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Klinikal Sains (Jurnal Analis Kesehatan)
Published by Universitas Abdurrab
ISSN : 23384921     EISSN : 26141515     DOI : -
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology
Jurnal klinikal sains program studi analis kesehatan adalah jurnal ilmiah yang membahas tentang kompetensi analis kesehatan yang meliputi kompetensi Mikrobiologi, Hematologi, Parasitologi, Imunoserologi, Toxikologi, dan Kimia Klinik. Jurnal klinikal sains akan terbit setiap enam bulan, dalam satu periode setiap tahun ajaran akan terbit dua kali yakni pada bulan Juni dan Desember.
Arjuna Subject : -
Articles 134 Documents
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PERBANDINGAN TOKSISITAS ANTARA EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura) DAN DAUN KAPAS (Gossypium hirsutum) TERHADAP LARVA UDANG (Artemia Salina Leach) DENGAN METODE BSLT (Brine Shrimp Lethality Test) Mega Pratiwi Irawan; Alfin Surya
Klinikal Sains : Jurnal Analis Kesehatan Vol 11 No 1 (2023): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v11i1.3331

Abstract

Gossypium hirsutum cotton is a member of the Malvaceae family, and its seeds and leaves have been widely used for health care. G. hirsutum cotton has secondary metabolites in the form of flavonoids, tannins, saponins and steroids that can provide pharmacological effects. This study aims to determine the comparison of the toxicity between the ethanol extract of cherry leaves (Muntingia calabura) and cotton leaves (Gossypium hirsutum) using the BSLT (Brine Shrimp Lethality Test) method. The extract was made by maceration method using 96% ethanol as solvent. This toxicity test was carried out using 48 hours old Artemia salina L. shrimp larvae. The results of this study were analyzed using a probit table with the LC50 value of the ethanolic extract of cherry leaves, which was 100 ppm, while the LC50 value of the ethanolic extract of cotton leaves was 158 ppm. This indicates that the extract is highly toxic to the mortality test of Artemia salina L. larvae
UJI IN VIVO TIKUS WISTAR DENGAN BIT MERAH (Beta vulgaris L ) UNTUK PERBAIKAN KELAINAN PROFIL DARAH AKIBAT PAPARAN PESTISIDA Kartika - Ikawati
Klinikal Sains : Jurnal Analis Kesehatan Vol 11 No 1 (2023): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v11i1.3334

Abstract

Pesticides increase the number of free radicals, triggering oxidative stress causing inflammation and blood profile abnormalities such as anemia, agranulocytosis, neutropenia and thrombopenia. One of the plants that is rich in antioxidants and nutrients to form blood cells is red beet (Beta vulgaris L). The purpose of this study was to determine the ability of red beet (Beta vulgaris L) to improve blood profile abnormalities due to pesticide exposure through in vivo test of Wistar male rats. This research is a laboratory experimental type with a Post Test Only Randomized Control Group Design. The sample of the study was 25 male Wistar rats which were randomly divided into 5 different treatment groups. Mice were exposed to 140 ml/day of pesticides and various doses of red beet ethanol extract for 14 days. The blood profile parameters examined were hemoglobin level, hematocrit, erythrocyte count and leukocyte count. Examination of blood profile parameters manually and automatically. Data analysis with ANOVA and Post Hoc tests. The results of the study proved that the ethanol extract of red beetroot was able to improve blood profile damage due to pesticide exposure in the form of a significant increase in hemoglobin levels, hematocrit values, erythrocyte counts and reduced leukocyte counts from leukocytosis (P<0.05). The optimal dose of red beet ethanol extract is 400 mg/kgBB. Red beets are able to improve blood profile abnormalities due to exposure to pesticides. Red beets are recommended as a non-pharmacological alternative to improve blood profile abnormalities due to exposure to pesticides.
KELARUTAN KALSIUM BATU GINJAL DALAM FRAKSI ETIL ASETAT, N-HEKSANA DAN AIR DARI EKSTRAK ETANOL BUAH TAKOKAK (Solanum torvum Swartz) Armydha Dwi Susanti; Alip Sofiyatun Nisa
Klinikal Sains : Jurnal Analis Kesehatan Vol 11 No 1 (2023): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v11i1.3337

