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Jurnal Farmasi Indonesia

farmasi-indonesia
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Published by Universitas Setia Budi

ISSN : 16938615 EISSN : 23024291 DOI : -

Core Subject : Health, Science, Engineering,

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.

Arjuna Subject : -

Articles 271 Documents

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Aktivitas Antibakteri dan Penyembuhan Luka Fraksi-Fraksi Ekstrak Etanol Daun Kamboja (Plumeria acuminata Ait) pada Kulit Kelinci yang Diinfeksi Staphylococcus aureus Gunawan Pamudji Widodo; Dwi Ningsih; Dan Mona Aprilia
Jurnal Farmasi Indonesia Vol 7 No 2 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Kamboja (Plumeria acuminata Ait.) plant is traditional medicine used as medication for abscess and yaws. Flavonoid is a component of chemical compound in kamboja leaves that supposed to have antibacterial activity. The aim of the experiment was to find out the ability of kamboja leaves fractions creams in healing the infection of Staphylococcus aureus on rabbit skin and to know the most effective concentration. Kamboja leaves were extracted by soxhletation method using 96% ethanol solvent, and then the obtained extract was fractionated using n-hexane, ethyl acetate and 70% ethanol solvents. The antibacterial activities of the three fractions were tested in the form of creams by in vivo method. It was found that ethyl acetate fraction was the most effective, and then various doses were conducted with concentrations of 15%, 20%, and 25% using test animals infected by Staphylococcus aureus.The result of the experiment showed that ethyl acetate fraction had the best ability compared with n-hexane and ethanol 70% fractions. Ethyl acetate fraction cream concentration of 15%, 20%, and 25% could heal the infection for 11.40, 10.60 and 9.40 days, respectivelly.

Aktivitas Antioksidan Herba Kate Mas (Euphorbia heterophylla L.) terhadap Radikal DPPH (1,1-Difenil-2-Pikrilhidrazil) Louis Madalena; Titik Sunarni; Fransiska Leviana
Jurnal Farmasi Indonesia Vol 7 No 2 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Antioxidant is very important to keep humanâ€™s health because of it can scavenge free radical. Flavonoid is usual natural antioxidant got on plants. Euphorbia heterophylla L. which is used by people as traditional herbal medicine and it has traditional name kate mas is known contain of flavonoid, tannin and saponin. The aim of the experiment was to find out the antioxidant activity of kate mas (Euphorbia heterophylla L.) herb and the potency of methanolic extract, hexane, etil acetat and water fractions, and also of kate mas herb on DPPH (2,2-difenil-1-pikrilhidrazil) radical with IC50 parameter. Kate mas herb were extracted by maceration method using methanol. The obtained extract was partitioned with water and hexane, and then with etil acetat. The antioxidant activity of the obtained fraction was tested against DPPH radical. The test was conducted in 4 series of concentrations by adding 4.0 ml test solutions with 1.0 ml DPPH 0.45 mM. The radicals scavenging activity was measured with spectrophotometer at 515 nm wavelength and determined the IC50 value. The experiment used rutin as positive control. The result of the experiment showed that kate mas herb had antioxidant activity with IC50 of methanolic extract, water fraction, n-hexane fraction, and etil acetat fraction: 44,43 ppm; 130,63 ppm; 212,81 ppm; and 5,88 ppm respectively. The etil acetat fraction has the strongest activity compairing to the other with the IC50 is almost near often rutinâ€™s IC50 is 5,11 ppm as the positif control.

Optimasi Campuran Carbopol 941 dan HPMC dalam Formulasi Sediaan Gel Ekstrak Daun Jambu Mete secara Simplex Lattice Design Ilham Kuncahyo
Jurnal Farmasi Indonesia Vol 8 No 1 (2011): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Cashew leaves can be used as an antibacterial. The use of this cashew leaves in direct application can an unpractical, so it was made in the form of gel. This research was to get the gel optimum formula of the cashew leaves extract using two addition substances they were carbopol 941 and HPMC based on the simplex lattice design. The cashew leaves extract was obtained by maceration using ethanol 70% then it was evaporated to obtain concentrated extract. The optimum gel was based on simplex lattice design method with 2 components i.e. carbopol 941(C) and HPMC (H) used 3 formulations: formula I (100% C: 0% H), formula II (50% C: 50% H) and formula III (0% C: 100% H). Observation of physical properties included viscosity, the time of sticking and spreading ability, than it used to obtain SLD equation. The equation is used to make optimum gel formulation with the highest total respond of gelâ€™s physical properties. The obtained data of simplex lattice design was compared to the result of real test by T-test. The result of the experiment showed that cashew leaves extract can be optimum formula of cashew leaves gel extract was obtained from the mixture of carbopol 941 60% - HPMC 40%. The result of t-Test of viscosity, adhesiveness and distribution showed that there was no significant difference between prediction and the result of real test.

