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INDONESIA
Jurnal Farmasi Indonesia
Published by Universitas Setia Budi
ISSN : 16938615     EISSN : 23024291     DOI : -
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology
Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.
Arjuna Subject : -
Articles 301 Documents
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Karakterisasi Simplisia, Ekstrak dan Spektra Infra Merah Senyawa Analgesik Daun Dadap Serep (Erythrina Subumbrans) Dari Kabupaten Magelang Arief Kusuma Wardani; Perdana Priya Haresmita; Tesia Aisyah Rahmania; Missya Putri Kurnia Pradani
Jurnal Farmasi Indonesia Vol 22 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v22i1.2702

Abstract

Medicinal raw materials from agricultural products or groups of wild plants cannot be guaranteed; their chemical content is always constant due to variations in seedlings, body location, climate, or raw material conditions (age and harvest method). The content of the chemical compounds responsible for the biological response must have a chemical specification, i.e., information about the composition of both type and content. Standardization was carried out on specific parameters, including organoleptics, yield, the content of drying losses, water-soluble extract content, ethanol-soluble extract content, and chromatogram patterns. Non-specific parameters of the extract included water content, total ash content of powder and extract. The method of determination is carried out in accordance with the procedures established by Farmakope Herbal Indonesia (FHI 2017). Profiling has been done using infrared spectroscopy. Specific parameters showed that the organoleptic was a semisolid form with a dark green color, a distintive smell of dadap serep leaf extract, bitter sweetness, a yield of 7,63%, a drying loss of 7,51%, a water-soluble extract content of 4,86%, a level of ethanol-solubility extract content of 33,47%, and chromatogram patterns that were typical. Non-specific parameters indicate that the water content is 1,11%, acid-insoluble ash powder content 5,050 ± 0,036%; extract 0,986% and total ash powder content is 8,671 ± 0,303%; extract 4,123%. The results of parameter simplicia as well as ethanol extracts of leaves of Dadap Serep obtainable from the Magelang in accordance with the specifications in FHI 2017 and the spectroscopic photometer profile showing the typical pattern of extract and simplisia leaves.
Formulasi Sediaan Krim Sari Buah Mangga Harum Manis (Mangifera Indica L.) Sebagai Pelembab Kulit Dan Tabir Surya Putri Elvia Sari; Mamik Ponco Rahayu; Anita Nilawati
Jurnal Farmasi Indonesia Vol 22 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v22i1.2713

Abstract

UV rays can cause wrinkles, dryness and spots so the skin needs sunscreen nutrition. Sweet fragrant mango fruit contains flavonoids, tannins, and vitamin c as potential sunscreen. This study aims to formulate mango juice as a moisturising and sunscreen cream preparation in the form of hand cream. Mango fruit juice was extracted using a juicer and dried with a freeze dryer, then formulated into creams with concentrations of 2.5%; 5%; 7.5%; 10%. The preparation was evaluated for physical quality and tested for anti- irritation activity, moisture, and SPF value using a spectrophotometer. Data were statistically analysed using SPSS One Way Anova. The results showed that mango juice contains flavonoids, tannins, and vitamin C compounds. The cream formula fulfils the physical quality evaluation requirements of the preparation, does not irritate and has skin moisture activity. Formula 4 is the most effective cream preparation in moisturizing the skin with a moisture percentage of 72% but does not have SPF activity.
Aktivitas Antibakteri Ekstrak dan Fraksi Kulit Buah Jambu Biji (Psidium guajava L.) serta Analisis Bioautografi terhadap Pertumbuhan Staphylococcus aureus Rista Dias Yunitasari; Ana Indrayati; Reslely Harjanti
Jurnal Farmasi Indonesia Vol 22 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v22i1.2715

Abstract

Guava (Psidium guajava L.) is a plant from the Myrtaceae family that is widely found in Indonesia. Guava skin contains flavonoids, alkaloids, saponins, tannins and terpenoids that have the potential to overcome various infections. This study aims to determine the antibacterial activity of guava skin extracts and fractions and to determine the group of compounds from the most active extract or fraction against the growth of Staphylococcus aureus using the bioautography method. Guava skin was extracted by the maceration method using 70% ethanol solvent, then fractionated using n-hexane, ethyl acetate, and water solvents to optimize the separation of substances. Antibacterial activity testing of guava fruit peel extract and fractions was done with concentrations of 8, 10, and 12%, positive control ciprofloxacin, and negative control DMSO 3%. Diffusion results were obtained from measuring the diameter of the inhibition zone around the disc paper. The results of the largest diameter were continued to determine the compound group of the most active extract or fraction through bioautography tests. The results showed that a concentration of 12% in the water fraction had the largest diameter of 16.55 mm which was included in the strong category. The water fraction that showed the most active antibacterial activity was then subjected to the bioautography method. The results obtained showed the presence of flavonoid compounds at Rf 0.34 with a diameter of 1.1 mm in the water fraction and 1.2 mm in the quercetin standard.
Hubungan Tingkat Pengetahuan dan Persepsi terhadap Kesediaan Menggunakan Telefarmasi pada Mahasiswa Farmasi Christina Angelica Stephani Sianturi; Lucia Vita Inandha Dewi; Carolina Eka Waty
Jurnal Farmasi Indonesia Vol 22 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v22i1.2716

