Oceana Biomedicina Journal
Oceana Biomedicina Journal is an open access journal of health and medicine.Specifically, the journal focuses on marine medicine, hyperbaric medicine and health, medicine on ships, harbor health, maritime and coastal health, medicolegal studies related to ships, ports and districts, maritime/coastal communities and fishermen, epidemiological aspects of diseases, disabilities and disorders that occur on ships and affect boat workers, ports and maritime zones, coastal areas, fishermen communities and their families, including pharmacological and non-pharmacological prevention and treatment management policies; and miscellanous.
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110 Documents
<![CDATA[EFEKTIVITAS ANTIVIRUS CORONA BERBASIS EUCALYPTUS DI INDONESIA ]]>
<![CDATA[Imamul Choir AM]]>
<![CDATA[ Oceana Biomedicina Journal Vol 4 No 2 (2021): Oceana Biomedicina Journal Volume 4 Issue (No) 2 ]]>
Publisher : <![CDATA[Universitas Hang Tuah ]]>
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DOI: 10.30649/obj.v4i2.17
<![CDATA[COVID-19 adalah penyakit yang disebabkan oleh Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dan menyerang pada sistem pernapasan. Gejala awal dari penyakit ini antara lain batuk, demam, nyeri pada tenggorokan, sakit kepala, hilangnya indra perasa dan penciuman. COVID-19 (Corona Virus Disease 2019) pertama kali ditemukan di Wuhan, China pada akhir Desember 2019. Epidemi menyebar dengan cepat diseluruh dunia dalam 3 bulan dan dicirikan sebagai pandemi oleh WHO. Hingga saat ini vaksin masih melalui tahap uji dan masih belum berhasil. Beberapa upaya pembuatan antivirus untuk COVID-19 telah dilakukan Kementerian Pertanian di Indonesia. Diantaranya dengan menggunakan tanaman eucalyptus yang memiliki potensi ampuh melawan virus. Minyak atsiri eucalyptus memiliki senyawa 1,8-cineole (eucalyptol) yang merupakan komponen utama dari minyak atsiri dan ditemukan dalam daun eucalyptus dan Senyawa ini memiliki aktivitas antivirus, anti-inflamasi, dan antimikroba. Senyawa eucalyptol dapat berfungsi menghambat replikasi coronavirus dengan mengikat protein Mpro yang terdapat pada virus. Protein tersebut berperan dalam pematangan virus dan pembelahan polyprotein virus sehingga dapat mencegah penyebaran infeksi.]]>
<![CDATA[Extended Spectrum Beta-Lactamase (ESBL) ]]>
<![CDATA[Verna Biutifasari]]>
<![CDATA[ Oceana Biomedicina Journal Vol 1 No 1 (2018): Oceana Biomedicina Journal Vol 1 Issue (No) 1 January-June 2018 ]]>
Publisher : <![CDATA[Universitas Hang Tuah ]]>
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DOI: 10.30649/obj.v1i1.3
<![CDATA[Antibiotics have been widely used today. Use of antibiotics is also often used in mass and not in accordance with the indication, among others, in a particular case of fish poisoning on the beach, often the treatment is given antibiotics without clearlyindication. Use of antibiotics are excessive and not in accordance with the clinical, can cause resistance to these antibioticsOne of the antibiotics used is a beta-lactam antibiotic, that works inhibits cell walls. The inappropriate use of beta-lactam antibiotics can lead to resistance to these antibiotics. Resistance to beta-lactam can occur at various levels. One of the resistances can occur is resistance to Extended Spectrum Broad Lactamase (ESBL)Extended spectrum beta-lactamase is an enzyme that has the ability to hydrolyze penicillin-type antibiotics, first-generation cephalosporins, two, and three as well as monobactam groups and cause resistance throughout the antibiotic.ESBL is produced by many Enterobactericeae (especially Escherichia coli) and Klebsiella pneumoniae. Enterobacteriaceae has 3 resistance patterns caused by broadspectrum beta-lactamase, beta-lactamase-resistant inhibitors (TEM derivatives), excessive cephalosporinase. ESBL can be difficult to detect because ESBL has differentiatedactivity to various cephalosporinsESBL can be detected in clinical microbiology (phenotypic) and molecular detection (genotypic)]]>
<![CDATA[Recent Therapeutics Policies of Arthritis Rheumatoid (part I) ]]>
<![CDATA[Hendrata Erry Andisari]]>
<![CDATA[ Oceana Biomedicina Journal Vol 1 No 1 (2018): Oceana Biomedicina Journal Vol 1 Issue (No) 1 January-June 2018 ]]>
