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Oceana Biomedicina Journal
Published by Universitas Hang Tuah
ISSN : -     EISSN : 26140519     DOI : https://doi.org/10.30649/obj.v5i1.67
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Dentistry Medicine & Pharmacology Nursing Public Health
Oceana Biomedicina Journal is an open access journal of health and medicine.Specifically, the journal focuses on marine medicine, hyperbaric medicine and health, medicine on ships, harbor health, maritime and coastal health, medicolegal studies related to ships, ports and districts, maritime/coastal communities and fishermen, epidemiological aspects of diseases, disabilities and disorders that occur on ships and affect boat workers, ports and maritime zones, coastal areas, fishermen communities and their families, including pharmacological and non-pharmacological prevention and treatment management policies; and miscellanous.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 110 Documents
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Comparison of Cerebral Malaria Mice Models Infected by P. berghei ANKA Prawesty Diah Utami; R. Varidianto Yudo Tjahjono; Indi Jazilah; Ismy Azizah Sisnawati
Oceana Biomedicina Journal Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i2.49

Abstract

The high morbidity and mortality due to malaria infection makes it a global health problem. The pathogenesis and pathophysiology of cerebral malaria has not been fully understood. The use of cerebral malaria model mice is one alternative to understand its pathogenesis and pathophysiology. The purpose of this study was to compare Swiss mice and C57BL / 6 mice inoculated by P.berghei ANKA as a model of cerebral malaria mice. Methods: The study design was a randomized Post Test Control Only Group Design using 12 Swiss mice and 12 C57BL / 6 mice divided into 2 groups each: the treatment group inoculated by P. berghei ANKA and the control group without inoculation. Observation of clinical manifestations and parasitemia level was carried out from day 1 to day -10. The study results showed that K2 group showed a significant increase in the degree of parasitemia compared to K4. K4 group showed clinical manifestations of cerebral malaria while K2 did not show clinical manifestations of cerebral malaria. Conclusion: C57BL / 6 mice inoculated by PbA can be used as cerebral malaria animal models.
Perawatan Space Regainer pada Premature Loss Gigi Molar Sulung Rahang Atas dan Bawah – Laporan Kasus Anatasya Rachmadani; Jeffrey Jeffrey
Oceana Biomedicina Journal Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i2.56

Abstract

Caries is one of the most common illnesses in children and young adults. Dental caries and dental trauma that occur in children can cause missing teeth prematurely, commonly called premature loss, which can cause occlusion abnormalities caused by narrowing of the arch. A space regainer is an active device used to recover space that has narrowed to the dental arch a result of premature loss. A 9-year-old boy accompanied by his mother came to RSGMP Unjani in 2018 with complaints of upper right and back right and lower left teeth missing because extraction. The patient's mother is worried that her replacement teeth will overlap. Intra oral examination showed tooth loss 54,75,84,85. Analysis of the model shows a narrowing of the -0.9 space in the maksila and -0.7 in the mandible. Patients were treated for maksila and mandibular removable space regainer accompanied by expansion screws. Activation of expansion screws is done once a week with ¼ turns. Space regainer treatment in this patient was done 4 times and the results were very satisfying.
Pengaruh Ekstrak Daun Jeruju (Acanthus ilicifolius) terhadap Penurunan Kadar LDL Darah pada Tikus Putih (Rattus norvegicus) Jantan Galur Wistar Diabetes yang Diinduksi Aloksan Anggita Saraswati; Irmawati M. Dikman; Retno Budiarti
Oceana Biomedicina Journal Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i2.50

