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Oceana Biomedicina Journal
Published by Universitas Hang Tuah
ISSN : -     EISSN : 26140519     DOI : https://doi.org/10.30649/obj.v5i1.67
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Dentistry Medicine & Pharmacology Nursing Public Health
Oceana Biomedicina Journal is an open access journal of health and medicine.Specifically, the journal focuses on marine medicine, hyperbaric medicine and health, medicine on ships, harbor health, maritime and coastal health, medicolegal studies related to ships, ports and districts, maritime/coastal communities and fishermen, epidemiological aspects of diseases, disabilities and disorders that occur on ships and affect boat workers, ports and maritime zones, coastal areas, fishermen communities and their families, including pharmacological and non-pharmacological prevention and treatment management policies; and miscellanous.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 110 Documents
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Detection of genes encoding ompW and ctxA of Vibrio cholerae isolated from shrimp and shellfish at Kedonganan fish market, Bali-Indonesia Rian Ka Praja; I Dewa Made Sukrama; Ni Nengah Dwi Fatmawati
Oceana Biomedicina Journal Vol 2 No 1 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 1 January - June 2019
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v2i1.23

Abstract

Contamination of pathogenic bacteria in food can lead to the emergence of foodborne disease. One of foodborne disease which often occurs in some developing countries such as Africa, Southeast Asia, and Latin America is cholera which is caused by Vibrio cholerae. The disease is transmitted through beveragesand food, especially contaminated seafood. V. cholerae has several virulence factors including the outer membrane protein W (ompW) and cholerae toxin (ctx).The ompWacts as a protective barrier and can also be used as a marker specific species of V. cholerae and cholerae toxin is an enterotoxin responsible for the incidence of diarrhea in a cholera outbreak produced by pathogenic V. cholerae. This study was an observational study to determine the level of contamination of V. cholerae by detecting the outer membrane protein W (ompW) and cholerae toxin subunit A (ctxA)gene of V. cholerae in shrimp and shellfish sold at Kedonganan fish market. Samples were taken using total sampling technique and obtained 24 samples consisting of 14 shrimp samples and 10 shellfish samples. Samples were examined using culture methods and biochemical tests, and then further tested using Duplex Polymerase Chain Reaction (dPCR) to detect ompW and ctxA gene. The dPCR assay results showed 8 out of 14 (57.1%) samples from shrimp and 1 out of 10 (10%) samples from the shellfish positive carried ompW gene, and found no positive samples carrying the ctxA gene in samples derived from shrimp and shellfish. Chi square test analysis results indicated contamination of V. cholerae in shrimp washigher than shellfish based on ompW gene (p<0.05). It can be concluded that the shrimp and shellfish at Kedonganan fish market are contaminated by V. cholerae. Further research is needed to detect the virulence factors besides ompW and ctxA ofV. cholerae in seafood.
Perbedaan Pandangan Positif Atau Negatif terhadap Pasien Gangguan Jiwa Antara Mahasiswa Fakultas Kedokteran Universitas Hang Tuah Surabaya Semester 5 dengan Semester 7 Fifin Yulia Candra Pangestika; Sadya Wendra; Edward Imanuel Simon
Oceana Biomedicina Journal Vol 2 No 1 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 1 January - June 2019
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v2i1.39

