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Jurnal Farmasi Indonesia

farmasi-indonesia
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Published by Universitas Setia Budi

ISSN : 16938615 EISSN : 23024291 DOI : -

Core Subject : Health, Science, Engineering,

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.

Arjuna Subject : -

Articles 271 Documents

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Uji Aktivitas Antibakteri Salep Hidrokarbon Ekstrak Etil Asetat Daun Jengkol (Pithecollobium labatum Benth) terhadap Staphylococcus aureus ATCCÂ® 25923 Ismi Rahmawati; Novia Yucca Tiara; Agnes Sri Harti
Jurnal Farmasi Indonesia Vol 6 No 3 (2009): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Jengkol (Pethecollobium labatum Benth) leaf is a traditional medicine used to treat eczema, scabies, wound and ulcer, and the fruit peel is for sore. Jengkol leaf contains saponin, flavonoid, and tannin. The experiment was aimed to know the antibacterial activity of jengkol leaves ethyl acetate extract ointment against Staphylococcus aureus ATCC 25923 infection indicated by recovery time from infection on rabbitâ€™s back with effective basic and concentration. Jengkol leafâ€™s ethyl acetate extract was then made into hydrocarbon basics ointments with concentrations of 10%, 20%, and 30%. The examination of the ointment consist of stability, homogenity, spreadability, adhesion capacity, protection capability, and viscosity test. The ointments were rubbed once a day on the infection area. The observation was carried out until the infection was healed which is confirmed by the disappearing of pus, drying wound, and when it was inoculated in Vogel Jhonson Agar media there was no growth of bacteria. The result of this experiment showed that the most effective ointment of jengkol leaves extract was ointment with 30% concentration. All the tests taken demonstrated that the ointment of jengkol leaves reached the standard of good ointment.

Analisis Etanol dalam Hair Tonic dan Hair Spray secara Kromatografi Gas Endang Sri Rejeki
Jurnal Farmasi Indonesia Vol 7 No 1 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Hair tonic and hair spray is a cosmetic for hair treatment. Hair tonic is a cosmetic treatment of the scalp and hair which is used after shampooing or when the scalp is clean. Hair spray is a cosmetic preparation used to strengthen temporary on hair that has been formed previously. The aim of the study was to determine the ethanol content in hair tonic and hair spray by gas chromatography. The quantitative analysis method used in this study was internal standard. The experiment began with looking for appropriate analysis. The chosen analysis condition was then used for quantitative analysis. The calibration curve equation was used to determine the ethanol content in hair tonic and hair spray samples. The results showed that the chosen analysis condition to determine the ethanol content in hair tonic and hair spray were: column temperature 50oC, injector temperature 70oC, detector temperature 100oC, and gas pressure 80 kPa. The ethanol content obtained in hair tonic sample was 15,2365% Â± 0,2475, while in hair spray sample was 17,2528% Â± 0,5765.

Analisis Besi (Fe) dalam Air Sumur di Daerah Kergan, Sukoharjo secara Spektrofotometri Serapan Atom Elina Hartono; Dyah Susilowati; Sarastriningsih Sarastriningsih
Jurnal Farmasi Indonesia Vol 7 No 1 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Well water is a vital water source for Indonesian inhabitant especially at rural area. Well water is made by digging the ground manually with difference depth according to the kind of land and the site of water source i.e. about 5-20 meters or more. The experiment was aimed to find out whether there was iron in well water and the content of iron at Kergan â€“ Sukoharjo. The method used to find out iron content was Atomic Absorption Spectrophotometer. Preparation of sample was done by wet destruction method because the sample was already in liquid form. Analysis could be done by putting the obtained sample absorbance into linier regression equation using standard curve until the content was obtained. The result of the experiment showed that all samples of well at Kergan â€“ Sukoharjo that analyzed qualitatively contained iron. The iron content in sample A = (0.3751 Â± 0.0416) ppm; sample B = (1.0437 Â± 0.0119) ppm, and sample C = (1.4845 Â± 0.0830) ppm. The iron content in sample A fulfilled the requirement of Indonesian National Standard 01 â€“ 0220 â€“ 1987, while sample B and C were more than the requirement of Indonesian National Standard 01 â€“ 0220 â€“ 1987.