Abstract

Background : DM is a chronic disease that has long-term complications. Alloxan is a fast way to produce experimental diabetic (hyperglycemic) in animal experiments related to elevated LDL. Jeruju (Acanthus ilicifolius) is a low-growth herbaceous plant that easily grows containing secondary metabolites such as Alkaloids, Saponins, Flavonoids, Terpenoids, and Phenols. Objective : To determine the effect of jeruju leaf extract on the decrease in blood levels of LDL of male Wistar rat (Rattus norvegicus) induced Alloxan.Methods : This research is an experimental laboratory type with Post Test Only Control Group Design. The sample using 24 rats, which were divided into 3 groups: negative control group (K-) were given standard feed; positive control group (K +) induced alloxan 120 mg/kgBW on 1st day; the treatment group (P) induced alloxan 120 mg/kgBW on 1st day and was given jeruju leaf extract 67.2 mg/kgBW on 5th-14thday. The 15th day a blood sample was taken to determine LDL levels.Result : The results of One-Way ANOVA test showed an insignificant mean difference (p = 0.270) in LDL level of K- ( = 9.75 mg/dl) and the K+ ( = 11.38 mg/dl ). Insignificant mean difference (p = 0.270) in P ( = 9 mg/dl) with blood LDL levels in theK+ ( = 11.38 mg/dl) and the K- ( = 9, 75 mg/dl).Conclusion : Giving alloxan can increase blood levels of LDL and administration of jeruju leaf extract can reduce blood levels of LDL in experimental animals but not statistically significant.
PERBANDINGAN EFEKTIVITAS OBAT KUMUR POVIDONE IODINE DENGAN KLORHEKSIDIN TERHADAP INDEKS PLAK Novia Septiani Fauzia; Hanri Hartman; Jeffrey Jeffrey
Oceana Biomedicina Journal Vol 4 No 1 (2021): Oceana Biomedicina Journal Volume 4 Issue (No) 1 January - June 2021
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v4i1.64

Abstract

Plaque is the main cause of the tooth and supporting tissues damage, so plaque control must be done. Chemical plaque control can be done by using mouthwash such as povidone iodine and chlorhexidine which is an effective antiseptics in reducing plaque formation. Both are proven to have antibacterial activity against Streptococcus mutans which is one of the plaque-causing bacteria. This research aims is to determine the difference of both mouthwash effectiveness to the plaque index. This research is pre-post test control group design by examining the plaque index before and after gargling. The subjects in this study are 32 students from SMPN 2 Cimahi who were 13 - 15 years old and were divided into two groups. This research was conducted by examining the plaque index before and after gargling using Silness and Loe plaque index. Data were tested for normality using Chi-square and analyzed by T-test. The results showed a difference average in plaque index before and after gargling with povidone iodine by 0.68 and chlorhexidine by 0.51 with a p-value of 0.11. Both mouthwash have almost the same effect on the plaque index.
PEMBERIAN EKSTRAK RUMPUT KEBAR (Biophytum petersianum Klotszch) TERHADAP VIABILITAS SPERMATOZOA MENCIT (Mus musculus) DIABETES MELITUS Prima Arundani; Rany I'tishom; Bambang Purwanto
Oceana Biomedicina Journal Vol 4 No 1 (2021): Oceana Biomedicina Journal Volume 4 Issue (No) 1 January - June 2021
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v4i1.58