Abstract

Background: Most people in Indonesia still negatively regard mental patients as someone who is dangerous and the disease cannot be cured. This happens because people do not understand well the causes and methods of care for patients with mental disorders. Negative views that exist in the community cause mental patients to get less appropriate and humane treatment in the community even in their own families, such as being installed, ignored, insulted, and alienating family members who experience mental disorders.Objectif: This study aims to determine the differences in positive or negative views of mental patients between students of the Faculty of Medicine, Hang Tuah Surabaya, 5th semester with 7th semester.Methods: The population in this study were students of the Faculty of Medicine, University of Hang Tuah Surabaya in semester 5 with semester 7. with a large sample taken as many as 136 people. The independent variables in this study were positive or negative views about mental patients while the dependent variables in this study were students of semester 5 and semester 7 students. Analysis of the data of this study using Chi Square statistical tests.Results: Obtained results of respondents from semester 5 with a positive outlook that is 38 people (55.9%) and negative views namely 30 people (44.1%), then the results of respondents from 7th semester with a positive outlook that is 53 people (77.9%) and negative view of 15 people (22.1%). Where the total number of all respondents who answered a positive view was 91 people (66.9%) and all respondents who answered negative views were 45 people (33.1%). And based on gender, male respondents who looked positively about mental patients were 51 people (66.2%) and those who viewed negativity were 26 people (33.8%). Whereas female respondents who viewed positively regarding mental patients were 40 people (67.8%) and those who viewed negatively were 19 people (32.2%).Conclusions: The results showed a significant difference regarding the differences in positive or negative views of mental patients between semester 5 students and 7th semester students, as evidenced by the acquisition of the Sig. = 0.006 (<0.05).
Pengaruh Terapi Oksigen Hiperbarik terhadap Kadar Testosteron pada Tikus Model Sindroma Ovarium Polikistik dengan Resistensi Insulin Fajar Sudiono; Lunardhi Susanto; Wachjudi Kurnia
Oceana Biomedicina Journal Vol 3 No 1 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 1 January - June 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i1.25

Abstract

Background:Polycystic ovary syndrome (PCOS) is an endocrine disorder that has the broadest and best in women often springs reproduktif age. Factors underlying the recovery of PCOS are excessive androgens, insulin resistance, and disturbance of gonadotropin dynamics. Excessive androgen causes LH and FSH to develop. In the theory hyperbaric oxygen therapy allows to increase sensitivity tissue to insulin. The . The purpose of this research was to know effect using hyperbaric oxygen therapy 2.4 ATA 3x30 minutes for 5 sessions on testosterone levels on rats model of Polycystic Ovary Syndrome with insulin resistance.Metode:The research is experimental with post test only control group design. The total sample used as 12 rats that is divided into 2 groups. Independent variable is therapeutic oxygen hiperbarik, dependent variable testosteron level from blood sample of rats and control variables are room temperature and standard feed and control variables of androgen injection, types and specifications of experimental animals, cage size and animal care. Data analysis of this study was processed using Mann Whitney U test.Result:The results of using Mann Whitney U Test with p-value = 0,150 > α (0.05), showed no difference between testosterone levels in the experimental group given androgen injection with the group of animals given androgen injection and hyperbaric oxygen therapy.Conclusion:Therapy oxygen hyperbarik has not been effecting testosteron levels in white rats (Rattus Norvegicus) model syndroma ovarium polycystic with resistensi insulin
Ethanolic Extract Oitment of The Graptophylum Pictum L Griff Leaves as Analgesic agent to Male White Rat Setya Enti Rikomah; Ninsi Fitri
Oceana Biomedicina Journal Vol 3 No 1 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 1 January - June 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/onj.v3i1.45

Abstract

Graptophyllum pictum L Griff Leaves in the community are used as medicinal ingredients, one of which is for analgesics. Black pudding leaves contain secondary metabolite compounds that act as suspected analgesics, namely flavonoids. The ethanolic extract of black pudding leaves has been formulated into cream and ointment preparations. The purpose of this study was to determine the effectiveness of analgesic preparations of black pudding leaves (Graptophyllum pictum L. Griff) ethanol extract in white male mice. The effectiveness of analgesics was tested using the hotplate method. The test animals used were 25 white male mice which were divided into 5 groups: negative control (F0), positive control (Ichtiol® ointment), and black pudding leaf F1 (10%), F2 (15%) ethanol extract treatment group, and F3 (20%). Observation of stretching of mice was done after the feet of mice were induced and immediately given treatment. Observation of analgesic percentage in each mouse was carried out every 5 minutes for 60 minutes. The data obtained were processed and analyzed using one-way ANOVA and Duncan test with a 95% confidence level. One-way ANOVA test results showed that there were significant differences between treatment groups (0.003 <0.05). The results of the average percentage of analgesic effectiveness of formula 2 have a good effect that is equal to 77.969%. Duncan's test results showed that the group that gave the best analgesic effectiveness was formula 2 (15%) comparable to positive control.
Formulasi Sabun Cuci dari Minyak Jelantah dengan Penambahan Air Asam Sunti Azmalina Adriani; Rinaldi Rinaldi; Hardiana Hardiana; Suci Suci; Irfan Mustafa
Oceana Biomedicina Journal Vol 3 No 1 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 1 January - June 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i1.38

