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Jurnal Farmasi Indonesia yang diterbitkan oleh Pengurus Pusat Ikatan Apoteker Indonesia. Isi website memuat seluruh jurnal yang telah diterbitkan mencakup semua aspek dalam ilmu pengetahuan dan teknologi kefarmasian antara lain farmakologi, farmakognosi, fitokimia,farmasetika, kimia farmasi, biologi molekuler, bioteknologi, farmasi klinik,farmasi komunitas, farmasi pendidikan, dan lain-lain.

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Articles 443 Documents

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Antiproliferative Activities of Dianella nemorosa Lam. Leaves Methanol Extract Against HCT-116, C2C12 and 293A Cell lines Karim, Aditya Krishar; Asmara, Widya; Sismindari, .; Istriyati, .; Nohno, Tsutomu
Jurnal Farmasi Indonesia Vol 6, No 2 (2012)
Publisher : Jurnal Farmasi Indonesia

Dianella nemorosa Lam. (Liliaceae) is a medicinal plant traditionally used in Papua for treatment of cancer, injury, fracture, inflammation and also for antiseptic. The aim of this study was to evaluate antipriliferative activities of methanol extract of D. nemorosa leaves against HCT+116 (colorectal cell line), C2C12 (adherent mouse myoblast cell line) and 293A (Primary embryonal human kidney transformed with human adenovirus type 5 DNA). Powder of leaves was extracted using methanol. Antiproliverative activities were determined by cell proliferation reagents WST-1 assay for 1 h, 2h and 4h after 72h incubation. The result showed that methanol extract of D.nemorosa leaves showed remarkable antiproliferatiove activities against HTC-116 cell line with IC50 values of 199.31 Î¼g/ml (1h), 197.87Â Î¼g/ml (2h) and 161.12Â Î¼g/ml (4h). The activities against C2C12 cell line resulted in the IC50 values of 405.51 Î¼g/ml (1h), 435.12Â Î¼g/ml (2h) and 394.38Â Î¼g/ml (4h), while the IC50 values for 293A cell line were 580.81Â Î¼g/ml (1h), 442.21Â Î¼g/ml (2h) and 366.74Â Î¼g/ml (4h), respectively. Those results indicated that methanol extract of D.nemorosa leaves posses potential antiproliferative activities against HCT-116, C2C12 and 293A cell line. Further study is necessary to investigate the inhibitory mechanism of methanol extract of D. nemorosa leaves on HCT-116, C2C12 and 293A cell lines.Keywords : Dianella nemorosa Lam, cancer cell, HCT-116, C2C12, 293A

Formulasi Sediaan Gel Niosom Kafein dan Usaha Peningkatan Absorpsi melalui Kulit Nafi'ah, Rahma; Darijanto, Sasanti Tarini; Mudhakir, Diky
Jurnal Farmasi Indonesia Vol 7, No 1 (2014)
Publisher : Jurnal Farmasi Indonesia

Cellulite is a condition in the skin that changes the topographic of the skin surface. Caffeine can be used as an active compound for its slimming effect. To improve the penetration into the skin and increasing its solubility for cellulite treatment, caffeine was formulated as niosome vesicles. Niosome was made by using thin layer hydration method. Span 60, caffeine and cholesterol dissolved in chloroform and evaporated to produse a thin layer. The dispersion of caffeine and niosome was formulated in the form of gel using 6% of HPMC gel base. To determine the formulation stability, caffeine niosome gel was stored at a room temperature and accelerated condition using climatic chamber at a temperature of 40â°C, 75% RH for 28 days. The result was then compared with caffeine gel. The diffusion rate of both gels was determined in vitro using flow through method. The results showed that the niosome system improved the solubility of caffeine up to 20,34 mg/ml and also showed that the pH and viscosity of caffeine niosome gel were stable under room temperature and accelerated condition.The diffusion test showed that the flux of caffeine niosome gel is 13.991 Î¼g/cm2Keywords : Caffeine, niosome, cellulite, diffusion test.

