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Erina Yatmasari
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Oceana Biomedicina Journal
Published by Universitas Hang Tuah
ISSN : -     EISSN : 26140519     DOI : https://doi.org/10.30649/obj.v5i1.67
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Dentistry Medicine & Pharmacology Nursing Public Health
Oceana Biomedicina Journal is an open access journal of health and medicine.Specifically, the journal focuses on marine medicine, hyperbaric medicine and health, medicine on ships, harbor health, maritime and coastal health, medicolegal studies related to ships, ports and districts, maritime/coastal communities and fishermen, epidemiological aspects of diseases, disabilities and disorders that occur on ships and affect boat workers, ports and maritime zones, coastal areas, fishermen communities and their families, including pharmacological and non-pharmacological prevention and treatment management policies; and miscellanous.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 110 Documents
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Molecular Mechanism of Cholerae Toxin (ctx) in Causing Diarrhea Rian Ka Praja; Reny Rosalina
Oceana Biomedicina Journal Vol 1 No 2 (2018): Oceana Biomedicina Journal Volume 1 Issue (No) 2 July - December 2018
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v1i2.16

Abstract

Vibrio cholerae is one of the pathogenic bacteria transmitted through contaminated food, especially contaminated seafood and beverages. V. cholerae produces cholerae toxin (ctx) which is encoded by the ctx gene located within its chromosome. This toxin has been recognized as one of the toxins responsible for cholera outbreaks. The mechanism of ctx gene expression is induced by environmental signals such as pH, osmolarity, temperature, bile, amino acids, and CO2. These signals will be a positive transcriptional factor to the ToxR gene that regulates the biogenesis of cholerae toxin. After cholerae toxin has been successfully expressed, V. cholerae uses a type II secretion (T2S) pathway to deliver cholerae toxin to the extracellular environment. Cholerae toxin consists of A and B subunits. The B subunit plays a role in attaching to the receptor Manosialosyl Ganglioside (GM1 ganglioside) and the Asubunit plays a role in catalyzing ADP-ribosylation of Gs (stimulatory) protein and turning them into active condition. The Gs protein will convert the inactive adenilate cyclase (AC) into active AC. The increase of AC activity will increase the cyclic adenosine 3'5'-monophosphate (cAMP) concentration along the cell membrane. The cAMP then causes theactive secretion of sodium (Na+), chloride (Cl-), potassium (K+), bicarbonate (HCO3-), and water (H2O) out of the cell into the intestinal lumen, resulting in large fluid losses and electrolyte imbalances.
PENGARUH OBAT KUMUR HERBAL DENGAN KANDUNGAN ZAT AKTIF FLAVONOID, SAPONIN, DAN TANIN TERHADAP HALITOSIS (STUDI LITERATUR) Eddea Marselyna A.D.; Riani Setiadhi; Vinna Kurniawati Sugiaman
Oceana Biomedicina Journal Vol 5 No 2 (2022): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v5i2.29

Abstract

Introduction: Herbal mouthwash has been developed for its antibacterial properties. Halitosis is bad breath that comes from the mouth. Volatile sulfur compounds (VSCs) are the result of oral bacterial activity production, by Porphyromonas gingivalis which is an gram-negative anaerobic bacteria causing halitosis. Flavonoids have the potential to be an antioxidant and have antibacterial, anti-inflammatory, anti-allergic and anti-thrombotic activities, while saponins and tannins are a group of active plant compounds that are phenolic, have a septic taste and antibacterial activity. The aim of this literature study was to improve knowledge about the effect of herbal mouthwashes with active substances of flavonoids, saponins and tannins on halitosis. Methods: Literature review using research results, articles and other literatures related to herbal mouthwash and medicinal plant content against halitosis. Results: Some researchers had shown that herbal mouthwashes with antibacterial content in the form of flavonoids, saponins and tannins could inhibit the growth of oral bacteria such as Streptococcus mutans, Porphyromonas gingivalis and Streptococcus sanguinis, which would inhibit plaque formation, reducing halitosis, overcoming gingivitis, increasing salivary pH and reducing salivary viscosity. Conclusion: Based on the search results of the search, it can be concluded that herbal mouthwash containing active substances of flavonoids, saponins and tannins has an effect in overcoming halitosis.
Prospek Pemanfaatan Biji Pepaya sebagai Biomaterial Pengendali Populasi Tikus Liar melalui Mekanisme Antifertilitas Erfan Andrianto Aritonang
Oceana Biomedicina Journal Vol 2 No 1 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 1 January - June 2019
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v2i1.19