Pengaruh Fraksi Air Ekstrak Etanol Umbi Bawang Merah (Allium cepa L.) terhadap Kadar Kolesterol Total Serum Darah Tikus Putih Erna Dwi Hastutik; Kisrini Kisrini; Dwi Ningsih
Jurnal Farmasi Indonesia Vol 7 No 1 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Onion (Allium cepa L.) is one of medical plants that widely used, and onion tuber is supposed to have beneficial to decrease cholesterol level. The aim of this study was to find out the effect of water fraction of onion ethanol extract that given orally on decreasing total cholesterol level in blood serum of white rats wistar and to see the dose that gave the effect equal with simvastatin in decreasing total cholesterol level. The study to determine cholesterol level of the animal testing was conducted by CHOD-PAP method. Test animals were divided into 5 groups and each group consists of 5 rats. Group I as negative control was contain CMC 1%. Group II was contain CMC 1% and treated water fraction of onion etanol extracts with three variations of dose, namely 25, 50, 100 mg/200 g body wight obtained from the ethanol extract fraksinasi using water and ethyl acetate. Group III as positive control was contain simvastatin and CMC 1%. Test animals were given pig oil and cholesterol powder for one week until hypercholesterolemia condition, and then were given test preparation until the 14th day. The cholesterol level was measured on the 1st, 7st and 14st day. The results of this study were that water fraction of onion ethanol extracts that given orally could decrease total cholesterol level in blood serum of white male rat. According to the results of one way anova statistical test, it was indicated that water fraction of onion ethanol extracts of 100 mg/ 200 g body wight dose had the effect to decrease total cholesterol level equal with simvastatin.

Uji Aktivitas Antifungi Fraksi n-Heksan, Etil Asetat, dan Air dari Daun Pepaya (Carica Papaya Linn.) terhadap Candida albicans ATCC 10231 Ismi Rahmawati; Shinta Noviana; Yudi Rinanto
Jurnal Farmasi Indonesia Vol 7 No 1 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Papaya leaf (Carica papaya, Linn) contains alkaloid, saponin and flavonoid. Papaya leaf can be used for treating whiteness, increasing appetite, treating malaria. The objective of this research is to find out the activity of macerate, n-hexane, ethyl-acetate, and water fractions of papaya leaf (Carica papaya, Linn) as antifungal agent to Candida albicans ATCCÂ® 10231, the primary cause of candidiasis. The papaya leaf powder was macerated using ethanol 70%, that was then concentrated, followed with fractionation using water, ethyl acetate, and n-hexane solvent. The method employed in this research was dilution (tube dilution), method of antifungal test was conducted by dilution method a series of dilutions in various concentrations 100%; 50%; 25%; 12,5%; 6,25%; 3,12%; 1,56%; 0,78%; 0,39%; dan 0,195%(b/v). The result of research showed that ethyl acetate fraction of papaya leaf hs the most effective antifungal activity compared with the macerate, n-hexane and water fractions. Ethyl acetate fraction has Minimum Killing Concentration of 25% (b/v), macerate and n-hexane fraction have Minimum Killing Concentration of 50% (b/v), and water fraction does not have Minimum Killing Concentration on Candida albicans ATCC 10231.

Identifikasi Minyak Atsiri dalam Kalus Daun Lavender (Lavandula officinalis Chaix) dengan Perlakuan Penambahan Zat Pengatur Tumbuh NAA pada Medium MS Ratno Agung Samsumaharto; Fransiska Leviana; Prapita Sari Widayanti
Jurnal Farmasi Indonesia Vol 7 No 1 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Lavender (Lavandula officinalis Chaix) plant contains secondary metabolite such as volatile oil. Lavender oil can be used as antiseptic, anti-inflammation, repellant and antifeedant. The experiment was aimed to know the influence of NAA hormone in inducing lavender leaves callus and stimulating volatile oil in lavender leaf callus. The experiment was done by plant tissue culture technique. Explant cultivation in MS media with various NAA plant growth regulator concentrations, i.e. 1 mg/L, 2 mg/L, 3 mg/L. Observation and evaluation were conducted for the success of callus forming, callus induction time, and callus weight and then the volatile oil was analyzed by color test and TLC using mobile phase hexane-ethyl acetate (96:4) and stationary phase silica gel 60F254 and the spot was observed by anisealdehyde- H2SO4 spray. The result of the experiment showed that NAA plant growth regulator with difference concentrations affected callus formation 86,67%, the fastest callus induction time 5,69 days, and the biggest average weight of dry callus 0,070 gram. The callus obtained from tissue culture with addition of NAA plant growth regulator contained volatile oil component the same as mother plant.

Uji Aktivitas Antibakteri Ekstrak Etanolik Daun Sisik Naga (Drymoglossum piloselloides (L) Presl) terhadap Shigella dysenteriae ATCC 9361 dengan Metode Soxhletasi dan Perkolasi Tinuk Wuryandari; Bambang Iskamto; Ismi Rahmawati
Jurnal Farmasi Indonesia Vol 7 No 2 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Leaves of Drymoglossum piloselloides [L.] Presl. were used as dysentery drug. The experiment was aimed to find out whether soxhletation and percolation extracts of Drymoglossum piloselloides [L.] Presl. leaves had antibacterial activity against Shigella dysenteriae ATCC 9361. Lleaves were dried and then blended to make powder. The extraction method used was soxhletation and percolation methods using ethanol 70% solvent. The obtained extract was evaporated until it was thick, and then the antibacterial activity test was conducted by dilution method against Shigella dysenteriae ATCC 9361. he concentrations of the test solutions were: 100%, 50%, 25%, 12.5%, 6.25%, 3.125%, 1.56%, 0.78%, 0.39%, 0.19%. The result of the experiment showed that soxhletation and percolation extracts had antibacterial activity against Shigella dysenteriae ATCC 9361 test bacteria. There was no difference in antibacterial activity between soxhletation extract and percolation extract against Shigella dysenteriae ATCC 9361 showed by minimum bactericidal concentration i.e. 50% both.