Efek Perbandingan Surfaktan dan Kosurfaktan Terhadap Karakteristik dan Efisiensi Penjebakan Ovalbumin Dalam Mikroemulsi Hendradi, Esti; Yuwono, Mochammad
Jurnal Farmasi Indonesia Vol 8, No 1 (2016)
Publisher : Jurnal Farmasi Indonesia

ABSTRACT: The study was conducted to investigate the effect of composition of surfactant (Span 80 and Tween 80) and cosurfactant (butanol) on characteristics and ovalbumin entrapment in the microemulsion water in oil (w/o).The composition of surfactant (Span 80 and Tween 80) and cosurfactant (butanol) used were 6:3, 7:3 and 8:3. Evaluation was conducted on the surface tension, viscosity, droplet size, pH and the efficiency of ovalbumin trapping in microemulsion system. Results were analyzed by statistic using one way analysis of variance (ANOVA) with 95% confidence level (Î± = 0,05). From the results it was concluded that the composition of surfactant and cosurfactant 7:3 resulted in the best microemulsion. Keywords: microemulsion, surfactant, cosurfactant, butanol, ovalbumin ABSTRAK : Penelitian ini dilakukan untuk mengetahui pengaruh komposisi surfaktan (Span 80 dan Tween 80) dan kosurfaktan (butanol) terhadap karakteristik dan penjebakan ovalbumin dalam mikroemulsi minyak dalamm air (w/o). Perbandingan surfaktan (Span 80 dan Tween 80) dan kosurfaktan (butanol) adalah 6:3, 7:3 dan 8:3. Evaluasi yang dilakukan meliputi tegangan permukaan, viskositas, ukuran droplet, pH dan efisiensi penjebakan ovalbumin dalam sistem mikroemulsi. Hasil dianalisis dengan statistik menggunakan ANOVA dengan tingkat kepercayaan 95% (Î± = 0,05). Dari hasil penelitian ini disimpulkan bahwa bahwa perbandingan surfaktan dan kosurfaktan sebesar 7:3 menghasilkan mikroemulsi yang terbaik. Kata Kunci: mikroemulsi, surfaktan, kosurfaktan, butanol, ovalbumin Â Â

Aktivitas Anti inflamasi Ekstrak Etanol Uwi Banggai Ungu (DioscoreaAlataL.) Terhadap Tikus Putih Galur Wistar Yang Induksi Putih Telur Khaerati, Khildah; Rivani, Rivani; Ihwan, Ihwan
Jurnal Farmasi Indonesia Vol 9, No 1 (2017)
Publisher : Jurnal Farmasi Indonesia

ABSTRACT: Purple uwi Banggai (Dioscorea alata L.) is a plant used as a source of carbohydrates and also has many benefits. This research aimed is to know the dosage of ethanol extract of purple uwi Banggai which is effective as anti-inflammatory to white rat (Rattus norvegicus). This research used 25 test animals that were divided into five groups. All groups were induced with 100% egg whites with subplantar method, after 60 minutes each group was given different suspension. The negative control group was given a 0.5% Na CMC suspension, meanwhile positive control group was given 9 mg / 200 gBB mefenamic acid, and the third, fourth, and fifth groups were given test suspension with variation of doseÂ 200, 250, 300 mg / 200 gBB, then measured again inflammation volume with pletismometer for 6 hours with 60 minutes interval. Data were analyzed statistically using ANOVA. The result showed that the ethanol extract of purple uwi Banggai have anti-inflammatory effect on white rat induced egg white 100%. The effective dose as antiinflammatory is 200 mg / 200gBB.