Publisher : <![CDATA[Universitas Hang Tuah ]]>
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DOI: 10.30649/obj.v1i1.2
<![CDATA[Therapy in RA has undergone many advances today and in line with knowledge of the pathogenesis of RA, the current therapeutic goal is to alter the journey and control the activity of RA disease. Several groups of drugs have been used in RA therapy including non-steroidal anti-inflammatory drugs (NSAIDs), conventional diseasemodifying antirheumatic drugs (DMARDs) as well as biological agents (bDMARD), glucocorticoids and anti-pain medicines. In recent years, the development of biological agents that have specific targets for inflammatory mediators such as interleukin (IL) -1, IL-6 and Tumor Necrosis Factor (TNF) suggests a potent therapeutic effect on RA. In this article will be presented the latest biological agents as the latest therapy on RA.]]>
<![CDATA[HIV Infection: Immunopathogenesis and Risk Factor to Fishermen ]]>
<![CDATA[Retno Budiarti]]>
<![CDATA[ Oceana Biomedicina Journal Vol 1 No 1 (2018): Oceana Biomedicina Journal Vol 1 Issue (No) 1 January-June 2018 ]]>
Publisher : <![CDATA[Universitas Hang Tuah ]]>
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DOI: 10.30649/obj.v1i1.4
<![CDATA[AIDS (Acquired Immuno Deficiency Syndrome) caused by HIV (Human Immunodeficiency Virus) infection, is still one of the infectious diseases that causes fatalistic and have not already found a universal and reliable vaccine. As the name given to the virus as well as the disease it causes, the signs and symptoms experienced by the sufferer are persistent and severe disorders of the body's defense mechanism against the disease, or the person's immunological system.Epidemiology of AIDS in Indonesia, which is a tropical country and its territory is mostly sea area still high, even East Java was the highest accumulatively until March 2016. HIV infection itself until March 2016, East Java accumulatively was on the second level after DKI Jakarta. Based on the data of The Ministry of Health during 2014, farmer and fishermen were on the fourth level of AIDS in Indonesia.This mechanism of immune system disorders by HIV is important to explain and understand, so that current researchs, as well as in the future, can solve the problems posed by this viral infection, either by the discovery of vaccines or their preventive measures, formulation of a therapeutic management which is reliable.]]>
<![CDATA[The Infection of Vibrio parahaemolyticus in Shrimp and Human ]]>
<![CDATA[Rian Ka Praja]]>;
<![CDATA[Dwi Putri Safnurbaiti]]>
<![CDATA[ Oceana Biomedicina Journal Vol 1 No 1 (2018): Oceana Biomedicina Journal Vol 1 Issue (No) 1 January-June 2018 ]]>
Publisher : <![CDATA[Universitas Hang Tuah ]]>
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DOI: 10.30649/obj.v1i1.6
<![CDATA[Vibrio parahaemolyticus is an aquatic zoonotic agent that can threaten human and aquaculture animal health. Humans can be infected by consuming contaminated raw seafood or wound-related infections. Generally infection of V. parahemolyticus is orally transmitted and causes gastroenteritis in humans while in aquaculture animals especially shrimp can cause Acute Hepatopancreatic Necrosis Disease (AHPND) or Early Mortality Syndrome (EMS) with a very high mortality rate and cause economic losses. Shrimp species susceptible to infection are Litopenaeus vannamei, Penaeus monodon, and P. chinensis. V. parahaemolyticus produces several toxins in human disease such as thermostable direct hemolysin (TDH), TDH-related haemolysin (TRH), and thermolabile hemolysin (TLH). Meanwhile, Photorabdus insect-related (Pir) toxins consisting of PirAvp and PirBvp are the toxins associated with AHPND in shrimp. The genes that encode the toxin are used as targets to diagnose V. parahaemolyticuspathogens molecularly. Until now the treatment of V. parahaemolyticus infection is using antibiotics and fluid therapy, but there were V. parahaemolyticus isolates from aquaculture that have been resistant to antibiotics so that the use of antibiotics in aquaculture must be controlled and the use of alternative therapy are very important to be developed to control V. parahaemolyticus infection.]]>
