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Journal Of Widya Medika Junior
Published by Universitas Katolik Widya Mandala Surabaya
ISSN : -     EISSN : 26561409     DOI : https://doi.org/10.33508/jwmj
Core Subject : Health,
Medicine & Pharmacology Public Health
Journal of Widya Medika Junioris our faculty's very first project in publishing the students' research, making them available for both students and faculty members to read. It is an endeavour to nurture our students' passion in doing scientific research through which process they will be encouraged to develop critical thinking, academic writing, an in-depth analysis of a particular topic using scientific method, and eventually produce knowledge.
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Articles 206 Documents
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ANTIBACTERIAL EFFECT OF EUGENIA POLYANTHA WIGHT WITH CORYNEBACTERIUM DIPHTHERIAE NON-TOXIGENIC Murbarani, Ivita T; Isbandiati, Endang; Puspitasari, Chrisdina
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 3, No 2 (2021): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v3i2.3182

Abstract

Introduction: Corynebacterium diphtheriae is a bacteria that causes diphtheria. In recentyears, the bacterium is resistant to antibiotics. Eugenia polyantha wight might be a suitableantibiotic alternative as it has antibacterial effect against Staphylococcus aureus. The contentof the antibacterial compound in Eugenia polyantha wight at specific concentrations isexpected to be able to kill the Corynebacterium diphtheriae.Purpose: This study aimed to examine the antibacterial effect of Eugenia polyantha wight toCorynebacterium diphtheriae non-toxic.Method: Bay leaf extract (Eugenia polyantha wight) made with maceration method. Thisresearch is an experimental study conducted in vitro using a microdilution test on 96 wellplates then count value with the streaking method to find out MBC.Results: bactericidal power was quite effective at the concentration of 40%, while at the concentrationof 80%-100% has very strong bactericidal power that could destroy the growth of bacteria 99.9%. Thehigher the concentration of bay leaves extract, the higher the bactericidal power of bacteria Conclusion: Eugenia polyantha wight has an antibacterial effect against Corynebacteriumdiphtheriae non-toxic.
Blood Sugar Levels With Neutrophil-Lymphocyte Ratio As a Marker of Diabetes Mellitus In Elderly da Silva, Theodora E; Christine, Ika; Djaputra, Edith M
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 2, No 3 (2020): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v2i3.2667

Abstract

Introduction: Diabetes mellitus is a chronic metabolic disease, characterized by high blood sugar levels due to abnormal insulin secretion by the pancreas, insulin action, or both. Based on the Basic Health Research results in 2018, the elderly group dominates patients with diabetes mellitus. The diagnosis of diabetes mellitus requires an expensive examination that is not available in all laboratories, especially primary care facilities. Some research suggested that the neutrophil-lymphocyte ratio can be an alternative marker for establishing a diagnosis of diabetes mellitus. Purpose: To determine the correlation between blood sugar levels and lymphocyte ratio as a marker of diabetes mellitus in the elderly. Method: This study was an observational analytic study with a cross-sectional approach. Data was collected by conducting interviews, physical examinations, and laboratory examinations. Hypothesis testing in this study used the Spearman correlation test. Results: A total of 53 respondents were included in this study, with a proportion of 32 female subjects (60.4%). The mean age of respondents was 76.0 ± 7.29 years. An insignificant correlation was obtained between fasting blood sugar levels and the ratio of neutrophil lymphocytes in the elderly (p = 0.161; r = 0.195). An insignificant correlation was found between blood glucose levels after two hours of postprandial with the neutrophil-lymphocyte ratio in the elderly (p = 0.595; r = 0.075). HbA1c level and the lymphocyte ratio in the elderly also showed a non-significant correlation (p = 0.873; r = -0.023) Conclusion: There is no significant correlation between blood sugar level and neutrophillymphocyte ratio as a marker of diabetes mellitus in the elderly.
STUDY CORRELATION BETWEEN BURDEN AND QUALITY OF LIFE OF DEPENDENT ELDERLY CAREGIVERS IN KLITREN, YOGYAKARTA Kristina, Hana; Widagdo, The MM; Perdamaian, Teguh K
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 3, No 3 (2021): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v3i3.3342