Abstract

Diabetes mellitus yang tidak ditangani dengan baik akan mengakibatkan infertilitas yang disebabkan oleh adanya kerusakan salah satu organ reproduksi yaitu testis. Hiperglikemia atau tingginya kadar gula dalam darah berperan dalam kerusakan sel dengan cara peningkatan reactive oxygen spescies (ROS) sehingga terjadi stres oksidatif jaringan yang mengakibatkan radikal hidroksil. Peningkatan Reactive Oxygen Species (ROS) menyebabkan cedera sel melalui mekanisme peroksidasi lipid dan kerusakan oksidatif protein serta DNA. Proses lipid periksidase pada akhirnya merusak membran spermatozoa dan mitokondria DNA sehingga menyebabkan penurunan kualitas spermatozoa.Penelitian ini bertujuan mengetahui efek ekstrak rumput kebar terhadap viabilitas spermatozoa mencit jantan (Musmusculus) model diabetes melitus.Penelitian ini merupakan penelitian eksperimental dengan rancangan post test only control group design. Ekstrak rumput kebar menggunakan metode maserasi dengan pelarut etanol 96%. Sebanyak 30 ekor mencit yang dibagi ke dalam 5 kelompok, yaitu kelompok kontrol negatif yaitu mencit diabates mellitus yang di sonde cmc na, kelompok kontrol positif yaitu mencit diabetes mellitus yang di sonde metformin, kelompok I, II, dan III yang di sonde ekstrak rumput kebar dengan dosis 67,5; 130; dan 270 mg/kg BB. Viabilitas spermatozoa dianalisis dengan mengambil sampel spermatozoa dari kauda epididimis. Hasil uji Kruskal Wallis menunjukkan hasil yang signifikan p = 0,005 (p ˂ 0,05) pada viabilitas spermatozoa mencit diabetes mellitus dan perbedaan yang bermakna pada kelompok kontrol negatif mencit dengan diabetes mellitus dengan kelompok perlakuan 3 yang diberi metformin dan ekstrak rumput kebar dosis 270 mg/kg BB. viabilitas spermatozoa pada kelompok kontrol negatif memiliki persentase terendah sedangkan pada kelompok perlakuan 3 memiliki persentase tertinggi. Simpulan penelitian ini adalah ekstrak rumput kebar (Biophytum petersianum Klotzsch) meningkatkan viabilitas spermatozoa mencit (Mus musculus) model diabetes melitus.
UJI EFEKTIVITAS ANTIINFLAMASI KRIM TIPE M/A DARI EKSTRAK ETANOL DAUN RANDU (Ceiba pentandra.(L) Gaertn ) PADA HEWAN UJI MENCIT PUTIH JANTAN (Mus musculus.L) Setya Enti Rikomah; Luky Dharmayanti; Melandika Dwi Sakinah
Oceana Biomedicina Journal Vol 4 No 1 (2021): Oceana Biomedicina Journal Volume 4 Issue (No) 1 January - June 2021
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v4i1.55

Abstract

Daun Tanaman Randu (Ceiba Pentandra .(L) Gaertn) dimasyarakat digunakan sebagai obat, salah satunya untuk antiinflamasi. Daun randu mempunyai kandunganflavonoid sebagai senyawa metabolit sekunder yang diduga berperan sebagai antiinflamasi. Ekstrak etanol daun randu telah diformulasikan menjadi sediaan krim. Tujuan dari penelitian ini adalah untuk mengetahui efektifitas antiinflamasi sediaan krim ekstrak etanol daun randu pada mencit jantan putih. Efektifitas antiinflamasi diuji menggunakan metode Inflammation-associated edema. Hewan uji yang digunakan sebanyak 30 ekor mencit jantan putih yang dibagi menjadi 6 kelompok yaitu kontrol normal, kontrol negatif (F0), kontrol positif (Krim Hidrokortison), dan kelompok perlakuan krim ekstrak etanol daun randu F1 (10%), F2 (15%), dan F3 (20%). Pengamatan dan pengukuran volume tebal lipat kulit punggung mencit menggunakan jangka sorong digital dilakukan saat sebelum diinduksi dan setelah diinduksi karagenan 2%. Pengamatan penurunan volume tebal lipat kulit punggung mencit dilakuan setiap satu jam sekali selama 6 jam. Data yang didapatdiolahdandianalisa menggunakan one-way anovadanuji duncandengan tingkat kepercayaan 95%.Hasil uji one-way anova menunjukan tidak terdapat perbedaan yang nyata antar kelompok perlakuan (0,967>0,05). Hasil uji duncan menunjukan bahwa antar kelompok perlakuan memiliki efektivitas antiinflamasi yang hampir sama.
Pengaruh Pemberian Ekstrak Rumput Laut Cokelat (Sargassum duplicatum) terhadap Peningkatan Kadar Hematokrit pada Darah Tikus Putih Jantan Galur Wistar (Rattus norvegicus) Anemia yang Diinduksi NaNO2 Emy Noviana Sandy; Liliawanti Liliawanti; Wachjudi Kurnia
Oceana Biomedicina Journal Vol 4 No 1 (2021): Oceana Biomedicina Journal Volume 4 Issue (No) 1 January - June 2021
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v4i1.51

