. 7 No. 4 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Data from the pulmonary disease polyclinic at Bangil Hospital showed an increase in Chronic Obstructive Pulmonary Disease (COPD) patient visits. In 2018 the number of COPD patients who visited the pulmonary disease clinic for the last 3 months was 219 COPD patients. COPD patients experience deficits in caring for themselves due to various symptoms that manifest as a manifestation of the development of COPD disease. This study aimed to determine the differences in the effect of the combination of home-based walking exercise and pursed lip breathing with pranayama exercise on increasing lung capacity in COPD conditions.Subjects and Method: The design of this study is a two-group pre and post-test design. As many as 8 respondents to the pursed lip breathing intervention and home-based walking exercise and 8 respondents to the pranayama exercise according to the inclusion and exclusion criteria. This study compared the effect of walking exercises combined with pursed lip breathing and pranayama exercise on increasing lung vital capacity in COPD patients. The independent variable is lung capacity. The dependent variable is home-based walking exercise and pursed lip breathing This research was conducted once a week for 12 weeks in May-August 2021 at Dungus Madiun Lung Hospital. All categories were analyzed using a Mann-Whitney run on SPSS.Results: The results before being given the combination of pursed lip breathing and home-based exercises (Mean= 95.39; SD= 0.70) compared to after being given the combination of pursed lip breathing and home-based exercises (Mean= 98.08; SD= 1.23) and statistically significant p<0.001 increases lung capacity in COPD conditions. The results before being given pranayama exercises (Mean= 95.83; SD= 0.71), after being given pranayama exercises (Mean= 97.54; SD= 0.81) and statistically significant p<0.001 increased lung capacity in COPD conditions. score in the elderly was 32.57 (Mean= 32.57; SD= 4.49).Conclusion: There is an effect of giving a combination of home-based walking exercises and pursed lip breathing in increasing the lung capacity of COPD patients. There is an effect of providing pranayama exercise in increasing the lung capacity of COPD patients.Keywords: home-based walking exercise, pranayama exercise, pursed lip breathing, lung capacityCorrespondence: Nurul Fithriati Haritsah. Department of Physiotherapy, Health Polytechnic Surakarta, Ministry of Health. Jl. Letjend Sutoyo, Mojosongo, Jebres, Surakarta 57127, Central Java, Indonesia. Email: nurulfithriati_haritsa@yahoo.com.Indonesian Journal of Medicine (2022), 07(04): 439-448https://doi.org/10.26911/theijmed.2022.07.04.09

Role of Copeptin in predicting of Major Adverse Cardiovascular Events (MACE) during Hospitalization on Acute Myocardial Infarction Patients Wasyanto, Trisulo; Raynantha, I Putu; Yasa, Ahmad
Indonesian Journal of Medicine Vol. 6 No. 2 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Copeptin has been considered as a potential biomarker for AMI which also give information regarding the prognostic of the Acute myocardial infarction (AMI). The aim of this study is to understand the role of copeptin as a predictor of major adverse cardiovascular events (MACE) during hospitalization in AMI patients.Subjects and Method: This was a cohort analytical study conducted at Dr. Moewardi Hospital, Surakarta, from March to May 2021. The dependent variable was MACE. The independent variable was the copeptin level. We observe the MACE during hospitalization and analyze the cut-off point value for optimal copeptin levels to predict the occurrence of MACE using the receiver operating characteristic (ROC) curve. Linear multiple regression was conducted to predict determinants of MACE in hospitalization patients.Results: 52 patients recruited in this research (44 males, 8 females). During hospitalization, MACE occurred in 52% of these subjects, with the respective proportions for acute heart failure, cardiogenic shock, arrhythmias, cardiopulmonary resuscitation, and mortality of 28%, 10%, 8%, 4%, and 2%. The ROC curve showed that the cut-off point of copeptin was 2,141.50 pg/mL and area under curve (AUC) value of 0.710 with sensitivity of 75.0%, specificity of 68.80% and accuracy of 71.15%. Hence, the AUC values and accuracy present fair results for predicting MACE during hospitalization in AMI patients.Conclusion: Copeptin has a role as a predicttor of MACE during hospitalization in AMI patients.Keywords: copeptin, mayor adverse cardiovascular events, acute myocardial infarctionCorrespondence: Trisulo Wasyanto. Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi Hospital. Jl. Kol. Sutarto 132, Surakarta 57126, Central Java. Email: trisulo.wasyanto@gmail.com.Indonesian Journal of Medicine (2021), 06(02): 230-238https://doi.org/10.26911/theijmed.2021.06.02.12.