Abstract

Introduction: Elderly with disabilities need caregiver’s assistance in their activities of dailyliving. The caregiver can experience a burden during caring for dependent elderly. The burden can affect the caregiver’s quality of life. Purpose: To measure and test the correlation between dependent elderly’s caregiver burdenand quality of life in Klitren Kampong, Gondokusuman District, Yogyakarta Municipality.Method: The subjects were primary informal caregivers aged ≥ 18 years with an excellent cognitive function caring for the elders with an ADL score <12. Respondents were selected using the consecutive sampling technique. This is quantitative research with a cross-sectional study design. Zarit Burden Interview and Caregiver Reaction Assessment were used to assessing the caregiver’s burden. WHO Quality of Life-BREF was used to assess caregiver’s quality of life. Data were analyzed using spearman’s rank correlation.Results: There were 21 female study subjects. The caregivers ' burden tended to be low in each of the CRA and ZBI domains (mean=8.63±10.730–72.42±10.983). Caregivers’ quality of life tended to be low (mean=49.76±11.962–60.76±11.726). There was a strong and statistically significant correlation between the impact on finance (p=0.000, ρ=-0.678) and the impact on health (p=0.002, ρ=-0.602) on CRA with the environmental domain of WHOQoLBREF. There was a strong and statistically significant correlation between the impact of  the schedule domain on CRA with the psychological domain of WHOQoL-BREF (p=0,000, ρ=0.683). Conclusion: There are significant correlations between caregivers’ burden and quality of life, especially in specific domains. Caregivers with a higher burden have a lower quality of life. 
EFFECT OF AFRICAN LEAF EXTRACT (Vernonia amygdalina) ON ALLOXANINDUCED DIABETES MELLITUS LEYDIG CELL MYTOSIS OF WISTAR RATS Tanaem, C Angela; Rosalind, L Aurellia
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 3, No 3 (2021): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v3i3.3338

Abstract

Introduction: Diabetes mellitus can reduce the quality of human life when accompanied bycomplications, one of which is sexual dysfunction. In diabetics, there is an increase in ROSproduction which can cause damage to local Leydig cell proliferation so that Leydig cellactivity and testosterone secretion decrease. African leaves can be used as a control of bloodsugar levels and antioxidants to overcome oxidative stress. Purpose: To determine the effect of administration of African leaf extract (Vernoniaamygdalina) on alloxan-induced Leydig cell mitosis in male rats with diabetes mellitus.Method: This experimental study used 31 male Rattus norvegicus white rats divided into K,P0, P1, P2, and P3 groups. Each group consisting of six rats and one rat outside the study group was used as a reference. Experimental animals will be induced alloxan with a single dose of 150 mg/kgBW for four days. African leaf extract was administered using a probe togroups P1, P2, P3 at a dose of 100, 200, and 400 mg/kgBW for 14 days. Rats wereanaesthetized and euthanized so that the testes could be used to make preparations with HEstaining and analysis of preparations using a 400x magnification light microscope. Theresearch data were analyzed using One-Way Annova with P<0.05. Results: The administration of African leaf extract affected increasing the number of mitoticLeydig cells (P=0.026). There was a significant increase in the number of mitotic Leydig cellsat a dose of 100 mg/kgBW (P=0.021), but not effective at a dose of 200 mg/kgBW (P=0.188)and 400 mg/kgBW (P=0.823). Conclusion: The administration of African leaf extract at a dose of 100 mg/kgBW has beenshown to increase the number of mitotic Leydig cells so that it can be used to improve sexualfunction in diabetics.
DIFFERENCES OF MASS AND DIAMETER MUSCLE RATTUS NORVEGICUS IN GIVING KETOGENIC DIETS AND EXERCISE Danika, Andri; Dewi, Dewa AL; Sindrawati, Sindrawati
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 3, No 3 (2021): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v3i3.3343

Abstract

Introduction: Saturated ketogenic diet without exercise can lead to muscle mass decrease and disturb body metabolism. Therefore, the researcher is interested in discovering the differences between a saturated and unsaturated ketogenic diet with exercise to muscle mass and diameter. Purpose: This study aimed to analyze the difference in muscle mass and diameter of Rattus norvegicus, which were given a ketogenic diet and exercise. Method: This experimental research used Rattus norvegicus that had been adapted for two weeks. Rats are divided into five groups; control (K), a saturated ketogenic diet (P1), a saturated ketogenic diet with exercise (P2), an unsaturated ketogenic diet (P3), and anunsaturated ketogenic diet with exercise (P4). Upright running wheel exercise was given to the group with exercise for 10 minutes daily. The ketogenic diet was given with oral gavage. Muscle mass was examined in the second and fourth weeks. Muscle diameter was examined before treatment, second week, and fourth week. Results: There are differences in mass and diameter muscle Rattus norvegicus that givenketogenic diet and exercise (p=0,000). In second week, there are significant increase inmuscle diameter for saturated ketogenic diet without exercise (P1(p=0,000)) and significantdecrease in muscle diameter for three other group (P2(p=0,000), P3(p=0,001), P4(p=0,000)). In the fourth week, there is a significant increase in muscle diameter for an unsaturated ketogenic diet with exercise (P4). Conclusion: An unsaturated ketogenic diet with exercise could increase the mass anddiameter of quadriceps muscle at the end of this research. 
EFFECTIVENESS OF MUSIC-BASED THERAPY AS A POSSIBLE INTERVENTION FOR DEMENTIA IN SOCIAL RESTRICTIVE SITUATIONS: A SYSTEMATIC REVIEW OF RCTS Asyura, Muhammad MAZ; Putri, Kassie G; Chandra, Angelina P
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 3, No 3 (2021): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v3i3.3339