Abstract

Background: In Indonesia, the prevalence of iron deficiency anemia reaches 25,2 percent, it indicates that anemia is a medical condition in society that needs attention. Brown seaweed (Sargassum duplicatum) is a group of algae that contains minerals such as iron and vitamin B12. So that the content in Sargassum duplicatum can be used for anemia therapy that serves as the main forming hemoglobin. Objective: The purpose of this experimental research was to determine the administration of Sargassum duplicatum affects the increase in blood haemoglobin levels of rats that are anemia induced NaNO2..Methods: This research used the Post-test only control group design, the samples were 30 male rats divided into 3 treatment groups (K0, K1, and K2). The process of treating anemia in rats using sodium nitrite (NaNO2) at a dose of 125 mg / KgBB. K0 group is a group that is not treated. K1 group is a group that was given NaNO2 for 18 days without dieting Sargassum duplicatum. The K2 group was the group that was given NaNO2 for 18 days and received the Sargassum duplicatum diet at a dose of 2.45 g/kgBB for 14 days.Result: From this research it can be seen that K0 has an average hemoglobin level of 12,71 g/dL, K1 has an average hemoglobin level of 11.96 g / dL, and K2 has an average hemoglobin level of 12,99 g/dL which shows that descriptively there is a difference between groups K1 and K2. Based on the KruskalWallis statistical test, a value of 0,290 was obtained so that p > 0.05 showed that H0 was accepted, which means there was no difference in the administration of Sargassum duplicatum in increasing blood hemoglobin levels in anemic rats.Conclusion: From the results of this research, the conclusion in descriptively there was an increase in the blood hemoglobin level of white rats in the group receiving Sargassum duplicatum extract therapy but it was not statistically significant.
UJI AKTIVITAS SENYAWA FLAVONOID DARI EKSTRAK ETANOL KULIT BUAH MANGGA (Mangifera indica L.) TERHADAP BAKTERI STAPHYLOCOCCUS AUREUS Yuska Noviyanty; Hepiyansori Hepiyansori; Tamara Dwi Insani
Oceana Biomedicina Journal Vol 4 No 1 (2021): Oceana Biomedicina Journal Volume 4 Issue (No) 1 January - June 2021
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v4i1.67

Abstract

Salah satu bahan alam yang dapat digunakan sebgai obat yaitu kulit buah mangga (Mangifera indica L.) yang mempunyai manfaat sebagai antioksidan, antibakteri, antivirus dan antikanker. Kulit buah mangga memiliki kandungan senyawa flavonoid yang diketahui memiliki aktivitas sebagai antibakteri. Tujuan penelitian ini untuk mengetahui potensi terhadap aktivitas antibakteri dari ekstrak etanol kulit buah mangga (Mangifera indica L.)terhadap bakteri Staphylococcus aureus.Pembuatan ekstrak etanol kulit buah dilakukan dengan menggunakan metode maserasi selanjutnya dilakukan pengujian daya hambat bakteri staphylococcus aureus, dengan proses peremajaan biakan murni bakteri staphylococcus aureus dengan menggunakan metode difusi cakram, dilanjutkan dengan pembuatan media Na (Nutrient agar) dan media Nb (Nutrien broth), konsentrasi ekstrak etanol Kulit Buah Mangga (Mangifera indica L.) yang digunakan adalah 5%, 7,5%, 10%. Kontrol positif yang digunakan adalah Amoxsan capsul dan kontrol negatif menggunakan aquadest.Hasil data dianalisis dengan menggunakan metode Kruskal Wallis Test pada program SPSS 16 dengan tingkat kepercayaan 95% atau α = 0,05. Ekstrak Kulit Buah Mangga (Mangifera indica L.) mempunyai daya hambat terhadap bakteri Staphylococcus aureus. Telah di buktikan dengan adanya zona bening dan uji Kruskal Wallis Test adalah Asymp.Sig<0,05 maka ada perbedaan konsentrasi ekstrak Kulit Buah Mangga (Mangifera indica L.)
THYROTOXICOSIS IN PATIENTS WITH HYDATID MOLE Rahadianto Rahadianto; Maimun Z. Arthamin
Oceana Biomedicina Journal Vol 4 No 1 (2021): Oceana Biomedicina Journal Volume 4 Issue (No) 1 January - June 2021
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v4i1.57