Analisis Distribusi Obat Rawat Inap di Instalasi Farmasi RSUD Tarakan Jakarta Pusat Ika Purwidyaningrum
Jurnal Farmasi Indonesia Vol 8 No 1 (2011): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Drug management in hospital which consist of stages are selection, procurement, distribution and use. Result of preliminary observation done in Pharmacy Installation of Tarakan Hospital found some inefficiency problem in distribution steps such as expired and damage control, conformity of record to physical checks on drug management, etc. Therefore, it necessary to evaluation the efficiency rate of inpatient ward drug management distribution. Research using a design description is retrospective and concurrent with the evaluation of documents relating to inpatient drug distribution process. The study used a sample of drugs including medicines criteria Class A. Data collected in the form of qualitative and quantitative data from observations of documents and interviews with relevant officers. Presentation of data in tabular and textual descriptions, evaluations descriptively using SPSS. Measurement of the efficiency of drug distribution is done by using indicators of the efficiency of Depkes, Pudjaningsih (1996) and WHO (1993), then compared with the standard or the results of a study to determine the existence of inefficiency. The results showed, according to several indicators of drug distribution and hospitalization have not beenefficient. Inefficiency drug management indicators at this stage of the distribution occurs on a match between the physical card stock is 93,27%; the damaged and expired drugs in 2008 was 0,23% in 2009 was 0,48%; TOR in 2008 was 6 times and in 2008 was 6,9 times.

Analisis Sistem Distribusi Obat di Instalasi Farmasi Rawat Inap Jogja International Hospital Tri Wijayanti; Sulanto Saleh Danu; Inayati Inayati
Jurnal Farmasi Indonesia Vol 8 No 1 (2011): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

The research was to determine the drug distribution system used in pharmacy installation Jogja International Hospital and to know the factors that effect the drug distribution system in pharmacy installation Jogja International Hospital. This study used observasional method by case study design. The data was collected by retrospektif and prospektif, with interview and collection data from drug distribution document and the recipe survey in pharmacy installation Jogja International Hospital (JIH). The results showed that drug distribution system used in JIH was UDDS, individual prescription, floorstock and emergency kit. The UDDS used in JIH was not have problem.

Analisis Kinerja Instalasi Farmasi RS Medika Mulya Wonogiri pada Perspektif Pertumbuhan dan Pembelajaran dan Perspektif Proses Bisnis Internal Samuel Budi; Achmad Fudholi; Satibi Satibi
Jurnal Farmasi Indonesia Vol 8 No 1 (2011): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Accompanying to higher demands and expectations of customers to healthy service, so that healthy servicing agent needs to improve a quality service. Balanced Scorecard is a power-full instrument to evaluate management, it can asses work quality of Hospital Pharmacy Department from four perspectives such as financial, customer, servicing process, and regularly learning and growth. This research included descriptively study case research. Qualitatively and quantitatively data were collected by retrospective and prospective methods. These were collected by: document observation, direct observation, and questionnaire distribution. Qualitatively data have been analyzed for contents, and quantitatively data have been analyzed statistically.Result of research showed that: 1) work qualities based on perspectives of learning and growth are: 44% and 82% IFARS employee who have job training in 2008 and 2009, respectively; productivity of employee is 84,65%; indicator of SIM development is 45% in 2009, percentage of work ethos scale is 78,54%. 2) work quality based on perspective of internal business process: 99,35% for medicines available in 2008; the average time that is needed to preparing non-blended and blended medicines is 7,63 minutes and 20,33 minutes, respectively; the average time that is needed to providing information is 42,25 seconds; in line level is 100%; and proportion for give medicines correctly is 100%.

Perbandingan Efektivitas Antibiotik Thiamfenikol dan Ofloksasin pada Demam Tifoid Pasien Rawat Jalan Di RS Panti Waluyo Purworejo Lucia Vita Inandha
Jurnal Farmasi Indonesia Vol 8 No 1 (2011): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Typhoid fever is one of the bacterium infections frequently found in many developing countries including Indonesia. The case also occurs in Purworejo based on the data obtained from Panti Waluyo Hospital, Purworejo. The hospital mostly use thiampenicol and ofloxacin antibiotics for the medication of it. The research project was aimed to recognizing the efficacy of them based on the result of clinical observation toward the patients after taking the antibiotics. The research was conducted using prospective experimental method on the patients in the on going care installation in Panti Waluyo Hospital Purworejo. They had been diagnosed as having typhoid fever. The research subjects were divided into two groups: 25 subjects got 500 mg thiamphenicol antibiotic wich was taken three times a day, the other 25 subjects got 200 mg ofloxacin taken twice a day. The observation was done since the first day the patients took the medicine until their subsequent visit for the check-up. The clinical result of the patient were noted and investigated to see how many days the fever and other clinical symptoms finally came to an end after taking the antibiotics. The result demonstrated that the means of the end of the fever for the patients who had taken thiampenicol occured on day 3.44, whereas the means of the end of the fever for the patients who had taken ofloxacin occured on the second day. The statistical analysis reveals that there is a significant difference between the two antibiotics regarding the end of the fever. The means of other clinical symptoms concerning the typhoid fever for the patients who had taken thiampenicol occured on day 3.16, whereas the means of these symptoms for the patients who had taken ofloxacin occured on day 3.08. The statistical analysis demonstrates that there is no significant difference toward the duration of the end of other clinical symptoms generated by both antibiotics.