OPTIMASI KOMBINASI PENGHANCUR DAN PENGIKAT DALAM FORMULASI TABLET EKSTRAK ETANOL DAUN Eugenia cumini Merr. Lucida, Henny; Saputra, Harry; Arifin, Helmi
Jurnal Farmasi Indonesia Vol 4, No 3 (2009)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v4i3.19

Preclinical studies of the aethanolic extract of the leaves of Eugenia cumini Merr (Jamblang, jambu kaliang) showed that it decreased the blood glucose level of mice at the doses of 50, 100 dan 200 mg/kg BW respectively. The extract was not toxic with the LD50 >15g/kg BB. The acute and sub-acute toxicity studies indicated that the extract was safe for a long use in mice. These results supported the potencial of this extract to be formulated as drug. This study reported the optimization technique used in the formulation of tablet of the aethanolic extract of Eugenia cumini Merr leaves to obtain best formulation with combination of dissintegrant and binder with respect to tablet dissintegration time. Four formulations containingÂ 250 mg of extract were prepared by wet granulation. Results showed that granules of each formulas fulfilled the requirements of granules physical properties except granules a and b for its moisture content. The tablets also fulfilled the Indonesia Phamacopeia requirements except formula b for dissintegration time. Formulation of tablet based on optimization (amprotab 11% and PVP 2%) resulted in tablets with dissintegration time of 499 seconds (contour plot showed 443 seconds). ABSTRAK Uji preklinis menunjukkan bahwa ekstrak etanol daun Eugenia cumini Merr (Jamblang, jambu kaliang) dengan dosis 50, 100 dan 200 mg/kg BB dapat menurunkan kadar glukosa darah hewan percobaan. Ekstrak ini tergolong tidak toksik dengan LD50 >15g/kg BB. Uji toksisitas akutÂ dan toksisitas sub akut menunjukkan bahwa ekstraks ini aman digunakan dalam jangka waktu lama. Dengan demikian senyawa ini berpotensi untuk dikembangkan menjadi fitofarmaka. Makalah ini melaporkan hasil penelitian tentang optimasi kombinasi penghancur dan pengikat dalam formulasi tablet antidiabetes dari ekstrak etanol daun Eugenia cumini Merr. Dibuat empat formula tablet yang mengandung ekstrak sebesar 250 mg secara granulasi basah, dengan amprotab sebagai penghancur dan polivinilpirolidon (PVP) sebagai pengikat. Respon yang diukur adalah sifat fisik granul, sifat fisik tablet dan waktu hancur tablet. Hasil penelitian menunjukkan bahwa granul yang dihasilkan memenuhi persyaratan uji sifat fisik granul kecuali formula a dan b untuk uji kandungan lembab. Tablet yang dihasilkan memenuhi persyaratan tablet menurut Farmakope Indonesia kecuali formula b untuk waktu hancur tablet. Variasi konsentrasi amprotab berpengaruh dominan terhadap waktu hancur tablet dibandingkan dengan variasi konsentrasi PVP. Formulasi tablet ekstrak etanol daun Eugenia cumini Merr berdasarkan hasil optimasi (amprotab 11% dan polivinilpirolidon 2%) memberikan tablet dengan waktu hancur 499 detik.

HUBUNGAN STRUKTUR TURUNAN N-KLOROBENZOILAMOKSISILIN DAN AKTIVITAS ANTIBAKTERINYA TERHADAP Pseudomonas aeruginosa ATCC 27853 Kusumowati, Ika Trisharyanti Dian; Siswandono, .; Rudyanto, Marcellino
Jurnal Farmasi Indonesia Vol 5, No 3 (2011)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i3.49