Abstract

Tikus liar merupakan satwa liar yang paling sering bersosialisasi dengan masyarakat dan merupakan salah satu vektor serta penyebar penyakit yang beberapa diantaranya bersifat zoonosis. Pengendalian tikus liar sangat penting dilakukan guna mengurangi terjadinya penyakit zoonosis yang diakibatkan oleh hewan tersebut. Metode yang efektif digunakan sebagai pengendali populasi tikus liar adalah melalui mekanisme antifertilitas. Salah satu bahan yang memiliki mekanisme antifertilitas adalah biji pepaya. Kandungan saponin, flavonoid, alkaloid, dan papain pada biji pepaya terbukti memberikan efek infertil pada mencit dan tikus putih, dimana mencit dan tikus putih merupakan hewan yang semarga dengan tikus liar. Hewan yang semarga memiliki susunan anatomi dan fisiologis yang serupa, sehingga pengaruh antifertilitas tersebut menjadi sebuah prospek untuk mengembangkan biji pepaya sebagai biomaterial pengendali populasi tikus liar. Populasi tikus liar yang dihambat akan berdampak pada penurunan angka kejadian zoonosis dalam masyarakat
Characteristics of The Patients with Low Back Pain in The Medical Rehabilitation Clinic, dr. Ramelan Naval Hospital Surabaya Lena Wijayaningrum; Herin Setianingsih; Agustin Silfi Rahayu
Oceana Biomedicina Journal Vol 2 No 2 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 2 July - December 2019
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v2i2.32

Abstract

Background : The total number of visit of patients with low back pain in the Medical Rehabilitation Subdepartment of Dr. Ramelan Naval Hospital Surabaya from January to November 2018 is approximately 38.7% of all visits. Low back pain is defined as pain between the edge of the ribs and the gluteus fold which can be.Material and Methods : This was a cross sectional study, based on the analysis of the medical records from the LBP patients in July to September 2018, in the Dr. Ramelan Hospital RSAL Medical Rehabilitation Clinic. The inclusion criteria of LBP is: patient with main symptom of pain or other unpleasant feelings in the lower spine and surrounding areas, between the edge of the ribs and the gluteus fold. Results : There were 151 data analyzed from July to September 2018, patients with pain complaints were (86.84%). The data obtained showed majority of patients was 51-60 years old. Most of the patients were women.Conclusion : Most of the patients diagnosed with Low Back Pain (LBP) at the Medical Rehabilitation Clinic of RSAL Dr. Ramelan Surabaya, was 51-60 years old, women were the majority, 80%s had complain of pain and there were any of comorbidities.
Dental Calculus as The Unique Calcified Oral Ecosystem A Review Article Natallia Pranata
Oceana Biomedicina Journal Vol 2 No 2 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 2 July - December 2019
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v2i2.28

Abstract

The prevalence of periodontal disease in Indonesians is very high, which is around 95%, and 70% of these values occur above 30 years or the adult age group. There is controversy about whether dental calculus is an etiological factor in periodontal disease, or is it just a predisposing factor. Dental Calculus is a calcified oral ecosystem or dental plaque, can accumulate on supragingival or subgingival. Plaque is a bacterial biofilm complex on the tooth surface, including pathogenic microorganisms that invade periodontal tissue. Periodontal disease is the result of interactions between pathogens and the host immune system. Damage to periodontal tissue can occur if the pathogenicity of the microflora is more dominant in the immune response. In calcified conditions, these microorganisms lose their pathogenicity. The dental calculus is one form of the body's defense mechanism against pathogens. But the accumulation of dental calculus, with its rough surface, is a predisposing factor for plaque accumulation. The oral ecosystem trapping on the unique calcified material which are called dental calculus.
Utilization of Mesenchymal Stem Cells in Therapy in the Oral Cavity Vinna Kurniawati Sugiaman
Oceana Biomedicina Journal Vol 2 No 2 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 2 July - December 2019
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v2i2.29