Reduction of Fructosamine Levels after Ramadan Fasting in Children with Type 1 Diabetes Mellitus Faizi, Muhammad; Rochmah, Nur; Marcos, Imella; Endaryanto, Anang; Soetjipto, Soetjipto
Indonesian Journal of Medicine Vol. 7 No. 2 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Ramadan fasting is one religious challenge for children with type 1 diabetes mellitus (T1DM) which required specific management and strict monitoring. Fructosamine, which reflects glycemic control within 2-3 weeks, is an ideal parameter of glycemic control in Ramadan fasting. This study aimed to analyzed the effect of Ramadan fasting on fructosamine level of children with T1DM.Subjects and Method: This prospective cohort study included children aged under 18 years old diagnosed wit T1DM for >6 months at Dr. Soetomo Hospital, Surabaya, Indonesia in Ramadan 1438 H (May-June 2017). The independent variable from this study was Ramadhan fasting and the dependent variables were fructosamine and HbA1c. The sampling technique was total sampling. Forty-two children were included and devided into 27 children in the fasting and 15 children in the non-fasting group. Fructosamine and HbA1c levels were measured before, mid- and after Ramadan and the comparison between groups were analyzed using the independent T-test.Results: The mean age of all the subjects was 8.95 (SD=3.2) years old, 47.6% were males. The mean (SD) HbA1c level of all the subjects was 10.42 (1.16) %. There was a mild reduction of mean fructosamine level after Ramadan in the fasting group. There was no significat differece I fructsamie level before (Mean= 556.8; SD= 180.39; p= 0.620), mid (Mean= 568.07; SD= 175.37; p= 0.520), and after Ramadhan between groups (Mean= 539.41; SD= 173.04; p= 0.410) respectively. The average fructosamine levels after Ramadan was positively and strongly related to HbA1c (r=0.69; p<0.001). There was no case of severe hypoglycemia and diabetic ketoacidosis in both groups.Conclusion: There is a reduction of mean fructosamine level after Ramadan fasting in children with T1DM although it isn’t statistically significant.Keywords: type 1 diabetes, children, fasting, Ramadan, fructosamineCorrespondence: Nur Rochmah. Department of Child Health, Dr. Soetomo General Hospital/ Faculty of Medicine, Universitas Airlangga. Mayjend Prof. Dr. Moestopo No. 6-8, Surabaya, East Java, Indonesia, 60286. Number: +6281703501118. Email: drnurrochmah@gmail.com.Indonesian Journal of Medicine (2022), 07(02): 131-137https://doi.org/10.26911/theijmed.2022.07.02.02