<![CDATA[Ethanolic Extract of The Graptophyllum Pictum Griff Leaves to Male White Rat ]]>
<![CDATA[Setya Enti Rikomah]]>;
<![CDATA[Gina Lestrari]]>;
<![CDATA[Juwita Winanti]]>
<![CDATA[ Oceana Biomedicina Journal Vol 1 No 1 (2018): Oceana Biomedicina Journal Vol 1 Issue (No) 1 January-June 2018 ]]>
Publisher : <![CDATA[Universitas Hang Tuah ]]>
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DOI: 10.30649/objv1i1.5
<![CDATA[Utilization of plants as traditional medicinal are still always be used by people in Indonesian. Especially in rural areas that still rich with variety of plants. Plants of black pudding leaves (Graptophyllum pictum Griff) are one that efficacious for treating various of diseases. The content of flavonoid in the black pudding leaves have antipyretic effect, analgesic and anti-inflammatory. This research aims to find out whether the black pudding leaves have antipyretic effect or not. This research used the induction method of vaccineDPT-Hb 0.022 / 20 gr a white rat as stimulant fever. Positive control with paracetamol 1.3 mg / 20 gram a white rat, negative control with Na CMC 0.5 ml / 20 grams a white rat, first extract test of black pudding leaves 0.8 mg / 20 gram a white rat, second extract test of black pudding leaves 1.6 / 20 gram a white rat, and third extract test of black pudding leaves 3.2 / 20 gram a white rat. The results of research showed that ethanol extract of black pudding leaves if it’s looked from statistic result of SPSS 16 program , it doesn’t show out of any effect as antipyretic effect because the significant value is P> 0.05.]]>
<![CDATA[ANALISIS BIAYA DAN NILAI UTILITAS PASIEN HEMODIALISA YANG DIBERIKAN TERAPI SEVELAMER KARBONAT ]]>
<![CDATA[Dwi Putri Safnurbaiti]]>;
<![CDATA[Tri Murti Andayani]]>;
<![CDATA[Fredie Irijanto]]>
<![CDATA[ Oceana Biomedicina Journal Vol 1 No 2 (2018): Oceana Biomedicina Journal Volume 1 Issue (No) 2 July - December 2018 ]]>
Publisher : <![CDATA[Universitas Hang Tuah ]]>
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DOI: 10.30649/obj.v1i2.12
<![CDATA[Sevelamer karbonat merupakan alternatif lain sebagai terapi pengikat fosfat yang diberikan kepada pasien hemodialisa selain CaCO3. Sevelamer karbonat dapat menurunkan kadar fosfat, mengurangi kejadian kalsifikasi vaskular dan mortalitas yang secara langsung berdampak pada perbaikan kualitas hidup pasien hemodialisa, namun harga sevelamer karbonat lebih mahal dibandingkan dengan CaCO3. Penelitian ini bertujuan untuk mengetahui gambaran biaya yang diperlukan untuk terapi sevelamer karbonat dan nilai utilitas pasien hemodialisa yang menggunakan terapi sevelamer karbonat di RS UGM Yogyakarta.Penelitian dilakukan secara prospektif selama 8 minggu di RS UGM Yogyakarta pada bulan Oktober-November 2016. Desain penelitian adalah quasi eksperimental dengan “pretest posttest design with control group”. Kelompok eksperimental adalah sevelamer karbonat dan kontrol adalah CaCO3. Pengukuran health related quality of life(HRQOL) pasien hemodialisa salah satunya dengan mengukur utilitas pasien hemodialisa dengan kuesioner EQ-5D-5L pada awal (pre) dan akhir (post) penelitian. Analisis biaya dilihat berdasarkan perspektif rumah sakit dengan menghitung total direct medical cost.Jumlah total responden dalam penelitian ini adalah 37 pasien yang terdiri atas 16 pasien kelompok eksperimental dan 21 pasien kelompok kontrol. Rata-rata biaya yang diperlukan pasien hemodialisa dengan sevelamer karbonat untuk menangani kondisi gangguan mineral dan tulang adalah sebesar Rp 2.999.188,75±167.920,75 per pasien selama 8 minggu terapi. Nilai utilitas dan skor EQ-5D VAS baseline pasien hemodialisa yang diberikan sevelamer karbonat adalah masing-masing 0,91±0,13 dan 75,93±9,34, dan di akhir penelitian (posttes) terdapat perubahan nilai utilitas dan skor EQ-5D VAS sebesar 0,93±0,08 dan 77,44±11,12. Hasil uji statistik menunjukkan bahwa perubahan nilai utilitas dan skor EQ-5D VAS pasien hemodialisa yang diberikan sevelamer karbonat antara awal (pre) dan akhir penelitian (posttes) adalah menunjukkan tidak berbeda bermakna (p>0,05).]]>
<![CDATA[Empirical Antibiotic Therapy Assessment of Patients diagnosed with Sepsis in Intermediate Care Ward of Internal Medicine Department of Dr. Soetomo General Hospital according to Gyssens Method ]]>