Abstract

Therapy by using stem cells has recently been considered a scientific breakthrough for the world of medicine and dentistry, and is considered an important weapon in combating various diseases. Mesenchymal stem cells are cells that have the ability to renew themselves, are multipotent, capable of differentiating and proliferating, and are immunosuppressive, so that they can be used to repair and regenerate various tissues through regenerative therapy. The purpose of this paper is to provide a brief overview of various sources of stem cells and the latest findings and also their implications for improving the health of the oral cavity through regeneration of various tissues in the oral cavity. The use of mesenchymal stem cells in the field of dentistry is considered that the new era of dentistry is being started and is expected to change the paradigm in carrying out treatment of diseases in the oral cavity. Mesenchymal stem cells can be isolated from various tissues that can be used in regenerative therapy through tissue engineering to repair and regenerate tissue in the oral cavity. In utilizing this technology, stem cells, regulators, and matrices are needed as a framework that can facilitate cells to cling to, differentiate, proliferate, form matrices, and increase specific interactions between cells. Conclusions, mesenchymal stem cells can be used in regenerative therapy in the oral cavity to repair and regenerate damaged tissue through tissue engineering technology.
Manalagi Apple Vinegar (Malus sylvestris Mill) as Anti Diabetic to Alloxan Induced Wistar White Male Rat Valentina Verrel Purnomo; A. Sareh Arjono Tjandra; Risma Risma
Oceana Biomedicina Journal Vol 2 No 1 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 1 January - June 2019
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v2i1.22

Abstract

Apple vinegar is estimated to be able to cure diabetes. Vinegar is able to control the increase of glicemic index. Apple has antioxidant substance such as quercetin and chlorogenic acid. Manalagi apple could be found easily in Indonesia.This research aims to reveal the effect of Manalagi apple vinegar (Malus sylvestris Mill) towards blood glucose level of alloxan induced Wistar white male rats (Rattus norvegicus).This research is experimental laboratory using Experimental methods. The samples are 30 white rats divided into three groups for 31 days, 1) group which only given standard diet; 2) group that induced by 120mg/dL alloxan; 3) group that induced by 120mg/dL alloxan and Manalagi apple vinegar 0.27ml/100gram weight for 14 days. The measurement of blood serum glucose level is done on day twenty four using homogenous colorimetric enzymatic test method for all groups.Blood glucose average in group with only given standard diet as negative control group (182.33 mg/dL), group which induced by 120mg/dL alloxan as positive control group (205.2 mg/dL), group which induced by 120mg/dL alloxan and Manalagi apple vinegar as treatment group (212.25 mg/dL). The result of One-Way Anova significance is 0.229.The conclusion of this research is that Manalagi apple vinegar treatment doesn’t able to decrease the blood glucose level of white Wistar male rats significantly.
Comparison of Anxiety Level on Medical Skill Examination Between Students of Medical Faculty of Hang Tuah University Surabaya in 1st Semester Who Have Received Mental Health Tests During The Entrance Test with 3rd Semester Who Have not Received A Mental H Edwin Timotius Martua Marpaung; Sadya Wendra; Edward Imanuel Simon
Oceana Biomedicina Journal Vol 2 No 1 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 1 January - June 2019
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v2i1.20