Pengaruh Cairan Penyari terhadap Rendemen dan Kadar Tanin Ekstrak Daun Jambu Biji (Psidium guajava L.) Arum Triyas Wardani; Fransiska Leviana
Jurnal Farmasi Indonesia Vol 7 No 2 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

The leaves of guava (Psidium guajava L.) has been used and produced by industrial as an antidiarrheal. Active substances that act as an antidiarrheal in the leaves of guava are the tannins. Tannins are phenolic compounds that are soluble in water, ethanol or water-ethanol mixture. This study aims to determine the influence of solvent on yield and tannins content in the guava leaf extract and to determine the most optimal solvent for the manufacture of guava leaf extract with the maximum tannins content. The research was conducted by extracting the leaves of guava by maceration with ethanol 50%, 70%, 90%. Viscous extract obtained is then analyzed yield and tannins content. Quantitative analysis of tannins performed by permanganometry titration method. In this research shows that qualitatively the ethanol extract of guava leaves contain tannins. The results showed that solvent affect the yield and tannins content in the guava leaves extract. The yield of extract for 50%, 70%, 90% ethanolic extracts were 22,07%; 31,87%; 25,13%. Tannins content in the 50%, 70%, 90% ethanolic extract were 23,37%; 14,28%; 10,96%. The most optimal solvent for the manufacture of guava leaf extract with the highest tannin content was ethanol 50%.

Uji Mutu Fisik Tablet Ekstrak Daun Jambu Monyet (Anacardium occidentale L.) dengan Bahan Pengikat PVP (Polivinilpirolidon) secara Granulasi Basah Dyah Susilowati; Yogi Adi Christanto
Jurnal Farmasi Indonesia Vol 7 No 2 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Leaves of Anacardium occidentale L. as a diabetes mellitus drug will be made tablets. test the physical quality of tablets of Anacardium occidentale L leaves extract made by wet granulation with a binder PVP (polyvinylpyrrolidone). The extract of leaves of Anacardium occidentale L was obtained by maceration. The leaves of Anacardium occidentale L extract tablets were produced by wet granulation method. The granules are then tested for physical properties include flow time, angle of repose, drying shrinkage and moisture content. Tablets are tested for physical properties including hardness test, friability test, weight uniformity test and disintegration time. The results of this study are based on existing literature and statistical analysis to test the physical quality of the tablet. The granules obtained had a drying shrinkage of 1,16%, flow time of 5,81 seconds, and angle of repose of 24,11 0. The results of this study is the average uniformity of tablet weight is 0.642 grams. The average tablet hardness was 7.61 kg. The average number of fragility tablet is 0.13%. Average duration of crushed tablets is 5 minutes 22 seconds.

Pengaruh Bahan Pengikat Gelatin dalam Formula Tablet Ekstrak Daun Kemuning (Murraya paniculata (L.) Jack) secara Granulasi Basah Yeni Fitriana; Titik Sunarni; Widodo Priyanto
Jurnal Farmasi Indonesia Vol 7 No 2 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Kemuning (Murraya paniculata (L.) Jack) is one of Indonesia medicine plants. Kemuning leaves can be used to decrease cholesterol. The experiment was aimed to make tablets of kemuning leaves extract with gelatin as binding agent that fulfilled the requirements of tabletâ€™s physical quality. Extract of kemuning leaves was obtained from kemuning leaves powder by maceration method using ethanol 70%. The obtained extract was soaked for several days and then evaporated till thick extract was obtained. Kemuning leaves extract tablets were made in 3 formulation with difference concentrations of binding agent, i.e. formula I contained 1% of gelatin mucilage 5%, formula II contained 2% and formula III contained 3%. The method used to make tablets of kemuning leaves extract was wet granulation method. The obtained granules were physically tested in cluding flowing time, the angle of repose, and loss on drying. The obtained tablets were physically tested including weight homogeneity, hardness, friability and disintegration time. The obtained data was statistically analyzed using SPSS 11.0 for windows program i.e. one way anova added with one factor at 95% convidence. The conclusion of the experiment was that kemuning leaves extract could be made tablets that fulfilled therequirement of tabletâ€™s physical quality. The result of the experiment showed that the three formulations produced tablets with weight homogeneity, hardness, friability and disintegration time that fulfilled the requirement of good physical quality of tablet.

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