<![CDATA[Ronald Pratama Adiwinoto]]>
<![CDATA[ Oceana Biomedicina Journal Vol 1 No 2 (2018): Oceana Biomedicina Journal Volume 1 Issue (No) 2 July - December 2018 ]]>
Publisher : <![CDATA[Universitas Hang Tuah ]]>
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DOI: 10.30649/obj.v1i2.17
<![CDATA[Rational empirical antimicrobial therapy is an important component of sepsis patient management. This study aimed to assess the rationality of empirical antimicrobial therapy in patients diagnosed with sepsis admitted in intermediate care ward of internal medicine department (RPI) of Dr. Soetomo General Hospital from January 2016 to July 2017. Medical records of 91 patients diagnosed with sepsis were collected and studied retrospectively in period from July 2017 to November 2017. 91 (85.05%) medical records from 107 sepsis patients were evaluated. Cultures and antimicrobial sensitivity tests were carried out in 21 (23.07%) patients. 14 patients yielded positive culture results, 9 of which were MDRO positive with ESBL as resistant marker. Empirical antibiotic therapies for these patients were reviewed according to Gyssens method.73 (80.2%) of 91 patients were deemed receiving appropriate empirical antibiotic therapies. Ceftriaxone IV injection as monotherapy or combination therapy were the most common empirical antibiotic therapies (82 in 91 patients, 90.1%), despite local microbiologic flora and antibiogram show most pathogens were resistant to ceftriaxone. Mortality rate in this study was high, 92.3% (84 patients died) despite rational empirical antibiotic therapies were high.This study concluded that empirical antibiotic therapies in sepsis patients according to guidelines adopted in Soetomo General Hospital, albeit deemed rational, was no longer appropriate according to local antibiogram issued by microbiological department of Soetomo General Hospital.]]>
<![CDATA[PERKEMBANGAN TERKINI TERAPI RHEUMATOID ARTHRITIS (bagian 2) ]]>
<![CDATA[Hendrata Erry Andisari]]>
<![CDATA[ Oceana Biomedicina Journal Vol 1 No 2 (2018): Oceana Biomedicina Journal Volume 1 Issue (No) 2 July - December 2018 ]]>
Publisher : <![CDATA[Universitas Hang Tuah ]]>
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DOI: 10.30649/obj.v1i2.14
<![CDATA[Therapy in RA has undergone many advances today and in line with knowledge of the pathogenesis of RA, the current therapeutic goal is to alter the journey and control the activity of RA disease. Several groups of drugs have been used in RA therapy including non-steroidal anti-inflammatory drugs (NSAIDs), conventional disease-modifying antirheumatic drugs (DMARDs) as well as biological agents (bDMARD), glucocorticoids and anti-pain medicines. In recent years, the development of biological agents that have specific targets for inflammatory mediators such as interleukin (IL) -1, IL-6 and Tumor Necrosis Factor (TNF) suggests a potent therapeutic effect on RA. In this article will be presented the latest biological agents as the latest therapy on RA.]]>
<![CDATA[CERVIX CARCINOMA: PATHOLOGICAL ASPECT ]]>
<![CDATA[Eva Pravitasari Nefertiti]]>
<![CDATA[ Oceana Biomedicina Journal Vol 1 No 2 (2018): Oceana Biomedicina Journal Volume 1 Issue (No) 2 July - December 2018 ]]>
Publisher : <![CDATA[Universitas Hang Tuah ]]>
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DOI: 10.30649/obj.v1i2.15
<![CDATA[Cervix carcinoma is a malignancy at squamocollumnar junction, in the border between ecto and endo cervix. Lesion at this site is frequently correlated with chronic inflammatory of the cervix, displacia, and in situ carcinoma. In Indonesia, cervix carcinoma is the most common malignancy in women. At Obstetry and Gynecology Department of RSCM during 1986-1990 period, 2360 gynocology carcinoma were found, and 1821 (77,2%) cases of them were cervix carcinoma.The diagnosis was made based on cytology, colposcopy, biopsy, endocervix curettage and conitation. Papanicolaou test is a useful in detecting early stage of cervix carcinoma up to 90% accuration. The speciment for paps smear is secrets of the vagina, cervix, endocervix, endometrium, and posterior fornix.]]>