Analisis Penggunaan Obat di RSUD Kota Yogyakarta Berdasarkan Indikator WHO Inaratul Rizkhy Hanifah
Jurnal Farmasi Indonesia Vol 8 No 1 (2011): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Prescribing the rational drugs is the main orientation of the health care activity that should be increase in quality. The research objectiveâ€™s are to analyze of drug use of patient in RSUD Kota Hospital in the march 2010 period based on WHOâ€™s core indicator and complementary indicator. This research is non-experimental, descriptive design, and prospective data collective. The results obtained in RSUD Kota hospital are appropriate with standards WHO percentage of encounter with an antibiotic prescribed 21.89%, and injection 0%, while inappropriate the standards is the average drug items used per encounter 2.33, percentage of drugs prescribed by generic name 29.29% and percentage of drugs prescribed from formulary 83.84%. Patient care indicators, the average dispensing time was 17.59 minutes (non-compounded) and 25.67 (compounded), where 94.29% of drugs are dispensed and no one adequately labeled. Health facility indicators, there was formulary availability, and availability of key drugs 100%. WHO complementary indicators in RSUD Kota Hospital that average drug cost per encounter 50914.60 IDR, with 28.95% cost spent on antibiotics and injections of 0%.

Sintesis Senyawa 1,5-Difuril-1,4-Pentadien-3-On Ismi Rahmawati
Jurnal Farmasi Indonesia Vol 8 No 1 (2011): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Modification on the curcumine structure by altering the Î²-diketon to monoketon resulting in the curcumine-analog compounds with antioxidan, antiinflamation, and antibacterial activity. The objectives of this research are to produce compound 1,5-difuril-1,4-pentadiene-3-one. The syntesis of the compounds used keton (aceton) and furfural as base materials and KOH as a catalyst in the akuades solvent. The purity test were carried out with thin layer chromatography, gas chromatography, and melting distance test. Structure elucidation was performed with IR spectrophotometer, H1-NMR and mass spectrometer analysis. The result of this study demonstrate that 1,5-difuril-1,4-pentadiene-3-one have been successfully synthesized and purified, and have chemical structure as expected. The yield of the synthesis yield is 85.99% and 60.13% is the result of recrystallization.

Pengaruh Konsentrasi Tragakan terhadap Mutu Fisik Sediaan Pasta Gigi Ekstrak Etanolik Daun Mahkota Dewa (Phaleria papuana Warb var. Wichnannii) sebagai Antibakteri Streptococcus mutans Ika Andriana; Mimiek Murrukmihardi; Dewi Ekowati
Jurnal Farmasi Indonesia Vol 8 No 1 (2011): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Mahkota dewa leaf formulated in toothpaste preparation for easy it use. The physical properties of toothpaste preparations are influenced by the binder that tragacant. This study aims to determine the influence of tragacant concentration on the physical quality toothpaste Mahkota dewa leaf extract and antibacterial activity against Streptococcus mutans. This research is done with three toothpaste formula Mahkota dewa leaf maceration extract 70% ethanol with different concentrations of tragacant, these are 0,5% tragacant (FI), 1,0% tragacant (FII), and 1,5% tragacant (FIII). Toothpaste of Mahkota dewa leaf extract on the physical quality test (homogeneity, viscosity, dispersive power, and checks the degree of acidity) and test the antibacterial activity against Streptococcus mutans. Viscosity and dispersive power data were analyzed with two way anova. Data Minimum Inhibitory Concentration (MIC) and Minimum Bactericid Concentration (MBC) were analyzed by Kruskal Wallis test followed by Mann-Whitney analysis. The results showed that the MIC toothpaste Mahkota dewa leaf extract against Streptococcus mutans at a concentration of 18,75% and the MBC at a concentration of 37,5%. Tragacant binder concentration difference in each formula has effect on antibacterial activity but affects the viscosity and dispersive power supply.

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