Abstract

Soap is a cleaning agent made from oil. Coconut oil that has been used is usually discarded as waste (minyak jelantah), with the additionof syringe acid water. Sunti acid water is one of the spices that contains quite high acidic compounds. The purpose of this study was to determine the characteristics of soaps containing Sunti acid water. This research is experimental to formulate laundry soap containing Sunti acid water, with used cooking oil. Soap formulation with Sunti acid waterconcentration 1.25% (F1), 1.50% (F2) and 1.75% (F3). The formula was evaluated with organoleptic parameters, moisture content, pH, homogeneity, high foam and clean power of soap. The results showed that soap (F1, F2, F3) was solid, brown in color and distinctively smelled of lemon, and the water content was 20.34%; 14.21% and 14.8%, pH ranges from 8-10, not homogeneous, foam height 48-78 cm and can be as a cleaner. So it can be concluded that Sunti acid water and used cooking oilcan be formulated in the form of soap and formula 3 is a good formula.
Seorang Penderita SLE dengan Emboli Paru Akut dan Hipertensi Pulmonal (Studi Kasus) Hendrata Erry Andisari; Gede Kambayana; Ketut Suega
Oceana Biomedicina Journal Vol 3 No 1 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 1 January - June 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i1.31

Abstract

Kondisi Pulmonary embolism (PE) merupakan bagian dari spektrum penyakit yang disebut Venous thromboembolism (VTE). Seorang pasien dengan keluhan utama batuk yang mengeluarkan dahak berwarna keputihan datang ke RSUP Sanglah, Bali untuk mendapatkan terapi. Riwayat sebelumnya, pasien pernah dirawat inap di RSUP Sanglah tersebut.Saat ini diagnosis akhir pasien ini: SLE on treatment dengan moderate pulmonary hipertension dan suspek emboli paru, suspek pneumonia (HCAP) dengan severe sepsis dan syok sepsis, asidosis metabolik, observasi transaminitis ec reaktif dan hiponatremia kronik asimptomatik hipoosmoler euvolemic cb SIADH. Selanjutnya dilakukan tindakan terapi dan evaluasi terhadap terapi yang diberikan.
Identifikasi dan Penetapan Kadar Senyawa Saponin Ekstrak Etanol Bunga Senggani (Melastoma malabathricum L) Metode Gravimetri Yuska Noviyanty; Hepiyansori Hepiyansori; Berliana Rosita Dewi
Oceana Biomedicina Journal Vol 3 No 1 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 1 January - June 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i1.46

Abstract

Traditional medicine is an ancestral cultural heritage derived from natural materials and to this day continue to be used by the general public. One of the plants that can be used as a traditional medicine is a plant Senggani (Melastoma malabathricum L). The purpose of this study was to determine the saponins contained from flower extracts Senggani (Melastoma malabathricum L) and percent saponin levels of Senggani flower extract (Melastoma malabathricum L). Extraction is done by maceration using ethanol 96% for 5 days. Extraction obtained is then concentrated by means of a rotary evaporator. The results were qualitative identification of the foam test and color test and quantitative assay with gravimetric method.Based on research conducted Senggani ethanol extracts of flowers (Melastoma malabathricum L) contains saponins types of triterpenoids seen from the ring in maroon and obtained the average level of interest saponin Senggani (Melastoma malabathricum L) is 11.46%.
Perawatan Komprehensif Geligi Campuran pada Anak Usia 8 Tahun dengan Riwayat Ibu memiliki Celah Bibir – Laporan Kasus Anisa Nursantika; Jeffrey Jeffrey
Oceana Biomedicina Journal Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i2.48