Abstract

Hydatid Mole, also often called grape pregnancy, is a pregnancy characterized by abnormal trophoblast development. The incidence of hydatidiform mole per 1,000 pregnancies occurs in Asia. In Indonesia, in 2002 cases of hydatidiform mole were found 1: 123 pregnancy, and in 2003 found cases of hydatidiform mole 1: 245 pregnancy. While the results of research conducted in the same place in 2012-2013 obtained 39 cases of hydatidiform mole that were distributed based on age groups, parity, education, and hemoglobin levels of patients. Trophoblastic hyperthyroidism is a rare case but can be life threatening. Alpha subunit-human chorionic gonadotropin (HCG) is similar to alpha sub-unit-thyroid stimulating hormone (TSH). If HCG concentrations increase over a long period of time, it can increase free T4 and free T3 levels. In this patient there was also a sudden onset of hypertension, proteinuria 3+, ketonuria 3+, hematuria 3+, leukosituria 1+, bacteriuria which could possibly be caused by the occurrence of a pre-eclampsia or UTI in this patient. The cause of pre-eclampsia in molar pregnancy is thought to be due to excessive levels of soluble fms-like tyrosine kinase 1 (sFlt1) in the circulation, an endogenous anti-angiogenic protein that enters the maternal circulation after overproduction in the placenta.
INTRACEREBRAL HEMORRHAGE (ICH) INCIDENCE PROFILE IN JEMURSARI ISLAMIC HOSPITAL DURING THE PERIOD 2017-2019 Hidayatullah Hidayatullah; Shobihatus Syifak; Choirotussanijjah Choirotussanijjah
Oceana Biomedicina Journal Vol 5 No 1 (2022): Oceana Biomedicina Journal Volume 5 Issue (No) 1
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v5i1.62

Abstract

Background: Intracerebral hemorrhage or ICH or hemorrhagic stroke is caused by bleeding within brain parenchyma. Riskesdas reported that stroke patients in Indonesia experienced an increase from 7 permil in 2013 to 10.9 permil in 2018. Mortality rate for ICH is estimated 40% in 1 month and 54% in 1 year. Rumah sakit Islam Jemursari (RSI) is the only type B hospital in Wonocolo sub-district, Surabaya city. This study aimed to analyze the pattern of incidents and variations of ICH at RSI Jemursari Surabaya.Method: This was a descriptive observational study. Medical record data is collected from 2017-2019. The data were obtained from medical records section of total number of ICH, gender, age and outcome of patients. Furthermore, data is analyzed and illustrated through a bar chart and the frequency of mortality is calculated.Results: Total ICH patients at Jemursari Hospital were 310 with 192 male patients and 118 female patients over 3 years. Meanwhile, the most groups experienced ICH were 45-64 years, followed by +65 age group. This is consistent with several epidemiological studies related to ICH, where the incidence of ICH increases with increasing age. The mortality rate for ICH patients, in the 2017-2019 periode, was around 23-30%.Conclusion: It can be concluded that male more susceptible to ICH than female subjects. Meanwhile, the mortality rate for ICH patients ranged from 23-30% in the 2017-2019 period. It is necessary to carry out further evaluation related to other data from the patient. So it could describe incidence rate as well as an overview of the ICH profile at RSI Jemursari.

Page 7 of 11 | Total Record : 110

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