The aim of this research is to determine structure-activity relationship N-chlorobenzoylamoxicillin derivatives against Pseudomonas aeruginosa ATCC 27853. Antibacterial activities of the N-benzoylamoxicillinÂ derivatives against Pseudomonas aeruginosa ATCC 27853 were tested using dilution method. The result showed that there was significance MIC of amoxycillin with N-benzoylamoxycillin, N-2-chlorobenzoylamoxycillin, and N-3-chlorobenzoylamoxycillin. Non linier regression between log MIC and lypophilic parameter N-chlorobenzoylamoxycillin derivatives showed -log KHM = 3,963 p2 - 3,001 p - 2,477, r = 0,906. To see more clearly quantitative strucuture-activity relationship of N-benzoylamoxicillin derivatives, further similar studies need to be done by increasing numbers of another N-benzoylamoxicillin derivative compounds.Â ABSTRAK Penelitian ini bertujuan mengetahui hubungan struktur-aktivitas antibakteri senyawa-senyawa turunan N-kolorobenzoilamoksisilin terhadap Pseudomonas aeruginosa ATCC 27853. Uji aktivitas antibakteri turunan senyawa N-klorobenzoilamoksisilin terhadap Pseudomonas aeruginosa ATCC 27853 dilakukan dengan metode dilusi. Nilai KHM menunjukkan adanya perbedaan aktivitas yang bermakna antara amoksisilin dengan N-benzoilamoksisilin, N-2-klorobenzoilamoksisilin, dan N-3-klorobenzoilamoksisilin. Persamaan non linier log KHM dengan sifat lipofilik senyawa turunan N-klorobenzoilamoksisilin diperoleh -log KHM = 3,963 p2 - 3,001 p - 2,477, dengan harga r = 0,906.

PENGARUH KADAR BAHAN PENGIKAT MUSILAGO GUMMI ARABICI DAN UKURAN GRANUL BASAH TERHADAP MIGRASI OBAT SELAMA PROSES PENGERINGAN Endarti, Dwi; Fudholi, Achmad
Jurnal Farmasi Indonesia Vol 3, No 3 (2007)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v3i3.81

Wet granulation is one of compressed tablet method that used widely. This experiment purposed to study the effect of gummi arabici mucilage binder concentration and wet granul size on drug migration during drying process which used vitamin B6 as a model of drug. Three formulation of granul was prepared using gummi arabici mucilage binder which concentration 10%, 15%,20%. Each formula was sieved used sieving number 8, 12, 16 mesh. Granul was dried in oven at temperature 60Â°C for 3,5 hours used drying cell. Drug migration was known by calculating the coefficient of migration value. The result was analyzed used statistic method ANOVA two way at 95% level of significant and student-t test if thereâ??s a significant of difference. The result of experiment showed a significant of difference on coefficient of migration that influenced by gummi arabici mucilage concentration, but the wet granul size didnâ??t give a significant of difference. The coefficient of migration value which resulted at granul size 8, 12, 16 mesh at each formula are FI 0,230, 0,215, 0,209; FII 0,161, 0,151, 0,138; FIII 0,087, 0,071, 0,063. ABSTRAK Granulasi basah merupakan salah satu metode pembuatan tablet yang digunakan secara luas. Penelitian ini bertujuan untuk mengetahui pengaruh kadar bahan pengikat musilago gummi arabici dan ukuran granul basah terhadap migrasi obat selama proses pengeringan dengan menggunakan vitamin B6 sebagai model obat. Untuk mencapai tujuan tersebut dibuat 3 macam formula granul dengan bahan pengikat musilago gummi arabici dengan kadar 10%, 15%, 20%. Masing-masing formula tersebut diayak dengan ayakan no 8, 12, 16 mesh. Granul dikeringkan dalam lemari pengering pada suhu 60Â°C selama 3,5 jam dengan menggunakan sel pengering. Besarnya migrasi obat diketahui dengan menghitung harga koefisien migrasi. Selanjutnya hasil yang diperoleh dianalisa dengan ANOVA dua jalan dengan taraf kepercayaan 95% dan dilanjutkan dengan uji t (student) jika terdapat perbedaan yang bermakna. Hasil penelitian menunjukkan adanya perbedaan yang bermakna pada koefisien migrasi obat karena pengaruh kadar bahan pengikat musilago gummi arabici yang digunakan, sedangkan ukuran granul basah tidak memberikan perbedaan yang bermakna. Harga koefisien migrasi yang diperoleh pada granul dengan ukuran 8, 12, 16 mesh pada masing-masing formula adalah FI 0,230, 0,215, 0,209; FII 0,161, 0,151, 0,138; FIII 0,087, 0,071, 0,063.