Abstract

Kidney stones are caused by calcium salts in the urine. Takokak fruit (Solanum torvum Swartz) contains chemical compounds of flavonoids, alkaloids, tannins, saponins, quinones and steroids. The content of flavonoids in the takokak plant is thought to be used as a decay of kidney stones. This study aims to determine the levels of dissolved calcium in ethanol extract and several fractions of takokak fruit in vitro. The process of soaking kidney stones was incubated at 37⁰C for 5 hours. Dissolved calcium was measured using a Visible spectrophotometer at a λmax of 506.5 nm. Based on the Ca standard calibration curve, a linear regression equation is obtained y = 0.0162 x + 0.1862 with r2 = 0.9939. In order to obtain the percentage of calcium kidney stones dissolved in the ethanol extract, n-hexane fraction, ethyl acetate fraction and the water fraction of takokak fruit respectively 80.49%; 16.3%; 71.85%, and 33.58%. From these results it can be concluded that the ethanol extract of takokak fruit dissolves calcium kidney stones the most because it is possible that the flavonoid compounds are more interested in the ethanol extract of takokak fruit compared to the ethyl acetate fraction and the water fraction.
PENGARUH WAKTU PENUNDAAN PADA PEMERIKSAAN KIMIA URIN METODE CARIK CELUP DENGAN SUHU PENYIMPANAN 2-8oC Sabrina Prisscilya Magdalena Pinontoan; Meildy E. Pascoal; Febbyola A. C. Samaili; Allan J. Andaria
Klinikal Sains : Jurnal Analis Kesehatan Vol 11 No 1 (2023): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v11i1.3350

Abstract

Changes in urine composition may occur in a specimen that allowed to remain unpreserved at room temperature for longer than 2 hours, without preservatives. Urine received in the laboratory often cannot be directly examined because the number of samples is not comparable to laboratory facilities or because urine collection is carried out at the patient's home or doctor's practice. So that urine is often delayed examination time. This study aims to determine the effect of the delay in urine samples stored at a temperature of 2-8oC on the results of urine chemistry examination using the strip-dip method. This type of research is a quasi-experimental research type. The samples used were 50 respondents who were determined by Quota sampling which were then examined for urine chemistry immediately, a delay of 1 hour, 2 hours, and 3 hours at a storage temperature of 2-8oC. Data analysis using Kruskal Wallis test.The results found there was an effect of delay time on urine chemistry examination using the stripping method on the results of leukocyte examination with a significant level value of 0.001 which means (p <0.05) and no effect on the results of the examination of nitrite, urobilinogen, protein, pH, blood, specific gravity, ketones, bilirubin and glucose.
AKTIVITAS ANTIBAKTERI EKSTRAK DAUN KITOLOD (Isotoma longiflora) TERHADAP PERTUMBUHAN BAKTERI Streptococcus pyogenes Ari Nuswantoro; Kartini Kartini
Klinikal Sains : Jurnal Analis Kesehatan Vol 11 No 2 (2023): Desember
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v11i2.3343

Abstract

Kitolod is a plant that is easy to grow in the tropics, including Indonesia. Kitolod leaves contain flavonoids, alkaloids, tannins, saponins and terpenoids that have the potential to be used as antibacterial agents to inhibit the growth of pathogenic bacteria such as Streptococcus pyogenes. This study aims to determine the antibacterial activity of kitolod leaf extract on the growth of Streptococcus pyogenes. This research is quasi-experimental with purposive sampling technique. Kitolod leaves were extracted by maceration method using ethanol then dissolved in 15% DMSO to obtain concentrations of 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, and 90%. Each concentration was replicated three times, and the control used the antibiotic bacitracin. After carrying out the antimicrobial sensitivity test using the Kirby-Bauer diffusion method, the results obtained were inhibition zones of 17.66 mm (sensitive), 18.16 mm (sensitive), 18.50 mm (sensitive), 19 mm (sensitive), 19. 83 mm (sensitive), 21.16 mm (sensitive), 21.83 mm (sensitive), 22.33 mm (sensitive), and 23.83 mm (sensitive) respectively, while the bacitracin control was 17.5 mm (sensitive). Thus, kitolod leaf extract proved to have antibacterial activity against the growth of Streptococcus pyogenes.
PENGARUH STABILITAS KADAR TRIGLISERIDA PADA SERUM SEGERA DIPERIKSA DAN DITUNDA 7 HARI PADA SUHU 2-8◦C Iis Afriayani94; Asrori Asrori
Klinikal Sains : Jurnal Analis Kesehatan Vol 11 No 2 (2023): Desember
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v11i2.3461