Abstract

Introduction: Patients with dementia experience painful, confusing, frustrating, and amnesialike emotional distress and instability because of their brain’s inability to correlate their emotions with the memory that causes the emotion. Moreover, the dependency of dementia patients also results in an additional emotional, physical, and financial burden to their families and caregivers. In addition, the COVID-19 pandemic forces drastic self-isolation, which are hard to comprehend for dementia patients, increasing their feeling of anxiety, loneliness, and frustration. Music therapy has gained popularity amongst other therapy alternatives for dementia for its easy accessibility, previously proven effectiveness to reduce dementia symptoms and its positive impact on the caregivers.Method: A systematic review was performed, searching for randomized controlled trials, according to the PRISMA statement, throughout five international databases with published studies up to 18 April 2021. Critical appraisal was further conducted utilizing the Cochrane Risk of Bias Tool 2.0.Results: The search yielded eight randomized controlled trials with a total of 534 subjects. The intervention conducted was in individual or group music therapy. The outcomes were measured using various indicators, and significant improvements found in agitated behaviour, behavioural and psychological symptoms, and general mood of the patient. Conclusion: Music therapy is a highly potential alternative therapy for elderly patients with dementia, showing significant and effective improvements to reduce dementia-related symptoms. Further studies in coherence with implementations of the therapy are urgently needed to aid the increasing prevalence of dementia worldwide, especially in Indonesia.
POLYMORPHISM OF INTERLEUKIN-10 (-819) GENE IS NOT ASSOCIATED WITH LIVER DAMAGE AMONG CHRONIC HEPATITIS B PATIENTS Ramadhani, Nur'aina ID; Arfianti, Arfianti
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 3, No 3 (2021): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v3i3.3340

Abstract

Introduction: Chronic hepatitis B (CHB) is characterized by chronic liver inflammation andhepatocellular damage caused by hepatitis B virus (HBV), leading to fatal liver diseases such as cirrhosis and hepatocellular carcinoma (HCC). Liver damage causes elevated levels of serum alanine aminotransferase (ALT). Previous studies have shown that IL-10 gene polymorphism (-819 C/T) is linked to several diseases, including inflammatory, autoimmune diseases, and cancer. Purpose: To investigate the relationship between IL-10 gene polymorphisms (-819 C/T) and liver damages in chronic hepatitis B patients at Arifin Achmad Regional Hospital, RiauProvince.Method: This study was an analytical study with a cross-sectional approach. Liver damages were examined by measuring ALT levels, and IL-10 gene polymorphisms were analyzed using Amplification-Refractory Mutation System Polymerase Chain Reaction (ARMS-PCR). Results: There were 74 subjects included in this study, aged 45.47±13.42 years old,consisting of 43 males (58.1%) and 31 females (41.9%). Of 74 subjects, 35 CHB patientswere presented without complication, 26 CHB patients were complicated with cirrhosis, and 13 CHB patients were complicated with hepatoma. The genotype of the IL-10 (-819) gene polymorphism in this study was found as follows: CT genotype in 34 subjects (45.9%), TT genotype in 30 subjects (40.5%), and CC genotype in 10 subjects (13.5%). There was nosignificant relationship between IL-10 gene polymorphisms (- 819) and liver damage inchronic hepatitis B patients (p> 0.05).Conclusion: IL-10 gene polymorphism (-819) may not contribute to liver damages amongCHB patients.
CORRELATION BETWEEN EXCLUSIVE BREASTFEEDING IN GROUP OF EARLY INITIATION OF BREASTFEEDING ON THE DURATION OF LACTATIONAL AMENORRHEA Febrianto, Edison; Prabantoro, Benedictus TR; Pangemanan, Lisa
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 3, No 3 (2021): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v3i3.3336