Abstract

Telepharmacy is the use of information and communication technology to provide long-distance services between patients and pharmacists. The success factor for implementing telepharmacy is good willingness by pharmacists today and in the future. Assessment of the level of knowledge and perception of pharmacy students is very important as a determinant of their willingness in telepharmacy services because good knowledge and perception of students can increase their willingness to provide telepharmacy services as their future work. This study is a descriptive study using a questionnaire. The population in this study were Pharmacy S1 students in semesters 6 and 8 totaling 323 students. The results of the study obtained a good level of knowledge, a positive level of perception, and a high level of willingness to provide telepharmacy services. In the Chi-square test, there was a relationship between the level of knowledge and perception of students' willingness to provide telepharmacy services in the future with a p-value of 0.011 and 0.000 (sig <0.05) indicating that good knowledge and positive perceptions are related to high student willingness.
CLOVIBACTIN : STUDI LITERATUR ANTIBIOTIK BARU YANG DIHARAPKAN DAPAT MENGATASI RESISTENSI Wulida Nuril Fajriyah; Zamrotul Izzah; Eko Budi Koendhori; Afifah Listiadewi; Melisa Nur Diniah
Jurnal Farmasi Indonesia Vol 22 No 2 (2025): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v22i2.2717

Abstract

This review discusses about that Clovibactin is a new antibiotic isolated from soil samples in the state of North Carolina. Clovibactin contains eight depsipeptide residues consisting of a macrolactone ring and a linear tail. This antibiotic is active against gram-positive bacteria, including drug-resistant human pathogens such as Methicillin-resistant Staphylococcus aureus, Vancomycin-resistant enterococci, dan Mycobacterium.tuberculosis. This review aims to assess the activity of clovibactin against Mycobacterium tuberculosis. Clovibactin works by inhibiting all cell wall biosynthesis reactions that consume lipid I, lipid II, lipid IIIwall teichoic acid or undecaprenyl-pyrophosphate (C55PP). Clovibactin showed no cytotoxicity to National Institute of Health/3T3 and HepG2 cells in mammals at a dose of 100 µg/mL. Clovibactin has bactericidal properties on gram-positive bacteria. Clovibactin has an MIC of 0.5-1 µg/mL on M.tuberculosis so it has good bactericidal efficacy with low toxicity.
Gambaran Kejadian Efek Samping Obat Antibiotik Golongan Sefalosporin Pada Pasien Rawat Inap di Rumah Sakit “X” Surakarta Periode 2024 Brianne Corina; Yane Dila Keswara; Francisca Tri Wituningtyas
Jurnal Farmasi Indonesia Vol 22 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v22i1.2724

Abstract

In the use of cephalosporin antibiotics, it is necessary to be aware of the side effects on patients. One of the effects of drug side effects on patients is the emergence of new diseases. This study is a descriptive observational study with data collection using a retrospective method to determine the description of the occurrence of side effects of cephalosporin antibiotic drugs. The results of this study were 15 patients who experienced side effects of the drug consisting of 6 male patients (40%) and 9 female patients (60%). Ceftriaxone is the drug that most often causes side effects (33.33%). The most common form of manifestation is shortness of breath accompanied by swelling and itching (26.67%). The end of the side effects of the drug is cured (93.33%). Inj Dexamethasone 5 mg (iv) and inj Diphenhydramine 10 mg (iv) (33.33%) are drugs that are often used to overcome side effects. The highest naranjo score results are on a scale of 7 or probable (60%). These results indicate that the use of cephalosporin antibiotics can cause side effects of the drug.
ANALISIS PERENCANAAN OBAT ANTIBIOTIK DENGAN METODE ABC DI INSTALASI FARMASI RUMAH SAKIT X TAHUN 2024 Feny Febrianti; Avianti Eka Dewi Aditya Purwaningsih; Fransisca Tri Wituningtyas
Jurnal Farmasi Indonesia Vol 22 No 2 (2025): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v22i2.2737