Abstract

Examination of triglyceride levels using serum specimens is recommended to be examined immediately, but the examination can be delayed due to factors such as power outages and equipment damage. Deferred serum should be stored in a proper manner. Storage of specimens is one of the pre-analytic stages with a large risk of error. Research Objectives: knowing effect of triglyceride levels in serum which were immediately examined and delayed for 7 days at temperature of 2-8oC. Research method: This research is experimental design with pre-test and post-test design. The research population, namely students of level 1 and 2 of the Department of Medical Laboratory Technology, Poltekkes Kemenkes Palembang, amounted to 221 people. The sampling technique used random sampling. Triglyceride levels were checked using the Biosystem-350 tool. Data analysis using Wilcoxon test. Results: the average serum triglyceride level immediately checked was 73.43mg/dl, the average serum triglyceride level was delayed 7 days at temperature of 2-8oC was 72.63mg/dl. The results of the Wilcoxon test data analysis obtained a Pvalue =0.493. Conclusion: There is no difference in the average results of the examination of triglyceride levels in serum which are immediately examined and delayed for 7 days at temperature of 2-8oC
HUBUNGAN PARAMETER HEMATOLOGI DENGAN HASIL SWAB PCR PASIEN COVID-19 Dona liazarti; May Valzon
Klinikal Sains : Jurnal Analis Kesehatan Vol 11 No 2 (2023): Desember
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v11i2.3481

Abstract

The gold standard for diagnosing COVID-19 is PCR examination, but it is difficult to implement. The earliest routine laboratory examinations requested by clinicians were hematology including hemoglobin, leukocytes, platelets, ALC and NLR. This examination is inexpensive and easy to obtain. This study aims to evaluate the relationship between hematological parameters and PCR results in patients with suspected COVID-19. The study had a cross-sectional design by conducting hematological examinations on suspected Covid-19 patients undergoing PCR swabs. The study used two specimens; first, naso/oropharyngeal swab for PCR examination; second, venous blood with EDTA anticoagulant for examination of hemoglobin, leukocytes, platelets, NLR and ALC using an automated hematology equipment. Univariate analysis was performed to determine the mean and standard deviation. Independent variable data were tested by Kolmogorov-Smirnov which were then analyzed bivariately by independent t test. The mean age of the research subjects was 48.94 years. Most of the subjects who underwent PCR swab examination were women (63%) with positive PCR swab results of 88%. The mean NLR parameter was higher in patients with positive PCR than in patients with negative PCR with p value =0.025 (p<0.05). The NLR parameter was significantly higher in patients with positive PCR so that it can be used as a guideline for clinicians in the initial evaluation of patients with suspected Covid-19.
EFEKTIVITAS PEMBUATAN SEDIAAN TETES TEBAL MALARIA MENGGUNAKAN DARAH K3EDTA DENGAN MODIFIKASI PENAMBAHAN CaCl2 Muhammad Arsyad; Muhammad Nazarudin; Putri Kartika Sari
Klinikal Sains : Jurnal Analis Kesehatan Vol 11 No 2 (2023): Desember
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v11i2.3506