Abstract

Anxiety is an unpleasant feeling of insecure tension and fear that arises because it feelssomething will happen that is disappointing but the source is largely unaware by theperson concerned. Various studies have shown a high frequency of anxiety symptomsin medical students.The aim of this study is knowing the comparison of the level of anxiety to the medicalskills test between students of Medical Faculty of Hang Tuah University Surabaya in 1STsemester who have received mental health tests during the entrance test with 3RDsemester who have not received a mental health test during the entrance test.This study was an observational analytic study with a cross-sectional study design. Thesampling technique used in this study is stratified random sampling. The population inthis study were the first and third semester students of the Medical Faculty of HangTuah University Surabaya in the 2017/2018 school year, while the samples taken were374 students meeting the inclusion criteria, Assessment of anxiety levels was carriedout using the Hamilton Rate Scale for Anxiety (HRSA) questionnaire.Mild anxiety levels are more numerous in first-semester students (75%) compared tothird-semester students (50%), while moderate-to-severe anxiety levels are morenumerous in third-semester students (40%) compared to first-semester students(12.5%) who have received mental health tests during the entrance test. This study concluded there is a difference of ansiety level on medical skill examinationbetween students of medical faculty of Hang Tuah University Surabaya in 1st semesterwho have received mental health tests during the entrance test with 3rd semester whohave not received a mental health test during the entrance test.
Pengaruh Pemberian Terapi Oksigen Hiperbarik 2,4 ATA terhadap Kadar C-Reactive Protein (CRP) Darah Mencit Model Rheumatoid Arthritis Thalia Tamara; Hendrata Erry Andisari; Totot Mudjiono
Oceana Biomedicina Journal Vol 2 No 2 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 2 July - December 2019
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v2i2.33

Abstract

Background: Rheumatoid Arthritis (RA) is an autoimmune disease with an increasingprevalence from year to year. RA mortality continues to increase in the last 1 decade due tothe absence of effective prevention and therapy. Hyperbaric oxygen therapy can be anadjuvant therapy for Rheumathoid Arthritis.Objective: This study uses Hyperbaric Oxygen Therapy to reduce the inflammatory reactionin patients with Rheumatoid Arthritis.Method: Samples used are 16 male balb/c mice, divided into 2 groups, 1) group of inducedexperimental animals as models of Rheumatoid Arthritis 2) group of induced experimentalanimals as models of Rheumatoid Arthritis and given 3x30 minutes of 2.4 ATA hyperbaricoxygen therapy for 10 consecutive days. On 59th day, ELISA screening test is performed forC-ReactiveProtein measurement.Result: The average results of C-Reactive Protein levels between 2 groups, are, the group ofmice with rheumatoid arthritis model that was not treated with HBO therapy had an averageCRP level of 0.204 Pg / ml, while the group of mice with rheumatoid arthritis model which istreated with HBO therapy has a mean CRP level of 0.113 Pg / ml.Conclusion: There is an effect of hyperbaric oxygen therapy to C-Reactive Protein level inmice with rheumatoid arthritis model.
Analisis Kalsium (Ca) pada Ikan Petek dan Mujair dengan Metode Kompleksometri Azmalina Adriani; Fauziah Fauziah; Riki Saputra
Oceana Biomedicina Journal Vol 2 No 2 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 2 July - December 2019
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/v2i2.30

Abstract

Fish is one of the example of a comestibles that contains a lot of protein and minerals, one ofwhich is calcium. Calcium functions for the body's metabolism in the bone and toothformation. Petek and Mujair fish contain calcium that is needed by the human body.The purpose of this study was to determine the levels of calcium contained in Petek andMujair fish.The sampling was done by purposive sampling, which the sample used was obtained by themarket in the Peunayong Banda Aceh. This research used complexometry methods. Thesamples of Petek and Mujair fish that had been cleared were titrated using Na2-EDTA as thetitrator.The result showed that Petek and Mujair fish had different calcium levels where the calciumlevels in Petek fish reach an average of 0.853% and the calcium levels in Mujair fish reachan average of 0.616%. Petek fish had higher calcium levels than Mujair fish, it was causedby their habit, where Petek fish was sea fish that contained fat, vitamins and minerals, whileMujair fish was freshwater fish that contained carbohydrates and proteins.

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