Abstract

Introduction: Based on data from "Survei Demografi dan Kesehatan Indonesia" (SDKI) in2012, about four percent of births occurred 18 months apart, and six percent were less thantwo years apart, about 75 percent occurred at least three years apart. WHO’s recommendation for birth spacing is at least 24 months. A gestation interval of fewer than six months can increase maternal mortality due to premature rupture of the amniotic sac, anemia, and puerperal endometritis. The Lactational Amenorrhea Method is a natural and easy method of contraception. The LAM method is one of the contraceptive methods with a success rate of 98 percent. One of the importance of contraception, such as LAM, is to adjust the optimal birth spacing. Purpose: This study aims to determine the correlation between exclusive breastfeeding in agroup of early initiation of breastfeeding on the duration of lactational amenorrhea. Method: This study is an observational analytic study with a retrospective cohort studydesign. A simple random sampling technique is used for the sampling method. The collectionof data on the history of breastfeeding and the duration of amenorrhea was collected from the main research results by doing interviews with respondents. Results: The results of statistical tests with Spearman correlation showed that the P-valueobtained is 0.005. This value is less than p (0.05), which means a significant correlationbetween exclusive breastfeeding and the duration of lactational amenorrhea. Conclusion: There is a significant correlation between exclusive breastfeeding in the earlyinitiation of the breastfeeding group and the duration of lactation amenorrhea.
RELATIONSHIP BETWEEN SLEEP QUALITY AND COGNITIVE FUNCTION IN ELDERLY IN THE TRESNA WERDHA SOCIAL ASSISTANCE KHUSNUL KHOTIMAH PEKANBARU Wulandari, Mia; Faisal, Faisal
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 3, No 3 (2021): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v3i3.3341

Abstract

Based on data on population projections in Indonesia in 2015-2045, age groups of 60 and over will continue to increase. A large number of the elderly population can be a burden if the elderly have health problems. As we get older, there will be physical appearance, function and response in daily activity. The occurrence of sleep disorders will have an impact on cognition. To determine the correlation of sleep quality with cognitive function in the elderly in UPT PSTW Khusnul Khotimah Pekanbaru. This type of research is observational analytic with the cross-sectional approach. The study was conducted at UPT PSTW Khusnul Khotimah Pekanbaru. The sampling technique used was total sampling, with 46 respondents from a total population of 58 respondents in the UPT PSTW Khusnul Khotimah Pekanbaru. Researchconducted on 46 respondents found 67% of respondents with poor sleep quality and as manyas 65% of respondents experiencing cognitive impairment. Statistical test to determine therelationship of sleep quality with cognitive function in the elderly using the SpearmanCorrelation test showed that there was a significant relationship between sleep quality andcognitive function in the elderly in UPT PSTW Khusnul Khotimah Pekanbaru with a p-valueof 0.003 (<0.05) and coefficient correlation (r) 0.427 shows the strength of the moderaterelationship with the direction of the positive correlation. Sleep quality is related to andinfluences cognitive function in the elderly at UPT PSTW Khusnul Khotimah Pekanbaru. 
THE EFFECT OF ADMINISTERING AFRICAN BITTER LEAF EXTRACT ON SPERMATOGENIC CELLS OF HYPERGLYCEMIC WISTAR RATS Kartana, Kartana; Tahalele, Paul L; Suwasanti, Niluh
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 3, No 3 (2021): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v3i3.3337

Abstract

Introduction: Diabetes is still a world health problem that can cause many complications.Male infertility is one of the diabetic complications. This condition is caused by oxidativestress in diabetic patients. African bitter leaf is believed to contain an antioxidant compoundthat can repair male infertility. Purpose: This study aims to determine the effect of administering African bitter leaf extracton spermatogenic cell count in hyperglycemic Wistar rats. Method: This study use Rattus norvegicus as an animal model, which was administrated withalloxan to induce hyperglycemic. P0 group were given Na CMC 0,1%, Control group were given glibenclamide 0,63/kg bodyweight for 14 days. 100mg/kg bodyweight (P1), 200mg/kg (P2), and 400mg/kg (P3) of African bitter leaf extract were administrated for 14 days. In theend, the animals were sacrificed, and testicle histopathologic sections were made. Results: Significant result (P<0,05) comparing spermatogonium, primary spermatocyte, andspermatid count between groups. Post-hoc test shows the significant result on comparison ofprimary spermatocyte and spermatid count between P0 and P1.Conclusions: There is an effect of bitter leaf extract administration on spermatogenic cellcount in hyperglycemic Wistar rats. The best improvement can be observed in the P1 group,administered with 100mg/kg bodyweight African bitter leaf.

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