Meta-Analysis Predictors of Sufficient Pain Management among Children at Pre-hospital Medical Service Arief Wahyudi Jadmiko; Sang Ayu Made Adyani
Indonesian Journal of Medicine Vol. 7 No. 4 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Safely treating pain in children is a critical but challenging task for emergency medical teams. Few studies have focused on pain management guidelines at the hospital or department level. This study aimed to examine predictors of good pain management in children in prehospital health services.Subject and Method: This research is a systematic review and meta-analysis study using PRISMA diagrams. The article search was conducted based on the PICO Model eligibility criteria. P: children with pre-hospital acute Pain. I: analgesic administration and male. C: no analgesic administration, and female. O: pain reduction. The articles used were from 5 databases: EBSCO, Pubmed, ProQuest, Scopus, and Science Direct. The search keywords for articles were as follows “pain management” OR “pain reduction” AND “predictors” AND “pre-hospital care” AND “children”. The inclusion criteria in this study include full-text articles with observational study designs, full-text available articles, the relationship size used is the adjusted Odds Ratio, articles published in the 2010-2022 range, and the research outcome is sufficient pain management or efficient pain reduction. Articles were analyzed using the Review Manager 5.3 application.Results: There are 8 articles in this study, 2 from Australia, 1 from the United States, 1 from Switzerland, and 4 articles from the United Kingdom. The article was analyzed using the PRISMA flow diagram. The study results show that analgesic administration has increased the odds of 3.36 times greater for pain reduction than without analgesic administration. This result was statistically significant (aOR= 3.36; 95% CI = 1.94 to 5.82; p<0.001). However, no significant results from the gender that showed there is no different between male and female patients for pain reduction (aOR= 1.12; 95% CI= 0.98 to 1.27; p= 0.100).Conclusion: Analgesic administration is sufficient pain management for children with acute Pain in pre-hospital medical care.Keywords: children, pre-hospital care, pain management, predictorsCorrespondence: Arief Wahyudi Jadmiko. Nursing Department, Faculty of Health, Universitas Pembangunan Nasional Veteran Jakarta. Jl. Raya Limo Depok 16515 West Java, Indonesia. Email: ariefwjadmiko@gmail.com. Mobile: 085647213628.Indonesian Journal of Medicine (2022), 07(04): 360-370https://doi.org/10.26911/theijmed.2022.07.04.01

Effect of Zingiber officinale Rhizome Powder on Fasting Blood Sugar Levels and HbA1c in Type 2 Diabetes Mellitus Patients: A Meta-Analysis Novianto, Fajar; Tamtomo, Didik Gunawan; Prasetya, Hanung
Indonesian Journal of Medicine Vol. 7 No. 1 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Diabetes mellitus (DM) type 2 is the most common type of diabetes caused by insulin resistance and relative deficiency of insulin secretion. Several studies have shown inconsistent results regarding the effect of Zingiber officinale powder in patients with type 2 DM. As a result of these inconsistencies, researchers are compelled to prove the effect of Zingiber officinale powder on fasting blood sugar (GDP) and HbA1c levels in type 2 DM patients through a meta-analysis study.Subject and Method: This study is a meta-analysis of a number of randomized controlled trials. The articles were obtained from the PubMed, Science Direct, Springerlink and Google Scholar databases published in 2012-2022. The search articles were carried out by considering the feasibility of the criteria determined using the PICO model. Population: type 2 DM patients, Intervention: Zingiber officinale rhizome powder, Comparison: placebo, Outcome: GDP and HbA1c levels. The keywords used are “Zingiber officinale” OR “Zingiber” OR “Z. officinale” OR “Ginger” AND “Fasting blood glucose” AND “HbA1c” OR “A1c” OR “Glicemic” OR “Glucose” OR “Diabetes Mellitus” OR “type 2 diabetes mellitus” AND “Randomized Controlled Trial”. Article selection with PRISMA flow diagram. Analysis of articles using the Revman 5.3 application.Results: A total of 11 articles were reviewed in this study. Analysis of 11 articles showed that administration of Zingiber officinale rhizome powder could significantly reduce GDP levels in type 2 DM patients (Standardized Mean Difference (SMD)= -0.79; 95% CI= -1.32 to -0.26; p= 0.004). Analysis of 10 articles showed that administration of Zingiber officinale rhizome powder could significantly reduce HbA1c levels (SMD = -0.38; 95% CI= -0.55 to -0.22; p<0.001).Conclusion: Zingiber officinale rhizome powder can significantly reduce GDP and HbA1c levels in type 2 DM patients.Keywords: Zingiber officinale, diabetes mellitus tipe 2, GDP, HbA1cCorrespondence: Fajar Novianto. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir.Sutami No.36, Surakarta, Central Java, Indonesia. Email: dr.fajarnovianto@gmail.com.Indonesian Journal of Medicine (2022), 07(01): 39-50https://doi.org/10.26911/theijmed.2022.07.01.05

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