Alga Merah (Gracilaria verrucosa) sebagai Bahan Bakto Agar Kumala, Shirly; Sumarny, Ros; Rachmani, Rum; Ruswita, Atut
Jurnal Farmasi Indonesia Vol 6, No 3 (2013)
Publisher : Jurnal Farmasi Indonesia

The used of bacto agar in microbiological studies increased tremendously, however, up till now, to fullfill its high demant the scientist were stil relying on imported bacto agar eventhough domestic production of bacto agar was as goog and reliable as those produced commercially overseas. The current study we focuseon the production of bacto agar from red algae Gracilaria verrucosa using fell press technique;Â followed by quality analysis of the product. Red algae samples were collected from two different locations (Bekasi and Subang). Quality of the product was tested for its content, acid insoluble as content, overall as content, pH, gel strength and its ability to be use as culture media to culture Escherichia coli and Staphylococcus aureus. Microbiological test was performed via pour plate. The results clearlydemonstrated that red algae sample from Bekasi produced bacto agar that meets the criteria of commercial bacto agar. It has 10.3% water content, 3.9% overall as content, 0.4% acid insoluble as content, pH of 7.3 and gel strength of 600.8-602.8 g/square cm.Keywords : Bacto agar, red Algae, Gracilaria verrucosa, Microbe media

Kepatuhan Penderita Diabetes Mellitus di Apotik Ubaya Berdasarkan Tinkgkat Kepatuhan dan Motivasi Kristianto, Franciscus Cahyo; Susilo, Astrid Pratidina
Jurnal Farmasi Indonesia Vol 7, No 3 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v7i3.214

Adherence is one of the important things for diabetic patients to control their blood glucose level and preventing for complications in the future. There are two major factors that influence the adherence, patientâ??s knowledge and motivation. Design of this study was sequential mixed method. Thirty type 2 diabetes mellitus patients were recruited based on patient medication record prepared by the community pharmacist. At the first stage, subjects were asked to answer four validated questionnaires that related with level of knowledge (health literacy and medication knowledge) and motivation (readiness to change and social support). At the second stage, they were interviewed based on their response to readiness to change questionnaire. All data collected were then analysed descriptively and qualitatively. From knowledge aspects, there were 93% of patients has high level of health literacy and 87% has high medication knowledge. From motivation aspects, there were 70% has changed and maintained their adherence, 20% were still prepare to change (preparation) and 10% were not ready to change (contemplation). Need for social supports were very high (97%) within the diabetic patients. Most of the subjects (80%) have high level of knowledge and motivation. There were 17% who has variable knowledge and motivation and only 3% who has low level of knowledge and motivation.

Isolasi dan Skrining Aktivitas Antimikroba Jamur Laut pada Alga Kappaphycus alvarezii dari Kabupaten Takalar Sulawesi selatan Fitriana, Fitriana; Julianti, Elin; Wibowo, Marlia Singgih
Jurnal Farmasi Indonesia Vol 8, No 2 (2016)
Publisher : Jurnal Farmasi Indonesia

Marine microorganisms, especially actinomycetes bacteria and fungi produce a variety of secondary metabolites that biologically active and have a unique structure. This study aims to isolate some strains of marine fungi that grow on marine algae as a potential source of antimicrobial agent. Marine fungal strains isolated from the marine algae with antimicrobial activity screening is done by using the disc diffusion method. In this study, it was obtained 18 strains of fungal isolates. The screening results that give best antimicrobial activity shown by the activity of the extract liquid culture of fungal isolate strain AKT.C6 are 10.0 mm against the bacteria Escherichia coli and 10.8 mm against Bacillus subtilis. Mycelium extract of fungal isolates strain AKT.C4 is 16.9 mm against the bacteria Escherichia coli and 17.6 mm against Bacillus subtilis, while the liquid culture extract and mycelium extract did not show any activity against Candida albicans. The isolation of fungi from Kappaphycus alvarezii algaee has potential as an antibacterial agent.

Page 34 of 45 | Total Record : 443

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