Abstract

Efficient drug procurement planning is crucial in hospital pharmacy logistics, especially for antibiotics, which consume a significant portion of the budget. This study analyzes antibiotic procurement planning at the Pharmacy Department of Hospital X in 2024 using the ABC analysis method. Out of 132 antibiotic items, 9 items (6.8%) in category A accounted for 69.32% of total costs, 22 items (16.7%) in category B for 20.41%, and 101 items (76.5%) in category C for only 10.27%. These findings support the Pareto principle and highlight the need to prioritize control over category A items. The study recommends a cost-based procurement system, integration of early warning systems, and adjustment of reorder points to achieve more rational and cost-effective antibiotic inventory management.
ANALISIS FAKTOR YANG MEMPENGARUHI LENGTH OF STAY (LOS) PADA PASIEN PEDIATRI DENGAN DIARE YANG MENDAPAT TERAPI ZINC DI RUMAH SAKIT X TAHUN 2023 Rizka Ardita; Yane Dila Keswara; Fransisca Tri Wituningtyas
Jurnal Farmasi Indonesia Vol 22 No 2 (2025): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v22i2.2786

Abstract

Diarrhea is a significant contributor to child morbidity and mortality, with a prevalence of 10.2% in Indonesia. The purpose of this study is to examine factors affecting the length of stay (LOS) in pediatric diarrhea patients receiving zinc therapy at Hospital X in 2023. This was a retrospective observational study involving medical record analysis of 76 patients aged 0–18 years who met the inclusion criteria (diagnosed with diarrhea, received zinc therapy, and had complete data). Samples were selected using purposive sampling, with the minimum sample size calculated using the Lemeshow formula. Data were categorized based on the appropriateness of zinc dosage (10 mg/day for children <6 months and 20 mg/day for those ≥6 months) and duration of administration (10–14 days). Statistical analysis was performed using the Chi-Square test in SPSS version 26, with a significance level of p < 0.05. Results showed that 80.26% received the correct dose and 81.58% received zinc for the appropriate duration. There was a significant association between both zinc dosage (p = 0.012) and duration (p = 0.000) with LOS. This study highlights the importance of proper zinc therapy to shorten hospitalization in children with diarrhea.
POTENSI ANTIINFLAMASI EKSTRAK TERPURIFIKASI HERBA SAMBILOTO ANDROGRAPHIS PANICULATA) MELALUI INHIBISI ENZIM SIKLOOKSIGENASE Irfan Muris Setiawan; Arief Rahman Hakim
Jurnal Farmasi Indonesia Vol 22 No 2 (2025): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v22i2.2795

Abstract

Inflammation is a natural respond of the body to harmful stimuli from external environment. However, persistent and prolonged inflammation has been associated with the development of various chronic diseases. The objective of this study is to investigate the cyclooxygenase (COX) inhibitory activity of purified extract of Andrographis paniculata (sambiloto) herb. The extraction process was performed through maceration using ethanol 90 %, followed by fractionation with n-hexane and ethyl acetate solvent. This procedure yielded a purified extract of sambiloto herb 2.3 % relative to the dry weight of herb. The COX inhibition assay demonstrated IC50 value of 563.2 µg/mL and 5097.4 µg/mL for COX-1 and COX-2 respectively. These results indicate that purified extract of sambiloto herb exhibits greater inhibition selectivity towards COX-1 compared to COX-2.
(UJI AKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK DAUN KELOR (Moringa oleifera) DAN DAUN JAMBU BIJI (Psidium guajava L) TERHADAP Escherichia coli aurelia zahra; dian marlina; destik wulandari
Jurnal Farmasi Indonesia Vol 22 No 2 (2025): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v22i2.2836

Abstract

Moringa leaves (Moringa oleifera) and guava leaves (Psidium guajava L.) contain antibacterial compounds such as alkaloids, tanins, saponins, and flavonoids that effectively inhibit Escherichia coli bacteria. This study aims to determine the antibacterial activity of the combination of both extracts using dilution, diffusion, and paper tape methods with concentrations of 100%, 50%, 25%, 12.5%, 6.25%, 3.1%, 1.5%, and 0.7%, ciprofloxacin as a positive control and 10% DMSO as a negative control. The results of the dilution test showed that a concentration of 12.5% ​​was able to kill Escherichia coli bacteria, the 1:2 combination diffusion test provided the largest inhibition zone, indicating optimal antibacterial effectiveness. and the paper tape test showed an additive pattern indicating that the two extracts supported each other in inhibiting the growth of these bacteria

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