Abstract

Malaria remains a problem in South Kalimantan, with a malaria elimination rate of 53.8%. Accurate diagnosis is crucial for malaria elimination. The malaria diagnostic method utilized is the microscopic examination, which is easy and affordable. This method involves preparing thick and thin blood smears using capillary blood. However, when an anticoagulant is used in the preparation of thick blood smears for malaria, such as blood with anticoagulant, it may cause the blood smear to peel off or not adhere to the glass slide during hemolysis. Calcium chloride (CaCl2) is one of the reagents used in the hematology laboratory for prothrombin time testing. CaCl2 can activate platelets in blood with the anticoagulant K3EDTA to induce clotting. This study aimed to determine the concentration of CaCl2 that produces a 1.5 cm diameter thick blood smear for malaria. The experimental method was employed for this purpose. CaCl2 solutions were prepared at concentrations of 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1%, and 0.1%. Microscopic examination results showed clear lysis of red blood cells, distinct leukocytes, and visible Plasmodium vivax parasites. The ANOVA test yielded a significance value of 0.00, indicating a difference in the diameter of thick blood smears for malaria prepared using blood with anticoagulant reacted with CaCl2. Based on the Post Hoc test, the concentration of CaCl2 that yielded favorable results for preparing thick blood smears for malaria was 4%, resulting in a diameter of 1.5 cm
ANALISIS MIKROBIOLOGI PADA JAJANAN PEDAGANG KAKI LIMA DI SEPANJANG JALAN SUTOREJO SURABAYA Ainutajriani Ainutajriani; Dita Artanti; Mulya Fitrah Juniawan
Klinikal Sains : Jurnal Analis Kesehatan Vol 11 No 2 (2023): Desember
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v11i2.3559

Abstract

Coliform bacteria are indicators of food contamination that can cause diseases such as diarrhea. The presence of Coliform bacteria in food or beverages indicates poor hygiene and sanitation in food service providers. The purpose of this study was to determine Coliform bacteria in street vendors' snacks along Sutorejo street in Surabaya using the MPN (Most Probable Number) method, ALT (Total Plate Number) and identification of Coliform bacteria with Biochemical tests. This research method uses laboratory experiments. The results showed, of the 12 samples of snacks, there were 4 (33%) samples that met the MPN quality requirements and 8 (67%) samples that did not meet the requirements. Based on the ALT test, 3 (25%) samples met the SNI requirements and 9 (75%) samples did not meet the requirements. Coliform bacteria identification results, there were 6 (50%) positive samples of E.coli bacteria, 2 (17%) positive samples of Klebsiella sp., 1 (8%) positive sample of Enterobacter sp. and 3 (25%) samples were not contaminated by Coliform bacteria. From the results of this study it can be concluded that there are still many snacks contaminated by Coliform bacteria and dominated by E.coli.
PEMANFAATAN PERASAN BELIMBING WULUH (Averrhoa bilimbi L) DALAM MENGHAMBAT PERTUMBUHAN ANGKA KUMAN PADA DAGING AYAM Dyah Eka Kurniawati
Klinikal Sains : Jurnal Analis Kesehatan Vol 11 No 2 (2023): Desember
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v11i2.3644

Abstract

Abstract Damage to meat can be caused due to physical impacts, chemical changes, and microbial activity. Four hours after cutting, without preservatives chicken meat begins to spoil. Star fruit plants have many benefits from leaves, fruits and even stems. The flavonoid content in star fruit works by damaging the cytoplasmic membrane so that bacteria will be damaged and die. The purpose of this study was to determine the squeeze of star fruit (Averrhoa bilimbi L) in inhibiting the growth of germ numbers in fresh cut chicken. This type of research is a pure experiment with pre and post test design with control. Researchers provide treatment or intervention on a variable. From this treatment, changes or influences on other variables are expected. The results of this study resulted in the average number of germs in 0, 2, 4, and 6-hour controls was 1.1 × 109 CFU / gr; 1.65 × 108 CFU/gr ; 1.69 × 108 CFU/gr ; 5.7 × 108 CFU/gr. While the average germ number in marinated chicken meat using variations in soaking time using star fruit juice with various variations in soaking time at 0, 2, 4, and 6 hours is 1.1 × 109 CFU / gr; 7.4 × 107 CFU/gr ; 8.5 ×108 CFU/gr ; 1.4 × 109 CFU/gr. So it can be concluded that star fruit juice has an effect on reducing the number of germs within 2 hours of treatment. © 20xx Universitas Abdurrab

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