Abstract

Cleft lip and palate are abnormal clefts in the orofacial region that affect lip, alveolar bone, hard palate, and or soft palate. An eight-year-old girl came to Dental Hospital of Unjani with her mother, with chief complaint tooth cavity on the left and right of the lower arch and want to be treated. Intraoral findings found that the patient’s teeth are crowded with a narrow jaw arch. From the anamnesis, the mother of the patient had a cleft lip and extend to the alveolar bone, but the patient itself has no cleft lip and palate. The comprehensive treatments that done to the patient are amalgam restoration of tooth 75 and pulp capping of tooth 85 with stainless steel crown as follow up restoration.
Analisa in Silico Kunyit (Curcuma longa) sebagai Inhibitor Murine Double Minute 2 Protein untuk Terapi Glioblastoma Multiforme Benny Iswanto Pantoro; Nancy Margarita Rehatta; Siti Khaerunnisa; Anna Surgean Veterini; Yuani Setiawati
Oceana Biomedicina Journal Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i2.61

Abstract

Brain tumor consists of tumor which grows primarily from cells in the brain (primary brain tumor) or systemic tumor which metastasized into the brain (secondary brain tumor). From all types of primary brain tumor, Glioblastoma Multiforme is the most common and the most malignant tumor. In 85% of Glioblastoma Multiforme cases are found a molecular alteration of the tumor suppresor gene p53 pathway, which promotes current studies to focus on this pathway. One of the pathway that can be used as therapeutic model is through inhibiting the murine double minute 2 protein (MDM2), which in itself is a p53 inhibitor. Turmeric (curcuma longa) is one of the traditional plants which is commonly used as herbs and its extracts has been studied to have an anti-cancer properties. This study is an in silico study which evaluate the potential efficacy of turmeric extract as a murine double minute 2 protein inhibitor using AutoDock 4.2 based on the Lamarckian genetic algorithm principle. Docking result shows binding energy ranging from -4.81 kcal/mol to -2.34 kcal/mol, with curcumenol having the lowest binding energy and curcumin having the highest binding energy. This study may be used as a base in further study (consists of in vivo and in vitro) of turmeric extract and its effect as the therapeutic regiments for Glioblastoma Multiforme.
Pengaruh Pemberian Ekstrak Rumput Laut Cokelat (Sargassum duplicatum) terhadap Peningkatan Kadar Hematokrit pada Darah Tikus Putih Jantan Galur Wistar (Rattus norvegicus) Anemia yang Diinduksi NaNO2 Ayu Mayang; Liliawanti Liliawanti; Wachjudi Kurnia
Oceana Biomedicina Journal Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i2.47

Abstract

Anemia is still a high prevalence disease in Indonesia, caused by a lack of iron in the body. The components from brown seaweed such as cobalamin (vitamin B12), pyridoxine (vitamin B6), chlorophyll and iron (Fe) can increase red blood cells in the body. The purpose of this research was to determine the effect of brown seaweed (Sargassum duplicatum) which can increase hematocrit levels in the blood of white male wistar strain rat (Rattus norvegicus) suffered from anemia in induction NaNO2. This research uses an experimental laboratory method with a post test only control group design. The samples were 30 male rats divided into 3 treatment groups, the negative control group (K0) without treatment, the positive control (K1) be treated anemia given NaNO2 for 18 days without Sargassum duplicatum extract and treatment group (K2) treated with anemia given NaNO2 for 18 days without Sargassum duplicatum extract at a dose of 2,45gr / kgBB. On the 40th day, a blood sample was taken, then measured the hematocrit level.The results showed that the mean number of blood hematocrit levels in K2 was higher than K1, it showed a significant difference descriptively. Based on the KruskalWallis test, a value of 0.260 was obtained that p > 0,05 showed that there were no statistically significant differences between groups of experimental animals.From the results of this research, the conclusion is the administration of brown seaweed extract (Sargassum duplicatum) descriptively increased, but not statistically significant.

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